花强
发布人:生工学院网站管理员  发布时间:2016-10-20   动态浏览次数:926

  

花强

生物化工专业:博士生导师/硕士生导师
        生物工程专业:博士生导师/硕士生导师
        生物工程领域:工程硕士导师

生物工程学院、生物反应器工程国家重点实验室教授,博士生导师。

学习经历
1996–2000  
日本九州工业大学生命科学和生物信息学系,工学博士
1993–1996  
浙江大学化工系生物化学工程专业,工学硕士
1989–1993  
浙江大学化工系生物化学工程专业,工学学士

主要工作经历
2008–
至今 华东理工大学生物反应器工程国家重点实验室 教授
2007–2008  
美国Burnham医学研究所生物信息学和系统生物学部门 研究科学家
2004–2007  
美国加州大学圣迭戈分校生物工程系 博士后学者
2001–2004  
日本庆应大学先端生命科学研究所 助理教授

研究方向
1.
微生物细胞的代谢工程及系统生物技术开发
2.
细胞基因组规模代谢网络模型的开发及应用研究
3.
放线菌细胞代谢解析及抗生素合成的代谢工程改造
4.
酵母菌作为细胞工厂合成脂肪酸类、萜类等有用化合物

研究内容
研究重点在于开发基于代谢物质量同位素标记异构体信息的代谢网络解析法、基因组规模代谢网络模型的构建及模拟仿真等系统代谢工程技术,并将这些新型技术应用于理解和改造若干菌株的代谢功能,使之更有效地合成抗肿瘤次级代谢物或萜类化合物等。

近期论文
1.Gu DQ, et al. IdealKnock: A framework for efficiently identifying knockout strategies leading to targeted overproduction. Computational Biology and Chemistry, 61:229-237, 2016.
2.Fan YX, et al. Enhancement of UDPG synthetic pathway improves ansamitocin production in Actinosynnema pretiosum. Applied Microbiology and Biotechnology, 100:2651-2662, 2016.
3.Zhang C, et al. Applications of genome-scale metabolic models in biotechnology and systems medicine. Frontiers in Physiology, 6:413, 2015.
3.Nambou K, et al. Flux balance analysis inspired bioprocess upgrading for lycopene production by a metabolically engineered strain of Yarrowia lipolytica. Metabolites, 5(4):794-813, 2015.
5.Zhang C, et al. Logical transformation of genome-scale metabolic models for gene level applications and analysis. Bioinformatics, 31(14):2324-2331, 2015.
6.Zhao C. et al. Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources. Journal of Biotechnology, 206:42-51, 2015.
7.Li TL, et al. Improvement of ansamitocin P-3 production by Actinosynnema mirum with fructose as the sole carbon source. Applied Biochemistry and Biotechnology, 175(6):2845-2856, 2015.
8.Zhang C, et al. Logical transformation of genome-scale metabolic models for gene level applications and analysis. Bioinformatics, 31(14):2324-2331, 2015.
9.Zhao C, et al. Metabolome analysis and pathway abundance profiling of Yarrowia lipolytica cultivated on different carbon sources. Journal of Biotechnology, 206:42-51, 2015.
10.Fan YX, et al. Process optimization with alternative carbon sources and modulation of secondary metabolism for enhanced ansamitocin P-3 production in Actinosynnema pretiosum. Journal of Biotechnology, 192:1-10, 2014.
11.Nambou K, et al. Designing of a “cheap to run” fermentation platform for an enhanced production of single cell oil from Yarrowia lipolytica DSM3286 as a potential feedstock for biodiesel. Bioresource Technology, 173: 324-333, 2014.
12.Wei LJ, et al. Revealing in vivo glucose utilization of Gluconobacter oxydans 621H Δmgdh strain by mutagenesis. Microbiological Research, 169:469-475, 2014.
13.Gao Y, et al. Enhancement of ansamitocin P-3 production in Actinosynnema pretiosum by a synergistic effect of glycerol and glucose. Journal of Industrial Microbiology & Biotechnology, 41(1):143-152, 2014.
14.Zhao C, et al. Evaluation of metabolome sample preparation methods regarding leakage reduction for the oleaginous yeast Yarrowia lipolytica. Biochemical Engineering Journal, 82(15):63-70, 2014.

联系方式
地址:上海市梅陇路130号华东理工大学生物反应器工程国家重点实验室
邮编:200237
电话:021-64250972
Email
qhua@ecust.edu.cn