叶朝阳

生物工程专业：硕士生导师

生物化工专业：硕士生导师 

博士，华东理工大学生物工程学院副教授。入选上海市浦江人才和上海高校选拔培养优秀青年教师科研专项基金资助。作为负责人承担国家自然科学基金、高等学校博士点新教师基金、教育部留学回国人员科研启动基金、上海市自然科学基金等项目。迄今共发表SCI论文50余篇，撰写4篇专著章节，申请4项发明专利。现为中国组织工程研究杂志（2011年-至今）、Austin Journal of Biomedical Engineering（2014年-至今）和American Journal of Tissue Engineering and Stem Cell（2014年-至今）杂志编委，为Biomaterials、Stem Cells and Development、Tissue Engineering和Polymer Chemistry等期刊审稿，曾任Advanced Drug Release Reviews和Molecular Pharmaceutics客座编辑和智利国家科技发展基金外审专家。

教育经历
2002-2007   田纳西大学制药科学系，博士
1999-2002   浙江大学高分子科学与工程学系，硕士
1995-1999   浙江大学高分子科学与工程学系，学士

工作经历
2007-2009   约翰霍普金斯大学生物医学工程系，博士后研究员
2011-2012   田纳西大学制药科学系，客座副教授
2009-    华东理工大学生物反应器工程国家重点实验室，副教授

研究兴趣
聚焦组织工程与再生医学领域，依托生物材料和细胞培养技术手段，旨在理解细胞功能实现和组织结构形成的基础问题，实现再生医学临床转化。目前开展以下研究工作：构建功能生物材料调控干细胞分化；基于共培养构建复杂组织结构；开发新型组织构建技术；干细胞扩增技术。

