尹斌成
发布人:生工学院网站管理员  发布时间:2016-10-19   动态浏览次数:711

 

斌成

  

    生物工程专业:博士生导师

    生物化学与分子生物学:硕士生导师

    生物化工专业:硕士生导师

    生物工程领域:工程硕士生导师
 

    

女,副教授。博士生导师。现任职于华东理工大学生物反应器工程国家重点实验室。研究方向是生物分析技术,主要从事生物分析及生物传感技术开发、生物探针设计等分析化学和生命科学交叉领域的基础及应用研究,以解决疾病早期诊断及治疗、食品安全检测、环境污染物检测和非法药物检测等重要课题。近年来在J Am Chem SocAngew Chem Int EdProc Natl Acad Sci USAAnal ChemChem CommunBiosens & BioelectronChem Eur J等国际性刊物上发表SCI收录论文50余篇,其中以第一作者和通讯作者发表40余篇,他引用次数1500余次;申请中国发明专利6项,其中授权4项;撰写英文专著1部。近年来主持和作为主要成员承担了国家自然科学基金(青年、面上)、国家自然科学基金重点项目、国家863项目、上海市自然科学基金、上海市纳米专项等项目。曾获上海市技术发明奖二等奖、高等学校科学研究优秀成果奖(自然科学奖)二等奖、明治乳业生命科学奖、上海市研究生优秀成果(学位论文)、华东理工大学英才计划资助等荣誉。

研究方向:

1DNA分子机器的设计及细胞成像应用

2、高效纳米/生物分子探针的合成及生物分析应用

3、液体活检新技术的开发

4、新型生物传感及信号放大技术的研究

论著清单

1.Jin-Liang Ma, Bin-Cheng Yin,* Xin Wu, and Bang-Ce Ye. Simple and Cost-Effective Glucose Detection based on Carbon Nanodots Supported on Silver Nanoparticles. Analytical Chemistry 89 (2), 1323-1328, 2016.

2.Wen Zhou, Bin-Cheng Yin,* and Bang-Ce Ye*. Highly Sensitive Surface-Enhanced Raman Scattering Detection of Hexavalent Chromium based on Hollow Sea Urchin-Like TiO2@Ag Nanoparticle Substrate. Biosensors & Bioelectronics 87, 187-194, 2017.

3.Jin-Liang Ma, Bin-Cheng Yin,* Xin Wu, and Bang-Ce Ye*. Copper-Mediated DNA-Scaffolded Silver Nanocluster On-Off Switch for Detection of Pyrophosphate and Alkaline Phosphatase.Analytical Chemistry 88 (18), 9219-9225, 2016.

4.Ru-Dong Li, Bin-Cheng Yin,* and Bang-Ce Ye*. Ultrasensitive, Colorimetric Detection of MicroRNAs based on Isothermal Exponential Amplification Reaction-Assisted Gold Nanoparticle Amplification.Biosensors & Bioelectronics 86, 1011-1016, 2016.

5.Di You, Bin-Cheng Yin, Zhi-Hai Li, Ying Zhou, Wen-Bang Yu, Peng Zuo, and Bang-Ce Ye*. Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism. Proc Natl Acad Sci USA 113(24), 6653-6658, 2016.

6.Qian Wang, Bin-Cheng Yin,* and Bang-Ce Ye*.A Novel Polydopamine-based Chemiluminescence Resonance Energy Transfer Method for MicroRNA Detection Coupling Duplex-Specific Nuclease-Aided Target Recycling Strategy. Biosensors & Bioelectronics 80, 366-372, 2016.

7.Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*. A Versatile Proximity-Dependent Probe based on Light-Up DNA-Scaffolded Silver Nanoclusters.Analyst 141, 1301-1306, 2016.

8.Ru-Dong Li, Qian Wang, Bin-Cheng Yin,* and Bang-Ce Ye*. Enzyme-free Detection of Sequence-Specific MicroRNAs based on Nanoparticle-Assisted Signal Amplification Strategy. Biosensors & Bioelectronics 77, 995-1000, 2016.

