刘晓红
发布人:生工学院网站管理员  发布时间:2020-02-25   动态浏览次数:280


刘晓红


生物化学与分子生物学专业:硕士生导师


刘晓红,女,博士,华东理工大学生物工程学院讲师,生物化学与分子生物学硕士研究生导师。主要从事海洋鱼类疫苗开发及免疫应答机制研究,主持国家自然科学青年基金、国家重点研究计划子课题、重点科研基地创新基金中央高校基本科研业务费重点科研基地创新基金。累计发表SCI论文20余篇,申请中国发明专利2项,授权1项。

研究方向

1.      海洋动物疫苗分子设计:研发灭活疫苗、细菌弱毒疫苗或细菌减毒疫苗候选株;对不同疫苗菌株进行配伍形成多联疫苗。

2.      海洋动物疫苗佐剂开发:开展适用于海洋动物疫苗的佐剂筛选;开发完善佐剂的配制、乳化及抗原结合等技术。

3.      海洋动物疫苗免疫评价:疫苗激发鱼体细胞免疫与体液免疫应答时空变化;确立免疫参数变化和攻毒保护率的关系,建立疫苗有效性评价技术。

个人经历

2017.01-至今:华东理工大学生物工程学院讲师

2015.01-2016.12:华东理工大学生物工程学院师资博士生

2009.09-2014.12:华东理工大学生物工程学院/博研究生

2005.09-2009.07:青岛农业大学学士

代表性论文

1.      Xiang Sun, Peng Jin, Qin Liu, Qiyao Wang, Yuanxing Zhang, Xiaohong Liu*. A CpG-riched plasmid as vaccine adjuvant reduce antigen dose of an inactivated Vibrio anguillarum vaccine in turbot (Scophthalmus maximus L.). Fish and Shellfish Immunology 2020 (98): 312–317

2.      Yue Ma, Yabo Liu, Yanyan Wu, Jia Lei*, Xiaohong Liu*, Qiyao Wang, Yuanxing Zhang. An attenuated Vibrio harveyi surface display of envelope protein VP28 to be protective against WSSV and vibriosis as an immunoactivator for Litopenaeus vannamei. Fish and Shellfish Immunology 2019 (95): 195-202.

3.      Tianjian Hu, Ran Chen, Lingzhi Zhang, Zhuang Wang, Dahai Yang, Yuanxing Zhang, Xiaohong Liu*, Qin Liu*. Balanced role of T3SS and T6SS in contribution to the full virulence of Edwardsiella piscicida. Fish and Shellfish Immunology 2019 (93): 871-878.

4.      Dahai Yang#, Xiaohong Liu#, Wenting Xu, Zhaoyan Gu, Cuiting Yang, Lingzhi Zhang, Jingchao Tan, Xin Zheng, Zhuang Wang, Shu Quan, Yuanxing Zhang, Qin Liu. The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. PloS Pathogens 2019 (15): e1007917.

5.      Pengcheng Bao, Xiang Sun, Qin Liu, Yuanxing Zhang, Xiaohong Liu*. Synergistic effect of a combined live Vibrio anguillarum and Edwardsiella piscicida vaccine in turbot. Fish and Shellfish Immunology 2019 (88): 84-90.

6.      Tianjian Hu, Lingzhi Zhang, Wei Wang, Dahai Yang, Jingfan Xiao, Yuanxing Zhang, Xiaohong Liu*, Qin Liu*. Edwardsiella piscicida enters nonphagocytic cells via a macropinocytosis-involved hybrid mechanism. Journal of Bacteriology. 2019 (201): e00548.

7.      Wenting Xu, Chenglong Jiao, Pengcheng Bao, Qin Liu, Pengbo Wang, Ruilin Zhang, Xiaohong Liu*, Yuanxing Zhang. Efficacy of Montanide (TM) ISA 763 A VG as aquatic adjuvant administrated with an inactivated Vibrio harveyi vaccine in turbot (Scophthalmus maximus L.) Fish and Shellfish Immunology 2019 (84): 56-61.

8.      Ying Lou, Guorong Ji, Qin Liu, Pengbo Wang, Ruilin Zhang, Yuanxing Zhang, Xiaohong Liu*. Secretory expression and scale-up production of recombinant human thyroid peroxidase via baculovirus/insect cell system in a wave-type bioreactor. 2018 (149): 7-12.

