欧阳立明
生物学专业：博士生导师/硕士生导师
生物工程专业：硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
女，博士，副教授，硕士生导师。
学历及工作经历
2001年华东理工大学与军事医学科学院联合培养博士毕业，获生物化工专业博士。
2001年7月起任职于华东理工大学生物工程学院应用生物学系，2007年起受聘副教授。
2011.8-2012.8 在美国杜克大学生物学系访问一年
2017年在瑞典查尔姆斯理工大学生物工程系访问一年
获奖情况
2009年获华东理工大学育英奖一等奖
2019年华东理工大学教育教学成果二等奖
2022年联合国工业发展组织全球科技创新大会银奖
2024年石油高等教育（本科）教学成果奖二等奖
近年研究方向
主要涉及生物过程中多尺度数据整合分析过程生物学机制与过程智能化研究、代谢工程、反应器设计应用、酶结构功能研究和应用、治疗用细胞/外泌体生物学与工程应用等。
代表性研究成果为对以黑曲霉、解脂耶氏酵母为代表的微生物细胞工厂开展过程多组学整合分析与发酵过程多参数相关分析，解析发酵过程代谢网络的变化和限制性瓶颈。通过酶工程、辅因子工程、途径工程、细胞生长与生产代谢转换动态调控等技术优化宿主细胞，结合反应器装备开发和过程数据智能分析从菌株-工艺-装备对生物制造项目进行系统性优化，提高胞内代谢与发酵过程的动态适配，突破细胞工厂产能限制。在干细胞规模培养新技术和外泌体工程方面也正在开展创新研究工作。
负责和作为骨干参与了国家自然科学基金、上海市自然科学基金、国家重点研发计划项目、国家重大科研仪器研制项目、山东省重大专项、工信部高性能高性能生物反应器创新任务等多个纵向项目以及多项企业横向项目，已在Nat Biotechnol、Microb Cell Fact、Appl Microbiol Biotechnol、Syst Synth Biol、Bioresour Bioprocess、Stem Cell Res Ther等学术期刊发表科研论文60余篇，申请和授权专利10余项。
近年已发表代表性论著（*为通讯作者，#为共同作者）:
1. Hongzhong Lu#, Weiqiang Cao#, Xiaoyun Liu, Yufei Sui, Liming Ouyang*, Jianye Xia, Mingzhi Huang, Yingping Zhuang, Siliang Zhang, Henk Noorman, Ju Chu*. Multi-omics integrative analysis with GEMs simulation reveals global cellular adaptations of Aspergillus niger under industrial enzyme production conditions. Scientific Reports. 2018, 8(1):14404. doi: 10.1038/s41598-018-32341-1.
2. Liming Ouyang; Petter Holland; Hongzhong Lu; David Bergenholm; Jens Nielsen*.
Integrated analysis of the yeast NADPH-regulator Stb5 reveals distinct differences in NADPH requirements and regulation in different states of yeast metabolism. FEMS Yeast Research. 2018, 18(8); DOI:10.1093/femsyr/foy091 (Dec 2018)
3. Yuan Zhang; Liming Ouyang*; Yilin Nan; Ju Chu. Efficient gene deletion and replacement in Aspergillus niger by modified in vivo CRISPR/Cas9 systems. Bioresources and Bioprocessing. 2019, 6:4. DOI: 10.1186/s40643-019-0239-7
4. Yu-fei Sui#; Li-Ming Ouyang (#co-first author); Tabea Schütze; Shu Cheng; Vera Meyer*; Yingping Zhuang*. Comparative genomics of the aconidial Aspergillus niger strain LDM3 predicts genes associated with its high protein secretion capacity. Applied Microbiology and Biotechnology. 2020, 104, 2623–2637. DOI: 10.1007/s00253-020-10398-1
5. Yu-Fei Sui, Tabea Schütze, Li-Ming Ouyang, Hongzhong Lu, Peng Liu, Xianzun Xiao, Jie Qi, Ying-Ping Zhuang*, Vera Meyer*. Engineering cofactor metabolism for improved protein and glucoamylase production in Aspergillus niger. Microbial Cell Factory. 2020, 19(1):198. doi: 10.1186/s12934-020-01450-w.
6. Weiqiang Cao, Guan Wang, Hongzhong Lu, Liming Ouyang*, Ju Chu, Yufei Sui, Yingping Zhuang*. Improving cytosolic aspartate biosynthesis increases glucoamylase production in Aspergillus niger under oxygen limitation. Microbial Cell Factory. 2020. 19: 81. DOI: 10.1186/s12934-020-01340-1.
