纪小国 博士

食品科学与工程专业：硕士生导师

生物与医药专业（生物工程领域）：硕士生导师

个人简介

中共党员，特聘副研究员，食品系教工党支部书记。入选上海市“超级博士后”激励计划、上海市科技启明星“扬帆计划”，华东理工大学第30期青年干部培训班学员。主持国家自然科学基金青年项目、中国博士后科学基金面上项目、上海市自然科学基金面上项目等国家或省部级项目5项。Food Bioengineering编辑、Journal of Food Biochemistry编委、Microbiome Research Reports青年编委、中国微生物学会酿造分会专家委员，中国国际互联网+大学生创新创业大赛上海赛区银奖指导老师和“挑战杯”上海市大学生课外学术科技作品竞赛铜奖指导老师。

研究紧扣国家“大健康”发展战略，以产业化应用为导向，主要聚焦功能寡糖基菌群导向性食品理性设计策略构建和菌群导向性功能食品设计和产业化。累计发表SCI论文20多篇，获上海市科技进步一等奖（8/15）、全国农牧渔业丰收奖（成果奖）二等奖（4/25）、中国商业联合会科技进步一等奖（4/11）、河南省科技进步二等奖（4/10）和中国轻工业联合会科技进步奖二等奖（5/8）等省部级奖项多项。

教育经历

(1) 2011-09至2015-07, 河南工业大学, 生物工程, 学士

(2) 2015-09至2018-06, 河南工业大学, 微生物学, 硕士

(3) 2018-09至2022-06, 华东理工大学, 生物化工, 博士

科研与学术工作经历

(1) 2022-7至2025-04, 华东理工大学 生物工程学院, 博士后，助理研究员

(2) 2025-05至今, 华东理工大学 生物工程学院，特聘副研究员

研究方向：

1）功能糖调控肠道微生态的动态演变规律研究及改善代谢疾病的作用机制解析；

2）糖尿病、肾病等特医食品和功能食品配方设计及产业化；

3）白酒、食醋等固态发酵工艺研究及生物反应器的设计

主持的科研项目：

（1）国家自然基金青年科学基金，肠道微生物动态演变数学模型构建及壳寡糖转运代谢过程研究，2024.01-2026.12，30万元，主持；

（2）中国博士后科学基金，单一聚合度壳寡糖对肠道菌群动态演变的调控规律及动力学模型构建，2023.06-2024.06，8万元，主持，已结题；

（3）上海市自然科学基金面上项目，功能寡糖对特殊人群肠道微生态和情绪的调节及干预机制研究，2023.04-2026.03, 20万元，主持，已结题；

（4）上海市2023年度“科技创新行动计划”启明星（扬帆专项）, 23YF1409800,氨基寡糖对胰岛细胞移植过程中胰岛功能及肠道微生态的调节机制, 2023-04 至 2026-03, 20万元，主持，已结题；

代表性论文（#共同作者，*通讯作者）：

[1] Xuanxiao Lu, Jiaqi Zou, Geng Han, Mingyu Zhao, Tao Luo, Xiangru Feng, Liangliang Zhu, Yijia Chen, Xiaoguo Ji*, Jiayang Jin*, Liming Zhao*. Oligosaccharides with defined glycosidic bonds shape gut microbial succession and metabolism via bondspecific microbial responders, Advanced Science, 2026: ADVS77488.

[2] Xiangru Feng, Yan Hu, Lulu Sun, Xiaoxuan Lu, Liangliang Zhu, Jiayu Liu, Jiayang Jin*, Xiaoguo Ji*, Liming Zhao*. Gut microbiota dysbiosis‑induced neuroinflammation and IL‑22/STAT3 activation in emotional disorders, Brain, Behavior, and Immunity, 2026: 106979.

[3] Liangliang Zhu, Yijia Chen, Jiayang Jin, Mengyao Zhao, Jingfang Ran, Hao Yin, Xiaoguo Ji*, Liming Zhao*. Long-term capsaicin intake and gut inflammation: microbial alterations, metabolic mechanisms, and intervention effects. Food Research International, 2026, 231, 118796.

[4] Liangliang Zhu, Xiangru Feng, Xiaoxuan Lu, Geng Han, Jiaqi Zou, Zhaoyang Dong, Ting Luo, Jiayang Jin, Mengyao Zhao*, Xiaoguo Ji*, Liming Zhao*. Desulfovibrio-hydrogen sulfide mediates capsaicin-induced oxidative stress and gut inflammation via TXNIP/NLRP3 pathway. Food Bioengineering, 2026, 5 (1), 152-167.

[5] Kunlin Chang#, Yifan Feng#, Junfeng Dong, Xiaoyu Mou, Yuanzhen Hao, Duowen He, Yayu Zhang, Xiangru Feng, Xiaoxuan Lu, Yijia Chen, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji*, Shengxian Li*, Hao Yin*, Liming Zhao*. MicrobiotaTargeted Intervention in Pancreatic Islet Transplant Recipients: Remodeling GlucoseMetabolism Related Microbial Communities Restores Gut Microbiota Balance and Glucose Stability in Type 2 Diabetes, Food Science and Human Wellness, 2027: 9251109.