9.      Lifan Wei, Yanyan Wu, Haoxian Qiao, Wensheng Xu, Yuanxing Zhang, Xiaohong Liu*, Qiyao Wang*. YebC controls virulence by activating T3SS gene expression in the pathogen Edwardsiella piscicida. FEMS Microbiology Letters 2018 (365): fny137.

10.  Xiaohong Liu#, Chenglong Jiao, Yue Ma*, Qiyao Wang, Yuanxing Zhang. A live attenuated Vibrio anguillarum vaccine induces efficient immunoprotection in Tiger puffer (Takifugu rubripes). Vaccine 2018 (36): 1460-1466.

11.  Yunpeng Guan, Kaiyu Yin, Mian Zhou, Minjun Yang, Yuanxing Zhang, Xiaohong Liu*, Qiyao Wang*. EsrB negatively regulates expression of the glutamine sythetase GlnA in the fish pathogen Edwardsiella piscicida. FEMS Microbiology Letters 2018 (365): fny007.

12.  Xiaohong Liu#, Jiamin Sun, Haizhen Wu*. Glycolysis-related proteins are broad spectrum vaccine candidates against aquacultural pathogens. Vaccine 2017 (35): 3813-3816.

13.  Xiaohong Liu#, Hua Zhang, Chenglong Jiao, Qin Liu, Yuanxing Zhang, Jingfan Xiao*. Flagellin enhances the immunoprotection of formalin-inactivated Edwardsiella tarda vaccine in turbot. Fish and Shellfish Immunology 2017 (35): 369-374.

14.  Xiaohong Liu#, Jinmei Xu, Hua Zhang, Qin Liu, Jingfan Xiao*, Yuanxing Zhang. Design and evaluation of an Edwardsiella tarda DNA vaccine co-encoding antigenic and adjuvant peptide. Fish and Shellfish Immunology 2016 (59): 189-195.

15.  Xiaohong Liu#, Hua Zhang, Yuan Gao, Yang Zhang, Haizhen Wu*, Yuanxing Zhang. Efficacy of chitosan oligosaccharide as aquatic adjuvant administrated with a formalin-inactivated Vibrio anguillarum vaccine. Fish and Shellfish Immunology 2015 (47): 855-860.

16.  Xiaohong Liu#, Haizhen Wu*, Qin Liu, Qiyao Wang, Jingfan Xiao, Xinyue Chang, Yuanxing Zhang. Profiling immune response in zebrafish intestine, skin, spleen and kidney bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish and Shellfish Immunology 2015 (45): 342-345.

17.  Xiaohong Liu#, Haizhen Wu*, Qin Liu, Qiaoyao Wang, Jingfan Xiao, Yuanxing Zhang. Skin-injured zebrafish, Danio rerio, are more susceptible to Vibrio anguillarum infection. Journal of the World Aquaculture Society 2015 (46): 301-310.

18.  Xiaohong Liu#, Xinyue Chang, Haizhen Wu*, Jingfan Xiao, Yuan Gao, Yuanxing Zhang. Role of intestinal inflammation in predisposition of Edwardsiella tarda infection in zebrafish (Danio rerio). Fish and Shellfish Immunology 2014 (41): 271-278.

19.  Xiaohong Liu#, Haizhen Wu*, Xinyue Chang,Yufei Tang, Qin Liu, Yuanxing Zhang. Notable mucosal immune responses induced in the intestine of zebrafish (Danio rerio) bath-vaccinated with a live attenuated Vibrio anguillarum vaccine. Fish and Shellfish Immunology 2014 (40): 99-108.

承担科研项目

1.      海洋鱼类浸泡、口服型疫苗的探索性研究/国家重点研发计划子课题/2018.8-2021.12,主持

2.      可替换Signa因子RpoS在杀鱼爱德华氏菌致病力中的分子调控机制/国家自然科学基金青年项目/2017.1-2019.12,主持

联系方式:

地址:上海市梅陇路130号华东理工大学阿华所

电话:021-64252705

邮件:liuxiaohong@ecust.edu.cn