周胜敏
发布人:生工学院网站管理员  发布时间:2016-10-19   动态浏览次数:3459

 

胜敏


生物化工专业:硕士生导师

生物化学与分子生物学专业:硕士生导师


 

河北石家庄人,博士,副教授,生物反应器工程国家重点实验室固定成员。20093月取得东京大学博士学位。20094月至20148月先后在东京大学和日本筑波大学做博士后研究工作。20114月至 20133月期间任职日本学术振兴会(JSPS)特别研究员。201411月受聘于华东理工大学生物工程学院纳米生物工程实验室千人计划团队。入选上海市浦江人才(A类),华理青年英才引进与培育计划,生工学院优秀青年教师培育计划。主持国家自然科学基金面上项目,上海市浦江人才项目,国家重点实验室开放课题等多个项目。骨干参与科技部新药创制重大专项、国家重点研发计划(中日合作),以第一作者身份在《自然》子刊Nature Chemical Biology等期刊上发表论文多篇。

  

研究方向及内容:

研究类别:生命科学、合成生物学、化学生物学

研究对象:模式霉菌、病原真菌、工业真菌

研究内容:探索生物体内环境胁迫、信号传导,次级代谢调控,细胞凋亡等过程涉及的诸多功能基因,研究其作用机理,活用这些基因使之服务于工业、农业、医疗卫生等领域;以真菌为研究对象,从分子水平阐明其逃逸人体免疫杀菌系统进而感染人体的生物过程,同时挖掘致病因子,为新型抗真菌药物开发提供分子靶标;氧化应激及与之对应的信号传导、细胞凋亡与衰老等相关机制研究;产业化过程中工业微生物的集群效应(Quorum sensing)发生机制研究,开发集群效应基因模块,使之服务于绿色制造;真菌的基因编辑技术(CRISPR-Cas)的开发、基于纳米技术的生物探针的开发也是本课题组的重要研究方向。

具体课题:

1. 基于CRISPR-Cas和纳米技术的新型基因编辑技术开发

2. 智能型真菌蛋白表达体系的开发及其在天然药物产物合成生物学领域的应用

3. 新型纳米生物探针的开发

4. 真菌耐药和抗应激机制的解析及新型杀菌靶点的探索

5. 真菌产生生物被膜(biofilm)的分子机制,及其在绿色制造工业中的应用

 

研究业绩:

一作或通讯作者文章(Zhou S

1.        Yang Y, Zhou Y, Li J, Yu H, Takaya N, Wang P, Zhou S*. Novel peroxiredoxin-based sensor for sensitive detection of hydrogen peroxide.Biochem. Biophys. Res. Commun. 517(2):260-265, 2019.

2.        H Yu, H Li, C Chen, Zhou S*, P Wang*. Water-sensitive phase-transition of a carbon dot–calcium carbonate composite for moisture detection in organic solvents. Analytical Methods. 11, 2634-2638, 2019.

3.        He H, Liu Y, Zhou Z, Guo C, Wang HY, Wang Z, Wang X, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*.A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications.FreeRadical Biology and Medicine.123: 1-7, 2018.

4.        He H,Xia Y, Qi Y, Wang HY, Wang Z, Bao J, Zhang Z, Wu FG, Wang H, Chen D, Yang D, Liang X, Chen J, Zhou S*, Liang X, Qian X, Yang Y*.A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications.Bioconjugate Chemistry.18;29(4):1194-1198, 2018.

5.        Xia Y, Yu H, Zhou Z, Takaya N, Zhou S*, Wang P*.Peroxiredoxin system of Aspergillus nidulans resists inactivation by high concentration of hydrogen peroxide-mediated oxidative stress. Journal of Microbiology and Biotechnology.28(1): 145-156, 2018.

6.        Yu H, Chen C, Cao X, Liu Y, Zhou S*, Wang P*.Ratiometric fluorescent pH nanoprobes based on in situ assembling of fluorescence resonance energy transfer between fluorescent proteins.Analytical and Bioanalytical Chemistry409(21):5073-5080, 2017.

7.     Zhou Y, Zhou S*, Yu H, Li J, Xia Y, Li B, Wang X, Wang P*.Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans. Journal of Microbiology and Biotechnology. 26 (5): 928-937, 2016.

