谭高翼
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谭高翼


微生物学专业:硕士生导师

生物工程专业:硕士生导师

生物化学与分子生物学:硕士生导师

生物工程领域:工程硕士生导师


 

简介

谭高翼,男,198111月生于湖北宜昌。博士/副研究员/硕士生导师。20143月毕业于上海交通大学生命科学技术学院(微生物代谢国家重点实验室),获微生物学专业博士学位;20153月获武汉大学医学部助研任职资格;201610月加入华东理工大学任助理研究员、副研究员,目前为生物反应器工程国家重点实验室固定成员。主要从事微生物发酵与次级代谢调控、代谢工程及合成生物学相关的研究。现已发表学术论文20多篇,其中包括在Nature Communications (2019)Current Opinion in Biotechnology (2017)Metabolic Engineering (2015, 2017)ACS Synthetic Biology (2017)Biotechnology and Bioengineering (2013)等专业领域著名学术期刊发表第一作者/通讯作者论文15篇。申请/授权国家发明专利7项。研究论文曾获Faculty of 1000的推荐。多次参加国际会议并受邀作学术报告。带队/指导华东理工大学首届本科生iGEM(国际遗传工程机器大赛)项目,连续两年比赛获团队金奖(2017, 2018)。目前担任Sci. Rep.Appl. Microbiol. Biotechnol.Process Biochem.Biotechnol. J.Biochem. Eng. J.等多个SCI期刊论文审稿人。曾先后主持中国博士后科学基金、湖北省自然科学基金面上项目、国家自然科学基金青年基金、国家自然科学基金面上项目,同时还参与国家973项目、国家重点实验室开放课题等多个研究项目。

 

教育经历

2009. 9 - 2014. 3, 上海交通大学, 生命科学技术学院(微生物代谢国家重点实验室), 理学博士

2004. 9 - 2007. 7, 华南农业大学, 动物科学学院, 农学硕士

2000. 9 - 2004. 7, 武汉轻工大学, 动物科学与营养工程学院, 工学学士

 

研究经历

2016.11 至今,华东理工大学生物工程学院(生物反应器工程国家重点实验室),副研究员

2016.10 - 2016. 11, 华东理工大学生物工程学院,助理研究员

2014. 4 - 2016. 9,武汉大学药学院,博士后/助理研究员

2007. 8 - 2009. 8, 中国农业科学院, 北京畜牧兽医研究所(动物营养学国家重点实验室), 研究助理

 

主持的科研项目

1. 国家自然科学基金面上项目(No. 31870040); 2019.1 - 2022.12

2. 国家自然科学基金青年基金项目(No. 31500072 ); 2016.1 - 2018.12

3. 湖北省自然科学基金面上项目(No. 2015CFB415); 2015.10 - 2017.10

4. 中国博士后自然科学基金项目(No. 2014M562052); 2014.9 - 2016.9

 

研究兴趣

1. 工业微生物的代谢工程改良与遗传育种:利用代谢工程、合成生物学技术提高工业高产菌(e.g. Saccbaropolyspora spinosa, Rhodobacter sphaeroides, Streptomyces avermitilis)的产物合成效率。

2. 海洋放线菌次级代谢产物挖掘及合成与调控机制研究:海洋来源放线菌的沉默基因簇非靶向/靶向激活,例如新颖聚酮类化合物等。

3. 合成生物学新技术开发与应用:基于CRISPR/Cas系统的使能技术开发。例如大片段DNA的高效捕捉,代谢物的高通量检测和筛选等。

 

主讲课程

1,本科生课程:天然产物药物与合成生物学,32学时,秋季开课(2019-

2,研究生课程:Synthetic Biology and Nature Product Discovery32学时,春季开课(2017-

 

部分论文发表 (*:通讯作者;#:贡献相同)

16. Mindong Liang#, Zilong Li#, Weishan Wang#, Jiakun Li#, Leshi Liu, Loganathan Karthik, Guoliang Zhu, Kefeng Wang, Yuting Shuai, Jiaming Yu, Lu Zhang, Chuang Li, Qian Zhang, Tong Shi, Liming Zhou, Man Wang, Zhong Wang, Jing Yu, Feng Xie, Huanqin Dai, Xuetin Liu, Jingyu Zhang, Guang Liu, Buchang Zhang, Chenli Liu, Shanshan Li, Xuekui Xia, Yaojun Tong, Yanwen Liu, Gao-Yi Tan*, Li-Xin Zhang*. 2019. A CRISPR/Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Nature Communications. (Accepted)

15. Jiaqian Cao#, Yongpeng Yao#, Keqiang Fan, Gaoyi Tan, Wensheng Xiang, Xuekui Xia, Shanshan Li*, Weishan Wang*, Lixin Zhang*. 2018. Harnessing a previously unidentified capability of bacterial allosteric transcription factors for sensing diverse small molecules in vitro. Science Advances. 4(11): aau4602. [Fulltext]

