刘雪婷
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刘雪婷

生物工程专业:博士生导师/硕士生导师

生物工程领域:工程硕士生导师

  

刘雪婷,理学博士,教授。

1999年毕业于中国药科大学中药制药专业,获得理学学士学位(师从罗厚蔚教授和丁林生教授)。2006年毕业于中国药科大学药物化学专业,获理学博士学位(师从闵知大教授和梁敬钰教授),同年进入中科院上海有机化学研究所从事博士后研究工作(师从俞飚教授),并于2007-2010期间在美国威斯康辛大学进行博士后研究(师从Aaron Monte教授)。

201010月回国加入中科院微生物研究所成为副研究员,于201606月受聘成为教授,引进到华东理工大学生物工程学院工作。期间于2012年获得中国科学院公派出国留学,在美国加州大学圣地亚哥分校合作研究6个月(合作导师Pieter Dorrestein教授),并于2017年获得国家留学基金委资助,在波士顿大学进行合作研究一年(合作导师刘平华教授)。

研究成果发表SCI论文47篇,包含共同通讯作者或第一作者论文27篇,发表在AngewChem, Nat Prod Rep, Org Lett, ApplMicrobiolBiotechnol等期刊上;发表合作文章20篇在Nat Biotechnol, Org Lett等期刊上。获得授权专利8件。主持自然科学基金面上项目1项,主持完成自然科学基金青年项目1项和十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项子课题1项,参加国际抗结核联盟的合作研究项目和欧盟第七框架计划“PharmaSea”项目。

  

研究方向:

1. 微生物来源的活性天然产物研究

采用基因组生物信息学分析和多种谱学分析手段为导向,快速发现和鉴定微生物来源(包括放线菌和真菌)的新颖活性天然产物。

2. 利用合成生物学策略合成“非天然”的活性天然产物

运用合成生物学或系统生物学策略,扩大活性天然产物结构多样性。

  

主持和参加的科研项目:

1. 主持中央高校基本科研业务费研究基金2016-2017

2. 主持中国自然科学基金面上基金项目2016.01-2019.12

3. 主持十二五“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项子课题

2013.01-2015.12

4. 主持国家自然科学青年基金项目 2012.01-2014.12

6. 主持国家自然科学国际(地区)合作与交流项目 2013.01-2013.07

7. 参加欧盟第七框架研究计划 2012.10-2016.10

8. 参加盖茨基金会-全球结核病药物研发联盟项目 2009.01-2012.12

  

研究生教学:

参加教学研究生专业选修课,合成生物学与天然产物药物发现(全英文),32学时,2学分。

  

代表性论文(*通讯作者):

2018:

1.Shu-Shan Gao,aǂRonghaiCheng,b,†NathcharNaowarojna,b,†LixinZhang,cXueting Liu,b,c,* and PinghuaLiub,*. Recent Examples of a-Ketoglutarate Dependent Mononuclear Non-Haem Iron Enzymes in Natural Product Biosyntheses and Metabolisms. Nat. Prod. Rep., 2018, accepted.

2017

2.Wenni He, Yao Li, Yuejie Qin, Xiaomei Tong, Zhijun Song, Yu Zhao, Ran Wei, Li Li, Huanqin Dai, Wenzhao Wang, Houwei Luo, Xin Ye, Lixin Zhang*, Xueting Liu*. New cryptotanshinone derivatives with anti-influenza A virus activities obtained via biotransformation by Mucorrouxii. Appl. Microbiol. Biotechnol., 2017, 101(16), 6365-6374.

3.MeiLiu, Pei Huang, Qian Wang, Biao Ren, Oyeleye A, Mei Liu, Jian Zhang, Li X, Zhang X, LixinZhang*, Xueting Liu*. Synergistic antifungal indolecarbazoles from Streptomyces sp. CNS-42 associated with traditional Chinese medicine Alismaorientale. J.Antibiot. (Tokyo). 2017 May;70(5):715-717.

