安法梁
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安法梁


生物工程专业:硕士生导师


安法梁,特聘副研究员。主要从事海洋来源微生物次生代谢产物研究。主持国家自然科学基金青年基金、国家自然科学基金面上项目、国家重点研发计划课题、国家重点研发计划子课题、中国博士后基金特别资助、中国博士后基金面上项目、上海市“扬帆计划”和企业横向课题等科研项目,总经费560余万元。在天然产物领域主流期刊Organic LettersActa Pharmaceutica Sinica BOrganic & Biomolecular ChemistryPhytochemistryFood and Chemical ToxicologyMarine Drugs期刊上发表SCI论文30余篇;申请中国发明专利1项。


教育经历

2011.09-2016.06 中国药科大学药物化学理学博士导师: 孔令义教授

2007.09-2011.06 中国药科大学中药学  理学学士

工作经历

2019.01-至今华东理工大学生物工程学院特聘副研究员

2016.07-2018.12 华东理工大学生物工程学院师资博士后

研究方向

1. 海洋真菌来源活性复杂天然产物研究

基于真菌基因组的生物信息学和波谱学分析为导向的具有新颖结构的活性天然产物快速发现、鉴定和活性筛选。

2. 海洋微生物来源活性分子发酵过程优化与放大

通过对菌丝形态、前体代谢调控、生物合成途径、发酵过程参数优化与控制,提高微生物药用活性分子产量,满足药物开发需求。

3. 中药或药用植物来源化妆品添加剂的筛选和机制研究

通过对传统药用植物功能分子的活性筛选、生物转化和作用机制研究,提高植物提取物功效,阐明植物提取物活性物质基础和作用机理,开发新型天然化妆品添加剂。

纵向科研项目

1. 国家自然科学基金青年基金(81703388, 2018.01-2020.12, 主持)

2. 国家自然科学基金面上项目(41876189, 2019.01-2022.12, 主持)

3. 国家重点研发计划课题(2018YFC1706206, 2018.12-2020.12, 主持)

4. 国家重点研发计划子课题(2018YFC1706201, 2021.01-2024.12, 主持)

5. 中国博士后基金特别资助(2018T110359, 2018.07-2020.06, 主持)

6. 中国博士后基金面上项目(2016M601532, 2016.11-2018.10, 主持)

7. 上海市青年英才“扬帆计划”(17YF14033700, 2017.05-2020.04, 主持)

8. 中央高校基本科研业务费研究基金 (222201714023, 2017.03-2018.02, 主持)

代表性论文

1.  An, Fa-Liang; Wang, Xiao-Bing; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Bioactive A-ring rearranged limonoids from the root barks of Walsura robusta. Acta Pharmaceutica Sinica B 2019,9 (3), 545–556.

2.  Ding, Yi (#), An, Fa-Liang(#), Zhu, Xiao-Jing, Yu,Hai-Yuan, Hao, Li-Ling* and Lu, Yan-Hua*, Curdepsidones B–G, Six Depsidones with Anti-Inflammatory Activities from the Marine-Derived Fungus Curvularia sp. IFB-Z10. Marine Drugs2019,17, 266.

3.  An, Fa-Liang; Yin, Yong; Luo, Jun; Kong, Ling-Yi*, Highly oxygenous trichilin-type limonoids from Trichilia sinensis. Chinese Journal of Natural Medicines 2019,17 (12), 912-917.

4.  An, Fa-Liang; Liu, Wei-He; Zhang, Yi; Tao, Jun; Lu, Yan-Hua*, Spirocurvulaide, a novel spirobicyclic polyketide from a marine fungus Curvularia sp. IFB-Z10. Phytochemistry Letters2019,29, 12-16.

5.  Wei, Xing-Chen; Liu, Chang-Qing; Zhang, Ri-Yu; Zheng, Gao-Fan; An, Fa-Liang *; Lu, Yan-Hua*, Improvement of Curvulamine Production by Precursors Co-addition Strategy in Liquid Culture of Marine-Derived Fungus Curvularia sp. IFB-Z10. Applied Biochemistry and Biotechnology 2019, 1-17.

6.  Ji, Xiang; Wei, Xing; Qian, Jie; Mo, Xue-Jun; Kai, Guo-Yin; An, Fa-Liang*; Lu, Yan-Hua*, 2′,4′-Dihydroxy-6′-methoxy-3′,5′-dimethylchalcone induced apoptosis and G1 cell cycle arrest through PI3K/AKT pathway in BEL-7402/5-FU cells. Food and Chemical Toxicology2019,131, 110533.

