钱江潮
发布人:生工学院网站管理员  发布时间:2016-10-19   动态浏览次数:16

 

钱江潮

  

生物化学与分子生物学专业:博士生导师

生物化工专业:博士生导师/硕士生导师
    生物工程专业:硕士生导师

生物工程领域:工程硕士生导师

  


   
工学博士,教授,博士生导师。入选教育部“新世纪优秀人才支持计划”/上海市“浦江人才”计划。

学历及工作经历
1989, 9
1992,7  华东化工学院 生物化工专业  本科
1992, 9
1995,7  华东理工大学 生物化学专业  硕士研究生
1995, 9
1999,7  华东理工大学 生物化工专业  博士研究生
1995, 7
2003,8  华东理工大学 生物工程学院  助教/助理研究员
2003, 9
2005,9  美国宾夕法尼亚大学(university of Pennsylvania)医学院  博士后
2005, 10
至今  华东理工大学 生物工程学院  助理研究员/副研究员/研究员

研究方向
1. 
代谢工程:优化遗传操作手段,应用代谢调控和系统分析,结合高通量筛选和分析,优化和构建微生物细胞工厂。
2. 
生物材料的生物效应:纳米无机材料抗肿瘤及其机理研究。

负责的主要科研项目
1. 
国家自然科学基金(羟基磷灰石纳米颗粒选择性杀伤肝癌细胞的分子机理研究)
2. 
教育部新世纪优秀人才支持计划
3. “973”
课题(工业生物过程高效转化与系统集成的科学)
4. 
国家自然科学基金 (基于可控基因与环境扰动的毕赤酵母合成S-腺苷甲硫氨酸系统代谢工程研究)
5. 
上海市科委纳米专项(纳米羟基磷灰石的抗肿瘤活性及其分子机理研究)
6. 
上海市科委“浦江人才”计划(启动子文库及其在重组毕赤酵母合成S-腺苷甲硫氨酸代谢分析中的应用)
7. 
教育部留学归国人员基金(构建用于毕赤酵母表达系统的启动子文库)

代表性论著
1. Wu YQ, Tang W, Wang P, Liu CS, Yuan Y*, Qian JC*. Cytotoxicity and cellular uptake of amorphous silica nanoparticles in human cancer cells. Part. Part. Syst. Charact., 2015, 32(7): 779-787.
2. Tang W, Yuan Y, Liu CS, Wu YQ, Lu X, Qian JC*. Differential cytotoxicity and particle action of hydroxyapatite nanoparticles in human cancer cells. Nanomedicine, 2014, 9(3): 397-412.
3. Yao GF, Qin XL, Chu J, Wu XL, Qian JC*. Expression, purification and characterization of a recombinant methionine adenosyltransferase pDS16 in Pichia pastoris. Appl. Biochem. Biotech., 2014, 172(3): 1241-1253.
4. Nie YS, Huang MZ*, Lu JJ, Qian JC, Lin WL, Chu J, Zhuang YP, Zhang SL. Impacts of high β-galactosidase expression on central metabolism of recombinant Pichia pastoris GS115 using glucose as sole carbon source via 13C metabolic flux analysis. J. Biotechnol., 2014, 187: 124-134.
5. Liang T, Qian JC, Yuan Y*, Liu CS*. Synthesis of mesoporous hydroxyapatite nanoparticles using a template-free sonochemistry-assisted microwave method. J. Mater. Sci., 2013, 48 (5): 5334–5341.
6. Chu J*, Qian JC, Zhuang YP, Zhang SL, Li YR. Progress in the research of S-adenosyl-L-methionine production. Appl. Microbiol. Biotechnol., 2013, 97 (1): 41-49.
7. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL, Chu J*. GAP promoter library for fine-tuning gene expression in Pichia pastoris. Appl. Environ. Microb., 2011, 77(11): 3600-3608.
8. Qin XL, Qian JC*, Xiao CY, Zhuang YP, Zhang SL, Chu J*. Reliable high-throughput approach for screening of engineered constitutive promoters in the yeast Pichia pastoris. Lett. Appl. Microbiol., 2011, 52(6): 634-641.
9. Lu X, Qian JC, Zhou HJ, Gan Q, Tang W, Lu JX, Yuan Y*, Liu CS*. In vitro cytotoxicity and apoptosis-induction of silica nanoparticles in human hepatoma HepG2 cells. Int. J. Nanomed., 2011, 6: 1889-1901.
10. Wu JQ, Zhang QL, Deng W, Qian JC, Zhang SL, Liu W*. Toward improvement of erythromycin A production in an industrial Saccharopolyspora erythraea strain via facilitation of genetic manipulation with an artificial attB site for specific recombination. Appl. Environ. Microb., 2011, 77 (21): 7508-7516.
11. Gan Q, Lu XY, Yuan Y*, Qian JC, Zhou HJ, Lu X, Shi JL, Liu CS*. A magnetic, reversible pH-responsive nanogated ensemble based on Fe3O4 nanoparticles- capped mesoporous silica. Biomaterials, 2011, 32 (7): 1932-1942.
12. Qian JC, Qin XL, Yin Q, Chu J, Wang YH*. Cloning and characterization of Kluyveromyces marxianus Hog1 gene. Biotechnol. Lett., 2010, 33(3): 571-575.
13. Zhang QL, Wu JQ, Qian JC*, Chu J, Zhuang YP, Zhang SL, Liu W*. Knocking out of tailoring genes eryK and eryG in an industrial erythromycin-producing strain of Saccharopolyspora erythraea leading to overproduction of erythromycin B, C, and D at different conversion ratios. Lett. Appl. Microbiol., 2010, 52: 129-137.
14. Zhao QH, Qian JC*, Zhou HJ, Yuan Y, Mao YH, Liu CS*. In vitro osteoblast-like and endothelial cells response to calcium silicate/calcium phosphate cement. Biomed. Mater., 2010, 5(3): 035004.
15. Zhang SL*, Cao XJ, Chu J, Qian JC, Zhuang YP. Bioreactors and Bioseparation, Biotechnology in China: Chemicals, Energy & Envronment. Advances in Biochemical Engineering-Biotechnology, 2010, 122: 105-150.
16. Zou X*, Zeng W, Chen CF, Qi XC, Qian JC, Chu J, Zhuang YP, Zhang SL, Li WJ.  Fermentation optimization and industrialization of recombinant Saccharopolyspora erythraea strains for improved erythromycin A production.  Biotechnol. Bioproc. E, 2010, 15 (6): 959-968.
17. Hu H, Qian JC*, Chu J*, Wang Y, Zhuang YP, Zhang SL. DNA shuffling of methionine adenosyltransferase gene leads to improved S-adenosyl-L-methionine production in Pichia pastoris. J. Biotechnol., 2009, 141(3-4): 97-103.
18. Hu H, Qian JC*, Chu J*, Wang YH, Zhuang YP, Zhang SL. Optimization of L-Methionine feeding strategies for improving S-adenosyl-Lmethionine production by methionine adenosyltransferase overexpressed Pichia pastoris. Appl. Microbiol. Biotechnol., 2009, 83(6): 1105-1114.
19. Zhou HJ, Qian JC, Wang J, Yao WT, Liu CS*, Chen JG and Cao XH. Enhanced bioactivity of bone morphogenetic protein-2 with low dose of 2-N, 6-O-sulfated chitosan in vitro and in vivo. Biomaterials, 2009, 30 (9): 1715-1724.
20. Chen Y, Deng W, Wu JQ, Qian JC, Chu J, Zhuang YP, Zhang SL*, Liu W*. Genetic modulation of the overexpression of tailoring genes eryK and eryG leading to the improvement of erythromycin A purity and production in Saccharopolyspora erythraea fermentation. Appl. Environ. Microb., 2008, 74 (6): 1820-1828.
21. Qian JC, Lavker RM, Tseng H*. Mapping ribosomal RNA transcription activity in the mouse eye. Dev. Dynam., 2006, 235(7): 1984-1993.
22. Qian JC*, Cai XP, Chu J, Zhuang YP, Zhang SL. Nucleotide mutations in purA gene and pur operon promoter discovered in guanosine- and inosine-producing Bacillus subtilis strains. Biotechnol. Lett., 2006, 28(12 ): 937-941.