[6] Kunlin Chang, Duowen He, Junfeng Dong, Yayu Zhang, Shuxin Deng, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji*, Hao Yin*, Liming Zhao*. MicrobiotaTargeted Chitooligosaccharides Intervention Restores Glucose Homeostasis After Islet Cell Transplantation in RapamycinTreated Mice, Food Science & Nutrition, 2026: e72122.

[7] Fatima Albadwi, Jiayang Jin, Xiaoguo Ji*, Liming Zhao*. Effects of oligosaccharides in synergy with Enterococcus hirae F42 derived from infant intestines on the milk fermentation process and quality, Journal of Dairy Science, 2026: 60076023.

[8] Xuanxiao Lu, Jiaqi Zou, Xiangru Feng, Geng Han, Liangliang Zhu, Yijia Chen, You Yang, Jiayang Jin*, Xiaoguo Ji*, Liming Zhao*. Oligosaccharides with different glycosidic bonds regulate gut microbiota: differential modulation of bacterial and fungal communities and their metabolism in vitro, Food Research International, 2025: 04608.

[9] ZhaoyangDong, RanZhang, LiangShen, Hong-FangJi, HaidongHe, XiaoguoJi*, LimingZhao*. Gut microbiota and immunoglobulin A nephropathy: Exploration of dietary intervention and treatment strategies. Food Science & Nutrition, 2025, 13: e70218.

[10] Yayu Zhang^#, Xiaoguo Ji^#, Kunlin Chang, Hao Yin, Mengyao Zhao*, Liming Zhao*. The regulatory effect of chitooligosaccharides on islet inflammation in T2D individuals after islet cell transplantation: the mechanism behind Candida albicans abundance and macrophage polarization,Gut Microbes,2025,17(1)：2442051

[11] Shuxin Deng^#, Xiaoguo Ji ^#, Jiaming Wang, Liqiang Fan, Jiayang Jin*, Juan Li*, Liming Zhao*. The effect of black highland barley starch on regulating sustained glucose release and fluctuations in individuals with type 2 diabetes, Food Science and Human Wellness, 2024, 10.26599/FSHW.2024.9250390 

[12] Ran Zhang, Yuyan Tang, Xiangru Feng, Xiaoxuan Lu, Mengyao Zhao, Jiayang Jin, Xiaoguo Ji*, Haidong He*, Liming Zhao*. Targeted modulation of intestinal barrier and mucosal immune-related functional microbiota attenuates IgA nephropathy progression.Gut Microbes, 2025,17(1)：2458184. 

[13] Yu Wang^#, Xiaoguo Ji^#, Mengyao Zhao, Juan Li, Hao Yin, Jiayang Jin*, Liming Zhao*.Modulation of Tryptophan Metabolism via AHR-IL22 Pathway Mediates the Alleviation of DSS-Induced Colitis by Chitooligosaccharides with Different Degrees of Polymerization.Carbohydrate Polymers, 319 (2023) 121180.

[14] Xiaoguo Ji, Liangliang Zhu, Kunlin Chang, Ran Zhang, Yijia Chen, Hao Yin, Jiayang Jin*, Liming Zhao*. Chitooligosaccahrides: digestion characterization and effect of the degree of polymerization on gut microorganisms to manage the metabolome functional diversity in vitro. Carbohydrate Polymers, 275 (2022) 118716.

[15] Xiaoguo Ji, Kun Lin Chang, Mai Chen, Liang Liang Zhu, Arwa Osman, Hao Yin*, Liming Zhao*. In vitro fermentation of chitooligosaccharides and their effects on human fecal microbial community structure and metabolites, LWT - Food Science and Technology, 144 (2021) 111224. [16] Xiaoguo Ji, Mai Chen, Mengyao Zhao, Yudong Song, Yong Lin, Hao Yin*, Liming Zhao*. Effects of chitooligosaccharides on the rebalance of gut microorganisms and their metabolites in patients with nonalcoholic fatty liver disease, Journal of Functional Foods, 77 (2021) 104333.

[17] Shumin Chen, Xiaoguo Ji, Mengyao Zhao, Jiayang Jin, Haiping Zhang*, Liming Zhao*, Construction of chitooligosaccharide-based nanoparticles of pH/redox cascade responsive for co-loading cyclosporin A and AZD9291. Carbohydrate Polymers.291 (2022) 119619.

参与教学

本科生课程《食品工厂设计》

本科生课程《毕业小设计》

诚挚欢迎对功能糖产品开发和生物发酵有兴趣的本科生、研究生加入。导师组认真负责、科研氛围浓厚，期待您的加入！

联系方式：

上海市徐汇区梅陇路130号华东理工大学

邮编：200237

办公室：实验十八楼201（徐汇）、实验六楼410（奉贤）

电话：13460261521

邮箱：jixiaoguo@ecust.edu.cn