安法梁
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安法梁


生物工程专业:硕士生导师

生物化学与分子生物学专业:硕士生导师

微生物学专业:硕士生导师

生物与医药专业:硕士生导师


副教授,主要从事海洋微生物和中国特色植物来源次生代谢产物研究。主持国家自然科学基金面上项目、国家自然科学基金青年基金,国家重点研发计划课题、国家重点研发计划子课题、中国博士后基金特别资助,中国博士后基金面上项目,上海市“扬帆计划”和企业横向课题等科研项目,总经费600余万元。在天然产物领域主流期刊发表SCI论文40余篇;申请中国发明专利3项。


教育经历

2011.09-2016.06 中国药科大学药物化学理学博士导师: 孔令义教授

2007.09-2011.06 中国药科大学中药学  理学学士


工作经历

2021.09-至今  华东理工大学生物工程学院副教授

2019.01-2021.08 华东理工大学生物工程学院特聘副研究员

2016.07-2018.12 华东理工大学生物工程学院师资博士后


研究方向

1. 海洋来真菌来源活性复杂天然产物研究

基于真菌基因组的生物信息学和波谱学分析为导向的具有新颖复杂活性天然产物的快速发现、鉴定、生物合成和活性筛选;

2. 海洋微生物来源活性分子发酵过程优化与放大

通过对菌丝形态、前体代谢调控、生物合成途径、发酵过程参数优化与控制,提高霉菌产药用活性分子产物的产量;

3. 中国特色植物来源化妆品添加剂的筛选和机制研究

通过对传统药用植物功能分子的活性筛选、生物转化和作用机制研究,提高提取物活性,阐明提取物活性物质基础和作用机理,开发新型化妆品添加剂;


纵向科研项目

1. 国家自然科学基金青年基金(81703388, 2018.01-2020.12, 主持)

2. 国家自然科学基金面上项目(41876189, 2019.01-2022.12, 主持)

3. 国家重点研发计划课题(2018YFC1706206, 2018.12-2020.12, 主持)

4. 国家重点研发计划子课题(2018YFC1706201, 2018.01-2020.12, 主持)

5. 中国博士后基金特别资助(2018T110359, 2018.07-2020.06, 主持)

6. 中国博士后基金面上项目(2016M601532, 2016.11-2018.10, 主持)

7. 上海市青年英才“扬帆计划”(17YF14033700, 2017.05-2020.04, 主持)

8. 中央高校基本科研业务费研究基金 (222201714023, 2017.03-2018.02, 主持)


代表性论文

1. Qiu, Xiao-Han; Gong, Li-Zhi; Xin, Xiu-Juan; An, Fa-Liang*, Enhancement of Emodin Production by Medium Optimization and KH2PO4 Supplementation in Submerged Fermentation of Marine-Derived Aspergillus Favipes HN4-13. Marine Drugs 2021,19 (8), 421.

2. Wang, Zhi-Jie; Jiang, Yu; Xin, Xiu-Juan; An, Fa-Liang*, Bioactive indole alkaloids from insect derived endophytic Aspergillus lentulus. Fitoterapia 2021,153, 104973.

3. Yang, Fan; Hua, Qiang; Yao, Li-Gong; Liang, Lin-Fu; Lu, Yan-Hua; An, Fa-Liang*; Guo, Yue-Wei*, Further new nardosinane-type sesquiterpenoids from the Xisha soft coral Litophyton nigrum. Fitoterapia 2021,151, 104906.

4. Yang, Jin; Gong, Li-Zhi; Guo, Miao-Miao; Jiang, Yu; Ding, Yi; Wang, Zhi-Jie; Xin, Xiu-Juan; An, Fa-Liang*, Bioactive Indole Diketopiperazine Alkaloids from the Marine Endophytic Fungus Aspergillus sp. YJ191021. Marine Drugs 2021,19 (3), 157.

5. Ding, Yi; Zhu, Xiao-Jing; Hao, Li-Ling; Zhao, Meng-Yao; Hua, Qiang; An, Fa-Liang*, Bioactive Indolyl Diketopiperazines From the Marine Derived Endophytic Aspergillus versicolor DY180635.Marine drugs 2020,18(7), 338.

6. Zhu, Xiao-Jing; Mao, Yue; Guo, Miao-Miao; Yu, Hai-Yua; Hao, Li-Ling; Hua, Qiang; Lu, Zhi; Hong, Min-Hua; An, Fa-Liang*, Enhancement of anti-acne effect of Scutellaria baicalensis extract by fermentation with symbiotic fungus Penicillium decumbens. Journal of Bioscience and Bioengineering 2020,130 (5), 457-463.

7. An, Fa-Liang; Wang, Xiao-Bing; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Bioactive A-ring rearranged limonoids from the root barks of Walsura robusta. Acta Pharmaceutica Sinica B 2019,9 (3), 545–556.

8. Ding, Yi (#), An, Fa-Liang(#), Zhu, Xiao-Jing, Yu,Hai-Yuan, Hao, Li-Ling* and Lu, Yan-Hua*, Curdepsidones B–G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10. Marine Drugs2019,17, 266.

