万民熙
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万民熙


生物工程专业:硕士生导师

食品科学与工程专业:硕士生导师

生物与医药专业(生物工程领域):硕士生导师



 


19819月生,湖南衡阳人,中南大学和美国Johns Hopkins University(约翰斯·霍普金斯大学)联合培养博士,副教授,硕士导师。

入选云南省柔性引才(2018)、华东理工大学青年英才引进与培育计划(2015)、华东理工大学生物工程学院青年交叉创新提升计划(青椒计划,2020)。

一直从事微藻生物技术、合成生物学和光生物反应器方面的研究工作,专注于生物合成技术的产业化工作,已有多项技术实现了产业化。作为项目或课题负责人承担国家重点研发计划课题、863课题、973计划子课题、国家自然科学基金、中央高校基本科研业务费专项基金等多个国家级/省部级项目。在Bioresource TechnologyAlgal ResearchBiotechnology and BioengineeringJournal of Biotechnology等生物技术领域相关期刊上公开发表论文50余篇;编写专著1本、中英文书稿4章;申请发明专利10余项。

担任中国空间科学学会空间生命专业委员、中国藻业协会会员、中国科技核心期刊《现代生物医学进展》常务编委、SCI刊物《Applied Sciences》客座编辑。

 

教育经历/工作履历

2019/8 - 至今,华东理工大学,生物工程学院,副教授

2016/7 - 至今,华东理工大学,生物工程学院,硕士生导师

2012/7 - 2019.7,华东理工大学,生物工程学院,师资博士后、讲师

2007/9 - 2012/6,中南大学,微生物系,博士

2010/1 - 2012/1Johns Hopkins UniversityDepartment of Chemical and Biomolecular Engineering,联合培养博士

2004/9 - 2007/7,中南大学,生物工程系,硕士

1999/9 - 2003/7,中南大学,化学工程系,学士

 

研究方向

[1] 微藻生物技术:高价值生物活性物质的生产工艺开发、分子生物学研究、代谢途径改造、光合细胞工厂优化等。

[2] 合成生物学:主要各类微生物细胞为底盘生物,开发强鲁棒性的细胞工厂进行多肽、蛋白质以及萜类等多种活性物质的高效生物合成,并应用机器学习进行表达元件和生物合成过程的深度优化。

[3] 光生物反应器:用于光合微生物的高效反应器的研制与产业化。

 

承担科研项目

作为负责人承担9个项目/课题:

[1] 国家重点研发计划合成生物学领域课题一项(国拨经费362万)

[2] 国家高技术研究发展计划863课题高产虾青素的雨生红球藻异养-稀释-光诱导串联培养新工艺的优化与工业化放大(国拨经费750万,企业经费800万)

[3] 国家重点基础研究发展计划973项目微藻能源规模化制备的科学基础”-基于光照方向混合及光衰减特性的光生物反应器设计与放大原理子课题光生物反应器热模验证——雨生红球藻培养工艺优化与放大研究

[4] 国家自然科学基金青年科学基金项目雨生红球藻厚壁孢子形成对虾青素合成的相关基因转录调控的影响机制

[5] 云南省课题裸藻工业化生产技术的开发与产业化,(云南省拨经费70万)

[6] 华东理工大学生物工程学院2020 年度青年交叉创新提升计划(青椒计划)项目,异养过程中剪切力对裸藻细胞的伤害机制及其调控

[7] 中国博士后基金,特别资助雨生红球藻厚壁孢子形成与虾青素合成调控的关联机制

[8] 中国博士后面上项目,一等资助雨生红球藻异养-光诱导串联培养中细胞形态调控研究

[9] 中央高校基本科研业务费-探索研究基金雨生红球藻细胞形态转变规律与分子机制及其在细胞培养中的应用

 

教学工作

主讲本科生公选课程《微藻生物技术导论》,合讲本科生课程《海洋生化工程概论》、《海洋生物技术》和研究生课程《海洋生化工程》。

 

近年代表性论文(一作或通讯作者)

  1. Zhongnan Fei, Junjie Liao, Fei Fan, Minxi Wan*(通讯作者), Wenmin Bai, Maolei He, Yuanguang Li*. Improving astaxanthin production by using multivariate statistical analysis to evaluate green cells of Haematococcus pluvialis. Biochemical Engineering Journal, 2022, 183: 108456

  2. Jiangong Zhang, Fei Fan, Tao Yu, Jianpei Chen*, Minxi Wan*(通讯作者), Yuanguang Li. Controlling average number of photons received per biomass to promote the growth of Synechocystis sp. PPC 6803 [J]. Biotechnol Letters, 2022, 44, 767–775

  3. Zhongnan Fei, Fei Fan, Junjie Liao, Minxi Wan*(通讯作者), Wenmin Bai, Weiliang Wang, Maolei He, Yuanguang Li*. Improving astaxanthin production of Haematococcus pluvialis on the outdoor large scale cultivation by optimizing the disinfection strategy of photobioreactor. Algal Research, 2022, 64: 102708

  4. Fei Fan, Zhongnan Fei, Minxi Wan*(通讯作者), Jianke Huang, Weiliang Wang, Wenmin Bai, Maolei He, Yuanguang Li*. The optimization of centrifugal pump driving horizontal tubular photobioreactor for enhancing astaxanthin production using heterotrophic Haematococcus pluvialis. Journal of Biotechnology, 2021, 341: 168–174

