郭美锦
生物化工专业：博士生导师/硕士生导师
生物工程专业：博士生导师/硕士生导师
生物与医药专业（生物工程领域）：博士生导师/硕士生导师
工学博士，华东理工大学生物工程学院教授，博士生导师。主要从事工业微生物发酵与过程控制技术研究，以及干细胞和类器官大规模培养与制备。主讲研究生《发酵调控技术学》和本科生《智能生物制造》课程。研究成果获得国家科技进步二等奖2项、省部级奖一等奖2项、二等奖6项。
工作经历
2010/09-----现在， 华东理工大学，生物工程学院，教 授
2005/12-2010/08，华东理工大学，生物工程学院，副教授
2004/10-2005/10，英国Strathclyde大学，理学院，访问学者
1992/08-2004/08，江西农业大学，生物技术研发中心，实习研究员、讲师
社会兼职
2021-2026：中国微生物学会生化过程模型化与控制专委会 主任委员
2022-2024：中国科协“科创中国”生物医药产业科技服务团 首席专家
2025-2027：第十一届农业农村部肥料登记评审委员会 委 员
2025-2027：上海药学会第十一届抗生素专业委员会 副主任委员
主要研究方向
（1）动物细胞大规模培养与生物反应器设计：主要对CHO细胞、间充质干细胞（MSCs）、类器官（Organoids）和外泌体（Exosomes）等生物反应器大规模培养与工程化技术研究，以及相应的大规模生物反应器设计技术研究，为建立工业化大规模制备提供技术基础。
（2）植物细胞悬浮培养技术与生物反应器设计：主要对珍稀中草药进行悬浮细胞系的建立、细胞培养过程优化与控制，以及大规模培养的生物反应器设计等研究，为建立工业化大规模制备提供技术基础。
联系方式：
Tel: 021-64251131
Email: guo_mj@ecust.edu.cn
近5年主持科研项目（课题）
1. 中国科学院“ 器官重建与制造” 战略性先导科技专项资助课题《干细胞规模制备的生物反应器技术与制造》（编号：XDA16030702） (2019-2023)。
2. 国家自然科学基金项目：《基于多细胞拓扑重构与力学信号调控的标准化仿生肝脏类器官构建及组装调控机制研究》(2026-2029)。
3.长三角科技创新共同体联合攻关脑机接口项目：《微流控仿生的视觉通路搭建与光学脑机接口图像信息重构》(2026-2028)。
获得学术奖励（国家奖2项、省部级多项）
（1）高性能饲料酶绿色制造技术体系创新和应用，上海市科技进步二等奖，授予单位：上海市人民政府，2025年。
（2）基因合成和 DNA 重排技术在饲料酶研制中应用，神农中华农业科技三等奖，授予单位：国家农业农村部，2019年。
（3）黑曲霉细胞工厂氧代谢全局调控葡萄糖酸钠高效生产新技术，上海市科技进步二等奖，授予单位：上海市人民政府，2018年
（4）基于生理与过程信息处理的发酵优化新技术，国家部委，一等奖，2014年
（5）基于生理与过程信息处理的发酵优化新技术，科技部，国家科学技术进步奖，二等奖，2011年
（6）基于参数相关的发酵过程生物反应器优化与放大技术，科技部，国家科学技术进步奖，二等奖，2002年
（7）高比活植酸酶基因的获得及耐高温植酸酶的生产,上海市人民政府，上海市科学技术进步奖，一等奖，2003年
发表论文(*通讯作者)
1. 动物细胞培养与生物反应器设计
（1） Lihua Yang, Yiqun Sun, Qinbiao Yan, Meijun Ding, Lin Qi, Meijin Guo*, Ke Xue*. MiR‐185‐5p derived From hUC‐MSC exosomes via suspension culture under hypoxic conditions es scarless wound healing in mice by precisely regulating collagen I/III regeneration. Advanced Science. 2026 Feb 19:e16120. （中科院一区， IF：14.1）https://doi.org/10.1002/advs.202516120.
