安法梁
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安法梁


生物工程专业:硕士生导师

生物学专业:硕士生导师

生物与医药专业(生物工程领域):硕士生导师



安法梁,副教授。入选上海扬帆计划2017)。获华东理工大学“优秀兼职辅导员”(2020)、校园新星-科研新星2021)、奉贤区五美五强2021)等荣誉称号。担任上海市药学会海洋专业委员会秘书(2020-2024)。承担国家自然科学基金、国家重点研发计划课题、国家重点研发子课题等多个国家级/省部级项目。已在Acta Pharmaceutica Sinica BOrganic Letters, Plant JournalChinese Chemical LetterMarine Drugs专业领域Top期刊等杂志发表论文30余篇;申请发明专利6项,授权3项。指导本科生承担国家级/上海市级大学生创新创业训练计划”4项,挑战杯中国大学生创业计划竞赛上海市银奖


教育经历

2011.09-2016.06   中国药科大学   药物化学   理学博士   导师: 孔令义教授

2007.09-2011.06   中国药科大学   中药学      理学学士


工作经历

2021.09-至今        华东理工大学   生物工程学院   副教授

2019.01-2021.08  华东理工大学   生物工程学院   特聘副研究员

2016.07-2018.12  华东理工大学   生物工程学院   师资博士后


研究方向

1. 海洋来真菌来源活性复杂天然产物研究

基于真菌基因组的生物信息学和波谱学分析为导向的具有新颖复杂活性天然产物的快速发现和活性机制研究;

2. 海洋微生物来源活性分子发酵过程优化与放大

通过对菌丝形态、前体代谢调控、生物合成途径、发酵过程参数优化与控制,提高药用活性分子产物的产量,攻克“药源瓶颈”;

3.中药或药用植物来源化妆品添加剂的筛选和机制研究

通过对传统药用植物功能分子的活性筛选、生物转化和作用机制研究,提高植物提取物活性,阐明提取物活性物质基础和作用机理,开发新型化妆品添加剂;


代表性论文

1. Ding, Yi; Jiang, Yu; Xu, Sun-Jie; Xin, Xiu-Juan; An, Fa-Liang*, Perpyrrospirone A, an unprecedented hirsutellone peroxide from the marine-derived Penicillium citrinum. Chinese Chemical Letters 2022. (IF 8.455, JCR Q1)

2. Zhou, Chen; Yang, Yu-Hui; Tian, Jing-Yi; Wu, Yi-Han; An, Fa-Liang*; Li, Chang-Fu*; Zhang, Yan-Sheng*, 22R- but not 22S-hydroxycholesterol is recruited for diosgenin biosynthesis. Plant Journal2022, 109: 940-951. (IF 7.091, JCRQ1)

3. Yang, Fan; Hua, Qiang; Yao, Li-Gong; Liang, Lin-Fu; Lou, Yu-Xia, Lu, Yan-Hua; An, Fa-Liang*; Guo, Yue-Wei*, One uncommon bis-sesquiterpenoid from the Xisha soft coral Litophyton nigrum. Tetrahedron Letters2022, 88: 153571. (IF 2.032, JCR Q3)

4. Wang Ling-Xu; Zheng Gao-Fan; Xin Xiu-Juan; An, Fa-Liang*, Development of a high-titer culture medium for the production of cholesterol by engineered Saccharomyces cerevisiae and its fed-batch cultivation strategy. Journal of Microbiology and Biotechnology 2021,32 (1). (IF 3.277, JCR Q3)

5. Qiu, Xiao-Han; Gong, Li-Zhi; Xin, Xiu-Juan; An, Fa-Liang*, Enhancement of emodin production by medium optimization and KH2PO4 supplementation in submerged fermentation of marine-derived Aspergillus Favipes HN4-13. Marine Drugs 2021,19 (8), 421. (IF 6.085, JCR Q1)

6. Wang, Zhi-Jie; Jiang, Yu; Xin, Xiu-Juan; An, Fa-Liang*, Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus. Fitoterapia 2021,153, 104973. (IF 3.204, JCR Q3)

