鲍杰
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鲍杰

生物工程专业:博士生导师/硕士生导师 

生物化工专业:博士生导师/硕士生导师 

生物工程领域:工程硕士生导师

  

  工学博士,教授、博士生导师。南京理工大学学士学位、浙江大学硕士学位、日本国立山口大学博士学位,上海市浦江计划学者。先后在中石化、日本冈山大学、美国加州大学戴维斯分校从事研究工作。2006年至今任职华东理工大学生物工程学院和生物反应器工程国家重点实验室。作为课题负责人主持了973863、国家自然科学基金课题,以及中石油等工业应用课题数十项。现任SCI期刊Applied Biochemistry and Biotechnology副主编、Biofuels, Bioproducts and BiorefiningBioprocess and Biosystems Engineering编委、SpringerElsevier学术期刊客座编辑,亚洲生物技术联合会生物能源与生物炼制分会理事,生物反应器工程国家重点实验室副主任。作为秘书长或共同主席组织了亚洲生物技术大会、生物过程与生物技术国际研讨会等多次国际学术会议。

研究领域聚焦于木质纤维素生物炼制和生物能源方向的应用基础研究。提出了木质纤维素干法生物炼制技术,在液体燃料和生物基化学品生产上显示了巨大的技术优势和环境友好性,奠定了以木质纤维素替代粮食和石油资源的可持续生物与化学工业的技术基础;对一系列生物炼制工业发酵菌株的代谢工程改造,成倍提高了生物催化和发酵效率,达到了迄今国内外最高水平的生物炼制转化、能耗和排放指标;独特的生物脱毒菌株和代谢机制的发现,极大提高了生物炼制过程效率和环境质量,实现了抑制物脱毒关键瓶颈的突破;提出了基于严格热力学和流变学基础上的生物炼制流程模拟和计算流体力学模型,实施了多项面向产业化规模的工艺包设计和工业应用。在生物航空燃油、氨基酸生物炼制等前沿领域取得重大进展,并开拓了重金属土壤污染的生物炼制治理新方向。

  

通讯地址:上海市梅陇路130号华东理工大学283信箱(200237

实验室:华东理工大学实验十八楼1303

电话:021-64251799

Emailjbao@ecust.edu.cn

网页:http://sklbe.ecust.edu.cn/biomasslab



学历

1997-2001    工学博士,日本国立山口大学物质工学专业

1995-1997    工学硕士,浙江大学化学工程专业

1980-1984    工学学士,南京理工大学化学工程专业

  

研究经历

2006-现在     华东理工大学生物工程学院教授、博士生导师

2002-2006    美国加州大学戴维斯分校博士后研究员

2001-2002    日本国立冈山大学工学部客座研究员

1984-1995    中石化齐鲁石化研究院工程师、课题组长

  

学术兼职

Applied Biochemistry and Biotechnology (Springer)副主编 (Associate Editor)2012年至今;

Biofuels, Bioproducts and Biorefining (Wiley)编委 (Editorial Board Member)2008年至今;

Bioprocess and Biosystems Engineering (Springer)编委 (Editorial Board Member)2012年至今;

亚洲生物技术联合会生物能源与生物炼制分会理事 (AFOB Bioenergy and Biorefinery Division)2012年至今。

 

主要研究方向

生物炼制过程工程:木质纤维素先进预处理、生物脱毒、高固体含量酶促糖化,以及己糖和戊糖共发酵生产液体低碳醇、有机酸、氨基酸、长链脂肪酸、长链烃等能源和化学品为核心骨架的生物炼制过程工程研究、Aspen Plus流程模拟、流变学与计算流体力学研究。

生物炼制代谢工程:超级生物脱毒微生物的发现和改造;抑制物终极降解机制解析和合成生物学基因元件库构建;全糖转化发酵乙醇、手性乳酸、氨基酸、糖酸等产品的微生物代谢工程和合成生物学改造;微生物的生物炼制适应性进化和机制解析;木质纤维素维生素营养成分的提取与发酵应用。