（2） Lihua Yang, Cenlong Huang, Mingwei Shen, Chenyu Xu, Zonglin Guo, Juan Gallo, Meijin Guo, Ali Mohsin, Isolation-to-delivery hydrogel enables efficient isolation and sustained release of exosomes to enhance wound healing, Chemical Engineering Journal, 2026, 174990. https://doi.org/10.1016/j.cej.2026.174990（中科院一区， IF：13.2）
（3） Senyi Gong, Yu Liu, Jinzhao He, Mengdi Shang, Waleed Aldahmash, Juan Gallo, Kamran Ashraf, Saria Sajid, Muhammad Hammad Hussain, Mingwei Shen, Touseef Ur Rehman, Meijin Guo*, Ali Mohsin*. Intelligent bioinspired nanovesicles for controllable immune microenvironment reprogramming of drug-resistant breast cancer treatment. Nano Research. 2026. https://doi.org/10.26599/NR.2026.94908498（中科院一区， IF：9.0）
（4） Yu Liu, Senyi Gong, Xingyu Luo, Yuwen Hu, Qinbiao Yan, Zhe Yang*, Ali Mohsin*, Shusen Zheng*, Meijin Guo*. 3D-cultured hUC-MSC-derived exosomes as macrophage mediators to suppress cholestatic fibrosis in mice via miR-1291–mediated multi-targeted pathways. Chemical Engineering Journal 532 (2026) 174376. （中科院一区， IF：13.2）
（5） Wang, Bo et al. Exosomal miR-1246 of adipose stem cells attenuates obesity by polarizing M2 macrophages, reducing fat mass, and beiging of white adipose tissue. Journal of advanced research, 2025, S2090-1232(25)00369-8. （中科院一区， IF：13）
（6） Luo Y, Xie L, Mohsin A, Ahmed W, Xu C, Peng Y, Hang H, Zhuang, Chu J, Guo M*. Efficient generation of male germ-like cells derived during co-culturing of adipose-derived mesenchymal stem cells with Sertoli cells under retinoic acid and testosterone induction. Stem Cell Research & Therapy. 2019, 10: 91-108.
（7） Gong, Senyi et al. Scalable matrigel-free suspension culture for generating high-quality human liver ductal organoids. Cell proliferation. 2025,58 (9): e70033.
（8） Xu C, Mohsin A, Luo Y, Xie L, Peng Y, Wang Q, Hang H, Zhuang Y, Guo M*. Differentiation roadmap of embryonic Sertoli cells derived from mouse enbryonic stem cells. Stem Cell Research & Therapy. 2019, 10
（9） Xu C, Dai Y, Mohsin A, Hang H, Zhuang Y, Guo M*. Mapping molecular pathway for embryonic Sertoli cells derivation based on differentiation model of mouse embryonic cells. Stem Cell Research & Therapy. 2020, 11: 85-102.
