吴辉
发布人:生工学院网站管理员  发布时间:2022-09-13   动态浏览次数:24087

 


  


生物工程专业:博士生导师/硕士生导师

生物化工专业:博士生导师/硕士生导师

生物与医药专业(生物工程领域):博士生导师/硕士生导师


 


吴辉,江苏苏州,工学博士,教授,博导。现任华东理工大学生物工程学院党委书记、中国轻工业生物基材料工程重点实验室副主任,中国生物工程学会青年工作委员会委员,中国生物工程学会一碳生物技术专委会委员,上海市生物工程学会合成生物学委员会委员,生物反应器工程国家重点实验室固定人员。教育部霍英东青年教师基金获得者,获“宝钢优秀教师奖”、“德榜化工科学技术青年奖”、东富龙生物工程优秀青年科学家奖。获中国石油与化工教育教学优秀成果一等奖、华东理工大学教学成果一等奖,多次获得华东理工大学优秀研究生指导教师。

2004年毕业于南京工业大学生物工程系,获工学学士学位。2009年毕业于华东理工大学发酵工程专业,获工学博士学位。同年进入中科院上海生命科学研究院植物生理生态研究所从事博士后研究工作。2011年来到誉有南方的哈佛之称的美国莱斯大学生物工程系从事博士后研究工作。20149月引进华东理工大学生物工程学院,入选华东理工大学青年英才培育计划等。作为负责人主持国家自然科学基金面上项目(两项)、青年项目、国家重点研发计划子课题、教育部霍英东青年教师基金、上海市自然科学基金及企业技术开发等项目。作为负责人主持上海市教改项目2项:《微生物学(全英文)》入选上海市高校示范性全英语课程建设项目和《微生物学》入选上海市一流本科课程。近年来在Metabolic EngineeringBiotechnology AdvancesACS Synthetic BiologyBiotechnology and BioengineeringBioresource TechnologyRedox Biology等本领域重点期刊上发表SCI收录论文50余篇。已授权美国发明专利4项;已授权中国发明专利10项。指导研究生多次获得校外奖学金、学术会议最佳墙报奖和创新竞赛等奖项;共同指导本科生多次获得国际遗传工程机器大赛(iGEM)竞赛金奖,指导多项大学生创新创业训练计划国家级、上海市级项目,多次获省部级竞赛奖项。

 

研究方向:

1.微生物代谢工程合成平台化合物和生物活性物质

运用微生物代谢工程和合成生物学的最新技术和方法,合理设计及重构微生物代谢途径,结合精细化代谢调控策略,建立以可再生生物质资源(糖、甘油、乙酸、乙醇、甲酸、CO2等)为原料,利用多元化能量来源(化能和电能等)的新型高效微生物细胞工厂,合成多种生物基化学品与生物基材料,如丁二酸、3-羟基丙酸、丙酮、异丙醇、生物聚酯(生物可降解塑料)、氨基酸、脂肪酸及其衍生物等。

2.合成生物学中代谢晶体管研究及其应用

在微生物代谢调控合成生物学研究中,代谢晶体管控制模式借鉴电子元器件晶体管的放大控制模式,通过精细调节细胞中微量关键物质的浓度,进而对整个细胞进行代谢重编程,实现目标代谢产物的“智能”控制。

 

主持和参加的科研项目:

1.主持国家自然科学基金面上基金 2023.1-2026.12

2.主持国家重点研发计划子课题2021.12 - 2023.11

3.主持国家自然科学基金面上基金 2018.1-2021.12

4.主持国家重点研发计划子课题2017.07 - 2021.06

5.主持霍英东教育基金会第十六届高等院校青年教师基金 2018.3-2021.3

6.主持上海市自然科学基金 2019.6-2022.6

7.主持中科院合成生物学重点实验室开放课题 2020.6-2022.6

8.主持国家自然科学基金青年科学基金 2015.1-2017.12

9.主持生工学院优秀青年教师远志计划”2017.1-2018.12

10.主持工业生物催化教育部重点实验室开放课题 2015.12-2017.12

11.主持中央高校基本科研业务费探索研究基金  2015.7-2017.6

12.主持生工学院优秀青年教师培育计划,2015.07-2017.07

 

