周英
生物学专业：博士生导师
食品科学与工程专业：硕士生导师
生物化工专业：硕士生导师
生物与医药专业（生物工程领域）：硕士生导师
周英，博士，教授，博士生导师。2008年毕业于华东理工大学，获生物化工博士学位。兼任上海市食品学会副秘书长。2018年-2019年赴荷兰瓦赫宁根大学微生物研究所进行访学。主要研究方向聚焦于合成生物学及活菌生物药，代表性成果发表在Cell Host & Microbe (IF=30.3), PNAS, Biosensors and Bioelectronic , Analytical Chemistry, ACS Synthetic Biology, Applied & Environmental Microbiology等期刊上。主持并参与多项国家自然科学基金（重点、面上、青年）、国家重点研发计划（课题、子课题）、上海市科委重点项目、中央高校基本科研业务费探索基金及企业横向等。
研究方向：
1. 合成生物学及活菌生物药
构建工程化益生菌用于疾病的在体精准诊疗。以益生菌为底盘细胞，设计构建胞内传感、记录、调控等不同代谢功能模块，赋予工程化益生菌智能感应及原位诊疗功能，实现全细胞对肠道疾病及代谢性疾病的及时诊断和治疗的目标。
2. 食源性致病菌的致病机制解析
从翻译后修饰角度解析沙门氏菌、大肠杆菌等肠道致病菌在侵染宿主、增殖过程中的调控机制。通过研究宿主环境中小分子信号物质激活调控蛋白，引起关键位点的酰基化修饰而导致侵染能力变化，期望达到控制、预防食源性致病菌对宿主的侵害，维护肠道健康的目标。
教学：
本科：《食品微生物学》、《食品工艺学》、《食品感官分析》
硕士：《现代微生物学》
近三年代表性论文（*通讯作者）：
(1) Xin-Ge Wang#, Zhen-Ping Zou#, Yue Du, Bang-Ce Ye, Ying Zhou*. Construction of an engineered Escherichia coli with efficient chemotactic and metabolizing ability of tetrathionate. ACS Synthetic Biology. 2023. 12 (11), 3414-3423.
(2) Liu-Qing Zhang#, Yi-Lin Shen#, Bang-Ce Ye, Ying Zhou*. Acetylation of K188 and K192 Inhibits the DNA-Binding Ability of NarL to Regulate Salmonella Virulence. Applied and Environmental Microbiology. 2023. DOI:10.1128/aem.00685-23.
(3) Yan Zhang, Zhen-Ping Zou, Sheng-Yan Chen, Ying Zhou*, Bang-Ce Ye*. Biological Sentinel: An Efficient Engineered Bacterial System for Monitoring and Tracing Regulated Hazardous Chemicals. Analytical Chemistry. 2023. 95, 26, 9734-9738.
(4) Zhen-Ping Zou, Yue Du, Ting-Ting Fang, Ying Zhou*, Bang-Ce Ye*. Biomarker-responsive engineered probiotic diagnoses, records, and ameliorates inflammatory bowel disease in mice, Cell Host & Microbe. 2023, 31(2): 199-212.