  5. Minxi Wan, Haoyu Zhao, Jiacai Guo, Lulu Yan, Daojing Zhang, Wenmin Bai, Yuanguang Li*, Comparison of C-phycocyanin from extremophilic Galdieria sulphuraria and Spirulina platensis on stability and antioxidant capacity, Algal Research, 2021, 58: 102391

  6. Lei Fang, Jingkui Zhang, Zhongnan Fei, Minxi Wan*(通讯作者), Astaxanthin accumulation difference between non-motile cells and akinetes of Haematococcus pluvialis was affected by pyruvate metabolism, Bioresources and Bioprocessing, 2020, 7, 5

  7. Zhen Zhang, Yingying Tan, Weiliang Wang, Wenmin Bai, Jianhua Fan, Jianke Huang, Minxi Wan*(通讯作者), Yuanguang Li*, Efficient heterotrophic cultivation of Chlamydomonas reinhardtii. Journal of applied phycology, 2019,31(3): 1545–1554

  8. Haohua Wang, Zhen Zhang, Minxi Wan*(通讯作者),, Ruixuan Wang, Jianke Huang, Kaikai Zhang, Jiacai Guo, Wenmin Bai, Yuanguang Li*, Comparative study on light attenuation models of Galdieria sulphuraria for efficient production of phycocyanin, Journal of applied phycology, 2019, 32, 165–174

  9. Minxi Wan, Zhen Zhang*, Ruixuan Wang, Wenmin Bai, Jianke Huang, Weiliang Wang, Guomin Shen, Anquan Yu, Yuanguang Li*, High-yield cultivation of Botryococcus braunii for biomass and hydrocarbons, Biomass and Bioenergy, 2019, 131, 105399

  10. Lei Fang, Jingkui Zhang, Zhongnan Fei, Minxi Wan*(通讯作者), Chlorophyll as key indicator to evaluate astaxanthin accumulation ability of Haematococcus pluvialis, Bioresources and Bioprocessing, 2019, 6, 52

  11. Weiliang Wang, Tingting Wei, Jianhua Fan, Jun Yi, Yuanguang Li*, Minxi Wan*(通讯作者), Jun Wang, Wenmin Bai. Repeated mutagenic effects of 60Co-γ irradiation coupled with high-throughput screening improves lipid accumulation in mutant strains of the microalgae Chlorella pyrenoidosa as a feedstock for bioenergy. Algal Research, 2018, 33:71-77

  12. Bin Sheng, Fei Fan, Jianke Huang, Wenmin Bai, Jun Wang, Sulan Li, WeiLi, Minxi Wan*(通讯作者), Yuanguang Li*. Investigation on models for light distribution of Haematococcus pluvialis during astaxanthin accumulation stage with an application case. Algal Research, 2018, 33:182-189

  13. Minxi Wan, Zhenyang Wang, Zhen Zhang, Jun Wang, Shulan Li, Anquan Yu, Yuanguang Li*. A novel paradigm for the high-efficient production of phycocyanin from Galdieria sulphuraria. , Bioresource Technology, 2016, 218: 272-278

  14. Dongda Zhang*#, Minxi Wan#(并列一作), Ehecatl A. del Rio-Chanona, Jianke Huang, Weiliang Wang, Yuanguang Li, Vassilios S. Vassiliadis*. Dynamic Modelling of Haematococcus pluvialis Photoinduction for Astaxanthin Production in both Attached and Suspended Photobioreactors, Algal Research, 2016, 13: 69-78

  15. Minxi Wan#, Zhen Zhang#, Jun Wang, Jianke Huang, Jianhua Fan, Anquan Yu, Weiliang Wang, Yuanguang Li*. Sequential Heterotrophy–Dilution–Photoinduction Cultivation of Haematococcus pluvialis for efficient production of astaxanthin, Bioresource Technology, 2015, 198: 557-563

  16. Minxi Wan, Jingkui Zhang, Dongmei Hou, Jianhua Fan, Yuanguang Li *, Jianke Huang, Jun Wang, The effect of temperature on cell growth and astaxanthin accumulation of Haematococcus pluvialis during a light-dark cyclic cultivation. Bioresource Technology, 2014, 167(8):1958-1964

  17. Minxi Wan, Xuejie Jin, Jinlan Xia *, Julian N. Rosenberg, Geng Yu, Zhenyuan Nie, George A. Oyler, Michael J. Betenbaugh *. The effect of iron on growth, lipid accumulation, and gene expression profile of the freshwater microalga Chlorella sorokiniana. Applied Microbiology and Biotechnology, 2014, 98(22):9473-9481

  18. Minxi Wan#, Dongmei Hou#, Yuanguang Li*, Jianhua Fan, Jianke Huang, Songtao Liang, Weiliang Wang, Ronghua Pan, Jun Wang, Shulan Li. The effective photoinduction of Haematococcus pluvialis for accumulating astaxanthin with attached cultivation. Bioresource Technology, 2014, 163(4), 26-32 

 

 

联系方式:上海市梅陇路130号实验181101室;电话:021-64252104

E-mailwanminxi@ecust.edu.cn