学术与社会兼职:

Frontiers in Microbiology, IF=6.064副主编2019-

Journal of Industrial Microbiology & Biotechnology, IF=4.258编委2021-

Journal of Chemical Technology and Biotechnology, IF=3.709编委2022-

Bioresources and Bioprocessing, IF=4.983青年编委2020-

Frontiers in Bioengineering and Biotechnology, IF=6.064编委2016-

Microbial Biotechnology, IF=6.575, 客座编辑(2021-2022)

Frontiers in Bioengineering and Biotechnology, IF=6.064客座副主编2019,2020

美国微生物学会ASM会员2015-

美国工业微生物与生物技术学会SIMB会员2013-

中国生物工程学会一碳生物技术专委会委员(2022-2026

中国生物工程学会青年工作委员会委员(2019-2023

上海市生物工程学会合成生物学委员会委员(2018-2022

多个国际杂志如Biotechnology AdvancesMetabolic EngineeringBiotechnology and BioengineeringBiotechnology for BiofuelScientific ReportsMicrobial Cell FactoriesFrontiers in MicrobiologyJournal of Agricultural and Food ChemistryBioresource TechnologyBiotechnology JournalBiochemical Engineering JournalProcess BiochemistryBioprocess and Biosystems EngineeringBioresources and BioprocessingFrontiers in Bioengineering and BiotechnologyApplied Biochemistry and BiotechnologyBiotechnology and Applied Biochemistry等审稿人。多个国内杂志《生物工程学报》、《微生物学报》、《生物加工过程》、《微生物学报》等期刊审稿人。

 

本科和研究生教学:

1. 主讲本科专业必修课,《微生物(全英文)》,48学时,3学分;参与本科选修课《国际遗传工程机器竞赛与合成生物技术》,16学时,1学分,团队教学。

2. 博士研究生专业课程,《系统代谢工程》(与花强教授合作),32学时,2学分;

3. iGEM竞赛导师,Bio-maker创新活动指导老师,大创指导老师。

 

代表性论文(*通讯作者):  

1. Juefeng Lu, Yuying Wang, Mingcheng Xu, Qiang Fei, Yang Gu, Yuanchan Luo, Hui Wu*Efficient biosynthesis of 3-hydroxypropionic acid from ethanol in metabolically engineered Escherichia coli. Bioresource Technology. 2022. 363:127907 (IF=11.889, JCR Q1)

2. Yuanchan Luo, Lei Chen, Zhibo Lu, Weijian Zhang, Wentong Liu, Yuwei Chen, Xinran Wang, Wei Du, Jinyan Luo*, Hui Wu*. Genome sequencing of biocontrol strain Bacillus amyloliquefaciens Bam1 and further analysis of its heavy metal resistance mechanism. Bioresources and Bioprocessing. 2022, 9:74. (IF= 4.983, JCR Q2)

3. Dongqing Zhou, Yeling Luo, Yingqiu Zhang, Chenni Zhao, Hui Wu*, Jianhua Fan*. Perturbing electron carriers of green algae Chlamydomonas reinhardtii for efficient physiological and metabolic regulation. Food Bioengineering. 2022. 1:148-158.