（10） Gao T, Zhao X, Hao J, Tian Y, Ma H, Liu W, An B, Sun F, Liu S, Guo B, Niu S, Li Z, Wang C, Wang Y, Feng G, Wang L, Li W, Wu J*, Guo M*, Zhou Q*, Gu Q*. A scalable culture system incorporating microcarrier for specialized mesenchymal stem cells from human embryonic stem cells. Materal Today Bio. 2023; 20:100662
（11） Huan Tian, Meijin Guo*, Yingping Zhuang, Ju Chu, Siliang Zhang. Enhanced proliferation of bone marrow mesenchymal stem cells by co-culture with TM4 mouse Sertoli cells: involvement of the EGF/PI3K/AKT pathway. Molecular and Cellular Biochemistry, 2014, 393(1-2): 155-164
（12） Lei Deng, Bingyang Shi, Yingping Zhuang, Ju Chu, Xiaolin Shi, Siliang Zhang, and Meijin Guo*. Performance and mechanism of neuroleukin in the growth and survival of Sertoli cell induced-neurons in the co-culture system. Cell Transplantation, 2013
（13） Lang Zhou, Jiantao Kong, Yingping Zhuang, Ju Chu, Siliang Zhang, and Meijin Guo*. Ex vivo expansion of bone marrow mesenchymal stem cells using microcarrier beads in a stirred bioreactor. Biotechnology and Bioprocess Engineering, 18: 000-000, 2013
（14） Bingyang Shi, Lei Deng, Xiaolin Shi, Sheng Dai, Hu Zhang, Yonghong Wang, Jingxiu Bi, Meijin Guo* The enhancement of neural stem cell survival and growth by coculturing with expanded sertoli cells in vitro. Biotechnology Progress, 2012, 28(1): 196-205
（15） Haifeng Hang, Yuanxin Guo, Jian Liu, Li Bai, Jianye Xia, Meijin Guo* and Matthew Hui. Computational fluid dynamics modeling of an inverted frustoconical shaking bioreactor for mammalian cell suspension culture. Biotechnology and Bioprocess Engineering, 2011, 16(3): 567-575
（16） Bingyang Shi, Suxiang Zhang, Meijin Guo*, Yonghong Wang,Yingping Zhuang, Ju Chu, Siliang Zhang and Xiaolin Shi. Expansion of Mouse Sertoli Cells on Microcarriers. Cell Proliferation. 2010,43,275–286
（17） Suwen Hu, Lei Deng, Huamao Wang, Yingping Zhuang*, Ju Chu, Siliang Zhang, Zhonghai Li and Meijin Guo*. Bioprocess development for the production of mouse-human chimeric anti-epidermal growth factor receptor vIII antibody C12 by suspension culture of recombinant Chinese hamster ovary cells. Cytotechnology, 2011, 63(3), 247-258
2. 植物细胞培养与反应器设计
（1） Kamran Ashraf, Zebo Liu, Junxiong Yu, Touseef ur Rehman, Yingping Zhuang, Meijin Guo, Ali Mohsin,De Novo synthesis of selenium-doped CeO2@Fe3O4 nanoparticles for improving secondary metabolite biosynthesis in Carthamus tinctorius cell suspension culture, Chemical Engineering Journal, 2025,159705. （中科院一区，TOP期刊，IF：13.2）
（2） Ashraf, K., Q. Zaman, W. Tang, P. Jiang, X. Wan, K. Yuri, A. Mohsin and M. Guo*. Nano-elicitation strategy to improve specialized metabolite pathways in plant cell suspension culture. Frontier in Plant Science, 2025,16, 1679901. doi:10.3389/fpls.2025.1679901 (Impact Factor 4.80)
（3） Ashraf. K., Q. Zaman, L. Yu, G. Senyi, S. Aimon, A. Muhammad, M. Maria, R. Nazih, G. Meijin*, M. Ali*. Enhancing antioxidant and bioactive metabolite production in Carthamus tinctorius cell suspension culture through nanoparticle mediated elicitation. RSE Advances. 2026. (Impact Factor 4.60)
（4） Touseef Ur Rehman, Muhammad Rahman, Weihua Tang, Sebastiano Vascon, Pei Jiang, Yu Liu, Senyi Gong, Xun Wan, Ali Mohsin*, Meijin Guo*. ExoOrb: A novel visual and analytical system for therapeutic extracellular vesicles metrics. Computational and Structural Biotechnology Journal, 2025, 27:5289–5306
（5） Zebo Liu, Meihui Guo, Ali Mohsin, et al. A novel perspective on the role of long non-coding RNAs in regulating polyphenols biosynthesis in methyl jasmonate-treated Siraitia grosvenorii suspension cells. Industrial Crops and Products. 2024, 213: 118419（中科院一区，TOP期刊，IF：5.9）
（6） Xiaofeng Zhu, Zebo Liu, et al. Development of a novel noninvasive quantitative method to monitor Siraitia grosvenorii cell growth and browning degree using an integrated computer-aided vision technology and machine learning. Biotechnology and Bioengineering. 2021, 118(10): 4092-4104
（7） Zebo Liu, Linxiao Du, Nan Liu, et al. Insights into chlorogenic acids' efficient biosynthesis through Carthamus tinctorius cell suspension cultures and their potential mechanism as α-glucosidase inhibitors. Industrial Crops and Products. 2023, 194: 116337.（中科院一区，TOP期刊，IF：5.9）
（8） Zebo Liu, Xiaofeng Zhu, Ali Mohsin, et al. Embryogenic callus induction, cell suspension culture, and spectrum-effect relationship between antioxidant activity and polyphenols composition of Siraitia grosvenorii cultured cells. Industrial Crops and Products. 2022, 176: 114380.（中科院一区，TOP期刊，IF：5.9）
（9） Zebo Liu, Xiaofeng Zhu, Ali Mohsin, et al. Uncovering the role of hydroxycinnamoyl transferase in boosting chlorogenic acid accumulation in Carthamus tinctorius cells under methyl jasmonate elicitation. International Journal of Molecular Sciences. 2024, 25(5): 2710.