授权专利
1. 
刘昌胜, 袁媛, 钱江潮, 甘琪, 梁桐. 微波-超声法制备介孔羟基磷灰石纳米粒子及其应用. 专利号ZL 201110158051.3, 授权公告日: 2014-12-3 .
2. 
钱江潮, 秦秀林, 于晓光, 储炬, 武晓乐, 庄英萍, 张嗣良. GAP启动子文库在调节S-腺苷甲硫氨酸代谢途径中的应用. 专利号 ZL 201010621230.1, 授权公告日: 2013-10-9.
3. 
刘昌胜, 林俊, 钱江潮, 袁媛. 优化的基于大肠杆菌表达系统的重组人骨形态发生蛋白-2DNA序列及重组人骨形态发生蛋白-2的制备. 专利号 ZL 200910045832.4, 授权公告日: 2013-6-19.
4. 
钱江潮, 秦秀林, 储炬, 庄英萍, 张嗣良, 肖慈英. GAP启动子文库及其用途. 专利号 ZL 2009 1 0053198.9, 授权公告日: 2012-12-26.
5. Changsheng Liu, Jun Lin, Jiangchao Qian, Yuan Yuan, Optimized DNA sequences encoding recombinant human bone morphogenetic protein-2 (rhbmp-2), preparation method and the uses thereof. Patent No US 7947821 B2, Date of Patent May 24, 2011.
6. 
庄英萍, 王晖, 储炬, 张嗣良, 钱江潮, 王永红. 重组的降糖肽及其生产菌株的构建和培养方法专利号 ZL 200710037133.6, 授权公告日: 2011-1-12.

获奖
1. 2011
年国家科技进步二等奖:基于细胞生理与过程信息处理的工业发酵优化新技术. 6
2. 2008
年上海市科技进步一等奖:先进技术集成的红霉素生产新工艺. 6

联系方式
电话:021-64250736     
传真:021-64253702     
E-mail: jiangchaoqian@ecust.edu.cn
通讯地址: 上海市梅陇路130号,华东理工大学329信箱,200237