周胜敏
发布人:生工学院网站管理员  发布时间:2016-10-19   动态浏览次数:262

 

胜敏

生物化学与分子生物学专业:硕士生导师
 

河北石家庄人,博士,副教授,生物反应器工程国家重点实验室固定成员。20093月取得东京大学博士学位。20094月至20148月先后在东京大学和日本筑波大学做博士后研究工作。20114月至 20133月期间任职日本学术振兴会(JSPS)特别研究员。201411月受聘于华东理工大学生物工程学院纳米生物工程实验室千人计划团队。入选上海市浦江人才(A类),华理青年英才引进与培育计划,生工学院优秀青年教师培育计划。主持国家自然科学基金面上项目,上海市浦江人才项目,国家重点实验室开放课题等多个项目。以第一作者身份在《自然》子刊Nature Chemical Biology (IF: 16) Applied Environmental Microbiology (IF: 4)等著名期刊上发表论文多篇。


研究内容及研究方向:

研究领域为环境微生物、病原微生物及工业微生物的分子生物学。探索微生物环境胁迫信号传导及次级代谢调控等相关的诸多功能基因,活用这些基因使之服务于工业,农业,医疗卫生等领域。长期以来以真菌为研究对象,探索了天然免疫杀菌分子一氧化氮(NO)的杀菌机制,鉴定出一系列病原菌体内NO抗性基因,并阐明了其抗性原理,为新型抗真菌药物开发提供了多个分子靶标。同时开展了微生物氧化应激及与之对应的信号传导、细胞凋亡与衰老等相关机制研究。近期又开展了产业化过程中工业微生物的集群效应发生机制研究,为通过人为调控集群效应提高发酵能力提供技术支持。研究课题如下

1.真菌的NO抗性分子机制解析及抗真菌药物杀菌靶点的定位

2.真菌的氧化应激抗性体系的解析及新型杀菌靶点的探索

3.真菌有用次级代谢产物合成途径及其调控机制的研究

4.工业微生物生物被膜形成的分子机制及其集群效应

5.智能型丝状真菌蛋白表达体系的开发

6.活体检测生物探针的开发

发表论文 :

(1). Shunsuke Masuo, Shengmin Zhou, Tatsuo Kaneko, Naoki Takaya*. Bacterial fermentation platform for producing artificial aromatic amines.Scientific Report, 11:6, 2016.

(2). Motoyuki Shimizu, Shunsuke Masuo, Eriko Itoh, Shengmin Zhou, Masashi Kato, Naoki Takaya*. Thiamine synthesis regulates the fermentation mechanisms in the fungus Aspergillus nidulans.Bioscience, Biotechnology, and Biochemistry. 80(9), 1768-1775, 2016

(3). Yao Zhou, Shengmin Zhou*, Haijun Yu, Jingyi Li, Yang Xia, Baoyi Li, Xiaoli Wang, Ping Wang*. Cloning and characterization of filamentous fungal S-nitrosoglutathione reductase from Aspergillus nidulans. Journal of Microbiology and Biotechnology. 26 (5): 928-937, 2016. (共同通讯)

(4). Jia Wei, Xiaodan Cao, Shengmin Zhou, Chao Chen, Haijun Yu, Yao Zhou, Ping Wang. Soluble expression and purification of the catalytic domain of human vascular endothelial growth factor receptor 2 in Escherichia coli.Journal of Microbiology and Biotechnology.25(8): 1227-1233, 2015

(5). Shunsuke Masuo, Lisa Osada, Shengmin Zhou, Tomoya Fujita, Naoki Takaya. Aspergillus oryzae pathways that convert phenylalanine into the flavor volatile 2-phenylethanol.Fungal Genetics and Biology. 77: 22-30, 2015.

(6).Shengmin Zhou and Naoki Takaya. Novel fungal nitrosothionein peptide involved in tolerance to nitric oxide. Bioscience&industry. 72(2): 55-56, 2014.

(7).Masanori Toyofuku, Shengmin Zhou, Isao Sawada, Naoki Takaya, Hiroo Uchiyama and Nobuhiko Nomura. Membrane vesicle formation is associated with pyocin production under denitrifying conditions in Pseudomonas aeruginosa PAO1. Environmental Microbiology. 16(9):2927-2938, 2014,

(8).Shengmin Zhou, Toshiaki Narukami, ShunsukeMasuo, Motoyuki Shimizu, Tomoya Fujita, Yuki Doi, Yosuke Kamimura, Naoki Takaya. NO-inducible nitrosothionein mediates NO removal in tandem with thioredoxin. Nature Chemical Biology. 9(10): 657-663, Aug, 2013.