14. Qiang Gao#, Gao-Yi Tan#, Xuekui Xia, Lixin Zhang*. 2017. Learn from microbial intelligence for avermectins overproduction. Current Opinion in Biotechnology. 48, 251-257. [Fulltext]

13. Gao-Yi Tan, Kunhua Deng, Xinhua Liu, Hui Tao, Yingying Chang, Jia Chen, Kai Chen, Xu Li, Zixin Deng, Tiangang Liu*. 2017. Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in Streptomyces. ACS Synthetic Biology. 6(6): 995-1005. [Fulltext]

12. Gao-Yi Tan, Tiangang Liu*. 2017. Rational synthetic pathway refactoring of natural products biosynthesis in Actinobacteria. Metabolic Engineering. 39: 228-236. [Fulltext]

11. Gao-Yi Tan, Fayin Zhu, Zixin Deng, Tiangang Liu*. 2016. In vitro Reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors. Synthetic and Systems Biotechnology. 1 (1): 25-33. [Fulltext]

10. Ziling Ye, Xiaowei Li, Yongbo Cheng, Zhijie Liu, Gaoyi Tan, Fayin Zhu, Shuai Fu, Zixin Deng, Tiangang Liu*. 2016. Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula. Journal of Industrial Microbiology & Biothechnolgy, 1(1): 25-33. [Fulltext]

9. Qian Liu, Liping Xiao, Yuanjie Zhou, Kunhua Deng, Gaoyi Tan, Yichao Han, Xinhua Liu, Zixin Deng, Tiangang Liu*. 2016. Development of Streptomyces sp. FR-008 as an emerging chassis. Synthetic and Systems Biotechnology, 1(3): 207-214. [Fulltext]

8. Gao-Yi Tan, Zixin Deng, Tiangang Liu*. 2015. Recent advances in the elucidation of enzymatic function in natural product biosynthesis. F1000Research, 4(F1000 Faculty Rev): 1399. [Fulltext]

7. Gao-Yi Tan, Yao Peng, Chenyang Lu, Linquan Bai*, Jian-Jiang Zhong*. 2015. Engineering validamycin production by tandem deletion of g-butyrolactone receptor genes in Streptomyces hygroscopicus 5008. Metabolic Engineering, 28:74-81. (Highlighted in F1000 Prime by Prof. Gregory Stephanopoulos, March 15, 2016) [Fulltext]

6. Gao-Yi Tan, Linquan Bai*, Jian-Jiang Zhong*. 2013. Exogenous 1, 4-butyrolactone stimulates A-factor-like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008. Biotechnology and Bioengineering. 110(11):2984-2993. [Fulltext]

5. Gao-Yi Tan, Min-Hong Zhang*, Jin-Hai Feng, Ai-Yun Han, Shan-Shan Zheng, Peng Xie. 2010. Effects of pretreatment by the flavanol ampelopsin on porcine kidney epithelial cell injury induced by hydrogen peroxide. Agricultural Sciences in China (Continued as Journal of Integrative Agriculture), 9(4): 598-604. [Fulltext]

4. Lin Yang#, Gao-Yi Tan#, Yu-Qiang Fu, Jing-Hai Feng, Min-Hong Zhang*. 2010. Effects of acute heat stress and subsequent stress removal on function of hepatic mitochondrial respiration, ROS production and lipid peroxidation in broiler chickens. Comparative Biochemistry and Physiology - Part C: Toxicology & Pharmacology 151: 204-208. [Fulltext]

3. Gao-Yi Tan, Lin Yang, Yu-Qiang Fu, Jin-Hai. Feng, Min-Hong Zhang*. 2010. Effects of different acute high ambient temperatures on function of hepatic mitochondrial respiration, antioxidative enzymes, and oxidative injury in broiler chickens. Poultry Science, 89:115-122. (Highlighted in “Insight into oxidative stress in varicocele-associated male infertility. Nature Reviews Urology. 2012, 9: 678-690”) [Fulltext]

2. Gao-Yi Tan, Shan-Shan Zheng, Min-Hong Zhang*, Jing-Hai Feng, Peng Xie, Jin-Ming Bi. 2008. Study of oxidative damage in growing–finishing pigs with continuous excess dietary chromium picolinate intake. Biological Trace Element Research, 126:129-140. [Fulltext]

1. Gao-Yi Tan, Jin-Ming Bi, Min-Hong Zhang*, Jing-Hai Feng, Peng Xie, Shan-Shan Zheng. 2008. Effects of chromium picolinate on oxidative damage in primary piglet hepatocytes. Biological Trace Element Research, 126: S69-S79. [Fulltext]

  

