任宇红
发布人:生工学院网站管理员  发布时间:2022-06-15   动态浏览次数:11465

 

任宇红

 

生物学专业:博士生导师/硕士生导师

生物工程专业:博士生导师/硕士生导师

生物与医药专业(生物工程领域):博士生导师/硕士生导师



个人简介:

男,196710月出生,中共党员,博士,华东理工大学生物工程学院、生物反应器工程国家重点实验室研究员,博士生导师。主持国家自然科学基金面上项目3项;主持国家“863”课题2项;作为骨干成员参加完成国家“863重大项目2项和国家自然科学基金项目4项;参加国家重大科学技术专项课题2项;主持和参加省部级项目12项;主持获得国家新药临床批件2项;获2012年上海市科技进步一等奖一项,2013年上海市技术发明奖一等奖一项;申请国家发明专利十余项;发表SCI论文60余篇,其中有多篇研究论文发表在Angewandte ChemieACS Synthetic BiologyMetabolic EngineeringBiomaterials Chemical CommunicationsBiotechnology and Bioengineering等国际顶级刊物上。

教育经历:

1988年毕业于电子科技大学(成都)微电子材料系,获应用化学专业学士学位;

1991年毕业于华东理工大学应用化学系,获无机化学专业理科硕士学位;

2004年毕业于华东理工大学生物工程学院,获生物化工专业工科博士学位;

2009-2010年在美国西北大学(Northwestern University)生物医药工程系访学。

工作履历:

19917-20019月:江西-OAI中德联合研究院,主要从事医学诊断试剂、精细化学品、食品添加剂合成、保健食品研发工作;

200911-201011月:美国西北大学(Northwestern University)生物医药工程系Phillip B. Messersmith教授实验室工作,从事生物仿生粘附材料研究。

20019月至今:华东理工大学生物工程学院、生物反应器工程国家重点实验室,主要从事化学生物学领域研究(基因治疗)、生物催化反应、新药研发以及天然产物功能评价等工作。

研究方向:

1  多酶自组装与酶催化工程:胞内外的多酶自组装技术、多酶级联催化技术研究;核苷酸类产品的全酶法合成技术研究;手性药物及手性医药中间体的生物合成。对酶催化反应以及生物转化生产手性药物及手性中间体有丰富的经验。有丰富的有机合成实验室经验以及工业放大实践经验,主持完成多项新药研发工作,获得2项国家新药临床批件,熟悉新药研发及报批程序。

2  合成生物学:天然产物的微生物合成系统构建与制备,研究复杂天然产物的模块化组装、合成途径优化、动态代谢调控策略等技术,利用微生物合成多个天然产物。

3  核酸药物研究:主要从事反义核酸、RNAi的研究,重点研究RNA药物在肿瘤多药抗性方面的作用机制以及药理药效学研究;肿瘤药物靶向运载体系的研究;抗体药物研究等。

4  仿生粘附材料:仿生粘附材料的制备、性能研究与应用,特别是在蛋白纯化、酶固定化、细胞培养中的应用研究。

5  中药及其有效成分新功能开发:建立了针对前列腺增生、肥胖、皮肤瘙痒、皮肤抗皱抗衰老等天然产物体外筛选模型;中草药有效成分的分离纯化以及结构鉴定。

 

近年代表性论文:

1  Yuting Li, Ming Zhao, Dongzhi Wei, Jian Zhang, Yuhong Ren*. Photocontrol of itaconic acid synthesis in Escherichia coli. ACS Synthetic Biology. 2022, https://doi: 10.1021/acssynbio.2c00014.

2  Ming Zhao, Yuting Li, Fengqing Wang, Yuhong Ren*, Dongzhi Wei. A CRISPRi mediated self-inducible system for dynamic regulation of TCA cycle and improvement of itaconic acid production in Escherichia coli. Synthetic and Systems Biotechnology. 2022, https://doi.org/10.1016/j.synbio.2022.05.008

3  Dongni Ji, Jianhua Li, Yuhong Ren*, Yong Wang. Rational engineering in Escherichia coli for high-titer production of baicalein based on genome-scale target identification. Biotechnology and Bioengineering. 2022, doi: 10.1002/bit.28087.

4  Zhantao Zhu, Mengmeng Du, Bei Gao, Xinyi Tao, Ming Zhao, Yuhong Ren, Fengqing Wang, Dongzhi Wei. Metabolic compartmentalization in yeast mitochondria: burden and solution for squalene overproduction. Metabolic Engineering. 2021,68: 232-245.

