张敬宇
发布人:生工学院网站管理员  发布时间:2020-02-23   动态浏览次数:3518

张敬宇

 

生物工程、生物化工、生物与医药专业:硕士生导师

 

 张敬宇,副教授。2012年6月毕业于中国药科大学药物化学专业,获得理学博士学位,同年进入中科院微生物研究所从事博士后研究(合作导师张立新教授)。2016年9月入职华东理工大学生物工程学院。长期从事微生物来源的活性天然产物发现、微生物天然产物的生物合成机制解析,现已发表学术论文10余篇,包括发表在Nature BiotechnologyScience BulletinOrganic LettersAppllied Microbiology Biotechnology等期刊上。申请/授权国家发明专利9件,授权3件。多次参加国际学术会议并做报告,获得2017年第六届实验室自动化与筛选国际会议的Travel award(全球6名/届),是国际学术期刊Appllied Microbiology BiotechnologyChemistry of Natural Compounds的论文审稿人。作为项目负责人主持国家自然科学基金面上项目、国家自然科学基金青年基金、上海市青年科技启明星计划(A类)、国家重点研发计划子课题,作为主要技术骨干参与国家重点研发计划子课题、十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项子课题、国家自然科学基金面上项目等多个项目。

 

研究方向:

1. 微生物来源的活性天然产物挖掘:基于生物信息学技术,快速发现放线菌和真菌来源的新颖活性天然产物。

2. 新颖活性天然产物的生物合成机制解析:利用异源表达等策略解析活性天然产物生物合成机制。

 

主持或参加的科研项目或基金:

1. 国家自然科学基金面上项目(21877038),2019/1-2022/12,63万,主持

2. 上海市青年科技启明星计划A类(20QA1402800),2020/5-2023/6,40万,主持

3. 国家自然科学基金青年基金(81302678),2014/1-2016/12,23万,主持

4. 合成生物学国家重点研发计划(2020YFA0907200),2021/1-2025/12,1918万(负责136万元),项目骨干

5. 国家重点研发计划子课题技术骨干(2019YFA0906201),2020/1-2024/12,425万,项目骨干 

6. 国家“十二五”重大传染病专项(2013ZX10005004-005),2013/1-2015/12,399.85万,项目骨干

7. 国家自然科学基金面上项目(81573341),2016/1-2019/12,64万,项目骨干

 

教学:

承担《化学生物学》、《生物化学》、《合成生物学与天然产物药物发现》等专业课程。

 

代表性论文(*通讯作者):   

1. Weishan Wang#,*, Shanshan Li#, Zilong Li#, Jingyu Zhang#, Keqiang Fan, Gaoyi Tan, Guomin Ai, Sin Man Lam, Guanghou Shui, Zhiheng Yang, Hongzhong Lu, Pinjiao Jin, Yihong Li, Xiangyin Chen, Xuekui Xia, Xueting Liu, H. Kathleen Dannelly, Chen Yang, Yi Yang, Siliang Zhang, Gil Alterovitz, Wensheng Xiang*, & Lixin Zhang* Harnessing the intracellular triacylglycerols for titer improvement of polyketides in Streptomyces, Nature Biotechnology, 2020, 38, 76–83.

2. Jingyu Zhang#, Lan Jiang#, Xiangyin Chen, Kangjie Lv, Mostafa Basiony, Guoliang Zhu, Loganathan Karthik, Liming Ouyang, Lixin Zhang, Xueting Liu* Recent advances in biotechnology for marine enzymes and molecules, Current Opinion in Biotechnology 2021, 69:308–315.

3. Lan Jiang#, Guoliang Zhu#, Jianying Han, Chengjian Hou, Xue Zhang, Zhixin Wang, Weize Yuan, Kangjie Lv, Zhanren Cong, Xinye Wang, Xiangyin Chen, Loganathan Karthik, Huanting Yang, Xuyuan Wang, Gaoyi Tan, Guang Liu, Liya Zhao, Xuekui Xia, Xiangyang Liu, Shushan Gao, Lei Ma, Mei Liu, Biao Ren, Huanqin Dai, Ronald J. Quinn, Tom Hsiang*, Jingyu Zhang*, Lixin Zhang, Xueting Liu*, Genome-guided investigation of anti-inflammatory sesterterpenoids with 5-15 trans-fused ring system from phytopathogenic fungi. Applied Microbiology Biotechnology, 2021, 105 (13): 5407–5417.