高能量密度航空燃油:基于微细胞密度差异的超级油脂微生物靶向性筛选;高产长链脂肪酸和长链烃(航空燃油)的油脂酵母代谢工程和合成生物学改造;纤维素原料合成超高指标长链脂肪酸和长链烃的生物炼制转化研究。

重金属土壤污染的生物炼制治理:生物炼制技术对重金属土壤污染植物治理的全封闭式生物炼制研究;重金属治理过程协同生物能源生产;重金属高丰度富集与资源化循环。

  

主讲课程

本科生专业课:生物炼制工程(Biorefinery Engineering

本科生专业课:过程工程过程设计(Aspen plus在生物工程设计上的应用)

研究生全英文专业课(硕士):生物能源过程工程(Bioenergy Process Engineering

研究生全英文专业课(博士):生物化工进展(Advances in Biochemical Engineering

  

科研课题

  自2006年实验室成立至今,作为课题负责人主持国家级、省部级等研究课题数十项项,代表性课题包括木质纤维素降解转化过程强化的工程学原理与方法(973)、极限低水稀酸预处理技术体系研究(863)、农作物秸秆制备生物化工醇产业化示范(863)、复杂酶反应体系的抑制效应解析与关键路径的加速(国家自然科学基金)、节能与清洁型木质纤维素生产燃料乙醇过程的关键技术研究(中石油)等。

  

近期学术著作

    1. Bioreactor Engineering Research and Industrial Applications II, Advances in Biochemical Engineering/Biotechnology, Volume 152, 2016. Editors: Jie Bao, Qin Ye, Jian-Jiang Zhong. ISBN: 978-3-662-48346-6 (Print), 978-3-662-48347-3 (eBook). Springer, Berlin, Heidelberg, Germany, 2016.

    2. Bioreactor Engineering Research and Industrial Applications I, Advances in Biochemical Engineering /Biotechnology, Volume 155, 2016. Editor: Editors: Qin Ye, Jie Bao, Jian-Jiang Zhong. ISBN: 978-3-662-49159-1 (Print), 978-3-662-49161-4 (eBook). Springer, Berlin, Heidelberg, Germany, 2016.

    3. 生物炼制产品与技术,鲍杰,高秋强,张建,曹学君,邓红波译。上海科学技术出版社,2013. ISBN 978-7-5478-1568-7

    4. 现代生物能源技术-美国国家可再生能源实验室生物能源技术报告(应用生物技术大系丛书),鲍杰,科学出版社,2009. ISBN 978-7-03-024519-9

  

本年度论文发表(2016-2017年,* 为通讯作者)

    1. Gang Liu, Qiang Zhang, Hongxing Li, Abdul Sattar Qurishi, Jian Zhang, Xiaoming Bao*, Jie Bao*. Dry biorefining maximizes the potentials of simultaneous saccharification and co-fermentation for cellulosic ethanol production. Biotechnology and Bioengineering (IF 4.481), 2017, DOI: 10.1002/bit.26444.

    2. Zhongyang Qiu, Qiuqiang Gao, Jie Bao*. Engineering Pediococcus acidilactici with xylose assimilation pathway for high titer cellulosic L-lactic acid fermentation. Bioresource Technology (IF 5.651), 2017, doi.org/10.1016/j.biortech.2017.09.117.

    3. Zhongyang Qiu, Qiuqiang Gao, Jie Bao*. Constructing xylose-assimilating pathways in Pediococcus acidilactici for high titer D-lactic acid fermentation from corn stover feedstock. Bioresource Technology (IF 5.651), 2017, doi.org/10.1016/j.biortech.2017.05.128.

    4. Gang Liu, Jie Bao*. Maximizing cellulosic ethanol potentials by minimizing wastewater generation and energy consumption: Competing with corn ethanol. Bioresource Technology (IF 5.651), 2017, doi.org/10.1016/j.biortech.2017.08.070.