2016

4.Wael M. Abdel-Mageed*, Soad A. L. Bayoumi, Lamya H. Al-wahaibi, Li Li, Hanaa M. Sayed, Mohamed S. A. Abdelkader, Ali A. El-Gamal, Mei Liu, Jingyu Zhang, Lixin Zhang*, and Xueting Liu*. NoncyanogenicCyanoglucoside Cyclooxygenase Inhibitors from Simmondsiachinensis. Org. Lett., 2016, 18(8), 1728-1731. (IF = 6.579)

5.Pei Huang, Feng Xie, Biao Ren, Qian Wang, Jian Wang, Qi Wang, Wael M. Abdel-Mageed, Mei Liu, Jianying Han, Ayokunmi Oyeleye, Jinzhao Shen, Fuhang Song, Huanqin Dai, Xueting Liu*,Lixin Zhang*. Anti-MRSA and anti-TB Metabolites from Marine-derived Verrucosispora sp. MS100047. Appl. Microbiol. Biotechnol., 2016, 100(17), 7437-7347.

6.Wenni He, Miaomiao Liu, Xiaolin Li, Xiaoping Zhang, Wael M. Abdel-Mageed, Li Li, Wenzhao Wang, Jingyu Zhang, Jianying Han, Huanqin Dai, Ronald J. Quinn, Hung-wen Liu, Houwei Luo, Lixin Zhang*, Xueting Liu*. Fungal biotransformation of tanshinone results in [4+2] cycloaddition with sorbicillinol: Evidence for enzyme catalysis and increased antibacterial activity. Appl. Microbiol. Biotechnol., 2016, 100(19), 8349-8357.

7.Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-MageedJianying HanJeramie D. Watrous Don D. NguyenWenzhao WangFuhang Song, HuanqinDaJingyu Zhang Ronald J. Quinn Tanja GrkovHouwei LuoLixin Zhang*Xueting Liu*. Discovery of tanshinone derivatives with anti-MRSA activity via targeted bio-transformation. Synth. Syst. Biotechnol., 2016, 1(3), 187-194.

8.Miaomiao Liu, Tanja Grkovic, Lixin Zhang, Xueting Liu*, Ronald J Quinn*. A model to predict anti-tuberculosis activity: value proposition for marine microorganisms. J. Antibiot. (Tokyo), 2016, 69(8), 594-599.

2015:

9.Nadia H. Mohamedab, Miaomiao Liu, Wael M. Abdel-Mageed, Lamya H. Alwahibi, Huanqin Dai, Mady Ahmed Ismail, Gamal Badr, Ronald J. Quinne, Xueting Liu*, Lixin Zhang*, Ahmed A. M. Shoreit.* Cytotoxic cardenolides from the latex of Calotropisprocera. Bioorg. Med. Chem. Lett., 2015, 25(20), 4615-4620.

10.Ren, B. #, Huang, P.#, Zhang J., He W., Han J., Xueting Liu*, and LixinZhang*. Chapter 2 “Main applications of antibiotics”, Antibiotics: Current Innovations and Future Trends, 2015, Caister Academic Press, Norfolk, U.K.

11.JianyingHan,Jingyu Zhang,Wenni He, Pei Huang, AyokunmiOyeleye, Xueting Liu*, and Lixin Zhang*. Bioassay-guided Identification of Bioactive Molecules from Traditional Chinese Medicines. Chemical Biology--Methods and Protocols. Springer. 2015, 187-196.

12.JingyuZhang,Jianying Han,AyokunmiOyeleye, Miaomiao Liu, Xueting Liu*, and Lixin Zhang*. Extraction methods of natural products from Traditional Chinese Medicines. Chemical Biology--Methods and Protocols. Springer. 2015, pp 177-185.

