马悦
发布人:生工学院网站管理员  发布时间:2022-06-09   动态浏览次数:13

 

马悦

  

生物学专业:硕士生导师

生物与医药专业(生物工程领域):硕士生导师



马悦,男,华东理工大学生物化工专业工学博士,生物工程学院副教授,国家现代农业产业技术体系海水鱼疾控岗位核心成员。主要从事病原微生物分子致病机制及免疫防控技术研究,专注于水产动物重大疫病新型疫苗创制的科学研究与成果转化。主持与参与国家自然科学基金重点项目、面上项目、国家海水鱼产业技术体系项目、国家重点研发计划政府间国际合作科技创新合作项目、上海市“科技科技创新行动计划”农业重点攻关项目。近五年来,以第一/通讯/共通作者等在Appl Environ MicrobiolVaccineFish Shellfish ImmunMicrobiol ResPLoS PathogNucleic Acids ResSCI期刊累计发表论文20余篇。第一发明人授权鱼类疫苗中国发明与实用新型专利7项、美国专利1项。主编和参编国内和国外专著3部;制定发布水产疫苗团体标准1项(第一起草人)。获批国内首例鱼类基因工程活疫苗转基因生物安全证书1项、国内首例鱼类基因工程活疫苗国家一类新兽药注册证1项(获选2021年度中国农业农村十大新技术)。在教学方面,主讲研究生课程《微生物病原与疫苗学》及本科生课程《感染病学与疫苗工程》。

 

研究方向


1. 水生病原微生物分子致病机制与VBNC机制:揭示阐明致病菌在鱼类宿主和水生环境中的存活流行、免疫逃逸和发病分子机制,为创新疫苗的理性设计提供防控靶点。

2. 水生动物多病原共感染分子机制:面对水生环境中广泛存在的多病原共感染的复杂疾病科学问题,致力于共感染下病原-宿主互作关键信号分子的发现,以期阐释病毒共感染下的细菌定植与侵袭分子机制,为广谱疫苗的创制提供创新靶点。

3. 水产动物疫苗智造技术开发与产业标准制定:在灭活技术、疫苗抗原保护与递送等工程制造环节进行新技术、新材料与新工艺的创新开发研究。



代表性论文

  1. Mengqing Zhou, Yuping Huang, Yuanxing Zhang, Qiyao Wang, Yue Ma, Shuai Shao. Roles of virulence regulator ToxR in viable but non-culturable formation by controlling reactive oxygen species resistance in pathogen. Microbiological Research 2021, 254:126900.

  2. Jun Zhang, Bing Liu, Dan Gu, Yuan Hao, Mo Chen, Yue Ma, Xiaohui Zhou, David Reverter, Yuanxing Zhang and Qiyao Wang. Binding site profiles and N-terminal minor groove interactions of the master quorum-sensing regulator LuxR enable flexible control of gene activation and repression. Nucleic Acids Research, 2021, 49(6):3274-3293.

  3. Kaiyu Yin, Yue Peng, Moamer A.H. Ahmed, Jiabao Ma, Rongjing Xu, Yuanxing Zhang, Yue Ma, Qiyao Wang. PepA binds to and negatively regulates esrB to control virulence in the fish pathogen Edwardsiella piscicida. Microbiological Research 2020, 232:126349.

  4. Dan Gu, Jun Zhang, Yuan Hao, Rongjing Xu, Yuanxing Zhang, Yue Ma, Qiyao Wang. Alternative sigma factor RpoX is a part of the RpoE regulon and plays distinct roles in stress responses, motility, biofilm formation, and hemolytic activities in the marine pathogen Vibrio alginolyticus. Applied and Environmental Microbiology 2019, 85(14):e00234-19.

  5. Lifan Wei, Yanyan Wu, Guanhua Yang, Rongjing Xu, Xiaohong Liu, Qin Liu, Yuanxing Zhang, Yue Ma, Qiyao Wang. Genome-wide identification of fitness factors in seawater for Edwardsiella piscicida. Applied and Environmental Microbiology 2019, 85(10): e00233-9.

  6. Ruiqing Ma, Guanhua Yang, Rongjing Xu, Xiaohong Liu, Yuanxing Zhang, Yue Ma, Qiyao Wang. Pattern analysis of conditional essentiality (PACE)-based heuristic identification of an in vivo colonization determinant as a novel target for the construction of a live attenuated vaccine against Edwardsiella piscicida. Fish and Shellfish Immunology 2019, 90:65-72.