    5. Gang Liu, Jie Bao*. Evaluation of electricity generation from lignin residue and biogas in cellulosic ethanol production. Bioresource Technology (IF 5.651), 2017, 243:1232-1236.

    6. Ruimiao Yao, Weiliang Hou, Jie Bao*. Complete oxidative conversion of lignocellulose derived non-glucose sugars to sugar acids by Gluconobacter oxydans. Bioresource Technology (IF 5.651), 2017, 244: 1188-1192.

    7. Hongsen Zhang, Xushen Han, Chengxiang Wei, Jie Bao*. Oxidative production of xylonic acid using xylose in distillation stillage of cellulosic ethanol fermentation broth by Gluconobacter oxydans. Bioresource Technology (IF 5.651), 2017, 224:573-580.

    8. Ping-Ping Zhou, Jiao Meng, Jie Bao*. Fermentative production of high titer citric acid from corn stover feedstock after dry dilute acid pretreatment and biodetoxification. Bioresource Technology (IF 5.651), 2017, 224:563-572.

    9. Shuai Shao, Jian Zhang*, Weiliang Hou, Abdul Sattar Qureshi, Jie Bao. Lower pressure heating steam is practical for the distributed dry dilute sulfuric acid pretreatment. Bioresource Technology (IF 5.651), 2017, 238: 744-748.

    10. Abdul Sattar Qureshi, Jian Zhang*, Leonardo da Costa Sousa*, Jie Bao*. An antibacterial peptide secreted by Pediococcus acidilactici enables efficient cellulosic open L-lactic acid fermentation. ACS Sustainable Chemistry & Engineering (IF 5.951), 2017, DOI: 10.1021/acssuschemeng.7b02212.

    11. Yi Jiang, Kuimei Liu, Hongsen Zhang, Yingli Wang, Quanquan Yuan, Ning Su, Jie Bao, Xu Fang*. Gluconic acid production from potato waste by Gluconobacter oxidans using sequential hydrolysis and fermentation. ACS Sustainable Chemistry & Engineering (IF 5.951), 2017, 5: 6116-6123.

    12. Xia Wang, Qiuqiang Gao, Jie Bao*. Enhancement of furan aldehydes conversion in Zymomonas mobilis by elevating dehydrogenase activity and cofactor regeneration. Biotechnology for Biofuels (IF 5.203), 2017, 10:24.

    13. Dong Tian, Jinguang Hu, Jie Bao, Richard P. Chandra, Jack N. Saddler, CanhuiLuhongyang. Lignin valorization: lignin nanoparticles as high-value bio-additive for multifunctional nanocomposites. Biotechnology for Biofuels (IF 5.203), 2017, 10:192.

    14. Shuai Shao, Jian Zhang, Jie Bao*. Reduction of reactor corrosion by eliminating liquid phase existence in dry dilute acid pretreatment of corn stover. Energy & Fuels (IF 3.091), 2017, 31(6): 6140-6144.

    15. Qiang Zhang, Jie Bao*. Industrial cellulase performance in the simultaneous saccharification and co-fermentation (SSCF) of corn stover for high titer ethanol production. Bioresources and Bioprocessing, 2017, 4:17.

    16. Juan Wang, Mingshan Hu, Huizhan Zhang*, Jie Bao*. Converting chemical oxygen demand (COD) of cellulosic ethanol fermentation wastewater into microbial lipid by oleaginous yeast Trichosporon cutaneum. Applied Biochemistry and Biotechnology (IF 1.751), 2017, 182:1121-1130.

    17. Hongsen Zhang, Gang Liu, Jian Zhang, Jie Bao*. Fermentative production of high titer gluconic and xylonic acids from corn stover feedstock by Gluconobacter oxydans and techno-economic analysis. Bioresource Technology (IF 5.651), 2016, 219:123-131.

