报告题目:  METABOLIC ENGINEERING OF YEAST FOR PRODUCTION OF FUELS AND CHEMICALS

开始时间:  2017-04-20 10:00:00

报告地点: 逸夫楼演讲厅

报 告 人: 瑞典查尔姆斯理工大学Jens B. Nielsen院士

主办单位: 生物工程学院

摘 要:     In this lecture it will be demonstrated how the Design-Build-Test cycle of Metabolic Engineering has allowed for development of yeast cell factories for production of a range of different fuels and chemicals. Some examples of different technologies will be presented together with examples of metabolic engineering designs, in particular for development of platform strains that can be used for production of a fatty acid derived products, e.g. fatty alcohols and alkanes. It will be argued that with advancement in genome-editing technologies and novel methods for rapid phenotypic screening, advancement in the field is hampered by our design abilities, i.e. to predict genotype-phenotype connections. For this genome-scale metabolic modeling is a strong technology, and in the presentation recent advancements in mathematical modeling for cell factory design will be presented. Finally, the presentation will also demonstrate how the Design-Build-Test cycle can be expanded to incorporate adaptive laboratory evolution to identify targets for engineering complex traits, such as improved tolerance to toxic metabolites like elevated temperatures or low pH.