（10） Zebo Liu, Ali Mohsin, Zejian Wang, et al. Enhanced biosynthesis of chlorogenic acid and its derivatives in methyl-jasmonate-treated Gardenia jasminoides cells: A study on metabolic and transcriptional responses of cells. Frontiers in Bioengineering and Biotechnology. 2021, 8(1418): 604957.
3. 应用微生物分子生理与过程工程方向
（1） Xueli Zhao, Haisong Lu, Sen Peng, Haifeng Hang, Waleed Aldahmash, Muath Q. Al-Ghadi, Weihua Tang, Jiang Pei, Wan Xun, Meijin Guo*, Ali Mohsin*. Improving butenyl-spinosyn production in Saccharopolyspora pogona through combination of metabolic engineering and medium optimization. Frontiers in Microbiology. 2025, 1561042.
（2） Junxiong Yu, Zejian Wang, Meijin Guo*, et al. Physiological metabolic topology analysis of Halomonas elongata DSM 2581T in response to sodium chloride stress. Biotechnology and Bioengineering, 2022, 119, 3509–3525.
（3） Junxiong Yu, Yue Zhang, Hao Liu, Meijin Guo*, Zejian Wang, et al. Temporal dynamics of stress response in Halomonas elongata to NaCl shock: physiological, metabolomic, and transcriptomic insights. Microbial Cell Factories, 2024, 23(1): 88.
（4） Guanxue Lai, Junxiong Yu, Jing Wang, Zejian Wang, Meijin Guo, et al. Machine learning methods for predicting the key metabolic parameters of Halomonas elongata DSM 2581T. Applied Microbiology and Biotechnology, 2023, 107(17): 5351-5365.
