赵莉
生物工程专业：硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
个人简介：
赵莉，女；工学博士，讲师。2008年博士毕业于华东理工大学，并留校工作。2018-2019年获国家留学基金委资助，赴美国佐治亚理工学院(Georgia Institute of Technology)访学一年。
主要研究方向：
1. 功能微生物及天然活性物质的筛选及应用；
2. 有机酸、氨基酸、多元醇等平台化合物的绿色生物制造；
3. 重组酶蛋白、药物蛋白的发酵代谢调控
主持或主要参与项目：
1.双菌两步法产3-羟基丙酸机制解析及高效体系构建(NO.21506017)，国家自然科学基金，主持
2.1,3-丙二醇氧化还原酶强化对克雷伯杆菌生长代谢的影响机制(NO.13ZR1412100)，上海市自然科学基金，主持
3.乳酸菌发酵食用酵素产品开发，上海清美绿色食品（集团）有限公司，主持
4.具有情绪调节作用精油分子的虚拟高通量筛选，资生堂（中国）投资有限公司，主持
5.护肤生物活性肽开发研究，上海皓以科技有限公司，主持
6.几种工业用酶酶库的构建及酶的功能研究，生物反应器国家重点实验室特别资助项目，主持
7.药品与食品工业酶高效制备与催化技术(2021YFC2100300)，创新国家重点研发子课题，参与
8.新型农药精草铵膦绿色制造技术及应用，企业横向，参与
9.微生物甾醇侧链降解过程中母核降解机制研究与改进(NO.3157011389)国家自然科学基金，参与
10.分岐杆菌植物甾醇侧链降解与辅因子循环相关性研究(NO.21276083)，国家自然科学基金，参与
11.生物技术药物中试放大及分离纯化技术平台(NO.2012ZX09304009)，重大新药创制项目，参与
12.柠檬酸、葡萄糖酸的生物转化技术(NO.20111102A213)，863计划课题重大化工产品的先进生物制造，参与
教学工作：
《食品微生物学实验》，本科专业必修课程，48学时，1.5学分
《食品原料安全控制》，本科专业必修课程，16学时，1学分
《食品营养与健康》，本科公共选修课程，32学时，2学分
代表性论文（*通讯作者）：
1. Deyi Yin #, Li Zhao#, Sijing Deng, Yaqi Xie, Kum-Song Ro, Zeyong Yang, Lei Du*, Jingli Xie*, Dongzhi Wei, Lactiplantibacillus plantarum X7022 Plays Roles on Aging Mice with Memory Impairment Induced by D-Galactose Through Restoring Neuronal Damage, Relieving Inflammation and Oxidative Stress, Probiotics Antimicrob Proteins, 2024 Jan 6. doi: 10.1007/s12602-023-10208-w.
2. Kum-Song Ro#, Li Zhao#, Yangting Hu, Minli Ge, Lei Du*, Jingli Xie*, Anti-hyperuricemic properties and mechanism of Lactiplantibacillus plantarum X7023, Process Biochemistry, 2024,36: 26-37.
3. Xiaoying Xie#, Kum-Song Ro#, Huiling Wu, Lei Du, Li Zhao*, Jingli Xie*, Dongzhi Wei, A novel γ-aminobutyric acid biosynthetic pathway in Lentilactobacillus curieae，CCTCC M 2011381T，Process Biochemistry，2023，124:160-167.
4. Li Zhao, Jiawei Zhu, Kum-Song Ro, Jingli Xie*, Dongzhi Wei*，Discovery of a novel acrylic acid formation pathway in Gluconobacter oxydans and its application in biosynthesis of acrylic acid from glycerol，Process Biochemistry, 2022,18:182-189.
5. Kum-Song Ro, Ying Chen, Lei Du, Lixin Wang, Li Zhao*, Jingli Xie*, Dongzhi Wei，Improvement of S-allyl-L-cysteine content, probiotic properties and constipation prevention effect of black garlic by the lactic acid bacteria fermentation，Process Biochemistry, 2022,115: 110-117.
6. Guang Liu, Yafan Liu, Kum-Song Ro, Lei Du, Ya-Jie Tang，Li Zhao*, Jingli Xie, Dongzhi Wei ，Genomic characteristics of a novel strain Lactiplantibacillus plantarum X7021 isolated from the brine of stinky tofu for the application in food fermentation，LWT-Food Science and Technology,2022,156:113054
7. Wencheng Liang, Mingli Jiang, Junyong Zhang, Xiaoming Dou, Yan Zhou, Yun Jiang, Li Zhao*, Meidong Lang∗，Novel antibacterial cellulose diacetate-based composite 3D scaffold as potential wound dressing，Journal of Materials Science & Technology, 2021,89:225-232.
8. Jiawei Zhu, Jingli Xie, Liujing Wei, Jinping Lin, Li Zhao*, Dongzhi Wei*，Identification of the enzymes responsible for 3-hydroxypropionic acid formation and their use in improving 3-hydroxypropionic acid production in Gluconobacter oxydans DSM 2003, Bioresource Technology, 2018,265:328-333.
9. Yunlong Sun, Changlin Chen, Heng Xu, Kun Lei, Guanzhe Xu, Li Zhao*, Meidong Lang*, Surface modification of silicon wafer by grafting zwitterionic polymers to improve its antifouling property,Applied Surface Science, 2017,419: 642-649.
10. Yunlong Sun, Changlin Chen,·Heng Xu,·Guanzhe Xu, Li Zhao*, Meidong Lang*, Synthesis and antibacterial performance of functional organic-inorganic silica nanocomposites based on novel zwitterionic polymer, Journal of Inorganic and Organometallic Polymers and Materials,2017,27(5):1351-1364.
11. Li Zhao, Jinping Lin, Hualei Wang, Jingli Xie, Dongzhi Wei*, Development of a two-step process for production of 3-hydroxypropionic acid from glycerol using Klebsiella pneumoniae and Gluconobacter oxydans,Bioprocess and Biosystems Engineering,2015, 38(12):2487-2495.
12. Zhao Li, Zheng Yu, Ma Xingyuan*, Wei Dongzhi*, Effects of over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase on bioconversion of glycerol into 1,3-propandediol by Klebsiella pneumoniae under micro-aerobic conditions, Bioprocess and Biosystems Engineering, 2009,32(3):313-320.
13. Zhao Li, Ma Xingyuan, Zheng Yu, Zhang Jianguo, Wei Guodong, Wei Dongzhi*, Over-expression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase in Klebsiella pneumoniae and their effects on conversion of glycerol into 1,3-propanediol in resting cell system, Journal of Chemical Technology and Biotechnology, 2009,84(4):626-632.
参编教材：
《食品微生物检验学》中国轻工业出版社2019.2，中国轻工业“十三五”规划教材
《现代食品微生物学》科学出版社2021.11，科学出版社“十三五”高等教育研究生规划教材
联系方式：
上海市徐汇区梅陇路130号，邮编：200237
办公室：实验十八楼707室
手机号：13817206675
办公电话：021-64251803
微信：1387206675
邮箱：zhaoli@ecust.edu.cn