鲍杰
生物化工专业：博士生导师/硕士生导师
生物工程专业：博士生导师/硕士生导师
生物与医药专业（生物工程领域）：博士生导师/硕士生导师
工学博士，教授、博士生导师。南京理工大学获学士学位、浙江大学获硕士学位、日本国立山口大学获博士学位。2006年至今任职华东理工大学生物工程学院和生物反应器工程全国重点实验室。作为课题负责人主持科研项目数十项。现任SCI期刊Applied Biochemistry and Biotechnology高级编辑、Bioprocess and Biosystems Engineering副主编、ACS Sustainable Chemistry and Engineering编委、Springer和Elsevier学术期刊客座编辑，亚洲生物技术联合会生物能源与生物炼制分会理事。
研究方向：
研究领域聚焦于生物炼制过程技术和工程微生物研究。提出的木质纤维素类淀粉化干法炼制技术，显示了巨大的技术优势和环境友好性，奠定了可持续碳中和生产聚合物和液体燃料的技术基础；生物炼制菌株的代谢工程和合成生物学改造，成倍提高了生物转化和发酵效率，达到了迄今国内外最高水平的生物炼制转化、能耗和排放指标。
1. 纤维素生物质合成聚乳酸等生物聚合物、生物航煤等液体燃料的工程微生物细胞工厂合成生物学；
2. 超级生物炼制微生物的发现、进化、代谢工程改造，以及工程化底盘微生物合成关键生物基产品；
3. 先进生物炼制过程工程及其计算机模拟。
联系方式：
通讯地址：上海市梅陇路130号华东理工大学283信箱（200237）
实验室位置：华东理工大学徐汇校区实验十八楼1303室
电话/传真：021-64251799
Email：jbao@ecust.edu.cn
微信：jbao1231
实验室网页：http://sklbe.ecust.edu.cn/biomasslab
近期代表性论文（*通讯作者）：
（年均SCI论文10-15篇，硕士人均1-2篇、博士人均4-6篇）
1. Zhibin Li, Lingxiao Zhang, Bin Zhang, Jie Bao*. pH shifting adaptive evolution stimulates the low pH tolerance of Pediococcus acidilactici and high L-lactic acid fermentation efficiency. Bioresource Technology, 2025, 416, 131813
2. Xiaomeng Guo, Zhibin Li, Niling He, Bin Zhang, Xiucai Liu, Jie Bao*. Detection and elimination of trace p-lactic acid in lignocellulose biorefining chain: Generation, flow, and impact on chiral lactide synthesis. Biotechnology and Bioengineering, 2024, 121, 670-682.
3. Agustian Chen, Bin Zhang, Jie Bao*. Adaptive evolution of Paecilomyces variotii enhanced the biodetoxification of high-titer inhibitors in pretreated lignocellulosic feedstock. Bioresource Technology, 2024, 411: 131351.
4. Bin Zhang, Qingmei Han, Qi Liu, Ya Wang, Jie Bao*. Recycling of waste calcium carbonate in lignocellulosic biorefining chain for chiral lactic acid production. Bioresource Technology, 2024, 395,130303.
5. Bin Zhang, Xiucai Liu, Jie Bao*. High solids loading pretreatment: The core of lignocellulose biorefinery as an industrial technology – An overview. Bioresource Technology, 2023, 369:128334.
6. Niling He, Jia Jia, Zhongyang Qiu, Chun Fang, Gunnar Lidén, Xiucai Liu, Jie Bao*. Cyclic L-lactide synthesis from lignocellulose biomass by biorefining with complete inhibitor removal and highly simultaneous sugars assimilation. Biotechnology and Bioengineering, 2022, 119:1903-1915. (Cover Image)
7. Ci Jin, Jing Li, Zhen Huang, Xushen Han, Jie Bao*. Engineering Corynebacterium glutamicum for synthesis of poly(3-hydroxybutyrate) from lignocellulose biomass. Biotechnology and Bioengineering, 2022, 119:1598-1613.
8. Qi Liu, Mingping Lu, Ci Jin, Weiliang Hou, Liao Zhao, Jie Bao*. Ultra-centrifugation force in adaptive evolution changes the cell structure of oleaginous yeast Trichosporon cutaneumin to a favorable space for lipid accumulation. Biotechnology and Bioengineering, 2022, 119:1509-1521.
9. Ying-Ying Xu, Ke-Jun Hua, Zhen Huang, Ping-Ping Zhou, Jing-Bai Wen, Ci Jin, Jie Bao*. Cellulosic hydrocarbons production by engineering dual synthesis pathways in Corynebacterium glutamicum. Biotechnology for Biofuels and Bioproducts, 2022, 15:29.
10. Bin Zhang, Jing Li, Xiucai Liu, Jie Bao*. Continuous simultaneous saccharification and co-fermentation (SSCF) for cellulosic L-lactic acid production. IndustrialCrops & Products, 2022, 187:115527.
11. Bin Zhang, Faryal Ahemed, Baorui Zhan, Jie Bao*. Transformation of lignocellulose to starch‐like carbohydrates by organic acid-catalyzed pretreatment and biological detoxification. Biotechnology and Bioengineering, 2021, 118:4105-4118.
12. Bin Zhang, Baorui Zhan, Jie Bao*. Reframing biorefinery processing chain of corn fiber for cellulosic ethanol production. Industrial Crops & Products, 2021, 170:113791.