7. Yang, Fan; Hua, Qiang; Yao, Li-Gong; Liang, Lin-Fu; Lu, Yan-Hua; An, Fa-Liang*; Guo, Yue-Wei*, Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum. Fitoterapia2021,151, 104906. (IF 3.204, JCR Q3)

8. Yang, Jin; Gong, Li-Zhi; Guo, Miao-Miao; Jiang, Yu; Ding, Yi; Wang, Zhi-Jie; Xin, Xiu-Juan; An, Fa-Liang*, Bioactive indole diketopiperazine alkaloids from the marine endophytic fungus Aspergillus sp. YJ191021.Marine Drugs2021, 19 (3), 157. (IF 6.085, JCR Q1)

9. Ding, Yi; Zhu, Xiao-Jing; Hao, Li-Ling; Zhao, Meng-Yao; Hua, Qiang; An, Fa-Liang*, Bioactive indolyl diketopiperazines from the marine derived endophytic Aspergillus versicolor DY180635. Marine Drugs2020, 18 (7), 338. (IF 6.085, JCR Q1)

10. Zhu, Xiao-Jing; Mao, Yue; Guo, Miao-Miao; Yu, Hai-Yua; Hao, Li-Ling; Hua, Qiang; Lu, Zhi; Hong, Min-Hua; An, Fa-Liang*, Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens. Journal of Bioscience and Bioengineering2020, 130 (5), 457-463. (IF 3.185, JCR Q3)

11. An, Fa-Liang; Wang, Xiao-Bing; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Bioactive A-ring rearranged limonoids from the root barks of Walsura robusta. Acta Pharmaceutica SinicaB2019, 9 (3), 545-556. (IF 14.903, JCR Q1)

12. Ding, Yi (#), An, Fa-Liang(#), Zhu, Xiao-Jing, Yu, Hai-Yuan, Hao, Li-Ling* and Lu, Yan-Hua*, Curdepsidones B-G, six depsidones with anti-inflammatory activities from the marine-derived fungus Curvularia sp. IFB-Z10. Marine Drugs 2019, 17, 266. (IF 6.085, JCR Q1)

13. An, Fa-Liang; Yin, Yong; Luo, Jun; Kong, Ling-Yi*, Highly oxygenous trichilin-type limonoids from Trichilia sinensis. Chinese Journal of Natural Medicines 2019, 17 (12), 912-917. (IF 3.887, JCR Q2)

14. An, Fa-Liang; Liu, Wei-He; Zhang, Yi; Tao, Jun; Lu, Yan-Hua*, Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10. Phytochemistry Letters 2019, 29, 12-16. (IF 1.873, JCR Q3)

15. Wei, Xing-Chen; Liu, Chang-Qing; Zhang, Ri-Yu; Zheng, Gao-Fan; An, Fa-Liang *; Lu, Yan-Hua*, Improvement of curvulamine production by precursors co-addition strategy in liquid culture of marine-derived fungus Curvularia sp. IFB-Z10. Applied Biochemistry and Biotechnology 2019, 1-17. (IF 3.094, JCR Q3)

16. Ji, Xiang; Wei, Xing; Qian, Jie; Mo, Xue-Jun; Kai, Guo-Yin; An, Fa-Liang*; Lu, Yan-Hua*, 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells. Food and Chemical Toxicology 2019, 131, 110533. (IF 5.572, JCR Q1)

17. An, Fa-Liang; Sun, Dong-Mei; Wang, Xiao-Bing; Yang, Lei; Yin, Yong; Luo, Jun*; Kong, Ling-Yi*, Trichiconlides C-F, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides. Fitoterapia 2018, 125, 72-77. (IF 3.204, JCR Q3)

18. An, Fa-Liang; Sun, Dong-Mei; Wang, Rui-Zhi; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Trijugin- and mexicanolide-type limonoids from the fruits of Heynea trijuga that reverse multidrug resistance in MCF-7/DOX cells. Phytochemistry 2018,151, 42-49. (IF 4.004, JCR Q1)

19. Liu, Wei-He; Ding, Yi; Ji, Xiang.; An, Fa-Liang*; Lu, Yan-Hua*, Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp. The Journal of Antibiotics (Tokyo) 2018, 72, 111-113. (IF 3.424, JCR Q2)