(5) Zhen-Ping Zou, Yu-Hang Fan, Yue Du, Ting-Ting Fang, Wei Du, Ying Zhou*, Bang-Ce Ye*. Protocol for engineering E. coli Nissle 1917 to diagnose, record, and ameliorate inflammatory bowel disease in mice. STAR Protocols. 2023. 4(2):102254
(6) Shu-Shan Cai, Liu-Qing Zhang, Qian Zhang, Bang-Ce Ye, Ying Zhou*. Acetylation of NarL K188 and K192 is Involved in Regulating Escherichia coli Anaerobic Nitrate Respiration. Applied Microbiology and Biotechnology. 2022. Nov; 106(21):7209-7221
(7) Li Zhao#, Di You#, Bin-Cheng Yin*, Ying Zhou*, Bang-Ce Ye*. Acylation driven by intracellular metabolites in host cells inhibits Cas9 activity used for genome editing. PNAS Nexus. 2022. 1:1-8
(8) Jin-Yu Wang, Ying Zhou, Bin-Cheng Yin*, Bang-Ce Ye*. An miRISC-initiated DNA Nanomachine for Monitoring MicroRNA Activity in Living Cells. Biosensors and Bioelectronics. 2022. 220: 114828
(9) Bai-Qing Zhang, Zong-Qin Chen, Yu-Qi Dong, Di You*, Ying Zhou*, Bang-Ce Ye*. Selective recruitment of stress-responsive mRNAs to ribosomes for translation by acetylated protein S1 during nutrient stress in Escherichia coli. Communications Biology. 2022. 5:892
(10) Tian-Tian Chang, Zhi-Wei Lin, Bang-Ce Ye, Wei-Bing Liu*, Ying Zhou*. Efficient biodegradation of Di-(2-ethylhexyl) Phthalate by a novel strain Nocardia asteroides LMB-7 isolated from electronic waste soil. Scientific Reports. 2022.12:15262
(11) Zhen-Ping Zou, Ying Yang, Junshan Wang,Ying Zhou**, Bang-Ce Ye*. Coupling split-lux cassette with a toggle switch in bacteria for ultrasensitive blood markers detection in feces and urine. Biosensors and Bioelectronics. 2022. 214:114520-114528.
(12) Ting-Ting Fang, Zhen-Ping Zou, Ying Zhou*, Bang-Ce Ye*. Prebiotics-Controlled Disposable Engineered Bacteria for Intestinal Diseases. ACS Synthetic Biology. 2022. 11(9):3010-3014.
(13) Yan Zhang, Zhen-Ping Zou, Sheng-Yan Chen, Wen-Ping Wei, Ying Zhou, Bang-Ce Ye*. Design and optimization of E. coli artificial genetic circuits for detection of explosive composition 2,4-dinitrotoluene. Biosensors and Bioelectronics. 2022. 207: 114205.
(14) Yi-Lin Shen, Liu-Qing Zhang, Ying Yang, Bin-Cheng Yin, Bang-Ce Ye, Ying Zhou*. Advances in role and mechanism of lactic acid bacteria in treating obesity. Food Bioengineering, 2022, 1: 1-10.
(15) 张萍, 魏文平, 周英*, 叶邦策*. 解脂耶氏酵母中光控表达系统的构建及其应用研究. 合成生物学. 2021, 2(5):778-791.（入选中国生物工程学会会刊2022年度十大优秀论文奖）.
(16) Shu-Shan Cai, Ying Zhou*, Bang-Ce Ye*. Reducing reproductive toxicity activity of Lactiplantibacillus plantarum: A review of mechanisms and prospect. Environ Sci Pollut Res. 2021. 28(28): 36927-36941.
(17) Wei-Bing Liu, Zhi-Wei Lin, Ying Zhou*, Bang-Ce Ye*. Overexpression of Capsular Polysaccharide Biosynthesis Protein in Lactobacillus plantarum P1 to enhance Capsular Polysaccharide production of di-n-butyl phthalate adsorption. J. Microbiol. Biotechnol. 2021. 31(11): 1545-1551.
(18) Yu-Hang Fan, Yi-Lin Shen, Zhi-Wei Lin, Ying Zhou*, Bang-Ce Ye*. Key role of exopolysaccharide on di-butyl phthalate adsorbing by Lactobacillus plantarum CGMCC18980. Appl. Microbiol. Biotechnol. 2021. 105, 2587-2595.
(19) Xue Shi, Changhui Hu, Shushan Cai, Xinyi Tao,Ying Zhou*, Hauke Smidt, Bangce Ye*. Protective Effects of Lactobacillus plantarum P1 against Toxicity of the Environmental Estrogen Di-n-butyl Phthalate in Rats. Beneficial Microbes. 2020. 11(8):803-813.
(20) Wenping Wei, Ping Zhang, Yanzhe Shang, Ying Zhou, Bang-Ce Ye*. Metabolically engineering of Yarrowia lipolytica for the biosynthesis of naringenin from a mixture of glucose and xylose. Bioresource Technology. 2020. 314:123726
联系方式：
E-mail: zhouying@ecust.edu.cn