7. Yilin Nan; Liming Ouyang*; Ju Chu. In-vitro CRISPR/Cas9 System for Genome Editing of Aspergillus niger Based on Removable Bidirectional Selection Marker AmdS. Biotechnology and Applied Biochemistry. 2021, 68(5):964-970.
8. Yaojun Tong, Nuo Sun, Xiangming Wang, Qi Wei, Yu Zhang, Ren Huang, Yingying Pu, Huanqin Dai, Biao Ren, Gang Pei, Fuhang Song, Guoliang Zhu, Xinye Wang, Xuekui Xia, Xiangyin Chen, Lan Jiang, Jingyu Zhang, Liming Ouyang, Buchang Zhang, Yuanying Jiang, Xueting Liu, Richard Calderone, Fan Bai, Lixin Zhang, Gil Alterovitz. Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p. Science Bulletin. 2021, 66(18): 1895-1905.
9. Xianzun Xiao, Liming Ouyang*, Jie Qi, Ju Chu. Exploration and characterization of hypoxia-inducible endogenous ers in Aspergillus niger. Applied Microbiology and Biotechnology. 2021. 105, 5529–5539. DOI: 10.1007/s00253-021-11417-5
10. Shanshan Li, Bowen Yang, Gao-Yi Tan, Li-Ming Ouyang, Shiwen Qiu, Weishan Wang*, Wensheng Xiang*, Lixin Zhang*. Polyketide pesticides from actinomycetes. Current Opinion in Biotechnology. 2021, 69: 299-307.
11. Jingyu Zhang, Lan Jiang, Xiangyin Chen, Kangjie Lv, Mostafa Basiony, Guoliang Zhu, Loganathan Karthik, Liming Ouyang, Lixin Zhang, Xueting Liu*. Recent advances in biotechnology for marine enzymes and molecules. Current Opinion in Biotechnology. 2021, 69: 308-315. DOI: 10.1016/j.copbio.2021.05.009
12. Mostafa Basiony, Liming Ouyang*, Danni Wang, et al. Optimization of Microbial Cell Factories for Astaxanthin Production: Biosynthesis and Regulations, Engineering Strategies and Fermentation Optimization Strategies. Synthetic and Systems Biotechnology. 2022, 7(2): 689-704. DOI: 10.1016/j.synbio.2022.01.002
13. Xia Wang, Liming Ouyang*, Wenxia Chen, Yulin Cao, Lixin Zhang. Efficient Expansion and Delayed Senescence of hUC-MSCs by Microcarrier-Bioreactor System. Stem Cell Research & Therapy. 2023, 14(1), 284-301.
14. Wang XY, Huang YY, Zhang WY, Lv KJ, Li XY, Wang ZX, Zhang LX, Hsiang T, Zhang LX, Ouyang LM*, Liu XT*. Expanding catalytic promiscuity of a bifunctional terpene synthase through a single mutation-induced change in hydrogen-bond network within the catalytic pocket. Synthetic and Systems Biotechnology. 2024, 9(2): 380-387
15. Chen, H., Wang, Y., Wang, W. et al. High-yield porphyrin production through metabolic engineering and biocatalysis. Nat Biotechnol 2025, 43, 1717–1727.
16. Wenjie Xiao, Jiahao Guo, Xusheng Zhao, Jiacheng Huang, Guojun Jiang*, Liming Ouyang*, Zhen Gu*, Lixin Zhang, Huifeng Wang. A low-cost multi-layer microfluidic platform for on-site viability assessment of stem cells at single-cell resolution. Microchemical Journal, 2025, 214, 113948.
17. 《应用生物化学》（第二版）/十一五教材计划，欧伶，俞建瑛，欧阳立明，李素霞主编. 化工出版社. 2009.2. (ISBN 978-7-122-04348-1)
18. 《基因工程》（第三版）/“十二五”普通高等教育本科国家级规划教材 (张惠展, 欧阳立明, 叶江 编著). 高教出版社. 2015.3 (ISBN: 9787040417623).
19. 《细胞工厂设计原理》（第四章）, 李春 编著. 科学出版社，2024.11. (ISBN 978-7-03-079790-2)
联系方式：
E-mail: ouyanglm@ecust.edu.cn