9.Le Ying, Nuli Xie, Yanjing Yang, Xiaohai Yang, Qifeng Zhou, Bin-Cheng Yin, Jin Huang,* and Kemin Wang*. A Cell-Surface-Anchored Ratiometric I-Motif Sensor for Extracellular pH Detection. Chemical Communications 52, 7818-7821, 2016.

10.Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*.DNA Template-Regulated Intergrowth of Fluorescent Silver Nanocluster Emitter Pair. RSC Advances 5, 98467-98471, 2015.

11.Qian Wang, Ru-Dong Li, Bin-Cheng Yin,* and Bang-Ce Ye*. Colorimetric Detection for Specific MicroRNA Based on Duplex-Specific Nuclease-Assisted Nanoparticle Amplification. Analyst 140, 6306-6312, 2015.

12.Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel Linear Molecular Beacon based on DNA-Scaffolded Silver Nanocluster for DNA Detection via Exonuclease III-Assisted Cyclic Amplification. RSC Advances 5, 65437-65443, 2015.

13.Jin-Liang Ma, Bin-Cheng Yin,* Huynh-Nhu Le, and Bang-Ce Ye*. Label-Free Detection of Sequence-Specific DNA based on Fluorescent Silver Nanoclusters-Assisted Surface Plasmon Enhanced Energy Transfer. ACS Applied Materials & Interfaces 7(23), 12856-12863, 2015.

14.Peng-Qiang Leng, Feng-Lan Zhao, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel, Colorimetric Method for Biogenic Amine Detection based on Arylalkylamine N-Acetyltransferase. Chemical Communications 51, 8712-8714, 2015.

15.Bin-Cheng Yin, Shan Wu, Jin-Liang Ma, and Bang-Ce Ye*. A Novel Molecular Beacon-based Method for Isothermal Detection of Sequence-Specific DNA via T7 RNA Polymerase-Aided Target Regeneration. Biosensors & Bioelectronics 68, 365-370, 2015.

16.Cui-Yuan Yu, Bin-Cheng Yin,* Shilong Wang, Zengguang Xu, and Bang-Ce Ye*. Improved Ligation-Mediated PCR Method Coupled with T7 RNA Polymerase for Sensitive DNA Detection. Analytical Chemistry 86, 7214-7218, 2014.

17.Bin-Cheng Yin,* Jin-Liang Ma, Huynh-Nhu Le, Shilong Wang, Zengguang Xu, and Bang-Ce Ye*. A New Mode to Light Up Adjacent DNA-Scaffolded Silver Probe Pair and Its Application for Specific DNA Detection. Chemical Communications 50 (100), 15991-15994, 2014.

18.Yuan-Chen He, Bin-Cheng Yin,* Lihua Jiang, and Bang-Ce Ye*. Rapid Detection of MicroRNA based on p19-Enhanced Fluorescence Polarization. Chemical Communications 50 (47), 6236-6239, 2014.

19.Xiaoyan Lin, Liang Cui, Yishun Huang, Ya Lin, Yi Xie, Zhi Zhu*, Bin-Cheng Yin, Xi Chen, and Chaoyong James Yang*. Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules based on Nuclease-Assisted Target Recycling Signal Amplification.Chemical Communications 50, 7646-7648, 2014.

20.Jin Huang, Yong He, Xiaohai Yang, Kemin Wang, Le Ying, Ke Quan, Yanjing Yang, and Bin-Cheng Yin. I-Motif-Based Nano-Flares for Sensing pH Changes in Live Cells. Chemical Communications 50, 15768-15771, 2014.

21.Bin-Cheng Yin,Yu-Qiang Liu, and Bang-Ce Ye*. Sensitive Detection of MicroRNA in Complex Biological Samples via Enzymatic Signal Amplification Using DNA Polymerase Coupled with Nicking Endonuclease.Analytical Chemistry 85 (23), 11487-11493, 2013.

22.Cui-Yuan Yu, Bin-Cheng Yin,* and Bang-Ce Ye*. A Universal Real-Time PCR Assay for Rapid MicroRNA Quantification via the Enhancement of Base-Stacking Hybridization. Chemical Communications 49 (74), 8247-8249, 2013.