（5） Hong-Tu Zhao, Kun-Yun Pang, Wei-Lu Lin, Ze-Jian Wang, Da-Qi Gao, Mei-Jin Guo*,Ying-Ping Zhuang. Optimization of the n-propanol concentration and feedback control strategy with electronic nose in erythromycin fermentation processes. Process Biochemistry,2015, dx.doi.org/10.1016/j.procbio.2015.12.001
（6） Zhi-Qiang Xiong, Mei-Jin Guo*, Ju Chu, Ying-Ping Zhuang, Si-liang Zhang, On-line specific growth rate control for improving reduced glutathione production in Saccharomyces cerevisiae. Biotechnology & Bioprocess Engineering. 2015,20(5):887-893
（7） Taicheng Zhu, Haifeng Hang, Ju Chu, Yingping Zhuang, Siliang Zhang and Meijin Guo*. Transcriptional investigation of the effect of mixed feeding to identify the main cellular stresses on recombinant Pichia pastoris. Journal of Industrial Microbiology & Biotechnology. 2013: 40:183-189
（8） Lan Yu, Xiangyun Yan, Long Wang, Ju Chu, Yingping Zhuang, Siliang Zhang and Meijin Guo*. Molecular cloning and functional characterization of an ATP-binding cassette transporter OtrC from Streptomyces rimosus. BMC Biotechnology 2012, 12:52
（9） Xiaohe Chu, Zijing Zhen, Zhenyu Tang, Yingping Zhuang, Ju Chu, Siliang Zhang1 and Meijin Guo*. Introduction of extra copy of oxytetracycline resistance gene otrB enhances the biosynthesis of oxytetracycline in Streptomyces rimosus. J Bioprocess Biotechniq 2012, 2:117
（10） Lan Yu, Nan Cao, Long Wang, Ciying Xiao, Meijin Guo*, Ju Chu, Yingping Zhuang, Siliang Zhang. Oxytetracycline biosynthesis improvement in Streptomyces rimosus following duplication of minimal PKS genes, Enzyme and Microbial Technology, 2012,50(6):318–324
（11） Zhenyu Tang, Paul R. Herron, Iain S. Hunter, Siliang Zhang and Meijin Guo*. Insight into microevolution of Streptomyces rimosus based on analysis of zwf and rex genes. African Journal of Microbiology Research ,2012,6(24):5229-5236
（12） Zhenyu Tang, Ciying Xiao, Yingping Zhuang, Ju Chu, Siliang Zhang, Paul R. Herron, Iain S. Hunter, Meijin Guo*. Improved oxytetracycline production in Streptomyces rimosus M4018 by metabolic engineering of the G6PDH gene in the pentose phosphate pathway. Enzyme and Microbial Technology, 2011,49( 1): 17–24
（13） Zhenyu Tang, Yingping Zhuang, Ju Chu, Siliang Zhang, Paul Herron, Iain S. Hunter and Meijin Guo*. A molecular Redox Sensor from Streptomyces rimosus M4018 for Escherichia coli . African Journal of Microbiology Research, 2011, 5(31): 5682-5688
（14） Florence E. Pethick, Alison C. MacFadyen, Zhenyu Tang, Vartul Sangal, Tze-Tze Liu, Ju Chu, Gregor Kosec, Hrvoje Petkovic, Meijin Guo, Ralph Kirby, Paul A. Hoskisson, Paul R. Herron, Iain S. Hunter. Draft genome sequence of the oxytetracycline-producing bacterium Streptomyces rimosus ATCC 10970. Genome Announc. 2013,1(2): e00063-13. doi: 10.1128/genomeA.00063-13. PMCID: PMC3593331
（15） Taicheng Zhu , Meijin Guo* , Yingping Zhuang ,Ju Chu and Siliang Zhang. Understanding the effect of foreign gene dosage on the physiology of Pichia pastoris by transcriptional analysis of key genes. Appl Microbiol Biotechnol. 2011, 89:1127–1135
（16） Zhi-Qiang Xiong, Mei-Jin Guo*, Yuan-Xin Guo, Ju Chu, Ying-Ping Zhuang, Nam Sun Wang and Si-Liang Zhang. RQ feedback control for simultaneous improvement of GSH yield and GSH content in Saccharomyces cerevisiae T65. Enzyme and Microbial Technology. 2010, 46 (7): 598-602
