谭高翼
发布人:生工学院网站管理员  发布时间:2017-03-09   动态浏览次数:13


个人介绍

谭高翼:博士,副研究员,硕士生导师。20143月毕业于上海交通大学生命科学技术学院,微生物代谢国家重点实验室,获微生物学博士学位。20153月获武汉大学医学部助理研究员任职资格。201610月加入华东理工大学。主要从事微生物次级代谢及代谢工程相关的研究。现已在Biotechnology and BioengineeringACS Synthetic BiologyMetabolic Engineering等著名国际期刊发表论文十多篇,研究成果曾被Nature ReviewsFaculty of 1000大幅引用和评述。曾受邀参加2014年日本京都大学第十二届国际学生研讨会并获最佳墙报奖、获2016年第十三届国际工业微生物遗传学大会最佳墙报奖。担任Process BiochemistryBiotechnology JournalBiotechnology Engineering JournalApplied Microbiology and BiotechnologySCI期刊论文审稿人。目前主持国家自然科学基金青年基金、湖北省自然科学基金面上项目,同时还参与国家973项目、国家重点实验室开放课题等。


研究兴趣

1,工业微生物的代谢工程改良与遗传育种

2,海洋放线菌次级代谢产物挖掘及合成与调控机制研究

3,合成生物学元器件及底盘生物的开发与应用


研究经历

2016.11至今 华东理工大学生物工程学院,生物反应器工程国家重点实验室,副研究员

2016.10-2016.11华东理工大学生物工程学院,生物反应器工程国家重点实验室,助理研究员

2014.5-2016.9 武汉大学药学院,组合生物合成与新药发现教育部重点实验室,博士后/助理研究员

2007.7-2009.8 中国农业科学院北京畜牧兽医研究所,动物营养学国家重点实验室,研究助理


已发表的科研论文(*表示通讯作者;#表示共同第一作者)

1. Tan, G.-Y., Deng, K., Liu, X., Tao, H., Chang, Y., Chen, J., Chen, K.; Sheng, Z., Deng, Z., and Liu, T*. (2017) Heterologous biosynthesis of spinosad: an omics-guided large polyketide synthase gene cluster reconstitution in Streptomyces, ACS Synthetic Biology. DOI: 10.1021/acssynbio.6b00330

2. Tan, G.-Y., and Liu, T*. (2017) Rational synthetic pathway refactoring of natural products biosynthesis in actinobacteria, Metabolic Engineering39, 228-236.

3. Ye, Z., Li, X., Cheng, Y., Liu, Z., Tan, G., Zhu, F., Fu, S., Deng, Z., and Liu, T*. (2016) Evaluation of 3-hydroxypropionate biosynthesis in vitro by partial introduction of the 3-hydroxypropionate/4-hydroxybutyrate cycle from Metallosphaera sedula, Journal of Industrial Microbiology & Biotechnology43, 1313-1321.

4. Tan, G.-Y., Zhu, F., Deng, Z., and Liu, T*. (2016) In vitro reconstitution guide for targeted synthetic metabolism of chemicals, nutraceuticals and drug precursors, Synthetic and Systems Biotechnology1, 25-33.

5. Liu, Q., Xiao, L., Zhou, Y., Deng, K., Tan, G., Han, Y., Liu, X., Deng, Z., and Liu, T*. (2016) Development of Streptomyces sp. FR-008 as an emerging chassis, Synthetic and Systems Biotechnology1, 207-214.

6. Tan, G.-Y., Deng, Z., and Liu, T*. (2015) Recent advances in the elucidation of enzymatic function in natural product biosynthesis, F1000 Research4.

7. Tan, G.-Y., Peng, Y., Lu, C., Bai, L*., and Zhong, J.-J*. (2015) Engineering validamycin production by tandem deletion of γ-butyrolactone receptor genes in Streptomyces hygroscopicus 5008, Metabolic Engineering28, 74-81. (F1000推荐论文https://f1000.com/prime/725285293)

8. Tan, G. Y., Bai, L.*, and Zhong, J. J*. (2013) Exogenous 1, 4‐butyrolactone stimulates A‐factor‐like cascade and validamycin biosynthesis in Streptomyces hygroscopicus 5008, Biotechnology and Bioengineering110, 2984-2993.