4. Ju Wu#, Xiangju Wei#, Pengye Guo, Aiyong He, Jiaxing Xu, Mingjie Jin, Yanjun Zhang, Hui Wu*. Efficient P(3HB-co-LA) production from corn stover hydrolysate by metabolically engineered Escherichia coli. Bioresource Technology. 2021. 341:125873. (IF=11.889, JCR Q1)

5. Peng Fei#, Yuanchan Luo#, Ningyu Lai, Hui Wu*. Biosynthesis of (R)-3-hydroxybutyric acid from syngas-derived acetate in engineered Escherichia coli. Bioresource Technology. 2021. 336:125323. (IF=11.889, JCR Q1)

6. Ningyu Lai#, Yuanchan Luo#, Peng Fei, Peng Hu, Hui Wu*. One stone two birds: biosynthesis of 3-hydroxypropionic acid from CO2 and syngas-derived acetate in Escherichia coli. Synthetic and Systems Biotechnology. 2021, 6: 144-152. (IF=4.692, JCR Q2)

7. Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu*. Reprogramming the metabolism of Synechocystis PCC 6803 by regulating the plastoquinone biosynthesis. Synthetic and Systems Biotechnology. 2021, 6: 351-359. (IF=4.692, JCR Q2)

8. Pengye Guo#, Yuanchan Luo#, Ju Wu, Hui Wu*. Recent advances in the microbial synthesis of lactate-based copolymer. Bioresources and Bioprocessing. 2021, 8: 106. (IF=4.983, JCR Q2)

9. Na Zhang, Hui Wu, Yingzhi Liang, Jianming Ye, Huan Zhang, Yuqing Miao, Yane Luo*, Haiming Fan , Tianli Yue. Design and preparation of “corn-like” SPIONs@DFK-SBP-M13 assembly for improvement of effective internalization.  International Journal of Nanomedicine. 2021.16:7091-7102. (IF=7.033, JCR Q1).

10. Xiangju Wei, Ju Wu, Pengye Guo, Shengmin Zhou, Hui Wu*. Effect of short-chain thioesterase deficiency on p(3HB-co-LA) biosynthesis in Escherichia coli. Chinese Journal of Biotechnology. 2021. 37(1):196-206.

11. Guohui Li, Dixuan Huang, Xue Sui, Shiyun Li, Bing Huang, Xiaojuan Zhang*, Hui Wu*, Yu Deng*. Advances in microbial production of medium-chain dicarboxylic acids for nylon materials. Reaction Chemistry & Engineering. 2020. 5:221-238 (IF=5.2, JCR Q2)

12. Hao Yang, Can Zhang, Ningyu Lai, Bing Huang, Peng Fei, Dawei Ding, Peng Hu, Yang Gu, Hui Wu*. Efficient isopropanol biosynthesis by engineered Escherichia coli using biologically produced acetate from syngas fermentation. Bioresource Technology. 2020. 296:122337. (IF=11.889, JCR Q1)

13. Qiaofei He, George N. Bennett, Ka-Yiu San, Hui Wu*. Biosynthesis of medium-chain ω-hydroxy fatty acids by AlkBGT of Pseudomonas putida GPo1 with native FadL in engineered Escherichia coli. Frontiers in Bioengineering and Biotechnology. 2019. 7:273. (IF=6.064, JCR Q1)

14. Hao Yang#, Bing Huang#, Ningyu Lai, Yang Gu, Zhimin Li, Qin Ye, Hui Wu*. Metabolic engineering of Escherichia coli carrying the hybrid acetone-biosynthesis pathway for efficient acetone biosynthesis from acetate. Microbial Cell Factories.2019. 18:6. (IF=6.352, JCR Q1)

15. Jingxian Lu, Zhimin Li, Qin Ye, Hui Wu*. Effect of reducing the activity of respiratory chain on biosynthesis of poly(3-hydroxybutyrate-co-lactate) in Escherichia coli. Chinese Journal of Biotechnology.2019. 35(1):59-69.

