ALI MOHSIN博士
生物工程专业：硕士生导师
生物化工专业：硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
生物反应器工程全国重点实验室生物过程工程研究团队固定成员
个人简介
华东理工大学生物工程学院讲师。主要研究方向包括：细菌多糖的生物合成与可降解生物材料的制备，致力于以废弃生物质为原料发酵生产细菌多糖（如xanthan、curdlan and gellan等）；新型纳米材料的制备及其在细胞培养（动物/植物细胞系）和癌症细胞治疗中的应用。累计发表SCI论文100余篇，以第一或通讯作者在Carbohydrate Polymers、Chemical Engineering Journal、Nano Research、Critical Reviews in Biotechnology、Coordination Chemistry Reviews和Journal of Nanobiotechnology等国际权威期刊发表SCI论文30篇、并获得国家自然青年基金（主持）、国家外国专项目（主持）、国际合作提升计划，中国-意大利联合实验室（主持）、及国际交流引进计划等项目资助（主持）。
研究方向
1. Metabolic and evolutionary engineering
Metabolic and evolutionary engineering of microorganisms for the biosynthesis of value-added bioproducts (e.g., biochemicals, bacterial polysaccharides including xanthan and gellan, and biofuels) from agricultural and industrial food wastes.
1. 微生物代谢与进化工程：利用农业和工业废弃生物质为原料，通过代谢工程和适应性进化等手段改造微生物菌株，高效合成高附加值生物产品，包括生物化学品、细菌多糖（如黄原胶、结冷胶等）和生物燃料。
2. Nanobiomaterials and exosome biomanufacturing
Designingand synthesisinginorganic nanomaterials (e.g., Fe₃O₄, Au, and ceria) for biomedical applications in cancer therapy and wound healing. Besides that, developing bioprocess engineering strategies to facilitate the scalable production, isolation, purification, and functional characterization of high-quality exosomes derived from different sources such as animal cells, microorganisms, and plant suspension cells.
2. 纳米生物材料与外泌体生物制造：设计并合成无机纳米材料（如Fe₃O₄、Au和二氧化铈），用于癌症治疗和伤口愈合等生物医学应用。此外，开发生物工艺工程策略，以促进来源于不同来源（如动物细胞、微生物和植物悬浮细胞）的高质量外泌体的规模化生产、分离、纯化及功能表征。
主持或参加的科研项目或基金：
1.国家自然青年基金，主持。
2.国家外国专项目，主持。
3.国际合作提升计划，中国-意大利联合实验室
4.国际交流引进计划项目，主持。
5.中国博士后科学基金，主持。
6.企业横向项目，3项，主持。
7.国家自然科学基金面上基金项目，项目骨干
8.中国科学院战略性先导科技专项，项目骨干。
9.中华人民共和国科学技术部，国家重点研发计划，参与。
教学：
1. 本科生课程《微生物学》全英文课程（48学时）。
2. 研究生课程《微生物生理及代谢调控》全英文课程（32学时）。
3. 联合多学位项目国际本科生课程Joint MultiDegree (JMD) Program for International UndergraduateCourses
《微生物学》理论课、《微生物学实验》Microbiology Theory Course, Microbiology Experiment Class
《发酵工程》理论课、《发酵工程实验》Fermentation Engineering Theory Course, Fermentation Engineering Experiment Class
代表性论文： （一作或通讯论文）
1. Li Yang, Chenxi Huang, Meihua Shen, Cong Xu, Ziyi Guo, Juan Gallo, Meijin Guo*, Ali Mohsin*. Isolation-to-delivery hydrogel enables efficient isolation and sustained release of exosomes to enhance wound healing. Chemical Engineering Journal, 2026, 535, 174990.
2. Senyi Gong, Yu Liu, Jinzhao He, Mengdi Shang, W. Aldahmash, Juan Gallo, Kamran Ashraf, Saria Sajid, M.H. Hussain, Mingwei Shen, T.U Rehman, Meijin Guo*, Ali Mohsin*. Intelligent bioinspired nanovesicles for controllable immune microenvironment reprogramming of drug-resistant breast cancer treatment. Nano Research, 2026, 19(5): 94908498
3. Weifeng Li, Kaijie Xia, Yan Xin, J. Liu, Y. Sun, K. Ashraf, Y. Hu, T. Rehman, Fan Gao, S. Zhuang*, M. Guo*, Ali Mohsin*. Quantitative shear-window engineering enables scalable biomanufacturing of functional mesenchymal stem cell-derived exosomes. Chemical Engineering Journal, 2026, 178494.