2014:

13.MiaomiaoLiu, Wael M. Abdel-Mageed, Biao Ren, Wenni He, PeiHuang, Xiaolin Li, Krishna Bolla, Hui Guo, Caixia Chen, Fuhang Song, Huanqin Dai, Tanja Grkovic, XiaopingZhang,*Xueting Liu,* Lixin Zhang*. AntitubercularPluramycins from Endophytic Streptomyces sp. Y3111. Appl. Microbiol. Biotechnol., 2014, 98(3), 1077-1085.

14.Xiaolin Li, Pei Huang, Qian Wang, Lie Xiao, Miaomiao Liu, Krishna Bolla, Bo Zhang, Linyong Zheng, BingchengGan, Xueting Liu*, LixinZhang,* Xiaoping Zhang.*Staurosporine from the endophytic Streptomyces sp. strain CNS-42 acts as a potential biocontrol agent and growth elicitor in cucumber. Antonie van Leeuwenhoek, 2014, 106 (3), 515-525.

2013:

15.Qian Wang, Fuhang Song, Xue Xiao, Pei Huang, Li Li, Aaron Monte, Wael M. Abdel-Mageed, Jian Wang, Hui Guo, Wenni He, Feng Xie, Huanqin Dai, Miaomiao Liu, Caixia Chen, Hao Xu, Mei Liu, Andrew M. Piggott, Xueting Liu*, Robert J. Capon*, Lixin Zhang*. Abyssomicins from a South China Sea deep-sea sediment Verrucosispora sp.: Natural thioether Michael addition adducts as potential antitubercular prodrugs. Angew. Chem. Int. Ed. Engl., 2013, 52, 1231-1234.

16.Jingyu Zhang, Wael M. Abdel-Mageed, Miaomiao Liu, Pei Huang, Wenni He, Li Li, Fuhang Song, Huanqin Dai, Xueting Liu*, Jingyu Liang*, Lixin Zhang*. Caesanines A-D, new cassanediterpenes with unprecedented N bridge from Caesalpiniasappan. Org. Lett., 2013, 15 (18), 4726-4729.

17.Xueting Liu and Lixin Zhang*. Tanshinones against cancer and cardiovascular diseases and their biosynthesis. Handbook of Natural Products, 2013, chapter III.

18.Qi Wang, Biao Tang, Lifu Song, Biao Ren, Qun Liang, Feng Xie, Ying Zhuo, Xueting Liu*, Lixin Zhang*. 3DScapeCS: application of three dimensional, parallel, dynamic network visualization in Cytoscape. BioMed Central, 2013, 14, 322. doi: 10.1186/1471-2105-14-322.

2012

19.Xue-Ting Liu, William R. Schwan, Thomas J. Volk, Marc Rott, Miaomiao Liu, Pei Huang, Zhong Liu, Ying Wang, Nicholas C. Zitomer, Cassandra Sleger, Scott Hartsel, Aaron Monte,*LixinZhang*. Antibacterial Spirobisnaphthalenes from the North American Cup Fungus, Urnulacraterium. Journal of Natural Products, 2012, 75, 1534-1538.

20.Xueting Liu, Caixia Chen,Wenni He, Pei Huang, Miaomiao Liu,Qian Wang,Hui Guo,Krishna Bolla,Yan Lu, Fuhang Song,Huanqin Dai, Mei Liu,and Lixin Zhang. Exploring anti-TB leads from natural products library originated from marine microbes and medicinal plants. Antonie van Leeuwenhoek, 2012, 102, 447-451.

21.Xueting Liu, Bolla Krishna, Elizabeth Jane Ashforth, Ying Zhuo, Hong Gao, Pei Huang, Stanley SA, DT Hung,Lixin Zhang*. Antonie van Leeuwenhoek,2012, 101, 55-66.

2006-2010

22.Xue-Ting Liu, Abby L. Winkler, Marc Rott, Thomas J. Volk, William R. Schwan, Aaron Monte*. Antibacterial compounds from mushrooms II: lanostane triterpenoids and an ergostane steroid with activity against Bacillus cereus isolated from Fomitopsispinicola. Planta Med., 2010, 76(5), 464-466.