4. Li Zhang#, Jingyu Zhang#, Biao Ren, Wanying Lu, Chengjian Hou, Jian Wang, Xiaolong Ma, Rong Ma, Mei Liu, Zhiheng Liu, Jin-Ping Li, Kan Ding, Huanqin Dai, Lixin Zhang*, Xueting Liu*. Characterization of anti-BCG benz[α]anthraquinones and new siderophores from a Xinjiang desert–isolated rare actinomycete Nocardia sp. XJ31. Applied Microbiology Biotechnology, 2020, 104:8267–8278.

5. Yaojun Tong#*, Jingyu Zhang#, Nuo Sun#, Xiang-Ming Wang#, Qi Wei, Yu Zhang, Ren Huang,Yingying Pu, Huanqin Dai, Biao Ren, Gang Pei, Fuhang Song, Guoliang Zhu, Xinye Wang, Xuekui Xia, Xiangyin Chen, Lan Jiang, Shenlin Wang, Liming Ouyang, Ning Xie, Buchang Zhang, Yuanying Jiang, Xueting Liu, Richard Calderone, Fan Bai, Lixin Zhang*, Gil Alterovitz. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin, 2021, 66: 1895–1905.

6. Yaojun Tong#*, Jingyu Zhang#, Luoqiang Wang, Qinqin Wang, Huang Huang, Xiangyin Chen, Qing Zhang, Hantian Li, Nuo Sun, Guang Liu, Buchang Zhang, Fuhang Song, Gil Alterovitz, Huanqin Dai*, Lixin Zhang*, Hyper-Synergistic Antifungal Activity of Rapamycin and Peptide-Like Compounds against Candida albicans Orthogonally via Tor1 Kinase. ACS infectious diseases, 2021, doi:10.1021/acsinfecdis.1c00448

7. Jingyu Zhang#, Bixiao Li#, Yujie Qin, Loganathan Karthik, Guoliang Zhu, Chengjian Hou, Lan Jiang, Miaomiao Liu, Xin Ye, Mei Liu, Tom Hsiang, Huanqin Dai*, Zhang LX*, and Xueting Liu,*. A new abyssomicin polyketide with anti-influenza A virus activity from a marine-derived Verrucosispora sp. MS100137. Applied Microbiology Biotechnology, 2019, 104: 1533–1543.

8. Jingyu Zhang#, Zhenzhen Wang#, Zhijun Song#, Loganathan Karthik, Chengjian Hou, Guoliang Zhu, Lan Jiang, Jianying Han, Rong Ma, Li Li, Lixin Zhang*, Xueting Liu*, Tom Hsiang*. Brocaeloid D, a novel compound isolated from a wheat pathogenic fungus, Microdochium majus 99049. Synthetic and Systems Biotechnology. 2019, 4(4):173–179.

9. Jingyu Zhang#, Jianying Han#, Ayokunmi Oyeleye, Miaomiao Liu, Xueting Liu*, Lixin Zhang* Extraction Methods of Natural Products from Traditional Chinese Medicines, Chemical Biology: Methods and Protocols, 2015, 1263: 177185

10. Jianying Han#, Jingyu Zhang#, Wenni He, Pei Huang, Ayokunmi Oyeleye, Xueting Liu*, Lixin Zhang* Bioassay-Guided Identification of Bioactive Molecules from Traditional Chinese Medicines, Chemical Biology : Methods and Protocols, 2015, 1263: 187-196

11. Jingyu Zhang, Wael M. Abdel-Mageed, Miaomiao Liu, Pei Huang, Wenni He, Li Li, Fuhang Song, Huanqin Dai, Jingyu Liang, Xueting Liu*, Lixin Zhang* Caesanines A–D, New Cassane Diterpenes with Unprecedented N Bridge from Caesalpinia sappan, Organic Letters, 2013, 15(18): 4726-4729

12. Jingyu Zhang, Wei Qu, Jing Yu Liang*. A NOVEL INDOLOMONOTERPENIC ALKALOID FROM PROCESSED Semen Strychni. Chemistry of Natural Compounds, 2012, 48(5): 831-833

13. Jingyu Zhang, Fei Hua Wu, Wei Qu, Jing Yu Liang*. Two new cassane diterpenoids from the seeds of Caesalpinia sappan Linn. Chinese Journal of Natural Medicines, 2012, 10(3): 218-221

14. Jingyu Zhang, Wei Qu, Jing Yu Liang*. A new cassane furanoditerpenoid from the seeds of Caesalpinia sappan. Journal of China Pharmaceutical University, 2012, 43(3):209-210

15. Mindong Liang, Zilong Li, Weishan Wang, Jiakun Liu, Leshi Liu, Guoliang Zhu, Loganathan Karthik, Man Wang, Ke-Feng Wang, Zhong Wang, Jing Yu, Yuting Shuai, Jiaming Yu, Lu Zhang, Zhiheng Yang, Chuan Li, Qian Zhang, Tong Shi, Liming Zhou, Feng Xie, Huanqin Dai, Xueting Liu, Jingyu Zhang, Guang Liu, Ying Zhuo, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gil Alterovitz, Gao-Yi Tan* & Li-Xin Zhang*. 2019. A CRISPR-Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nature Communication. 2019, 14;10(1):3672.