4. Senyi Gong, Yu Liu, Xingyu Luo, Yuwen Hu, Qinbiao Yan, Zhe Yang, Shusen Zheng*, Meijin Guo*, Ali Mohsin*. Development of multi-lineage differentiated liver ductal organoids in suspension culture that generates therapeutic extracellular vesicles for sclerosing cholangitis treatment. Nano Research, 2026, 19(5): 94908498.
5. Jinzhao He, Senyi Gong, Yu Liu, Hongjin Chen, Kamran Ashraf, Saria Sajid, Juan Gallo, Meijin Guo,* Ali Mohsin*. Smart magnetic nanozyme for multimodal dynamic regulation to reverse multidrug resistance in breast cancer. Molecular Pharmaceutics (ACS), 2026, 23, 3023−304.
6. Senyi Gong, K. He, Y. Liu, X. Luo, K. Ashraf, J. He, W.Li, L. Yang, T.U. Rehman, Mingwei Shen, Q. Yan, Ali Mohsin*, S. Zheng*, Z. Yang*, M. Guo*. Scalable Matrigel‐Free Suspension Culture for Generating High‐Quality Human Liver Ductal Organoids. Cell Proliferation, 2025, 58, e70033.
7. Y. Liu, S. Gong, X. Luo, Y. Hu, Q. Yan, Z. Yang, Ali Mohsin*, S. Zheng*, M. Guo*. 3D-cultured hUC-MSC-derived exosomes as macrophage mediators to suppress cholestatic fibrosis in mice via miR-1291–mediated multi-targeted pathways.Chemical Engineering Journal, 2026, 2026, 532, 174376.
8. Li, W.-F., Y.-T. Sun, K.-j. Xia, Z.-L. Fan, C.-L. Mi, K. Ashraf, W. Aldahmash, Ali Mohsin*, T.-Y. Wang* and Meijin Guo*. Structure-guided Sodium Butyrate Analogs Enhance Antibody Productivity in CHO Cells via Metabolic and Cell-cycle State Reprogramming. New Biotechnology, 2026, 93.
9. T.U. Rehman, M.R.U. Rahman,W. Tang, S. Vascon, P. Jiang, Y. Liu, S. Gong, X. Wan, Ali Mohsin*, Meijin Guo*. ExoOrb: A Novel Visual and Analytical System for Therapeutic Extracellular Vesicles Metrics. Computational and Structural Biotechnology Journal, 2025, 27, 5289-5306.
10. Kamran Ashraf, Zebo Liu, Qamar uz Zaman, Muhammad Arshad, Waqas Qamar Zaman, Ali Shan, Junxiong Yu, Touseef ur Rehman, Yingping Zhuang, Meijin Guo*, Ali Mohsin*. De Novo Synthesis of Selenium-doped CeO2@Fe3O4 Nanoparticles for Improving Secondary Metabolite Biosynthesis in Carthamus tinctorius Cell Suspension Culture. Chemical Engineering Journal, 2025, 505: 159705.
11. Muhammad Hammad Hussain, Kamran Ashraf, Redhwan Ebrahim Abdullah Alqudaimi, Maria Martuscelli*, Shao-Yuan Leu, Salim-ur-Rehman, Muhammad Shahbaz Aslam, Zhanao Li, Adnan Khaliq, Yingping Zhuang, Meijin Guo, Ali Mohsin*. From Waste to Wealth: Unlocking the Potential of Cellulase Characteristics for Food Processing Waste Management. Foods, 2025, 14(21): 3639
12. Xueli Zhao, Haisong Lu, Sen Peng, Haifeng Hang, Waleed Aldahmash, Muath Q. Al-Ghadi, Weihua Tang, Jiang Pei, Wan Xun, Meijin Guo*, Ali Mohsin*. Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization. Frontiers in Microbiology. 2025, 1561042.
13. Muhammad Hammad Hussain,Lu Han, Yanlong Wei, Muhammad Javid, Kamran Ashraf, Maria Martuscelli, Waleed Aldahmash, Meijin Guo, Ali Mohsin*, Zhanxia Li*. Rational engineering of Escherichia coli strain for stable and enhanced biosynthesis of pinene. Frontiers in Microbiology. 2024, 1527113.