9. Yang, L., Tan, G.-Y.#, Fu, Y.-Q., Feng, J.-H., and Zhang, M.-H*. (2010) Effects of acute heat stress and subsequent stress removal on function of hepatic mitochondrial respiration, ROS production and lipid peroxidation in broiler chickens, Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology151, 204-208.

10. Tan, G.-Y., Zhang, M.-H.*, Feng, J.-H., Han, A.-Y., Zheng, S.-S., and Peng, X. (2010) Effects of pretreatment by the flavanol ampelopsin on porcine kidney epithelial cell injury induced by hydrogen peroxide, Agricultural Sciences in China9, 598-604.

11. Tan, G.-Y., Yang, L., Fu, Y.-Q., Feng, J.-H., and Zhang, M.-H*. (2010) Effects of different acute high ambient temperatures on function of hepatic mitochondrial respiration, antioxidative enzymes, and oxidative injury in broiler chickens, Poultry Science89, 115-122.

12. Tan, G.-Y., Zheng, S.-S., Zhang, M.-H.*, Feng, J.-H., Xie, P., and Bi, J.-M. (2008) Study of Oxidative Damage in Growing–Finishing Pigs with Continuous Excess Dietary Chromium Picolinate Intake, Biological Trace Element Research126, 129-140.

13. Tan, G.-Y., Bi, J.-M., Zhang, M.-H.*, Feng, J.-H., Xie, P., and Zheng, S.-S. (2008) Effects of chromium picolinate on oxidative damage in primary piglet hepatocytes, Biological Trace Element Research126, 69-79.


发明专利

谭高翼, 白林泉, 钟建江. 提高井冈霉素发酵水平的方法. 专利号: 201410009500.1 (已授权)


参加的国际会议

1. Tan GY, Bai L, Zhong JJ. 2012. Enhanced validamycin production by exogenous 1, 4-butyrolactone in Streptomyces hygroscopicus subsp. jinggangensis 5008. 15th International Biotechnology Symposium and Exhibition. September 2012. Daegu, Korea (口头报告)

2. Tan GY, Bai L, Zhong JJ. 2013. Improvement of validamycin production in Streptomyces hygroscopicus 5008 by engineering of TetR family transcriptional regulators. Asian Congress on Biotechnology 2013. December 2013. New Delhi, India (口头报告)

3. Tan GY, Bai L, Zhong JJ. 2014. Quorum sensing signaling cascade involved in validamycin biosynthesis in Streptomyces hygroscopicus 5008. 12th International Student Seminar (ISS). February 2014. Kyoto, Japan (邀请报告)

4. Tan GY, Liu X, Deng K, Tao H, Che K, Li X, Deng Z, Liu T. 2016. Heterologous biosynthesis and “omics”-guided metabolic engineering for overproduction of spinosad in Streptomyces. Metabolic Engineering XI. June 2016. Kobe, Japan (墙报)

5. Tan GY, Deng K, Liu X, Tao H, Chang Y, Chen J, Deng Z, Liu T. 2016. Heterologous biosynthesis and refactoring of biosynthetic pathway for the overproduction of spinosad in Streptomyces albus J1074. The 13th International Symposium on the Genetics of Industrial Microorganisms (GIM2016). October 2016. Wuhan, China (墙报)


获奖情况

2013.10, 上海交通大学, 获得“博士研究生国家奖学金”

2013.12, 上海交通大学, 获得“上海市优秀毕业生”称号

2014.2, 日本京都大学,受邀参加12th International Student Seminar, 获“优秀墙报奖”

2014.12, 参加《第二届中国放线菌生物学与产业化研讨会》,获得博士论坛“二等奖”

2016.10, 参加The 13th International Symposium on the Genetics of Industrial Microorganisms (GIM2016),获得“最佳墙报奖”


联系方式

地址:上海市徐汇区梅陇路130号,华东理工大学,实验十四楼509

邮编:200237

电话:021-6425

Emailtangy@ecust.edu.cn

https://www.researchgate.net/profile/Gao-Yi_Tan