（17） Taicheng Zhu, Meijin Guo*, Ming Zhang, Zhenyu Tang, Yingping Zhuang, Ju Chu, Siliang Zhang. Efficient generation of multi-copy strains for optimizing secretory expression of porcine insulin precursor in yeast Pichia pastoris, Journal of Applied Microbiology . 2009,107: 954–963
（18） Taicheng Zhu, Meijin Guo*, Chen Sun, JuChu, Yingping Zhuang, Siliang Zhang. A systematical investigation on the genetic stability of multi-copy Pichia pastoris strains. Biotechnol Lett. 2009. 31:679-684
（19） Haifeng Hang, Xinhao Ye, Meijin Guo*, Ju Chu, Yingping Zhuang, Ming Zhang, Siliang Zhang. A simple fermentation strategy for high-level production of recombinant phytase by Pichia pastoris using glucose as the growth substrate. Enzyme and Microbial Technology 2009,44:185–188
（20） Zhiqiang Xiong, Meijin Guo*, Yuanxin Guo, Ju Chu, Yingping Zhuang, Siliang Zhang, Efficient extraction of intracellular reduced glutathione from fermentation broth of Saccharomyces cerevisiae by ethanol, Bioresource Technology, 2009, 100 :1011–1014
（21） Zhiqiang Xiong, Meijin Guo*, Yuanxin Guo, Ju Chu,Yingping Zhuang and Siliang Zhang. Real time viable cell mass monitoring in high-cell-density fed-batch glutathione fermentation with industrial complex medium by Saccharomyces cerevisiae T65. Journal of Bioscience and Bioengineering, 2008, 105:409-413
（22） Xiao-Qing Hu, Ju Chu, Zhuo Zhang, Si-Liang Zhang, Ying-Ping Zhuang, Yong-Hong Wang, Meijin Guo*, Hua-Xin Chen, Zhong-Yi Yuan. Effects of different glycerol feeding strategies on S-adenosyl-L-methionine biosynthesis by PGAP-driven Pichia pastoris overexpressing methionine adenosyltransferase. Journal of Biotechnology ,2008, 137(1-4):44-49
（23） Haifeng Hang, Wen Chen, Meijin Guo*, Ju Chu, Yingping Zhuang, Siliang Zhang, A simple unstructured model-based control for efficient expression of recombination porcine insulin precursor by Pichia pastoris, Korean Journal of Chemical Engineering. 2008, 25(5):1065-1069
（24） Meijin Guo, Haifeng Hang, Taicheng Zhu, Yingping Zhuang*, Ju Chu, Siliang Zhang. Effect of glycosylation on biochemical characterization of recombinant phytase expressed in Pichia pastoris. Enzyme and Microbial Technology, 2008,43:334-338
（25） Meijin Guo, Yingping Zhuang*, Ju Chu, Siliang Zhang, Aisheng Xiong, Rihe Peng, Quanhong Yao. Production and purification of a novel thermostable phytase by Pichia pastoris FPHY34. Process Biochemistry, 2007,42:1660-1665
（26） Yaming Dong, Qinqin Fan, Xuefeng Yan*, Meijin Guo, Fei Lu. Development of a hybrid model for sodium gluconate fermentation by Aspergillus niger. Journal of Chemical Technology and Biotechnology, 2014, 89(12): 1875-1882
（27） Qingchao Jiang, Xuefeng Yan*, Zhaomin Lv, Meijin Guo. Fault detection in nonlinear chemical processes based on kernel entropy component analysis and angular structure. Korean Journal of Chemical Engineering, 2013, 30(6): 1181-1186
（28） Wang, L., Xiao, L. H., Duan, L. P., Ye J. B., Guo, Y. Q., Guo, M. J., Liu, L. L., Feng, Y. Y.* (2013) Concurrent infections of Giardia duodenalis, Enterocytozoon bieneusi, and Clostridium difficile in children during a cryptosporidiosis outbreak in a pediatric hospital in China. PLoS Neglected Tropical Diseases. 7, e2437
（29） Lin Wang, Hongwei Zhang, Xudong Zhao，Longxian Zhang, Guoqing Zhang, Meijin Guo, Lili Liu, Yaoyu Feng and Lihua Xiao. Zoonotic cryptosporidium species and Enterocytozoon bieneusi genotypes in HIV-positive patients on antiretroviral therapy. Clin. Microbiol. 2013,51: 2 557-563. doi:10.1128/JCM.02758-12J.