(9).Tomoya Fujita, HieuDuc Nguyen, Takashi Ito, Shengmin Zhou, Lisa Osada, Seiji Tateyama, Tatsuo Kaneko, Naoki Takaya. Microbial monomers custom-synthesized to build true bio-derived aromatic polymers. Applied Microbiology and Biotechnology. 97(20):8887-8894, Aug, 2013.

(10).Wenjing Cui, Xiaoyan Yang, Yueqin Fang, Shengmin Zhou, Song Liu, Guocheng Du, Kun Du, Jian Chen, Guanjun Tao and Zhemin Zhou. Discovery of two transglutaminases derived from same zymogen for the Streptomyces hygroscopicus and analysis of their formation processes.Journal of the Science of Food and Agriculture. 93(7): 1711-1717, May, 2013.

(11).Morio Miyahara, Sang-Wan Kim,Shengmin Zhou, Shinya Fushinobu, Takeshi Yamada, Wakako Ikeda-Ohtsubo, Akira Watanabe, Keisuke Miyauchi, Ginro Endo and Hirofumi Shoun.Survival of the aerobic denitrifier Pseudomonas stutzeri strain TR2 during co-culture with activated sludge under denitrifying conditions.Bioscience, Biotechnology, and Biochemistry. 76(3): 495-500, Mar, 2012.

(12).Shengmin Zhou, Toshiaki Narukami, Misuzu Nameki, Tomoko Ozawa, Yosuke Kamimura, Takayuki Hoshino and Naoki Takaya. Heme-biosynthetic porphobilinogen deaminase protects Aspergillus nidulans from nitrosative stress. Applied and Environmental Microbiology. 78(1): 103-109, Jan, 2012.

(13).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, Jun-ichi Maruyama,  Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. Functional analysis and subcellular location of two flavohemoglobins from Aspergillus oryzae. Fungal Genetics and Biology. 48(2): 200-207, Feb, 2011.

(14).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi and Hirofumi Shoun. The possible involvement of copper-containing nitrite reductase (NirK) and flavohemoglobin in denitrification by the fungus Cylindrocarpon tonkinense.Bioscience, Biotechnology, and Biochemistry.74 (7): 1403-1407, Jul, 2010.

(15).Shengmin Zhou*, Yoshito Nakanishi*, Shinya Fushinobu, Sang-Wan Kim, Jun-ichi Maruyama, Katsuhiko Kitamoto, Takayoshi Wakagi, and Hirofumi Shoun. A eukaryotic copper-containing nitrite reductase derived from a NirK homolog gene of Aspergillus oryzae. Bioscience, Biotechnology, and Biochemistry.74(5):984-991, May, 2010. (共同一作)

(16).Shengmin Zhou, Shinya Fushinobu, Sang-Wan Kim, Yoshito Nakanishi, TakayoshiWakagi, and Hirofumi Shoun. Aspergillus oryzae flavohemoglobins promote oxidative damage by hydrogen peroxide. Biochemical and Biophysical Research Communications.394(3):558-561, Apr, 2010.

(17).Sang-Wan Kim, Shinya Fushinobu, Shengmin Zhou, Takayoshi Wakagi, and Hirofumi Shoun. Eukaryotic nirK genes encoding copper-containing nitrite reductase: originating from the protomitochondrion? Applied and Environmental Microbiology. 75 (9): 2652-2658, Mar, 2009.

(18).Shengmin Zhou, Shinya Fushinobu, Yoshito Nakanishi, Sang-Wan Kim, Takayoshi Wakagi and Hirofumi Shoun. Cloning and characterization of two flavohemoglobins from Aspergillus oryzae. Biochemical and Biophysical Research Communications.381 (1): 7-11, Jan, 2009.

科研项目:

1.主持国家自然科学基金面上项目,216720652017.01-2020.12

2.主持上海市浦江人才项目(A)16PJ14025002016.07-2018.07

3.主持生工学院优秀青年教师培育计划项目,2015.07-2017.07

4.主持国家重点实验室开放课题,2015.01-2017.01

5.参与国家自然科学基金重点项目,216360032017.01-2021.12

学术荣誉:

2011年日本教育部JSPS特别研究员

2016年上海市浦江学者(A类)


课题组成员(含借调):

博士研究生:余海军(D2),周瑶(D1),李静宜(D1)

硕士研究生:李宝意(M3),夏阳(M3),李郝祥(M2), 阳瑜红(M1), 吕航亚(M1), 刘杨奕(17级推免生)

联络:

梅陇路130号实验18号楼1413

电话: 021-64250135

电邮: zhoushengmin@ecust.edu.cn