16. Jiapeng Tang, Zhenqing Qian, Hui Wu*. Enhancing cordycepin production in liquid static cultivation of Cordyceps militaris by adding vegetable oils as the secondary carbon source. Bioresource Technology. 2018. 268:60-67. (IF=11.889, JCR Q1)

17. Bing Huang, Hao Yang, Guochen Fang, Xing Zhang, Hui Wu*, Zhimin Li*, Qin Ye. Central pathway engineering for enhanced succinate biosynthesis from acetate in Escherichia coli. Biotechnology and Bioengineering. 2018. 115:943-954. (*Co-corresponding) (IF=4.395, JCR Q2)

18. Wei Li#, Hui Wu#, Mai Li, Ka-Yiu San*. Effect of NADPH availability on free fatty acid production in E. coli. Biotechnology and Bioengineering. 2018. 115:444-452. (IF=4.395, JCR Q2)

19. Han Liu, Guochen Fang, Hui Wu*, Zhimin Li*, Qin Ye. L-cysteine production in Escherichia coli based on rational metabolic engineering and modular strategy. Biotechnology Journal. 2018. 13:e1700695. (*Co-corresponding) (IF=5.726, JCR Q1)

20. Qing Li#, Bing Huang#, Qiaofei He, Jingxian Lu, Xun Li, Zhimin Li, Hui Wu*, Qin Ye. Production of succinate from simply purified crude glycerol by engineered Escherichia coli using two-stage fermentation. Bioresources and Bioprocessing. 2018. 5:41. (Feature Article) (IF=4.983, JCR Q2)

21. Jiaqi Jiang, Bing Huang, Hui Wu*, Zhimin Li*, Qin Ye. Efficient 3-hydroxypropionic acid production from glycerol by metabolically engineered Klebsiella pneumoniae. Bioresources and Bioprocessing. 2018. 5:34. (*Co-corresponding) (IF=4.983, JCR Q2)

22. Qing Li, Bing Huang, Hui Wu*, Zhimin Li, Qin Ye. Efficient anaerobic production of succinate from glycerol in engineered Escherichia coli by using dual carbon sources and limiting oxygen supply in preceding aerobic culture. Bioresource Technology. 2017. 231:75-84. (IF=11.889, JCR Q1)

23. Xing Zhang#, Hui Wu#, Bing Huang, Zhimin Li*, Qin Ye. One-pot synthesis of glutathione by a two-enzyme cascade using a thermophilic ATP regeneration system. Journal of Biotechnology. 2017. 241:163-169. (# First two authors contributed to this paper equally) (IF=3.595, JCR Q2)

24. Qing Li#, Hui Wu#, Zhimin Li, Qin Ye*. Enhanced succinate production from glycerol by engineered Escherichia coli strains. Bioresource Technology. 2016. 218:217-223. (# First two authors contributed to this paper equally) (IF=11.889, JCR Q1)

25. Yunjie Li, Bing Huang, Hui Wu*, Zhimin Li*, Qin Ye, Yi-Heng Percival Zhang. Production of succinate from acetate by metabolically engineered Escherichia coli. ACS Synthetic Biology. 2016. 5:1299-1307. (*Co-corresponding) (IF=5.249, JCR Q1)

26. Jianhua Yang, Wei Li, Dezheng Wang, Hui Wu*, Zhimin Li*, Qin Ye. Characterization of bifunctional L-glutathione synthetases from Actinobacillus pleuropneumoniae and Actinobacillus succinogenes for efficient glutathione biosynthesis. Applied Microbiology and Biotechnology. 2016. 100(14):6279-6289. (*Co-corresponding) (IF=5.56, JCR Q1)

27. Jing Zhang, Cong Quan, Cheng Wang, Hui Wu*, Zhimin Li*, Qin Ye. Systematic manipulation of glutathione metabolism in Escherichia coli for improved glutathione production. Microbial Cell Factories. 2016. 15:38. (*Co-corresponding) (IF=6.352, JCR Q1)

28. Dezheng Wang, Cheng Wang, Hui Wu*, Zhimin Li*, Qin Ye. Glutathione production by recombinant Escherichia coli expressing bifunctional glutathione synthetase. Journal of Industrial Microbiology and Biotechnology. 2016. 43:45-53. (*Co-corresponding) (IF=4.258, JCR Q2)

29. Cheng Wang, Jing Zhang, Hui Wu*, Zhimin Li*, Qin Ye. Heterologous gshF gene expression in various vector systems in Escherichia coli for enhanced glutathione production. Journal of Biotechnology. 2015. 214:63-68. (*Co-corresponding). (IF=3.595, JCR Q2)