（30） Li, N., Xiao, L. H., Cama, V. A., Ortega, Y., Gilman, R. H., Guo, M. J., Feng, Y. Y.* (2013) Genetic recombination and Cryptosporidium hominis virulent subtype IbA10G2. Emerging Infectious Diseases. 19, 1573-1582
（31） Li, N., Xiao, L. H.*, Wang, L., Zhao, S. M., Zhao, X. K., Duan, L. P., Guo, M. J., Liu, L. L., Feng, Y. Y.* (2012) Molecular surveillance of Cryptosporidium spp., Giardia duodenalis, and Enterocytozoon bieneusi by genotyping and subtyping parasites in wastewater. PLoS Neglected Tropical Diseases. 6: e1809
（32） Zhang, Wei; Sun, Wenfang; An, Shuai; Xiong, Bang; Lin, Kuangfei; Cui, Xinhong; Guo, Meijin . Acute and chronic toxic effects of chloramphenicol on Scenedesmus obliquus and Chlorella pyrenoidosa. Water Environment Research, ,2013 , 85, 8: 725-732
（33） Wei Zhang, Bang Xiong, Lin Chen, Kuangfei Lin, Xinhong Cui, Huasong Bi, Meijin Guo,Weiliang Wang. Toxicity assessment of Chlorella vulgaris and Chlorella protothecoides following exposure to Pb(II). Environmental Toxicology and Pharmacology. 2013, 36(1):51–57
（34） Wei Zhang, Meng Zhang, Kuangfei Lin, Wenfang Sun, Bang Xiong, Meijin Guo, Xinhong Cui, Rongbing Fu. Eco-toxicological effect of Carbamazepine on Scenedesmus obliquus and Chlorella pyrenoidosa. Environmental Toxicology and Pharmacology. 2012, 33 (2): 344–352
（35） Wei Zhang, Li Li, Kuangfei Lin, Bang Xiong, Bingzhi Li, Shuguang Lu, Meijin Guo and Xinhong Cui. Synergetic degradation of Fe/Cu/C for groundwater polluted by trichloroethylene. Water Science & Technology, 2012, 65(12):2258–226, doi:10.2166/wst.2012.146
（36） Wei Zhang, Kuangfei Lin, Youna Miao, Qiaoxiang Dong, Changjiang Huang, Huili Wang, Meijin Guo, Xinhong Cui. Toxicity assessment of zebrafish following exposure to CdTe QDs. Journal of Hazardous Materials, 2012,30:413–420
授权发明专利
（1） 郭美锦，祝小丰，一种植物细胞表型检测方法及系统，专利号:ZL 2021 1 0125780. 2
（2） 郭美锦，祝小丰，基于计算机视觉高通量筛选微生物的方法及存储介质，专利申请号:CN202210260905.7
（3） 郭美锦，祝小丰，一种基于机器学习的质粒发酵变温过程预测方法及系统，专利申请号: CN202310411779.5
（4） 王泽建，余君雄，张悦，刘昊，肖慈英，郭美锦，庄英萍. 提高依克多因生产效率的方法及应用.公布号：CN114807263A.
（5） 王泽建，张悦，余君雄. 一种双碳底物的全合成培养基及其用于生产依克多因的方法.公布号：CN117070397A.
（6） 郭美锦，张嗣良，于岚，颜湘云，王龙，储炬，庄英萍，一种提高土霉素产量的方法，授权日:2015.6.17，中国，ZL201210071770.6.
（7） 郭美锦;郑子静;姚高峰;储炬;庄英萍;张嗣良;钱江潮. 一种增加龟裂链霉菌的土霉素产量的方法, 申请日期：2011年4月27日, 专利申请号： 201110107321.8, 授权日：2015年3月4日
（8） 郭美锦，张嗣良，储炬，杭海峰，一全合成培养基及其应用方法，授权日:2001，10.09，中国，ZL 01 1 05699.1
（9） 储炬，李啸，张嗣良，庄英萍，钟承赞，葛友群，杭海峰，王永红，郭美锦，夏建业，章付林，杨明. 利用铵离子调控林可霉素发酵过程及提高林可霉素产素，申请日期2008年1月23日，申请号：200810032954.5，公开号：CN101220385.A，专利号：ZL200810032954.5