20. An, Fa-Liang; Sun, Dong-Mei; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Yin, Yong; Kong, Ling-Yi*; Luo, Jun*, Walrobsins A and B, two anti-inflammatory limonoids from root barks of Walsura robusta. Organic Letters 2017,19, 4568-4571. (IF 6.072, JCR Q1)

21. Yu, Wan-Guo; Pan, Zheng-Hua; Zhu, Yi-Xiang; An, Fa-Liang*; Lu, Yan-Hua*, Fumigaclavine C exhibits anti-inflammatory effects by suppressing high mobility group box protein 1 relocation and release. European Journal of Pharmacology 2017,812, 234-242. (IF 5.195, JCR Q2)

22. Tang, Liu; Wei, Xing-Chen; An, Fa-Liang*; Lu, Yan-Hua*, Preparative separation of TL1-1 from Daldinia eschscholzii extract by macroporous resin and evaluation of its antimicrobial activities. Journal of Chromatography B 2017, 1060, 22-29. (IF 3.318, JCR Q2)

23. An, Fa-Liang; Wang, Xiao-Bing; Wang, Hui; Li, Zhong-Rui; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Cytotoxic rocaglate derivatives from leaves of Aglaia perviridis. Scientific Reports 2016, 6, 20045. (IF 4.996, JCR Q2)

24. An, Fa-Liang; Luo, Jun; Wang, Xiao-Bing; Yang, Ming-Hua; Kong, Ling-Yi*, Trichiconlides A and B: two novel limonoids from the fruits of Trichilia connaroides. Organic & Biomolecular Chemistry2016, 14 (4), 1231-1235. (IF 3.89, JCR Q1)

25. An, Fa-Liang; Luo, Jun; Li, Rui-Jun; Luo, Jian-Guang; Wang, Xiao-Bing; Yang, Ming-Hua; Yang, Lei; Yao, He-Quan; Sun, Hong-Bin; Chen, Yi-Jun; Kong, Ling-Yi*, Spirotrichilins A and B: two rearranged spirocyclic limonoids from Trichilia connaroides. Organic Letters 2016,18 (8), 1924-1927. (IF 6.072, JCR Q1)

26. An, Fa-Liang; Wang, Jun-Song; Wang, Hui; Wang, Xiao-Bing; Yang, Ming-Hua; Guo, Qing-Long; Dai, Yue; Luo, Jun; Kong, Ling-Yi*, Cytotoxic flavonol-diamide [3+2] adducts from the leaves of Aglaia odorata. Tetrahedron 2015, 71 (16), 2450-2457. (IF 2.388, JCR Q2)

 

发明专利

1.安法梁,邱潇涵,弓丽芝,谭仁祥,陈勇。利用海洋真菌黄柄曲霉HN4-13生产大黄素的培养基及其制备方法。申请号:202011525989.X,公开号:CN112481139A

2.安法梁,王凌旭,叶蓓,章焰生。利用工程酿酒酵母高效生产胆固醇的发酵培养基及其制备方法。申请号:202110018952.6,公开号:CN112626159A

3.安法梁,郑高帆,朱云飞,鞠建华,马俊英。利用深海链霉菌生产怡莱霉素E的培养基及其制备方法。申请号:202110053546.3,公开号:CN112608965A

4.安法梁,郑高帆,朱云飞,鞠建华,马俊英。深海链霉菌基因工程突变株生产怡莱霉素E的高产培养基及其规模化发酵工艺。申请号:202210055630.3,公开号:CN114540446A

5.洪民华,朱筱婧,冒玥,段天碧,刘丹,安法梁,吕智。一种中草药的发酵方法及发酵产物的应用。申请号:202010182198.5,公开号:CN113398163A

6.弓丽芝,安法梁,胡杨,熊献美,辛秀娟,糜烨。一种生物碱的提取方法及其在制备消炎祛痘制品中的应用。申请号:202111650896.4,公开号:CN114191431A


联系方式

上海市徐汇区梅陇路130号,实验十八楼1203A

电话:021-64253823 Emailflan2016@ecust.edu.cn