23.Min Zhang, Yu-Qiang Liu, Cui-Yuan Yu, Bin-Cheng Yin,* and Bang-Ce Ye*. Multiplexed Detection of MicroRNAs by Tuning DNA-Scaffolded Silver Nanoclusters. Analyst 138 (17), 4812- 4817, 2013.

24.Xin-Ping Wang, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel Fluorescence Probe of dsDNA-Templated Copper Nanoclusters for Quantitative Detection of MicroRNAs. RSC Advances 3, 8633-8636, 2013.

25.Xin-Ping Wang, Bin-Cheng Yin,* Ping Wang, and Bang-Ce Ye*. Highly Sensitive Detection of MicroRNAs based on Isothermal Exponential Amplification-Assisted Generation of Catalytic G-Quadruplex DNAzyme. Biosensors & Bioelectronics 42, 131-135, 2013.

26.Min Zhang, Huynh-Nhu Le, Xiao-Qin Jiang, Bin-Cheng Yin,and Bang-Ce Ye*.Time-Resolved Probes Based on Guanine/Thymine-Rich DNA-Sensitized Luminescence of Terbium (III). Analytical Chemistry 85 (23), 11665-11674, 2013.

27.Bin-Cheng Yin, Yu-Qiang Liu, and Bang-Ce Ye*. One-step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification. Journal of the American Chemical Society 134 (11), 5064-5067, 2012.

28.Bin-Cheng Yin, Mingxu You, Weihong Tan, Bang-Ce Ye*. Mercury(II) Ions Detection via Pyrene-Mediated Photolysis of Disulfide Bonds. Chemistry - A European Journal 18(5), 1286-1289, 2012.

29.Bin-Cheng Yin, Bang-Ce Ye*, Hui Wang, Zhi Zhu, Weihong Tan*. Colorimetric Logic Gates based on Aptamer-Crosslinked Hydrogel. Chemical Communications 48, 1248-1250, 2012.

30.Bin-Cheng Yin, Yi-Meng Guan, and Bang-Ce Ye*. An Ultrasensitive Electrochemical DNA Sensor based on the ssDNA-assisted Cascade of Hybridization Reaction. Chemical Communications 48 (35), 4208-4210, 2012.

31.Yu-Qiang Liu, Min Zhang, Bin-Cheng Yin, and Bang-Ce Ye*. Attomolar Ultrasensitive MicroRNA Detection by DNA-Scaffolded Silver-Nanocluster Probe based on Isothermal Amplification. Analytical Chemistry 84(12), 5165-5169, 2012.

32.Di Wu, Bin-Cheng Yin, and Bang-Ce Ye*. A Label-Free Electrochemical DNA Sensor based on Exonuclease III-Aided Target Recycling Strategy for Sequence-Specific Detection of Femtomolar DNA. Biosensors & Bioelectronics 28, 232-238, 2011.

33.Mingxu You, Yan Chen, Lu Peng, Da Han, Bin-Cheng Yin, Bang-Ce Ye, and Weihong Tan*. Engineering DNA Aptamers for Novel Analytical and Biomedical Applications. Chemical Science 2, 1003-1010, 2011.

34.Hui-Jie Tong, Na Jin, Bin-Cheng Yin, and Bang-Ce Ye*. A Novel Separation and Enrichment Method of 17β-Estradiol using Aptamer-Anchored Beads. Bioprocess and Biosystems Engineering 34, 189-195, 2011.

35.Min Zhang, Bin-Cheng Yin, Weihong Tan, and Bang-Ce Ye*. A Versatile Graphene-Based Fluorescence “On/Off” Switch for Multiplex Detection of Various Targets. Biosensors & Bioelectronics 26, 3260-3265, 2011.

36.Min Zhang, Bin-Cheng Yin, Xian-Fei Wang, and Bang-Ce Ye*. Interaction of Peptides with Graphene Oxide and Its Application for Real-Time Monitoring of Protease Activity. Chemical Communications 47, 2399-2401, 2011.

37.Bin-Cheng Yin, Min Zhang, Weihong Tan*, and Bang-Ce Ye*. Peptide-Functionalized Spherical Polyelectrolyte Nanobrushes for Real-Time Sensing of Protease Activity. ChemBioChem 11, 494-497, 2010.