30. Hui Wu, Leepika Tuli, George N. Bennett, Ka-Yiu San*. Metabolic transistor strategy for controlling electron transfer chain in Escherichia coli. Metabolic Engineering. 2015. 28:159-168. (IF=8.829, JCR Q1)

31. Hui Wu, George N. Bennett, Ka-Yiu San*. Metabolic control of respiratory levels in coenzyme Q biosynthesis-deficient Escherichia coli strains leading to fine-tune aerobic lactate fermentation. Biotechnology and Bioengineering. 2015. 112(8):1720-1726. (IF=4.395, JCR Q2)

32. Hui Wu, Jane Lee, Mukund Karanjikar, Ka-Yiu San*. Simultaneous utilization of glucose and mannose from woody hydrolysate for free fatty acid production by metabolically engineered Escherichia coli. Bioresource Technology. 2015. 185:431-435. (IF=11.889, JCR Q1)

33. Hui Wu, Mukund Karanjikar, Ka-Yiu San*. Metabolic engineering of Escherichia coli for efficient free fatty acid production from glycerol. Metabolic Engineering. 2014. 25:82-91. (IF=8.829, JCR Q1)

34. Hui Wu, Ka-Yiu San*. Efficient odd numbered straight-chain free fatty acid production by metabolically engineered Escherichia coli. Biotechnology and Bioengineering. 2014. 111(11):2209-2219. (IF=4.395, JCR Q2)

35. Yane Luo*, Tao Zhang, Hui Wu*. The transport and mediation mechanisms of the common sugars in Escherichia coli. Biotechnology Advances. 2014. 32:905-919. (IF=17.681, JCR Q1)

36. Hui Wu, Jane Lee, Mukund Karanjikar, Ka-Yiu San*. Efficient free fatty acid production from woody biomass hydrolysate in metabolically engineered Escherichia coli. Bioresource Technology. 2014. 169:119-125. (IF=11.889, JCR Q1)

37. Hui Wu, Ka-Yiu San*. Engineering Escherichia coli for odd straight medium chain free fatty acid production. Applied Microbiology and Biotechnology.2014. 98(19):8145-8154. (IF=5.56, JCR Q1)

38. Hui Wu, Qing Li, Zhi-min Li*, Qin Ye*. Succinic acid production and CO2 fixation using a metabolically engineered Escherichia coli in a bioreactor equipped with a self-inducing agitator. Bioresource Technology. 2012. 107:376-384. (IF=11.889, JCR Q1)

39. Yuan Liu, Hui Wu, Qin Li, Xuwei Tang, Zhi-min Li*, Qin Ye. Process development of succinic acid production by Escherichia coli NZN111 using acetate as an aerobic carbon source. Enzyme and Microbial Technology.2011. 49(5):459-64. ( First two authors contributed to this paper equally) (IF=3.705, JCR Q2)

40. Hui Wu, Zhi-min Li, Li Zhou, Jingli Xie, Qin Ye*. Enhanced anaerobic succinic acid production by Escherichia coli NZN111 aerobically grown on gluconeogenetic carbon sources. Enzyme and Microbial Technology. 2009. 44:165-169. (IF=3.705, JCR Q2)41. Hui Wu, Zhi-min Li, Li Zhou, Qin Ye*. Improved succinic acid production in the anaerobic culture of an Escherichia coli pflB ldhA double mutant as a result of enhanced anaplerotic activities in the preceding aerobic culture. Applied and Environmental Microbiology. 2007. 73:7837-7843. (IF=5.005, JCR Q2)

 

其他合作发表文章:

1. Haitao Deng, Jingyi Li, Yao Zhou, Yang Xia, Chao Chen, Zhemin Zhou, Hui Wu, Ping Wang, Shengmin Zhou*. Genetic engineering of circularly permuted yellow fluorescent protein reveals intracellular acidification in response to nitric oxide stimuli, Redox Biology, 2021. 41: 101943. (IF=10.787, JCR Q1)