  7. Ma Yue, Liu Yabo, Wu Yanyan, Jia Lei, Liu Xiaohong, Wang Qiyao, Zhang Yuanxing. An attenuated Vibrio harveyi surface display of envelope protein VP28 to be protective against WSSV and vibriosis as an immunoactivator for Litopenaeus vannamei. Fish and Shellfish Immunology 2019, 95:195-202.

  8. Lifan Wei, Haoxian Qiao, Bing Liu, Kaiyu Yin, Qin Liu, Yuanxing Zhang, Yue Ma, Qiyao Wang. MarTrack: A versatile toolbox of mariner transposon derivatives used for functional genetic analysis of bacterial genomes. Microbiological Research 2019, 228:126306.

  9. Xiaohong Liu, Chenglong Jiao, Yue Ma, Qiyao Wang, Yuanxing Zhang. A live attenuated Vibrio anguillarum vaccine induces efficient immunoprotection in Tiger puffer (Takifugu rubripes). Vaccine  2018, 36:1460-1466.

  10. Zhen Yang, Xuetong Wang, Wensheng Xu, Mian Zhou, Yuanxing Zhang, Yue Ma, Qiyao Wang. Phosphorylation of PppA at threonine 253 controls T6SS2 expression and bacterial killing capacity in the marine pathogen Vibrio alginolyticus. Microbiological Research 2018, 209:70-78.

  11. Yang Guanhua, Cheng Wang, Xuetong Wang, Ruiqing Ma, Huajun Zheng, Qin Liu,Yuanxing Zhang, Yue Ma, Qiyao Wang. Complete genome sequence of the marine fish pathogen Vibrio anguillarum and genome-wide transposon mutagenesis analysis of genes essential for in vivo infection. Microbiological Research 2018, 216:97-107.

  12. Zhen Yang, Xiaohui Zhou, Yue Ma, Mian Zhou, Matthew K. Waldor, Yuanxing Zhang and Qiyao Wang. Serine/threonine kinase PpkA coordinates the interplay between T6SS2 activation and quorum sensing in the marine pathogen Vibrio alginolyticus. Environmental Microbiology 2018, 20(2):903-919.

  13. Yue Ma, Qiyao Wang, Wensheng Xu, Xiaohong Liu, Xiating Gao, Yuanxing Zhang. Stationary phase-dependent accumulation of ectoine is an efficient adaptation strategy in Vibrio anguillarum against cold stress. Microbiological Research 2017, 205:8-18.

  14. Yue Ma, Qiyao Wang, Xiating Gao, and Yuanxing Zhang. Biosynthesis and uptake of glycine betaine as cold-stress response to low temperature in fish pathogen Vibrio anguillarum. Journal of Microbiology  2017, 55(1): 44-55

 

科研著作

  1. Patrick T.K. Woo and Rocco C. Cipriano主编. 王启要, 马悦, 刘晓红. 主译. 鱼类病毒和细菌:病理学与防控. 华东理工大学出版社, 2021, ISBN: 9787562867944.

  2. 马悦, 王启要, 刘晓红, 秦启伟, 曲江波, 李荣, 于凯松. 海水鱼疫苗预防接种管理与实施规程. 标准号: T/HSY 0011-2021, 发布日: 20211207.

  3. Ma Yue (参编). Aquaculture in China: Success Stories and Morden Trends. John Wiley & Sons Ltd. 2018, ISBN: 9781119120742.

  4. 马悦(编委). 海洋生物制品开发与利用. 科学出版社, 2017. ISBN: 9787030551962.

 

    承担科研项目

  1. 脂滴代谢介导杀鱼爱德华氏菌与鱼类细胞的互作机制. 国家自然科学基金重点项目,2022.01-2026.12,参加(排序第3

  2. 靶向生物被膜的水产弧菌病绿色控制策略开发. 国家重点研发计划政府间国际创新合作项目, 2022.06-2025.05. 参加(排序第2

  3. 国家海水鱼体系岗位科学家. 国家现代农业产业技术体系项目,2021.01-2025.12, 参加(排序第2

  4. ToxR作为分子开关调控溶藻弧菌进入存活但不可培养状态(VBNC)的分子机制. 国家自然科学基金面上项目,2018.01-2021.12,主持

 

联系方式

办公地址:上海市梅陇路130号华东理工大学实验室18815

联系电话:021-64253306          Emailmymarine@ecust.edu.cn