23.Xue-Ting Liu, Abby L. Winkler, Marc Rott, Thomas J. Volk, William R. Schwan, Aaron Monte*. Antibacterial compounds from mushrooms I: Lanostane-type triterpene and prenylphenol derivatives from Jahnoporushirtus and Albatrellusflettii and their activities against Bacillus cereus. Planta Med., 2010, 76(2), 182-185.

24.Xue-Ting Liu*, Zhen-Zhong Wang, Wei Xiao, Hui-Wu Zhao, Jie Hu, Biao Yu*. Cholestane Glycosides Trihydroxy Fatty Acids from the Rhizomes of Dioscoreaseptemloba. Planta Med., 2010, 76(3), 291-294.

25.Xue-Ting Liu*, Zhen-Zhong Wang, Wei Xiao, Hui-Wu Zhao, Jie Hu, Biao Yu*. Cholestane and Spirostane Glycosides from the Rhizomes of Dioscoreaseptemloba. Phytochemistry, 2008, 69(6), 1411-1418.

26.Xue-Ting Liu, Yao Shi, Biao Yu, Ian D. Williams, Herman H-Y Sung, Qiong Zhang, Jing-Yu Liang, Nancy Y. Ip, Zhi-DaMin*. Antibacterial diterpenoids from Sagittariapygmaea.Planta Med., 2007, 73 (1), 84-90.

27.Xue-Ting Liu, Qin Pan, Yao Shi, Ian D. Williams, Herman H.-Y. Sung, Qiong Zhang, Jing-Yu Liang, Nancy Y. Ip, and Zhi-Da Min*. ent-Rosane and LabdaneDiterpenoids from Sagittariasagittifoliaand Their Antibacterial Activity against Three Oral Pathogens. J. Nat. Prod., 2006, 69, 255-260.

发明专利:

1.张立新,宋福行,陈彩霞,王倩,郭徽,傅成章,代焕琴,刘雪婷,谢峰,杨娜,余珂。一株链霉菌及其在生产棘霉素中的应用,专利号ZL 201110366624.1 (授权公告日:20121219日)。

2.张立新,宋福行,陈彩霞,郭徽,傅成章,代焕琴,刘雪婷谢峰,杨娜,余珂,王倩。一株链霉菌及其在生产放线菌素中的应用。专利号:ZL201110366034.9 (授权公告日:2013116日)。

3.张立新,宋福行,陈彩霞,任彪,刘雪婷,代焕琴,郭徽,杨娜。一种抗真菌的药物组合物。专利号:ZL201210245954.X (授权公告日:20131023日)

4.张立新,刘雪婷,亚伦蒙蒂,尼古拉斯齐特默,蓝苑元威廉斯沃恩, 汤姆沃克,代焕琴,陈彩霞。抗多种耐药菌化合物及其制备方法与应用。专利号:ZL201110436175.3(授权公告日:201425日)

5.张立新,宋福行,陈彩霞,郭徽,刘雪婷,代焕琴。抗肿瘤化合物及其制备方法与应用。授权号:ZL201210067370.8 (授权公告日:201464日)

6.张立新、梁敬钰、张敬宇、刘雪婷、刘苗苗。一种抗菌化合物及其制备方法与应用。专利号:ZL 201310378741.9 (授权公告日:2015527日)

7.张立新,刘雪婷,王倩,宋福行,陈彩霞,王剑,郭徽,代焕琴,黄佩。来源于海洋疣孢菌的多环聚酮类化合物及其制备方法与应用。专利号:ZL201210079317.X(授权公告日:2015617日)

8.张立新,何文妮,刘雪婷等。一种真菌转化的抗菌活性物质及其制备方法与应用。专利号:ZL20151016433. (授权公告日:201697日)

  

  

联系方式:

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电话:021-64253020

E-mail: liuxueting@ecust.edu.cn