专利

1. 谭高翼,白林泉,钟建江;提高井冈霉素发酵水平的方法;公开(公告)号:CN103740789B

2. 陆健,谭高翼,王启要,吴辉,夏建业,李友元,李晔,李媛媛;一种用于光合生物反应器的发光搅拌桨;公开(公告)号:CN207646198U

3. 高强,张立新,胡栋,张敬宇,谭高翼;一种阿维链霉菌合成培养基及其发酵液的制备方法;公开(公告)号:CN107338210A

4. 张立新,徐峥,陈必钦,谭高翼,苗靳,朱志春,戴昌华,钟锦潮,王霄凤;一种类球红细菌高产菌株的遗传转化方法;公开(公告)号:CN108795968A

5. 张立新,谭高翼,王为善,梁敏东,刘家坤;基于CIRSPR/Cas系统的生物传感器、试剂盒及其在小分子检测中的用途;专利号:201910285607.1

6. 张立新,王为善,李珊珊,李子龙,谭高翼,范可强,张敬宇;提高链霉菌聚酮化合物产量的方法;专利号:201910411123.7

7. 张立新,吴珂,刘雪婷,张敬宇,朱国良,谭高翼,王珍珍;来源于链霉菌的碳磷化合物及其制备方法与应用;专利号:201910440511.8

8. 张立新,谭高翼,张璐,朱国良,王科峰,李川,陈海红;一种利用微生物发酵生产卟啉类化合物及血红素的方法.

 

国际会议发表/摘要

1. Tan GY, Bai L, Zhong JJ. 2011. Quorum sensing molecular analog enhanced validamycin A production by Streptomyces hygroscopicus subsp. jingangensis 5008. Asian Congress on Biotechnology 2011. May 2011, Shanghai, China (墙报)

2. Tan GY, Bai L, Zhong JJ. 2012. Enhanced validamycin production by exogenous 1, 4-butyrolactone in Streptomyces hygroscopicus subsp. jinggangensis 5008. 15th International Biotechnology Symposium and Exhibition. September 2012. Daegu, Korea (口头报告)

3. Tan GY, Bai L, Zhong JJ. 2013. Improvement of validamycin production in Streptomyces hygroscopicus 5008 by engineering of TetR family transcriptional regulators. Asian Congress on Biotechnology 2013. December 2013. New Delhi, India (口头报告)

4. Tan GY, Bai L, Zhong JJ. 2014. Quorum sensing signaling cascade involved in validamycin biosynthesis in Streptomyces hygroscopicus 5008. 12th International Student Seminar (ISS). February 2014. Kyoto, Japan (口头报告)

5. Tan GY, Liu X, Tao H, Cheng Y, Deng Z, Liu T. 2015. Heterologous production of potent insecticide Spinosyn in Streptomyces chassis host. Metabolic Engineering Summit 2015. December 2015. Beijing, China (墙报)

6. Tan GY, Liu X, Deng K, Tao H, Che K, Li X, Deng Z, Liu T. 2016. Heterologous biosynthesis and “omics”-guided metabolic engineering for overproduction of spinosad in Streptomyces. Metabolic Engineering XI. June 2016. Kobe, Japan (墙报)

7. Tan GY, Deng K, Liu X, Tao H, Chang Y, Chen J, Deng Z, Liu T. 2016. Heterologous biosynthesis and refactoring of biosynthetic pathway for the overproduction of spinosad in Streptomyces albus J1074. The 13th International Symposium on the Genetics of Industrial Microorganisms (GIM2016). October 2016. Wuhan, China (墙报)

8. Tan GY, Wang Z, Zhang S, Zhuang Y* & Zhang L*. 2017. 5M strategy-guided coenzyme Q10 overproduction. The 6th Official Conference of the International Chemical Biology Society (ICBS2017). Shanghai, China, 2017.10.17-10.20 (口头报告. Young Chemical Biologists’forum)

9. Tan GY, Lixin Zhang, Weishan Wang, Mindong Liang. 2019. CaT-SMelor, a CRISPR/Cas12a-derived biosensing platform for the highly sensitive detection of diverse small molecules. Copenhagen Bioscience Conference 16 - Natural Products: Discovery, Biosynthesis and Application. Copenhagen, Denmark, 2019.5.5 – 5.9. (摘要)

 

获奖情况

1. 2013.10, 上海交通大学, 博士研究生国家奖学金

2. 2013.12, 上海交通大学, 上海市优秀毕业生称号

3. 2014.2, 京都,受日本京都大学邀参加12th International Student Seminar, 优秀墙报奖

4. 2014.12, 广州,参加《第二届中国放线菌生物学与产业化研讨会》,获得博士论坛二等奖

5. 2016.10, 武汉,参加《第十三届国际工业微生物遗传学大会》,获得最佳墙报奖

6. 2017.11, 波士顿,带队和指导华东理工大学本科生首届国际遗传工程机器大赛(iGEM),获团队金奖

7. 2018.10. 指导华东理工大学本科生第二届国际遗传工程机器大赛(iGEM),获团队金奖

8. 2019.5. 济南,参加中国生物工程学会《第二届全国生物传感、生物芯片与纳米生物技术高端论坛》,获得青年论坛“一等奖”

 

联系方式

华东理工大学生物工程学院,生物反应器工程国家重点实验室,实验室十四楼511

地址:上海徐汇区梅陇路130号,200237

电话:021-64253020

邮箱:tangy@ecust.edu.cn