陶欣艺

生物与医药专业（生物工程领域）：硕士生导师

女，理学博士，生物工程专业硕士生导师。2004年毕业于南京中医药大学获药学硕士学位，2018年毕业于华东理工大学，获生物化学与分子生物学博士学位。2004年7月进入华东理工大学生物工程学院工作至今，长期从事于生物药物和合成生物学等领域相关研究工作。主持和参与国家自然科学基金、“973”课题、重大专项以及企业横向项目12项，发表学术论文30余篇，授权发明专利3项，获得省部级科技奖项4项，科技成果转让4项。

主要研究方向：

1）纳米抗肿瘤药物：智能靶向释放纳米抗肿瘤前药平台技术研发及其新药临床前研究。

2）合成生物学：天然产物微生物异源合成研究，致力于链霉菌细胞工厂的开发与应用。

3）新型酶制剂研发与应用：酶资源开发及表达、酶制剂修饰、理性设计及应用。

代表性论文：

1. Xin-Yi Tao, Yang-Chen Lin, Feng-Qing Wang, Qing-Hai Liu, Yu-Shu Ma*, Min Liu *, Dong-Zhi Wei. Production of sesquiterpene patchoulol in mitochondrion-engineered Saccharomyces cerevisiae. Biotechnology Letters. (Accepted)

2. Ming Zhao, Mingrui Wang, Shuiling Wang, Liangbin Xiong, Bei Gao, Min Liu, Xinyi Tao*, Feng-Qing Wang*, and Dongzhi Wei. A Self-Sustained System Spanning the Primary and Secondary Metabolism Stages to Boost the Productivity of Streptomyces. ACS Synth. Biol. 2022, 11(1): 353–365.

3. Rui Niu, PeiLei Zhang, FengQing Wang, Min Liu, QingHai Liu, Ning Jia, ShengLi Yang, XinYi Tao*, DongZhi Wei. Preparation and purification of novel phosphatidyl prodrug and performance modulation of phosphatidyl nanoprodrug. Bioresources and Bioprocessing.2019, 6(42):43-55..

4. Tao Xinyi, Zhao M, Zhang Y, Liu M, Liu Q, Wang W, Wang FQ*, Wei D. Comparison of the expression of phospholipase D from Streptomyces halstedii in different hosts and its over-expression in Streptomyces lividans. FEMS Microbiol Lett. 2019,366(5):51-59.

5. Zhao Ming, Wang Shui-Ling, Tao Xinyi*, Zhao Guo-Ling, Ren Yu-Hong, Wang Feng-Qing, Wei Dong-Zhi. Engineering diverse eubacteria promoters for robust Gene expression in Streptomyces lividans. J. Biotechnol, 2019, 289: 93-102.

6. Zhao Ming, Tao Xinyi*, Wang, Feng-Qing, Ren Yu-Hong, Wei Dong-Zhi. Establishment of a low-dosage-IPTG inducible expression system construction method in Escherichia coli. J Basic Microb. 2018, 58(9): 806-810.

7. Xinyi Tao, Ning Jia, Nenghui Cheng, Yuhong Ren, Xuni Cao, Min Liu, Dongzhi Wei*, Feng-Qing Wang*. Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug. Biomaterials, 2017, 131: 1-14.

8. Jiaqi Wang, Xinyi Tao(共一作者), Yufei Zhang, Dongzhi Wei, Yuhong Ren*. Reversion of multidrug resistance by tumor targeted delivery of antisense oligodeoxynucleotides in hydroxypropyl-chitosan nanoparticles. Biomaterials, 2010, 05: 4426-33.

9. Ma Bin, Liu Min, Li Zhen-Hai, Tao Xinyi, Wei Dong-Zhi, Wang Feng-Qing*. Significantly Enhanced Production of Patchoulol in Metabolically Engineered Saccharomyces cerevisiae. J. Agric. Food Chem, 2019,67(31):8509-8598.

10. Liu Min, Xiong Liang-Bin, Tao Xinyi, Liu Qing-Hai, Wang Feng-Qing*, Wei Dong-Zhi*. Metabolic Adaptation of Mycobacterium neoaurum ATCC 25795 in the Catabolism of Sterols for Producing Important Steroid Intermediates. J. Agric. Food Chem., 2018, 66 (45): 12141–12150.

11. Min Liu, Liang-Bin Xiong, Xinyi Tao, Qing-Hai Liu, Feng-Qing Wang*, Dong-Zhi Wei*. Integrated Transcriptome and Proteome Studies Reveal the Underlying Mechanisms for Sterol Catabolism and Steroid Production in Mycobacterium neoaurum. J. Agric. Food Chem., 2018, 66(34): 9147-9157.

12. Hao-Hao Liu, Li-Qin Xu, Kang Yao, Liang-Bin Xiong, Xin-Yi Tao, Min Liu, Feng-Qing Wang*, Dong-Zhi Wei*. Engineered 3-Ketosteroid 9 alpha-Hydroxylases in Mycobacterium neoaurum: an Efficient Platform for Production of Steroid Drugs. Applied and Environmental Microbiology. 2018, 84(14): 2777-17

13. Jinmao Zhang, Xinyi Tao, Jianwen Liu, Dongzhi Wei, Yuhong Ren*. Fe3+-induced bioinspired chitosan hydrogels for the sustained and controlled release of doxorubicin. RSC Advances. 2016, 6, 47940 – 47947.

14. Jian Zhang, Rui Xu, Xinyi Tao, Yuguo Dong, Xinxin Lv, Aiyou Sun*, Dongzhi Wei*. An endoplasmic reticulum-targeted recombinant fusion protein TAT-IL-24-KDEL-induced apoptosis is inhibited by survivin but restored by the small molecular survivin inhibitor, YM155, in cancer cells. Oncotarget. 2016, 7：37030-37042

15. Min Liu, Zhan-Tao Zhu, Xin-Yi Tao, Feng-Qing Wang*, Dong-Zhi Wei*. RNA-seq analysis uncovers non-coding small RNA system of Mycobacterium neoaurum in the metabolism of sterols to accumulate steroid intermediates. Microbial cell Factories. 2016, 15:1-17.

16. Min Liu, Zhan-Tao Zhu, Xin-Yin Tao, Feng-Qing Wang*, Dong-Zhi Wei*. Single nucleotide polymorphism analysis for the production of valuable steroid intermediates in Mycobacterium neoaurum. Biotechnology Letters. 2016, 38: 1881-1892.

17. Xin-Bing Liu, Min Liu, Xin-Yi Tao, Zhong-Xi Zhang, Feng-Qing Wang*, Dong-Zhi Wei. Metabolic engineering Pichia pastoris for the production of dammarenediol-II. Journal of Biotechnology. 2015,216,47-55.

教学：

本科生专业课《生物化学》

本科生专业实验课《食品毒理学实验》

研究生专业课《医药生物技术前沿进展》

获奖

甾体转化的细胞工厂创建及甾体药物绿色制造技术，上海市技术发明奖二等奖，2018。

甾体药物细胞工厂与绿色制造技术，中国石油与化学工业联合会技术发明奖一等奖，2017。

定向转化多元醇的细胞催化剂创制及其应用关键技术，上海市技术发明奖一等奖，2013。

工业酶制剂的创制与产业化关键技术，上海市科技进步奖一等奖，2010。

联系方式：

上海市梅陇路130号311信箱 邮编:200237

办公室：鲁华生物技术研究所（实验14楼东楼）401室

电话: 021-64253287；13611713966

E-mail: xytao@ecust.edu.cn