5  Dongni Ji, Jianhua Li, Fanglin Xu, Yuhong Ren*, Yong Wang. Improve the biosynthesis of baicalein and scutellarein via manufacturing self-assembly enzyme reactor in vivo. ACS Synthetic Biology. 2021, 10(5):1087-1094..

6.    Jianlin Xu, Haili Liu, Zhifeng Liu, Yuhong Ren, Yong Wang. Acylated aminooligosaccharides from the yellow sea Streptomyces sp. HO1518 as both α-glucosidase and lipase inhibitors. Marin Drugs. 2020, 18(11): 576-589.

7.    Guosong Liu, Tian Li, Wei Zhou, Min Jiang, Xinyi Tao, Min Liu, Ming Zhao, Yuhong Ren, Bei Gao, Fengqing Wang, Dongzhi Wei. The yeast peroxisome: a dynamic storage depot and subcellular factory for squalene overproduction. Metabolic Engineering. 2020, 57: 151-161.

8.    Zhaoyu Chang, Jian Zhang, Wanyuan Dong, Xiangqi Meng, Hualei Wang, Dongzhi Wei, Yuhong Ren*. Cadmium sulfide net framework nanoparticles for photo-catalyzed cell redox. RSC Advances. 2020, 10(62): 37820-37825.

9.    Wanju Sun, Li Wang, Haohao Liu, Yongjun Liu, Yuhong Ren, Fengqing Wang, Dongzhi Wei. Characterization and engineering control of the effects of reactive oxygen species on the conversion of sterols to steroid synthons in Mycobacterium neoaurum. Metabolic Engineering. 2019, 56: 97-110.

10.   Tongjing Sun, Baoqi Zhang , Jinping Lin, Yuhong Ren*. Reversible Photocontrol of Oxidase Activity by Inserting a Photosensitive Domain into the Oxidase. Bioresources and Bioprocessing. 2019. 6:28-33

11.   Zhongwei Yang, Hongling Wang, Yuxiao Wang, Yuhong Ren*, Dongzhi Wei*. Manufacturing Multienzymatic Reactors In Vivo by Self-Assembly to Improve the Biosynthesis of Itaconic Acid in Escherichia coli. ACS Synthetic Biology. 2018. 7(5), 1244-1250.

12.   Pengyan Jiao, Jian Zhang, Yuguo Dong, Dongzhi Wei, Yuhong Ren*.              Construction and characterization of the recombinant immunotoxin RTA-4D5-KDEL targeting HER2/neu-positive cancer cells and locating the endoplasmic reticulum. Applied Microbiology and Biotechnology. 2018. 102:  9585–9594.

13.    Ying Liu, Xin Gao, Dongzhi Wei, Yuhong Ren*. Reversible Photocontrol  of  Lipase Activity by Incorporating a Photoswitch into the Lid Domain. Chemphotochem. 2017, 1, 393-396. DOI: 10.1002/cptc.201700045.

14.   Xingxing Zou, Jinping Lin, Xinlei Mao, Shengyun Zhao and Yuhong Ren *. Biosynthesis of L-Erythrose by Assembly of Two Key Enzymes in Gluconobacter oxydans. Journal of Agricultural and Food Chemistry. 2017, 65, 7721-7725.

15.   Zhongwei Yang, Xin Gao, Hui Xie, Fengqing Wang, Yuhong Ren* and Dongzhi Wei. Enhanced Itaconic Acid Production by Self-Assembly of Two Biosynthetic Enzymes in Escherichia coli. Biotechnology and Bioengineering. 2017, 114(2),457-462.

16.   Xinyi Tao, Ning Jia, Nenghui Cheng, Yuhong Ren, Xuni Cao, Min Liu, Dongzhi Wei*, Feng-Qing Wang*. Design and evaluation of a phospholipase D based drug delivery strategy of novel phosphatidyl-prodrug. Biomaterials. 2017. 131, 1-14

17.   Xin Gao, Chengcheng Zhao, Ting Yu, Shengli Yang, Yuhong Ren*, Dongzhi Wei. Construction of a Reusable Multi-enzyme Supramolecular Device via Disulfide Bond Locking. Chemical Communications. 2015, 51, 10131-10133.

18.   Xin Gao, Shuai Yang, Chengcheng Zhao, Yuhong Ren*, Dongzhi Wei. Artificial Multienzyme Supramolecular Device: Highly Ordered Self-assembly of Oligomeric Enzymes In Vitro and In Vivo. Angewandte Chemie. 2014, 53, 14027-14030.

 

联系方式:021-64253156,13816104558yhren@ecust.edu.cn,实验十四楼东楼301