7.  An, Fa-Liang; Sun, Dong-Mei; Wang, Xiao-Bing; Yang, Lei; Yin, Yong; Luo, Jun*; Kong, Ling-Yi*, Trichiconlides C-F, four new limonoids with 1,2-seco phragmalin-type carbon skeleton from the fruits of Trichilia connaroides. Fitoterapia2018,125, 72-77.

8.  An, Fa-Liang; Sun, Dong-Mei; Wang, Rui-Zhi; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Trijugin- and mexicanolide-type limonoids from the fruits of Heynea trijuga that reverse multidrug resistance in MCF-7/DOX cells. Phytochemistry2018,151, 42-49.

9.  An, Fa-Liang; Liu, Wei-He; Wei, Xing-Chen; Pan, Zheng-Hua; Lu, Yan-Hua*, Curdepsidone A, a Depsidone from the Marine-Derived Endophytic Fungus Curvularia sp. IFB-Z10. Natural Product Communications 2018,13 (7), 865-866.

10.  Liu, Wei-He; Ding, Yi; Ji, Xiang.; An, Fa-Liang*; Lu, Yan-Hua*, Curvulaide A, a bicyclic polyketide with anti-anaerobic bacteria activity from marine-derived Curvularia sp. The Journal of Antibiotics (Tokyo)2018,72, 111-113.

11.  An, Fa-Liang; Sun, Dong-Mei; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Yin, Yong; Kong, Ling-Yi*; Luo, Jun*, Walrobsins A and B, Two Anti-inflammatory Limonoids from Root Barks of Walsura robusta. Organic Letters2017,19, 4568-4571.

12.  Yu, Wan-Guo; Pan, Zheng-Hua; Zhu, Yi-Xiang; An, Fa-Liang*; Lu, Yan-Hua*, Fumigaclavine C exhibits anti-inflammatory effects by suppressing high mobility group box protein 1 relocation and release. European Journal of Pharmacology2017,812, 234-242.

13.  Tang, Liu; Wei, Xing-Chen; An, Fa-Liang*; Lu, Yan-Hua*, Preparative separation of TL1-1 from Daldinia eschscholzii extract by macroporous resin and evaluation of its antimicrobial activities. Journal of Chromatography B2017,1060, 22-29.

14.  An, Fa-Liang; Wang, Xiao-Bing; Wang, Hui; Li, Zhong-Rui; Yang, Ming-Hua; Luo, Jun*; Kong, Ling-Yi*, Cytotoxic Rocaglate Derivatives from Leaves of Aglaia perviridis. Scientific Reports2016,6, 20045.

15.  An, Fa-Liang; Luo, Jun; Wang, Xiao-Bing; Yang, Ming-Hua; Kong, Ling-Yi*, Trichiconlides A and B: two novel limonoids from the fruits of Trichilia connaroides. Organic & Biomolecular Chemistry 2016,14 (4), 1231-1235.

16.  An, Fa-Liang; Luo, Jun; Li, Rui-Jun; Luo, Jian-Guang; Wang, Xiao-Bing; Yang, Ming-Hua; Yang, Lei; Yao, He-Quan; Sun, Hong-Bin; Chen, Yi-Jun; Kong, Ling-Yi*, Spirotrichilins A and B: Two Rearranged Spirocyclic Limonoids from Trichilia connaroides. Organic Letters2016,18 (8), 1924-1927.

17.  An, Fa-Liang; Wang, Jun-Song; Wang, Hui; Wang, Xiao-Bing; Yang, Ming-Hua; Guo, Qing-Long; Dai, Yue; Luo, Jun; Kong, Ling-Yi*, Cytotoxic flavonol-diamide [3+2] adducts from the leaves of Aglaia odorata. Tetrahedron2015,71 (16), 2450-2457.

18.  Wei, Xingchen; Liu, Changqing; An, Fa-Liang; Lu, Yan-Hua*, Induced effect of Ca2+ on curvulamine synthesis by marine-derived fungus Curvularia sp. IFB-Z10 under submerged fermentation. Process Biochemistry2019, 83, 18-26.

19. Liu, Changqing; Wei, Xing-Chen; An, Fa-Liang; Lu, Yan-Hua*, Ammonium Acetate Supplement Strategy for Enhancement of Chaetominine Production in Liquid Culture of Marine-Derived Aspergillus fumigatus CY018. Journal of Microbiology and Biotechnology2019,29 (4), 587-595.