    18. Hongsen Zhang, Jian Zhang, Jie Bao*. High titer gluconic acid fermentation by Aspergillus niger from dry dilute acid pretreated corn stover without detoxification. Bioresource Technology (IF 5.651), 2016, 203:211-219.

    19. Juan Wang, Qiuqiang Gao, Huizhan Zhang, Jie Bao*. Inhibitor degradation and lipid accumulation potentials of oleaginous yeast Trichosporon cutaneum using lignocellulose feedstock. Bioresource Technology (IF 5.651), 2016, 218:892-901.

    20. Jian Zhang, Shuai Shao, Jie Bao*. Long term storage of dilute acid pretreated corn stover feedstock and ethanol fermentability evaluation. Bioresource Technology (IF 5.651), 2016, 201:355-359.

    21. Yanqing He, Jian Zhang, Jie Bao*. Acceleration of biodetoxification on dilute acid pretreated lignocellulose feedstock by aeration and the consequent ethanol fermentation evaluation. Biotechnology for Biofuels (IF 5.203), 2016, 9:19.

    22. Juan Wang, Qiuqiang Gao*, Jie Bao*. Genome sequence of Trichosporon cutaneum ACCC 20271: An oleaginous yeast with excellent lignocellulose derived inhibitor tolerance. Journal of Biotechnology (IF 2.599), 2016, 228:50-51.

    23. Xia Yi, Peng Zhang, Jiaoe Sun, Yi Tu, Qiuqiang Gao, Jian Zhang, Jie Bao*. Engineering wild-type robust Pediococcus acidilactici strain for high titer L- and D-lactic acid production from corn stover feedstock. Journal of Biotechnology (IF 2.599),2016, 217:112-121.

    24. Weiliang Hou, Ruixin An, Jian Zhang, Jie Bao*. On-site measurement and modeling of rheological property of corn stover hydrolysate at high solids content. Biochemical Engineering Journal (IF 2.892), 2016, 107: 61-65.

    25. WeiliangH ou, Jian Zhang, Jie Bao*. Rheology evolution and CFD modeling of lignocellulose biomass during extremely high solids content pretreatment. Biochemical Engineering Journal (IF 2.892), 2016, 105:412-419.

    26. Jian Zhang, Weiliang Hou, Jie Bao*. Reactors for high solid loading pretreatment of pretreatment of lignocellulosic biomass. Advances in Biochemical Engineering/Biotechnology (IF 2.222), 2016, 152:75-90.

    27. Gang Liu, Jian Zhang, Jie Bao*. Cost evaluation of cellulase enzyme for industrial scale cellulosic ethanol production based on rigorous Aspen plus modeling. Bioprocess and Biosystems Engineering (IF 1.870), 2016, 39:133-140.


近期代表性论文(* 为通讯作者)

    1. Hongwei Dong, Jie Bao*. Biofuel via biodetoxification. Nature Chemical Biology, 2010, 6:316-318.

    2. Hanqi Gu, Jian Zhang, Jie Bao*. High tolerance and physiological mechanism of Zymomonas mobilis to phenolic inhibitors in ethanol fermentation of corncob residue. Biotechnology and Bioengineering, 2015, 112:1770-1782.

    3. Lihao Guo, Jian Zhang, Fengxian Hu, Dewey DY Ryu, Jie Bao*. Consolidated bioprocessing of highly concentrated Jerusalem artichoke tubers for simultaneous saccharification and ethanol fermentation. Biotechnology and Bioengineering, 2013, 110:2606-2615.

    4. Hongwei Dong, Liqiang Fan, Zichen Lu, Jianjiang Zhong, Dewey D. Y. Ryu, Jie Bao*. Improvement of ethanol productivity and energy efficiency by degradation of inhibitors using recombinant Zymomonas mobilis (pHW20a-fdh). Biotechnology and Bioengineering, 2013, 110:2395-2404.

    5. Hongwei Dong, Jie Bao*, Dewey D. Y. Ryu*, Jianjiang Zhong*. Design and construction of improved new vectors for Zymomonas mobilis recombinants. Biotechnology and Bioengineering, 2011, 108:1616-1627.