2. Qianwen Shi, Cheng Chen, Wei Zhang, Ping Wu, Meng Sun, Hui Wu, Haizhen Wu, Pengcheng Fu*, Jianhua Fan*. Transgenic eukaryotic microalgae as green factories: providing new ideas for the production of biologically active substances. Journal of Applied Phycology. 2021, 33: 705-728. (IF=3.215, JCR Q1)

3. Qiyao Wang, Pengfei Li, Shuhong Gao, Youyuan Li, Hui Wu, Gaoyi Tan, Jianhua Fan, Mian Zhou, Lixin Zhang, Yingping Zhuang*. Exploration of an integrated competency development model for undergraduates training by participating the international Genetic Engineering Machine Competition. Chinese Journal of Biotechnology. 2021, 37(4): 1457-1463.

4. Haritha Meruvu, Hui Wu, Ziyue Jiao, Liyan Wang, Qiang Fei*, From Nature to Nurture: Essence and methods to isolate robust methanotrophic bacteria, Synthetic and Systems Biotechnology, 2020. 5(3):173-178.(IF=4.692, JCR Q1)

5Yunpeng Yang#, Nannan Lang#, Lu Zhang, Hui Wu, Weihong Jiang*, Gu Yang*. A novel regulatory pathway consisting of a two-component system and an ABC-2 type transporter controls butanol tolerance in Clostridium acetobutylicum. Applied Microbiology and Biotechnology. 2020. 104(11):5011-5023(IF=5.56, JCR Q1)

6Jiawei Li, Xiaoyan Zhang, Hui Wu, Yunpeng Bai*. Transcription factor screening and engineering for metabolic engineering and production of organic acids: an overview. Frontiers in Bioengineering and Biotechnology. 2020. 8:98 (IF=6.064, JCR Q1)

7Boliang Gao, Li Li, Hui Wu, Du Zhu, Min Jin, Wu Qu, Runying Zeng*. A novel strategy for efficient agaro-oligosaccharide production based on the enzymatic degradation of crude agarose in Flammeovirga pacifica WPAGA1. Frontiers in Microbiology. 2019. 10:1231. (IF=6.064,JCR Q1)

8Xiangwei Cui, Junxian Wan, Xing Zhang, Hui Wu, Zhimin Li*, Qin Ye. Efficient glutathione production in metabolically engineered Escherichia coli strains using constitutive promoters. Journal of Biotechnology. 2019. 289:39-45 (IF=3.307, JCR Q2)

9Bing Huang, Guocheng Fang, Hui Wu, Jibin Sun, Zhimin Li*, Qin Ye. Efficient biosynthesis of succinate from paper mill wastewater by engineered Escherichia coli. Applied Biochemistry and Biotechnology. 2019. 189:1195-1208. (IF=3.094, JCR Q3)

10.  Feng Li#, Yuanxiu Li#, Liming Sun, Xiaoli Chen, Xingjuan An, Changji Yin, Yingxiu Cao,Hui Wu, Hao Song*. Modular engineering intracellular NADH regeneration boosts extracellular electron transfer of Shewanella oneidensis MR-1. ACS Synthetic Biology. 2018. 7(3):885-895. (IF=5.249, JCR Q1)

11Zhuan Cheng, Jiaqi Jiang, Hui Wu, Zhimin Li*, Qin Ye. Enhanced production of 3-hydroxypropionic acid from glucose via malonyl-CoA pathway by engineered Escherichia coli. Bioresource Technology. 2016. 200:897-904. (IF=11.889, JCR Q1)

12Dan Wang, Hui Wu, Chandresh Thakker, Jared Beyersdorf, George N Bennett, Ka-Yiu San*. Efficient free fatty acid production in engineered Escherichia coli strains using soybean oligosaccharides as feedstock. Biotechnology Progress. 2015. 31:686-694. (IF=2.909, JCR Q2)