承担科研项目
1. 国家自然科学基金青年科学基金项目
2. 教育部留学回国人员科研启动基金
3. 高等学校博士学科点专项科研基金（新教师类）

代表性论文（*：通讯联系人）
1. Zhao Y, Tan K, Zhou Y, Ye Z*, Tan WS. (2016) A Combinatorial Variation in Surface Chemistry and Pore Size of Three-dimensional Porous Poly(ε-caprolactone) Scaffolds Modulates the Behaviors of Mesenchymal Stem Cells. Materials Science and Engineering: C, 59:193-202.
2. Chen M, Zhang Y, Zhou Y, Zhang Y, Lang M, Ye Z*, Tan WS*. (2015) Pendant Small Functional Groups on Poly(ε-caprolactone) Substrate Modulate Adhesion, Proliferation and Differentiation of Human Mesenchymal Stem Cells. Colloids and Surfaces B: Biointerfaces, 134:322-331.
3. Xu F, Xu L, Wang Q, Zhou Y, Ye Z*, Tan WS*. (2015) A three-dimensional dynamic coculture system enabling facile cell separation for chondrogenesis of mesenchymal stem cells. Biochemical Engineering Journal, 103:68-76.
4. Zhang Q, Xie J, Bao M, Yuan H, Ye Z, Lou X, Zhang Y*. (2015) Engineering aligned electrospun PLLA microfibers with nano-porous surface nanotopography for modulating the responses of vascular smooth muscle cells. Journal of Materials Chemistry, B, 3(11):4439-4450.
5. Su Y, Cai H*, Ye Z, Tan WS. (2015) BMP-7 improved proliferation and hematopoietic reconstitution potential of ex vivo expanded cord blood-derived CD34+ cells. Hum Cell, 28(1):14-21.
6. Xu J, Xie Y, Zhang H*, Ye Z*, Zhang W. (2014) Fabrication of PLGA/MWNTs Composite Electrospun Fibrous Scaffolds for Improved Myogenic Differentiation of C2C12 Cells. Colloids and Surfaces B: Biointerfaces, 123:907-15.
7. Xu F, Xu L, Wang Q, Ye Z*, Zhou Y, Tan WS*. (2014) 3D Dynamic Culture of Rabbit Articular Chondrocytes Encapsulated in Alginate Gel Beads Using Spinner Flasks for Cartilage Tissue Regeneration. BioMed Research International, 2014:539789.
8. Wang X, Jiao Q, Zhang S, Ye Z*, Zhou Y*, Tan WS. (2014) Perfusion culture induced template-assisted assembling of cell-laden microcarriers is a promising route for fabricating macrotissues. Biotechnology Journal, 9(11):1425-34.
9. Chen M, Zhou M, Ye Z*, Zhou Y*, Tan WS*. (2014) Ectopic Osteogenesis of Macroscopic Tissue Constructs Assembled from Human Mesenchymal Stem Cell-Laden Microcarriers through In Vitro Perfusion Culture. PLoS One, 9(10):e109214.
10. Luo H, Chen M, Wang X, Mei Y, Ye Z*, Zhou Y*, Tan WS. (2014) Fabrication of viable centimeter-sized 3D tissue constructs with microchannel conduits for improved tissue properties through assembly of cell-laden microbeads. Journal of Tissue Engineering and Regenerative Medicine, 8(6):493-504.
11. Zhang Q, Tan K, Zhang Y, Ye Z*, Tan WS, Lang M*. (2014) In Situ Controlled Release of rhBMP-2 in Gelatin-Coated 3D Porous Poly(ε-caprolactone) Scaffolds for Homogeneous Bone Tissue Formation. Biomacromolecules, 15(1):84-94.
12. Zhang Y, Liu J, Fu Y, Tan K, Ye Z, Lang M*. (2013) Self-assembly of polyion complex nanocarriers from ammonium glycyrrhizinate and monomethoxy poly (ethylene glycol)-b-poly (γ-amino-ε-caprolactone). Journal of Materials Chemistry, B, 1(11):1614-1621.
13. Xu L, Wang Q, Xu F, Ye Z*, Zhou Y, Tan WS. (2013) Mesenchymal Stem Cells Downregulate Articular Chondrocyte Differentiation in Non-contact Coculture Systems: Implications in Cartilage Tissue Regeneration. Stem Cells and Development, 22(11):1657-1669.
14. Zhang Q, Luo H, Zhang Y, Zhou Y, Ye Z*, Tan WS, Lang M*. (2013) Fabrication of Three-dimensional Poly(ε-caprolactone) Scaffolds with Hierarchical Pore Structures for Tissue Engineering. Materials Science and Engineering: C, 33(4):2094-2103.
15. Singh A, Zhan J, Ye Z, Elisseeff JH*. (2013) Modular Multifunctional Poly(ethylene glycol) Hydrogels for Stem Cell Differentiation. Advanced Functional Materials, 23(5):575-582.
16. Zhang Q, Jiang Y, Zhang Y, Ye Z, Tan WS, Lang M*. (2013) Effect of porosity on long-term degradation of poly (ε-caprolactone) scaffolds and their cellular response. Polymer Degradation and Stability, 98(1):209-18.
17. Zhang Q, Tan K, Ye Z, Zhang Y, Tan WS, Lang M*. (2012) Preparation of open porous polycaprolactone microspheres and their applications as effective cell carriers in hydrogel system. Materials Science and Engineering: C, 32(8):2589-95.
18. Zhang Y, Zhang Y, Chen M, Yan J, Ye Z, Zhou Y, Tan W, Lang M*. (2012) Surface properties of amino-functionalized poly(ε-caprolactone) membranes and the improvement of human mesenchymal stem cell behavior. Journal of Colloid and Interface Science, 368(1):64-9.
19. Wu W, Ye Z, Zhou Y*, Tan WS. (2011) AICAR, a Small Chemical Molecule, Primes Osteogenic Differentiation of Adult Mesenchymal Stem Cells. International Journal of Artificial Organs, 34(12):1128-1136.
20. Ye Z*, Mahato RI*. (2011) Combining Stem Cells and Genes for Effective Therapeutics. Molecular Pharmaceutics, 8(5):1443-1145.
21. Chen M, Wang X, Ye Z, Zhou Y*, Tan WS*. (2011) A Modular Approach of the Engineering of a Centimeter-sized Bone Tissue Construct with Human Amniotic Mesenchymal Stem Cells-Laden Microcarriers. Biomaterials, 32(30):7532-7542.
22. Yan J, Ye Z*, Chen M, Liu Z, Xiao Y, Zhang Y, Zhou Y, Tan WS, Lang M*. (2011) Fine Tuning Micellar Core-forming Block of Poly(ethylene glycol)-block-poly(ε-caprolactone) Amphiphilic Copolymers Based on Chemical Modification for the Solubilization and Delivery of Doxorubicin. Biomacromolecules, 12(7):2562–2572.
23. Yan J, Ye Z*, Luo H, Chen M, Zhou Y, Tan WS, Xiao Y, Zhang Y, Lang M*. (2011) Synthesis, characterization, fluorescence labeling and cellular internalization of novel amine-functionalized poly(ethylene glycol)-block-poly(ε-caprolactone) amphiphilic block copolymers. Polymer Chemistry, 2(6):1331-1340.
24. Ye Z*, Zhou Y, Cai H, Tan WS. (2011) Myocardial Regenerative Cell Therapy: Roles of Stem Cells and Hydrogels. Advanced Drug Delivery Reviews, 63(8):688-697.

专著章节
• Ye Z, Zhou Y, Cai H, Tan WS. (2013) Cell-based Therapeutics. In: Mitra AK, Lee CH and Cheng K (eds) Advanced Drug Delivery, John Wiley & Sons, Inc., New Jersey, p. 425-444.
• Ye Z, Elisseeff JH. (2010) Engineering Peptides in Hydrogels for Cartilage Tissue Regeneration. In: Jabbari E and Khademhosseini A (eds) Biologically Responsive Hybrid Biomaterials, World Scientific Publishing Company, New Jersey.

联系方式

电话：021-64251570

传真：021-64252099

Email: zhaoyangye@ecust.edu.cn