    6. Jian Zhang, Deqiang Chu, Juan Huang, Zhanchun Yu, Gance Dai, Jie Bao*. Simultaneous saccharification and ethanol fermentation at high corn stover solids loading in a helical stirring bioreactor. Biotechnology and Bioengineering, 2010, 105:718-728.

    7. Jie Bao, Dewey D.Y. Ryu. Total biosynthesis of deoxynucleoside triphosphates using deoxynucleoside monophosphate kinases for PCR application. Biotechnology and Bioengineering, 2007, 98:1-11.

    8. Jie Bao, Dewey D.Y. Ryu. Cloning of deoxynucleosidemonophosphate kinase genes and biosynthesis of deoxynucleosidediphosphates. Biotechnology and Bioengineering, 2006, 93:572-580.

    9. Jie Bao,Dewey D.Y. Ryu. Biosynthesis reaction mechanism and kinetics of deoxynucleosidetriphosphates, dATP and dGTP. Biotechnology and Bioengineering, 2005, 89:485-491.

    10. Xia Yi, HanqiGu, Qiuqiang Gao, Z. Lewis Liu*, Jie Bao*. Transcriptome analysis of Zymomonas mobilis ZM4 reveals mechanisms of tolerance and detoxification of phenolic aldehyde inhibitors from lignocellulose pretreatment. Biotechnology for Biofuels, 2015, 8:153.

    11. Xia Wang, QiuqiangGao, Jie Bao*. Transcriptional analysis of Amorphotheca resinae ZN1 on biological degradation of furfural and 5-hydroxymethylfurfural derived from lignocellulose pretreatment. Biotechnology for Biofuels, 2015, 8:136.

    12. Hong Ran, Jian Zhang, Qiuqiang Gao, Zhanglin Lin, Jie Bao*. Analysis of biodegradation performance of furfural and 5-hydroxymethylfurfural by Amorphotheca resinae ZN1. Biotechnology for Biofuels, 2014, 7:51.

    13. Shuhong Gao, Chun You, Scott Renneckar, Jie Bao, Yi-Heng Percival Zhang*. New insights into enzymatic hydrolysis of heterogeneous cellulose by using carbohydratebinding module 3 containing GFP and carbohydrate-binding module 17 containing CFP. Biotechnology for Biofuels, 2014, 7:24.

    14. Yanqing He, Longping Zhang, Jian Zhang*, Jie Bao*. Helically agitated mixing in dry dilute acid pretreatment enhances the bioconversion of corn stover into ethanol. Biotechnology for Biofuels, 2014, 7:1.

    15. Jian Zhang, Zhinan Zhu, Xiaofeng Wang, Nan Wang, Wei Wang, Jie Bao*. Biodetoxification of toxins generated from lignocellulose pretreatment using a newly isolated fungus Amorphotheca resinae ZN1 and the consequent ethanol fermentation. Biotechnology for Biofuels2010, 3:26.

    16. Gang Liu, Jiaoe Sun, Jian Zhang, Yi Tu, Jie Bao*. High titer L-lactic acid production from corn stover with minimum wastewater generation and techno-economic evaluation based on Aspen plus modeling. Bioresource Technology, 2015, 198:803-810.

    17. Ke Liu, Jian Zhang, Jie Bao*. Two stage hydrolysis of corn stover at high solids content for mixing power saving and scale-up applications. Bioresource Technology, 2015, 196:716-720.

    18. Abdul Sattar Qureshi, Jian Zhang, Jie Bao*. High ethanol fermentation performance of the dry dilute acid pretreated corn stover by an evolutionarily adapted Saccharomyces cerevisiae strain. Bioresource Technology, 2015, 189:399-404.

    19. Yanqing He, Zhenhong Fang, Jian Zhang, Xinliang Li, Jie Bao*. De-ashing treatment of corn stover improves the efficiencies of enzymatic hydrolysis and consequent ethanol fermentation. Bioresource Technology, 2014, 169:552-558.