13Yang Gu, Yu Jiang,Hui Wu, Xudong Liu, Zhilin Li, Jian Li, Han Xiao, Zhaobing Shen, Hongjun Dong, Yunliu Yang, Yin Li, Weihong Jiang*, Sheng Yang*. Economical challenges to microbial producers of butanol: feedstock, butanol ratio and titer. Biotechnology Journal. 2011. 6(11):1348-1357. (IF=5.726, JCR Q1)

 

撰写著作:

1.  Qiang Fei, Haritha Meruvu, Hui Wu, Rongzhan FuChapter 12: Biological Conversion of Natural Gas in Direct Natural Gas Conversion to Value-Added Chemicals, 512 Pages, ISBN 9780367077938, 2020, CRC Press.

2. Qin Ye*, Zhimin Li, Hui Wu. Principle and performance of gas self-inducing reactors and applications to biotechnology. Bioreactor Engineering Research and Industrial Applications II, Advances in Biochemical Engineering/Biotechnology, Volume 152, 2016. ISBN: 978-3-662-48346-6 (Print), 978-3-662-48347-3 (eBook). Springer, Berlin, Heidelberg, Germany.

 

发明专利:

1Ka-Yiu San, Xian Zhang, Hui Wu, Dan Wang. KAS III-free fatty acid synthesis. US Patent Number: 10851393B2. 授权.

2Ka-Yiu San, George N. Bennett, Hui Wu. Metabolic transistors in bacteria. US Patent Number: 10,011,839 B2. 授权.

3Ka-Yiu San, Xixian Xie, Leepika Tuli,Hui Wu. Hydroxy- and dicarboxylic-fat synthesis by microbes. US patent Number: 9,487,804 B2. 授权.

4Ka-Yiu San, George N. Bennett, Hui Wu. Metabolic transistors in bacteria. US Patent Number: 9,441,253 B2. 授权.

5. 罗远婵,吴辉. 一种高耐镉的生防解淀粉芽孢杆菌及其应用. 中国发明专利专利申请号: 202110666584. 授权.

6吴辉,陆静娴,李志敏,叶勤. 一种提高大肠杆菌合成的聚(3-羟基丁酸-co-乳酸)中乳酸组分含量的方法.中国发明专利专利号:ZL201810246568.X. 授权.

7吴辉,杨昊,李志敏,黄兵,叶勤. 利用乙酸生产丙酮或异丙醇的代谢工程大肠杆菌菌株的构建方法与应用. 中国发明专利专利号:ZL201710978174.9. 授权.

8吴辉,黄兵,李志敏,杨昊,叶勤. 利用乙酸生产羟基丙酸的代谢工程大肠杆菌菌株的构建方法与应用. 中国发明专利专利号:ZL201710969403.0. 授权.

9叶勤,李晴,李志敏吴辉. 利用重组大肠杆菌以甘油为碳源发酵生产琥珀酸的方法. 中国发明专利专利号:ZL201610305322.6. 授权.

10李志敏, 黄兵, 吴辉, 房国辰, 叶勤.一种利用造纸废液生物合成丁二酸的方法. 中国发明专利专利号: ZL201711142577.6. 授权

11李志敏, 李运杰, 吴辉, 叶勤. 利用乙酸生产丁二酸的代谢工程大肠杆菌菌株构建方法和应用. 中国发明专利专利号:ZL201410599042.1. 授权.

12周通,刘映淼,孙兵兵,王祎,吴辉,杨俊杰等. L-色氨酸基因工程菌,其构建方法以及使用其发酵生产L-色氨酸的方法. 中国发明专利专利号:ZL201010598350. 授权.

13叶勤李志敏吴辉. 利用四碳二元酸发酵固定二氧化碳的方法. 中国发明专利专利号:ZL200810207564. 授权.

14吴辉李志敏叶勤. 大肠杆菌生产琥珀酸的方法. 中国发明专利专利号:ZL200710135684. 授权.

 

 

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