周胜敏
发布人:生工学院网站管理员  发布时间:2021-09-08   动态浏览次数:8527

 

胜敏


生物化学与分子生物学专业:硕士导师

生物化工专业:硕士生导师

生物工程领域:工程硕士生导师



河北石家庄人,博士,副教授,生物反应器工程国家重点实验室固定成员。东京大学博士学位, 东京大学/筑波大学博士后, 学术振兴会(JSPS)特别研究员。201411月入职华东理工大学生物工程学院纳米生物工程实验室千人计划团队。入选上海市浦江人才(A类),华理青年英才引进与培育计划,生工学院优秀青年教师培育计划。承担国家自然科学基金-面上项目2项,科技部新药创制重大专项子课题1项,国家重点研发计划(中日合作) 1项,海市浦江人才项目1项,国家重点实验室开放课题1项。参与国自然重点项目1项。以一作或通讯作者在Nature Chemical BiologyRedox Biology等期刊上发表论文多篇。

研究方向:基础生物学、合成生物学、化学生物学

研究对象:模式霉菌、病原真菌、工业真菌

研究内容:1. 真菌基因编辑技术(CRISPR-Cas9先导编辑Prime editing)的开发、基于CRISPR和纳米技术的生物探针的开发;2. 真菌天然产物及其合成生物学;3. 以真菌为研究对象,阐明其逃逸人体免疫杀菌系统进而感染人体的生物过程,同时挖掘致病因子,为新型抗真菌药物开发提供分子靶标;4. 活性氧ROS抗性及ROS介导的信号传导、细胞凋亡及衰老等相关机制研究;5. 通过研究真菌的集群效应(Quorum sensing)和生物被膜(Biofilm)产生机制,开发基因调控模块,使之服务于药物研发和绿色制造。

具体课题:

1. 真菌的CRISPR-Cas9基因编辑和先导编辑Prime editing技术开发

2. 真菌中基因密码子扩展技术(蛋白药物的非天然氨基酸修饰技术)

3. 真菌基因工程及天然药物产物合成生物学

4. 基因编码型荧光探针技术

5. 真菌耐药机制的解析及新型杀菌靶点挖掘

6. 真菌生物被膜(biofilm)的分子机制,及其在绿色制造和生物医药领域的应用

承担科研项目:

1.  国家自然科学基金面上项目,74万,220770322021.01-2024.12

2.  国家重点研发计划(中日合作)80/230万,2019.06-2022.07

3.  科技部新药创制重大专项子课题,130/2000万,2019.04-2021.07

4.  国家自然科学基金面上项目,76万,216720652017.01-2020.12

5.  上海市浦江人才项目(A)20万,16PJ14025002016.07-2018.07

6.  生工学院优秀青年教师培育计划项目,20万,2015.07-2017.07

7.  国家重点实验室开放课题,10万,2015.01-2017.01

参与科研项目:

8.  参与国自然重点项目,145/300万,216360032017.01-2021.12

教学:

微生物综合实验(必修);天然产物药物与合成生物学(选修);能源生物技术(选修);遗传之神奇DNA(选修)

代表性论文(*通讯作者):

1. Li J, Sun Y, Liu F, Zhou Y, Yan Y, Zhou Z, Wang P*, and Zhou S*. Increasing NADPH impairs fungal H2O2 resistance by perturbing transcriptional regulation of peroxiredoxin. Bioresour. Bioprocess. Accepted. 2021.

2. Zhou Y, Lv H, Li H, Li J, Yan Y, Liu F, Hao W, Zhou Z, Wang P, Zhou S*. Nitroreductase Increases Menadione-Mediated Oxidative Stress in Aspergillus nidulans. Appl. Environ. Microbiol. 24;87(24):e0175821, 2021.

3. Deng H, Li J, Zhou Y, Xia Y, Chen C, Zhou Z, Wu H, Wang P, Zhou S*. Genetic engineering of circularly permuted yellow fluorescent protein reveals intracellular acidification in response to nitric oxide stimuli. Redox Biology. 41:101943, 2021.

4. Dong H, Zhang W, Xuan Q, Zhou Y, Zhou S*, Huang *, Wang P. Binding peptide-guided immobilization of lipases with significantly improved catalytic performance using Escherichia coli BL21(DE3) biofilms as a platform. ACS Appl Mater Interfaces. 13(5):6168-6179, 2021.

5. Liu Y, Li H, Li J, Zhou Y, Zhou Z, Wang P, Zhou S*. Characterization of the promoter of the nitrate transporter-encoding gene nrtA in Aspergillus nidulans. Mol Genet Genomics. 295(5):1269-1279, 2020.

6. Haijun Yu, Haoxiang Li, Yao Zhou, Shengmin Zhou*, and Ping Wang. Ultra-Sensitive Hydrogen Peroxide Sensor Based on Peroxiredoxin and Fluorescence Resonance Energy Transfer.Appl. Sci. 2020, 10, 3508

7. Yang Y, Zhou Y, Li J, Yu H, Takaya N, Wang P, Zhou S*. Novel peroxiredoxin-based sensor for sensitive detection of hydrogen peroxide. Biochem. Biophys. Res. Commun. 517(2):260-265, 2019.

8. H Yu, H Li, C Chen, Zhou S*, P Wang*. Water-sensitive phase-transition of a carbon dot–calcium carbonate composite for moisture detection in organic solvents. Analytical Methods. 11, 2634-2638, 2019.

9. He H, Liu Y, Zhou Z, Guo C, Wang HY, Wang Z, Wang X, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*. A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications. Free Radical Biology and Medicine.123: 1-7, 2018.

10. He H,Xia Y, Qi Y, Wang HY, Wang Z, Bao J, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*.A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications. Bioconjugate Chemistry.18;29(4):1194-1198, 2018.

11. Xia Y, Yu H, Zhou Z, Takaya N, Zhou S*, Wang P*.Peroxiredoxin system of Aspergillus nidulans resists inactivation by high concentration of hydrogen peroxide-mediated oxidative stress. Journal of Microbiology and Biotechnology. 28(1): 145-156, 2018.

12. Yu H, Chen C, Cao X, Liu Y, Zhou S*, Wang P*.Ratiometric fluorescent pH nanoprobes based on in situ assembling of fluorescence resonance energy transfer between fluorescent proteins. Analytical and Bioanalytical Chemistry409(21):5073-5080, 2017.

13. Zhou Y, Zhou S*, Yu H, Li J, Xia Y, Li B, Wang X, Wang P*. Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans. Journal of Microbiology and Biotechnology. 26 (5): 928-937, 2016.

14. Zhou S and Takaya N. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014.

15. Zhou S, Narukami T, Masuo S, Shimizu M, Fujita T, Doi Y, Kamimura Y, Takaya N.NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013.

16. Zhou S, Narukami T, Nameki M, Ozawa T, Kamimura Y, Hoshino T, Takaya N.Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.

18. Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Maruyama J, Kitamoto K, Wakagi T, Shoun H. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology. 48(2): 200-207, Feb, 2011.

19. Zhou S, Nakanishi Y, Kim SW, Fushinobu S, Maruyama J, Kitamoto K, Wakagi T, Shoun H. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010.

20. Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Wakagi T, Shoun H.Aspergillus oryzaeflavohemoglobins promote oxidative damage by hydrogen peroxide. Biochem. Biophys. Res. Commun. 394(3):558-561, 2010.

21. Zhou S, Fushinobu S, Nakanishi Y, Kim SW, Wakagi T, Shoun H. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae. Biochem. Biophys. Res. Commun. 381 (1): 7-11, Jan, 2009.


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