13. Tao Han, Bin Zhang, Hongxing Li, Hongsen Zhang, Yongfu Yang, Lizhen Hu, Xiaodong Ren, Shipeng Wang, Lixiang Zheng, Xushen Han, Gang Liu, Jian Zhang, Qiang Fei, Yueqin Tang, Shihui Yang, Xiaoming Bao, Jie Bao*. Year-round storage operation of three major agricultural crop residue biomass by operating dry acid pretreatment at regional collection depots. ACS Sustainable Chemistry & Engineering, 2021, 9:4722-4739.
14. Ci Jin, Jie Bao*. Lysine production by dry biorefining of wheat straw and co-fermentation of Corynebacterium glutamicum. Journal of Agricultural and Food Chemistry, 2021, 69:1900-1906.
15. Zhao Yan, Jian Zhang, Jie Bao*. Increasing cellulosic ethanol production by enhancing phenolic tolerance of Zymomonas mobilis in adaptive evolution. Bioresource Technology, 2021, 329:124926.
16. Ci Jin, Zhen Huang, Jie Bao*. High-titer glutamic acid production from lignocellulose using an engineered Corynebacterium glutamicum with simultaneous coutilization of xylose and glucose. ACS Sustainable Chemistry & Engineering, 2020, 8:6315-6322.
17. Zhongyang Qiu, Chun Fang, Qiuqiang Gao, Jie Bao*. A short-chain dehydrogenase plays a key role in cellulosic D-lactic acid fermentability of Pediococcus acidilactici. Bioresource Technology, 2020, 297:122473.
18. Niling He, Chun Fang, Zhongyang Qiu, Jie Bao*. Increasing sodium lactate production by enhancement of Na+ transmembrane transportation in Pediococcus acidilactici. Bioresource Technology, 2020, 323:124562.
19. Lixiang Zheng, Xushen Han, Tao Han, Gang Liu, Jie Bao*. Formulating a fully converged biorefining chain with zero wastewater generation by recycling stillage liquid to dry acid pretreatment operation. Bioresource Technology, 2020, 318:124077.
20. Zhao Yan, Xiaochuang Gao, Qiuqiang Gao, Jie Bao*. Mechanism of tolerance to the lignin-derived inhibitor p-benzoquinone and metabolic modification of biorefinery fermentation strains. Applied & Environmental Microbiology 2019, 85:e01443-19.
21. Pingping Zhou, Ruimiao Yao, Hongsen Zhang, Jie Bao*. Unique glucose oxidation catalysis of Gluconobacter oxydans constitutes an efficient cellulosic gluconic acid fermentation free of inhibitory compounds disturbance. Biotechnology and Bioengineering, 2019, 116:2191-2199.
22. Xia Yi, Qiuqiang Gao, Lei Zhang, Xia Wang, Yanqing He, Fengxian Hu, Jian Zhang, Gen Zou, Shihui Yang, Zhihua Zhou*, Jie Bao*. Heterozygous diploid structure of Amorphotheca resinae ZN1 contributes efficient biodetoxification on solid pretreated corn stover. Biotechnology for Biofuels, 2019, 12:126.
23. Jingbai Wen, Jie Bao*. Engineering Corynebacterium glutamicum triggers glutamic acid accumulation in biotin rich corn stover hydrolysate. Biotechnology for Biofuels, 2019, 12:86.
24. Ci Jin, Weiliang Hou, Ruimiao Yao1, Pingping Zhou, Hongsen Zhang, Jie Bao*. Adaptive evolution of Gluconobacter oxydans accelerates the conversion rate of non-glucose sugars derived from lignocellulose biomass. Bioresource Technology, 2019, 289:121623.
25. Xushen Han, Li Li, Chengxiang Wei, Jian Zhang, Jie Bao*. Rich vitamins B in lignocellulose biomass facilitates L-lactic acid fermentation. Journal of Agricultural and Food Chemistry, 2019, 67:7082-7086.
近期专著：
1. Handbook of Biorefinery Research and Technology, Section Editor, Springer Nature, 2019. 978-94-007-6724-9.
2. Bioreactor Engineering Research and Industrial Applications (I, II), Advances in Biochemical Engineering/Biotechnology, Volume 152/155, Editor, Springer, Germany, 2016. 978-3-662-48346-6 (Print), 978-3-662-48347-3 (eBook)/978-3-662-49159-1 (Print), 978-3-662-49161-4 (eBook).
主持科研项目或基金：
国家自然科学基金重点/面上项目:木质纤维素生产手性乳酸的生物合成路径与抗逆机制研究（31961133006）、木质纤维素水解液体系中最轻油脂酵母细胞的全通量精准筛选（21978083）、复杂酶反应体系的抑制效应解析与关键路径的加速（20976051）、DNA扩增前提材料的生物合成与过程集成研究（20676037）
国家重点研发计划项目/973/863/：微生物油脂生物炼制技术集成与示范（2023YFA0914404）、木质纤维素降解转化过程强化的工程学原理与方法（2011CB707406）、农作物秸秆制备生物化工醇产业化示范（2014AA021901）、低成本乳酸、丙交酯和聚乳酸制备关键技术及产业化研究（2017YFB0309302）等
产业化应用项目：农作物秸秆用于生产油脂和蛋白产品的菌种和工艺开发(F200-82320-S)、农作物秸秆原料生产生物基产品的15项专利技术转让（F200-Z2101Q）、农作物秸秆用于生产生物基产品的菌种和工艺开发、农作物秸秆酶促制糖技术开发与产业化应用（CXTY20110918）、节能与清洁型木质纤维素生产燃料乙醇过程的关键技术研究（HTB207-00005）
教学：
1. 本科生必修课：生物工程过程设计
2. 硕士生专业课：生物能源过程工程（全英文） (Biomass Processing Engineering)
3. 博士生专业课：生物工程进展 (Advances in Biochemical Engineering/ Biotechnology)