8.     Zhou S and Takaya N. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014.

9.     Zhou S, Narukami T, Masuo S, Shimizu M, Fujita T, Doi Y, Kamimura Y, Takaya N.NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013.

10.  Zhou S, Narukami T, Nameki M, Ozawa T, Kamimura Y, Hoshino T, Takaya N.Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.

11.  Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Maruyama J, Kitamoto K, Wakagi T, Shoun H. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology. 48(2): 200-207, Feb, 2011.

12.   Zhou S,Nakanishi Y, Kim SW, Fushinobu S, Maruyama J, Kitamoto K, Wakagi T, Shoun H. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010.

13.   Zhou S, Fushinobu S, Kim SW, Nakanishi Y, Wakagi T, Shoun H.Aspergillus oryzaeflavohemoglobins promote oxidative damage by hydrogen peroxide. Biochem. Biophys. Res. Commun. 394(3):558-561, 2010.

14.Zhou S, Fushinobu S, Nakanishi Y, Kim SW, Wakagi T, Shoun H. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae. Biochem. Biophys. Res. Commun. 381 (1): 7-11, Jan, 2009.

合作文章

15.     Pang B, Zhou L, Cui W, Liu Z, Zhou S, Xu J, Zhou Z. A Hyperthermostable Type II Pullulanase from a Deep-Sea Microorganism Pyrococcus yayanosii CH1. J. Agric. Food. Chem. 67(34):9611-9617,2019

16.     Shunsuke Masuo,AiriKomatsuzaki, Takeshita Norio, Eriko Itoh, Okazoe Takaaki, Shengmin Zhou, Naoki Takaya*. Spatial heterogeneity of glycogen and its metabolizing enzymes in Aspergillus nidulans hyphal tip cells. Fungal Genetics and Biology.110:48-55, 2018.

17.   Shunsuke Masuo, Shengmin Zhou, Tatsuo Kaneko, Naoki Takaya*. Bacterialfermentation platform for producing artificial aromatic amines.Scientific Report, 11:6, 2016.

18.  Motoyuki Shimizu, Shunsuke Masuo, Eriko Itoh, Shengmin Zhou, Masashi Kato, Naoki Takaya*. Thiamine synthesis regulates the fermentation mechanisms in the fungus Aspergillus nidulans.Bioscience, Biotechnology, and Biochemistry. 80(9), 1768-1775, 2016

19.  Jia Wei, Xiaodan Cao,Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli.Journal of Microbiology and Biotechnology.25(8): 1227-1233, 2015

20.   Shunsuke Masuo, Lisa Osada,Shengmin Zhou, Tomoya Fujita,Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.

21.  Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura.Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1. Environmental Microbiology. 16(9):2927-2938,2014

22.  Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya.Microbial monomers custom-synthesized to build true bio-derived aromatic polymers.Applied Microbiology and Biotechnology.97(20):8887-8894, Aug, 2013.

23.  Wenjing Cui, Xiaoyan Yang, Yueqin Fang,Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes.Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.

24.  Morio Miyahara, Sang-Wan Kim,Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun.Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions.Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012

25.  Sang-Wan Kim, Shinya Fushinobu,Shengmin Zhou,Takayoshi Wakagi and Hirofumi Shoun.The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense.Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010

26.  Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun.Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion?Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.

科研项目:

1.  主持国家自然科学基金面上项目,76万,216720652017.01-2020.12

2.  主持上海市浦江人才项目(A)20万,16PJ14025002016.07-2018.07

3.  主持生工学院优秀青年教师培育计划项目,20万,2015.07-2017.07

4.  主持国家重点实验室开放课题,10万,2015.01-2017.01

5.  参与国家自然科学基金重点项目,145/团队,216360032017.01-2021.12

6.  参与科技部新药创制重大专项,150/2000万,2018.4-2023.3

7.  参与国家重点研发计划(中日合作)100/230万,2020.4-2023.3

学术荣誉:

2011年日本教育部JSPS特别研究员

2016年上海市浦江学者(A类)

严谨的学风,活跃的气氛,前沿的研究,充足的经费,舒适的环境。欢迎报考!

 

联络:

    梅陇路130号实验18号楼1413

电邮: zhoushengmin@ecust.edu.cn