38.Bin-Cheng Yin, Peng Zuo, Hao Huo, Xinhua Zhong, and Bang-Ce Ye*. DNAzyme-Self-Assembled Gold Nanoparticles for Determination of Metal Ions using Fluorescence Anisotropy Assay. Analytical Biochemistry 401, 47-52, 2010.

39.Bin-Cheng Yin, Di Wu, and Bang-Ce Ye*. Sensitive DNA-based Electrochemical Strategy for Trace Bleomycins Detection. Analytical Chemistry 82(19), 8272-8277, 2010.

40.Bin-Cheng Yin, Bang-Ce Ye*, Hui Wang, Weihong Tan*, and Cong-Cong Xie. An Allosteric Dual-DNAzyme Unimolecular Probe for Colorimetric Detection of Copper(II). Journal of the American Chemical Society 131, 14624-14625, 2009.

41.Bin-Cheng Yin, Xian-Fei Wang, and Ye Bang-Ce*. Multiplex Genotyping and Allele Frequency Estimation using Non-Gel Capillary Electrophoresis. Analytical Biochemistry 387, 221-229, 2009.

42.Peng Zuo, Bin-Cheng Yin, Bang-Ce Ye*. DNAzyme-based Microarray for Highly Sensitive Detection of Metal Ions. Biosensors & Bioelectronics 25, 935-939, 2009.

43.Sheng-Quan Jin, Bin-Cheng Yin, and Bang-Ce Ye*. A Multiplexed Bead-based Mesofluidic System for Foodborne Pathogen Bacteria Detection. Applied and Environmental Microbiology 75, 6647-6654, 2009.

44.Bang-Ce Ye*, Yan Zhang, Hui Yu, Wen-Bang Yu, Bao-Hong Liu, Bin-Cheng Yin, Chun-Yun Yin, Yuan-Yuan Li, Ju Chu, Si-Liang Zhang. Time-resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine. PLoS ONE 4(9), e7073, 2009.

45.Bang-Ce Ye*, Bincheng Yin. Highly Sensitive Detection of Mercury (II) ion by Fluorescence Polarization via Gold Nanoparticle Enhancement. Angewandte Chemie International Edition 47, 8386-8389, 2008.

46.Bin-Cheng Yin, Honghua Li, and Bang-Ce Ye*. A Dual-Probe Hybridization Method for Reducing Variability in Single Nucleotide Polymorphism Analysis with Oligonucleotide Microarrays. Analytical Biochemistry 383, 270-278, 2008.

47.Bin-Cheng Yin, Honghua Li, and Bang-Ce Ye*. Microarray-based Estimation of SNP Allele-frequency in Pooled DNA using the Langmuir Kinetic Model. BMC Genomics 9, 605, 2008.

48.Bin-Cheng Yin, Fei Yue, and Bang-Ce Ye*. Construction of Microarrays for Genotyping of DQA using Unmodified 45-mer Oligonucleotide. Molecular Biotechnology 36, 142-150, 2007.

49.Bang-Ce Ye*, Xiaohe Chu, Fan Ye, Songyang Li, Bin-Cheng Yin, and Peng Zuo. Simultaneous Genotyping of DRB1/3/4/5 loci by Oligonucleotide Microarray. Molecular Diagnostics 5, 592-599, 2005.

50.Bang-Ce Ye*, Peng Zuo, Bin-Cheng Yin, and Songyang Li. Estimation of Relative Allele Frequencies of Single-Nucleotide Polymorphisms in Different Populations by Microarray Hybridization of Pooled DNA. Analytical Biochemistry 333, 72-78, 2004.

51.Bang-Ce Ye, Min Zhang, Bin-Cheng Yin. 英文专著《Nano-Bio Probe Design and Its Application for Biochemical Analysis, ISBN 978-3-642-29542-3, 施普林格出版社, 2012.

联系方式

上海市梅陇路130号华东理工大学实验18713(283信箱),邮编200237

办公电话:+86-21-64253832

电子邮箱:binchengyin@ecust.edu.cn