14. Muhammad Zubair Mohsin†, Ali Mohsin†,* (一作&通讯作者), Waqas Qamar Zaman, Xiaojuan Zhu, [...] Jiaofang Huang*. Efficient toluene degradation using Bacillus subtilis biofilm-supported Mn-Ce/zeolite catalysts, Green Synthesis and Catalysis, 2024.
15. Muhammad Zubair Mohsin, Jiaofang Huang, Muhammad Hammad Hussain,Waqas Qamar Zaman, [...] Ali Mohsin* （通讯作者）. Revolutionizing Bioremediation: Advances in Zeolite-based Nanocomposites. Coordination Chemistry Reviews, 2023, 491:215253.
16. Muhammad Hammad Hussain, Muhammad Zubair Mohsin, Waqas Qamar Zaman, [...] Ali Mohsin*（通讯作者）Meijin Guo*. Multiscale engineering of microbial cell factories: A step forward towards sustainable natural products industry. Synthetic and Systems Biotechnology, 7, 2022, 586-601.
17. Kai Wu†, Ali Mohsin† (共同一作), Waqas Qamar Zaman, Zefei Zhang, Wenyan Guan, [...] Meijin Guo*. Urchin-like magnetic microspheres for cancer therapy through synergistic effect of mechanical force, photothermal and photodynamic effects. Journal of Nanobiotechnology, 2022, 20:224.
18. Chenze Xu1†, Ali Mohsin1†(共同一作), Yanxia Luo, Lili Xie, [...] Meijin Guo*. Inducing Non-genetically Modified Induced Embryonic Sertoli Cells Derived From Embryonic Stem Cells With Recombinant Protein Factors. Frontiers in Cell and Developmental Biology. 2022, 8, 533543.
19. Ali Mohsin, Muhammad Hammad Hussain, Muhammad Zubair Mohsin, Waqas Qamar Zaman,* [...] Meijin Guo*. Recent Advances of Magnetic Nanomaterials for Bioimaging, Drug Delivery, and Cell Therapy. ACS Applied Nano Materials, 2022, 5, 10118-10136.
20. Ali Mohsin, Muhammad Hammad Hussain, Waqas Qamar Zaman, Muhammad Zubair Mohsin, [...] Meijin Guo*. Advances in sustainable approaches utilizing orange peel waste to produce highly value-added bioproducts. Critical Reviews in Biotechnology. 2021, 1284-1303.
21. Ali Mohsin, Kanagat Akbota Akyliyaevn, Waqas Qamar Zaman, Muhammad Hammad Hussain, [...] Meijin Guo*. Kinetically modelled approach of xanthan production using different carbon sources: A study on molecular weight and rheological properties of xanthan.International Journal of Biological Macromolecules,2021, 193: 1226-1236.
22. Ali Mohsin, Kanagat Akbota Akyliyaevna, Meijin Guo*, Waheed Ahmed, [...] Yingping Zhuang*. Xanthan-Curdlan nexus for synthesizing edible food packaging films.International Journal of Biological Macromolecules, 2020, 162: 43-49.
23. Ali Mohsin, Hui Ni, Yanxia Luo, Yanlong Wei, [...] Meijin Guo*. Qualitative improvement of camel milk date yoghurt by addition of biosynthesized xanthan from orange waste. LWT-Food Science & Technology. 2019, 108: 61-68.
24. Ali Mohsin, Jingyun Sun, Imran Mahmood Khan, Haifeng Hang*, [...] Meijin Guo*. Sustainable biosynthesis of curdlan from orange waste by using Alcaligenes faecalis: A systematically modeled approach. Carbohydrate Polymers. 2019, 205: 626-635.
25. Ali Mohsin,Kuipu Zhang, Junlang Hu, Salim-ur-Rehman, [...] Meijin Guo*. Optimized biosynthesis of xanthan via effective valorization of orange peels using response surface methodology: A kinetic model approach. Carbohydrate Polymers. 2018, 181: 793-800.
联系方式：
上海市徐汇区梅陇路130号华东理工大学
邮编：200237
办公室：实验18楼509室
电话：021-64252252
邮箱：alimohsin@ecust.edu.cn; alimohsin1991@hotmail.com