20.  Wei, Xing(#); Mo, Xue-Jun(#); An, Fa-Liang; Ji, Xiang.; Lu, Yan-Hua*, 2',4'-Dihydroxy-6'- methoxy-3',5'-dimethylchalcone, a potent Nrf2/ARE pathway inhibitor, reverses drug resistance by decreasing glutathione synthesis and drug efflux in BEL-7402/5-FU cells. Food and Chemical Toxicology 2018,119, 252-259.

21.  Tao, Jun; An, Fa-Liang; Pan, Zheng-Hua; Lu, Yan-Hua*, Stimulatory Effects of Sugarcane Molasses on Fumigaclavine C Biosynthesis by Aspergillus fumigatus CY018 via Biofilm Enhancement. Journal of Microbiology and Biotechnology2018,28 (5), 748-756.

22.  Sun, Dong-Mei; An, Fa-Liang; Wei, Shan-Shan; Zhang, Yan-Qiu; Wang, Xiao-Bing; Luo, Jun*; Kong, Ling-Yi*, Cipadessains A–K, eleven limonoids from the fruits of Cipadessa cinerascens. RSC Advances2018,8 (19), 10437-10445.

23.  Lu, Yan-Hua*; Pan, Zheng-Hua; Tao, Jun; An, Fa-Liang, Induced effect of Ca(2+) on dalesconols A and B biosynthesis in the culture of Daldinia eschscholzii via calcium/calmodulin signaling. Journal of Bioscience and Bioengineering 2018, 205-210.

24.  Liu, Chang-Qing; Pan, Zheng-Hua; An, Fa-Liang; Lu, Yan-Hua*, Co-addition Strategy for Enhancement of Chaetominine from Submerged Fermentation of Aspergillus fumigatus CY018. Applied Biochemistry and Biotechnology 2018,186 (2), 384-399.

25.  Zhang, Yao; An, Fa-Liang; Huang, Shan-Shan; Yang, Lei; Gu, Yu-Cheng; Luo, Jun; Kong, Ling-Yi*, Diverse tritepenoids from the fruits of Walsura robusta and their reversal of multidrug resistance phenotype in human breast cancer cells.Phytochemistry2017,136, 108-118.

26.  Tian, Xiao-Meng; Li, Hui; An, Fa-Liang; Li, Rui-Jun; Zhou, Miao-Miao; Yang, Ming-Hua; Kong, Ling-Yi*; Luo, Jun*, New Structurally Diverse Limonoids from the Seeds of Khaya senegalensis. Planta Medica2017,83 (3-04), 341-350.

27.  Guo, Miao-Miao; An, Fa-Liang; Yu, Hai-Yuan; Wei, Xing; Hong, Min-Hua; Lu*, Yan-Hua*, Comparative effects of schisandrin A, B, and C on Propionibacterium acnesinduced, NLRP3 inflammasome activation-mediated IL-1β secretion and pyroptosis. Biomedicine & Pharmacotherapy2017,96, 129-136.

28.  Guo, Miao-Miao; An, Fa-Liang; Wei, Xing; Hong, Min-Hua*; Lu, Yan-Hua*, Comparative Effects of Schisandrin A, B, and C on Acne-Related Inflammation. Inflammation2017,40 (6), 2163-2172.

29.  Zhang, Wen Yan; An, Fa-Liang; Zhou, Miao Miao; Chen, Meng Han; Jian, Kai Li; Quasie, Olga; Yang, Ming Hua; Luo, Jun*; Kong, Ling Yi*, Limonoids with diverse frameworks from the stem bark of Entandrophragma angolense and their bioactivities. RSC Advances2016,6 (99), 97160-97171.

30.  Zhang, Chao; Yang, Lei; Geng, Ya-Di ; An, Fa-Liang; Xia, Yuan-Zheng ; Guo, Chao ; Luo, Jian-Guang ; Zhang, Lu-Yong ; Guo, Qing-Long ; Kong, Ling-Yi*, Icariside II, a natural mTOR inhibitor, disrupts aberrant energy homeostasis via suppressing mTORC1-4E-BP1 axis in sarcoma cells. Oncotarget 2016,7, 27819-27837.

31.  Li, Jun He; Li, Yi; An, Fa-Liang; Zhou, Miao-Miao; Luo, Jie; Jian, Kai-Li; Luo, Jun*; Kong, Ling-Yi*, Limonoids with modified furan rings from root barks of Toona sinensis. Tetrahedron 2016,72 (47), 7481-7487.

 

联系方式

地址:上海市徐汇区梅陇路130号,实验181201

电话:021-64251185

邮箱:flan2016@ecust.edu.cn