16. Han J, Zhang Jingyu, Song Z, Liu M, Hu J, Hou C, Zhu G, Jiang L, Xia X, Quinn RJ, Feng Y, Zhang LX*,Hsiang T*, Liu X*. 2019. Genome- and MS-based mining of antibacterial chlorinated chromones and xanthones from the phytopathogenic fungus Bipolaris sorokiniana strain 11134. Appl Microbiol Biotechnol.103(13):5167-81.

17. Wael M. Abdel-Mageed, Soad A. L. Bayoumi, Lamya H. Al-wahaibi, Li Li, Mohamed S. A. Abdelkader, Hanaa M. Sayed, Mei Liu, Jingyu Zhang, Xueting Liu,*, Lixin Zhang*,. Non-Cyanogenic Cyanoglucoside Cyclooxygenase Inhibitors from Simmondsia chinensis. Organic Letters, 2016, 18(8):17281731.

18. Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Fuhang Song, Huanqin Dai, Jingyu Zhang, Krishna Bolla, Ronald Quinn, Tanja Grkovic, Houwei Luo, Lixin Zhang*, Xueting Liu*. Discovery of tashinone derivatives with anti-MRSA activity via targeted bio-transformation. Synthetic and Systems Biotechnology, 2016, 1, 187–194.

19. Wenni He, Miaomiao Liu, Xiaolin Li, Xiaoping Zhang, Wael M. Abdel-Mageed, Li Li, Wenzhao Wang, Jingyu Zhang, Jianying Han, Huanqin Dai, Ronald J. Quinn, Hung-wen Liu, Houwei Luo, Xueting Liu, * and Lixin Zhang* Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: Evidence for enzyme catalysis and increased antibacterial activity. Applied Microbiology and Biotechnology, 2016, 100(19), 8349–8357.

20. Ling Zhao, Jing Yu Liang*, Jingyu Zhang, Yun Chen. A novel diarylheptanoid bearing flavonol moiety from the rhizomes of Alpinia offcinarum Hance. Chinese Chemical Letters 2010, 21: 194–196.

 

发明专利:

1. 张立新、梁敬钰、张敬宇、刘雪婷、刘苗苗,一种抗菌化合物及其制备方法与应用,专利号:201310378741.9,授权公告日:2015年5月27日

2. 叶昕、张立新、秦玉洁、刘雪婷、叶榛、张敬宇、童晓梅,专利号:201510644254.1, 化合物AJ-4在制备治疗或预防流感病毒的药物中的应用, 授权公告日:2019年1月15日

1. 叶昕、张立新、秦玉洁、刘雪婷、叶榛、张敬宇、童晓梅,化合物AJ-2在制备治疗或预防流感病毒的药物中的应用,专利号:201510644234.4, 授权公告日:2019年2月12日

2. 张立新,刘雪婷,张敬宇,蒋岚,朱国良,韩建营,侯成剑,李碧霄,一类来源于植物病原真菌的helminthosporol型倍半萜类化合物及其制备方法与应用。专利号:201910566725.X

3. 张立新,刘雪婷,张敬宇,朱国良,蒋岚,韩建营,侯成剑,李碧霄,一类来源于植物病原真菌的5-15环二倍半萜化合物及其制备方法与应用。专利号:201910566720.7

4. 张立新,王婷,张敬宇,张丽,刘雪婷,李耀,王珍珍,吴珂,一个来源于海洋链霉菌的碳磷化合物的分离制备方法,专利号:201910441530.2

5. 张立新,吴珂,刘雪婷,张敬宇,朱国良,谭高翼,王珍珍,来源于链霉菌的碳磷化合物及其制备方法与应用,专利号:201910440511.8

6. 高强,张立新,胡栋,张敬宇,谭高翼,一种阿维链霉菌合成培养基及其发酵液的制备方法;公开(公告)号:CN107338210A

7. 张立新,王为善,李珊珊,李子龙,谭高翼,范可强,张敬宇,提高链霉菌聚酮化合物产量的方法;专利号:201910411123.7

 

联系方式:

华东理工大学生物反应器工程国家重点实验室

上海市徐汇区梅陇路130号实验十四楼511,200237

联系电话:021-64253020

邮箱:zhangjingyu@ecust.edu.cn