    20. Cheng Lei, Jian Zhang, Lin Xiao, Jie Bao*. An alternative feedstock of corn meal for industrial fuel ethanol production: Delignified corncob residue. Bioresource Technology, 2014, 167:555-559.

    21. Yanqing He, Jian Zhang, Jie Bao*. Dry dilute acid pretreatment by co-currently feeding of corn stover feedstock and dilute acid solution without impregnation. Bioresource Technology, 2014, 158:360-364.

    22. Hanqi Gu, Jian Zhang, Jie Bao*. Inhibitor analysis and adaptive evolution of Saccharomyces cerevisiae for simultaneous saccharification and ethanol fermentation from industrial waste corncob residues. Bioresource Technology, 2014, 157:6-13.

    23. QiuqiangGao, Zhenyang Cui, Jian Zhang, Jie Bao*. Lipid fermentation of corncob residues hydrolysate by oleaginous yeast Trichosporon cutaneum. Bioresource Technology, 2014, 152:552-556.

    24. Thai Ha Dao, Jian Zhang, Jie Bao*. Characterization of inulin hydrolyzing enzyme(s) in commercial glucoamylases and its application in lactic acid production from Jerusalem artichoke tubers (Jat). Bioresource Technology, 2013, 148:157-162.

    25. Jian Zhang, Zhenhong Fang, Hongbo Deng, Xiaoxi Zhang, Jie Bao*. Cost analysis of cassava cellulose utilization scenarios for ethanol production on flowsheet simulation platform. Bioresource Technology, 2013, 134:298-306.

    26. Kai Zhao, Qingan Qiao, Deqiang Chu, Hanqi Gu, Thai Ha Dao, Jian Zhang, Jie Bao*. Simultaneous saccharification and high titer lactic acid fermentation of corn stover using a newly isolated lactic acid bacterium Pediococcus acidilactici DQ2. Bioresource Technology, 2013, 135:481-489.

    27. Wei Liu, Yumei Wang, Zhanchun Yu, Jie Bao*. Simultaneous saccharification and microbial lipid fermentation of corn stover by oleaginous yeast Trichosporon cutaneum. Bioresource Technology, 2012, 118:13-14.

    28. Jian Zhang, Jie Bao*. A modified method for calculating practical ethanol yield at high lignocellulosic solids content and high ethanol titer. Bioresource Technology, 2012, 116:74-79.

    29. Xiao Huang, Yumei Wang, Wei Liu, Jie Bao*.. Biological removal of inhibitors leads to the improved lipid production in the lipid fermentation of corn stover hydrolysate by Trichosporon cutaneum. Bioresource Technology, 2011, 102:9705-9709.

    30. Jian Zhang, Xiusheng Wang, Deqiang Chu, Yanqing He, Jie Bao*. Dry pretreatment of lignocellulose with extremely low steam and water usage for bioethanol production. Bioresource Technology, 2011, 102:4480-4488.

    31. Jie Bao, Buliang Gao, Xiaofeng Wu, Makoto Yoshimoto, Katsumi Nakao. Simulation of industrial catalytic-distillation process for production of methyl tert-butyl ether by developing user’s model on Aspen plus platform. Chemical Engineering Journal, 2002,90:253-266.

    32. Jie Bao, Kenichi Koumatsu, Keiji Furumoto, Makoto Yoshimoto, Kimitoshi Fukunaga, Katsumi Nakao. Optimal operation of an integrated bioreaction-crystallization process for continuous production of calcium gluconate using external loop airlift columns. Chemical Engineering Science, 2001, 56:6165-6170.

    33. Jie Bao, Keiji Furumoto, Kimitoshi Fukunaga, Katsumi Nakao. Average and local oxygen transfer properties in bubble column with axial distribution of immobilized glucose oxidase gel beads. Chemical Engineering Science, 2000, 55:5405-5414.