9. An, Fa-Liang; Yin, Yong; Luo, Jun; Kong, Ling-Yi*, Highly oxygenous trichilin-type limonoids from Trichilia sinensis. Chinese Journal of Natural Medicines 2019,17 (12), 912-917.

10. An, Fa-Liang; Liu, Wei-He; Zhang, Yi; Tao, Jun; Lu, Yan-Hua*, Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10. Phytochemistry Letters2019,29, 12-16.

11. Wei, Xing-Chen; Liu, Chang-Qing; Zhang, Ri-Yu; Zheng, Gao-Fan; An, Fa-Liang *; Lu, Yan-Hua*, Improvement of Curvulamine Production by Precursors Co-addition Strategy in Liquid Culture of Marine-Derived Fungus Curvularia sp. IFB-Z10. Applied Biochemistry and Biotechnology 2019, 1-17.

12. Ji, Xiang; Wei, Xing; Qian, Jie; Mo, Xue-Jun; Kai, Guo-Yin; An, Fa-Liang*; Lu, Yan-Hua*, 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells. Food and Chemical Toxicology2019,131, 110533.

13. An, Fa-Liang; Sun, Dong-Mei; Wang, Xiao-Bing; Yang, Lei; Yin, Yong; Luo, Jun*; Kong, Ling-Yi*, Trichiconlides C-F, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides. Fitoterapia2018,125, 72-77.

14. An, Fa-Liang; Sun, Dong-Mei; Wang, Rui-Zhi; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Trijugin- and mexicanolide-type limonoids from the fruits of Heynea trijuga that reverse multidrug resistance in MCF-7/DOX cells. Phytochemistry2018,151, 42-49.

15. An, Fa-Liang; Liu, Wei-He; Wei, Xing-Chen; Pan, Zheng-Hua; Lu, Yan-Hua*, Curdepsidone A, a Depsidone from the Marine-Derived Endophytic Fungus Curvularia sp. IFB-Z10. Natural Product Communications 2018,13 (7), 865-866.

16. Liu, Wei-He; Ding, Yi; Ji, Xiang.; An, Fa-Liang*; Lu, Yan-Hua*, Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp. The Journal of Antibiotics (Tokyo)2018,72, 111-113.

17. An, Fa-Liang; Sun, Dong-Mei; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Yin, Yong; Kong, Ling-Yi*; Luo, Jun*, Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta. Organic Letters2017,19, 4568-4571.

18. Yu, Wan-Guo; Pan, Zheng-Hua; Zhu, Yi-Xiang; An, Fa-Liang*; Lu, Yan-Hua*, Fumigaclavine C exhibits anti-inflammatory effects by suppressing high mobility group box protein 1 relocation and release. European Journal of Pharmacology2017,812, 234-242.

19. Tang, Liu; Wei, Xing-Chen; An, Fa-Liang*; Lu, Yan-Hua*, Preparative separation of TL1-1 from Daldinia eschscholzii extract by macroporous resin and evaluation of its antimicrobial activities. Journal of Chromatography B2017,1060, 22-29.

20. An, Fa-Liang; Wang, Xiao-Bing; Wang, Hui; Li, Zhong-Rui; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis. Scientific Reports2016,6, 20045.

21. An, Fa-Liang; Luo, Jun; Wang, Xiao-Bing; Yang, Ming-Hua; Kong, Ling-Yi*, Trichiconlides A and B: two novel limonoids from the fruits of Trichilia connaroides. Organic Biomolecular Chemistry 2016,14 (4), 1231-1235.

22. An, Fa-Liang; Luo, Jun; Li, Rui-Jun; Luo, Jian-Guang; Wang, Xiao-Bing; Yang, Ming-Hua; Yang, Lei; Yao, He-Quan; Sun, Hong-Bin; Chen, Yi-Jun; Kong, Ling-Yi*, Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids from Trichilia connaroides. Organic Letters2016,18 (8), 1924-1927.

23. An, Fa-Liang; Wang, Jun-Song; Wang, Hui; Wang, Xiao-Bing; Yang, Ming-Hua; Guo, Qing-Long; Dai, Yue; Luo, Jun; Kong, Ling-Yi*, Cytotoxic flavonol-diamide [3+2] adducts from the leaves of Aglaia odorata. Tetrahedron2015,71 (16), 2450-2457.


发明专利

1.安法梁,邱潇涵,弓丽芝,谭仁祥,陈勇。利用海洋真菌黄柄曲霉HN4-13生产大黄素的培养基及其制备方法。申请号:202011525989.X,公开号:CN112481139A

2.安法梁,王凌旭,叶蓓,章焰生。利用工程酿酒酵母高效生产胆固醇的发酵培养基及其制备方法。申请号:202110018952.6,公开号:CN112626159A

3.安法梁,郑高帆,朱云飞,鞠建华,马俊英。利用深海链霉菌生产怡莱霉素E的培养基及其制备方法。申请号:202110053546.3,公开号:CN112608965A

 

联系方式

地址:上海市徐汇区梅陇路130号,实验181203A

电话:021-64253823

邮箱:flan2016@ecust.edu.cn