尹斌成
发布人:生工学院网站管理员  发布时间:2016-10-19   动态浏览次数:1157

 

斌成

         生物化学与分子生物学:博士生导师


    生物工程专业:博士生导师

    生物化学与分子生物学:硕士生导师,博士生导师

    生物化工专业:硕士生导师

    生物工程领域:工程硕士生导师
 

    

 

  尹斌成,女,副教授。博士生导师。现任职于华东理工大学生物反应器工程国家重点实验室。研究方向是生物分析技术,主要从事生物分析及生物传感技术开发、新型生物探针设计等分析化学和生命科学交叉领域的基础及应用研究,以解决疾病早期诊断及治疗、食品安全检测、环境污染物检测和非法药物检测等重要课题。近年来在J Am Chem SocAngew Chem Int EdProc Natl Acad Sci USAAnal ChemChem CommunBiosens & BioelectronChem Eur J等国际性刊物上发表SCI收录论文60余篇,其中以第一作者和通讯作者发表近50篇,他引用次数1500余次;申请中国发明专利6项,其中授权4项;合作撰写英文专著1部。近年来主持和作为主要成员承担了国家自然科学基金(青年、面上)、国家自然科学基金重点项目、国家863项目、上海市自然科学基金、上海市纳米专项等项目。曾获上海市技术发明奖二等奖、高等学校科学研究优秀成果奖(自然科学奖)二等奖、明治乳业生命科学奖、上海市研究生优秀成果(学位论文)等荣誉。


研究方向:

1、智能型DNA分子机器的设计及应用

2、高效纳米/生物分子探针的合成及应用

3、液体活检新技术的开发

4、新型生物传感及信号放大技术的研究


论著清单

1.Cheng-Pin Liang, Pei-Qiang Ma,Hui Liu, Xinggang Guo, Bin-Cheng Yin,* and Bang-Ce Ye. Rational Engineering of Dynamic, Entropy-Driven DNA Nanomachine for Intracellular MicroRNA Imaging. Angewandte Chemie International Edition 56 (31), 9077-9081, 2017.

2.Wen Zhou, Ya-Fei Tian, Bin-Cheng Yin,* and Bang-Ce Ye*. Simultaneous Surface-Enhanced Raman Spectroscopy Detection of Multiplexed MicroRNA Biomarkers. Analytical Chemistry 89 (11), 6120-6128, 2017.

3.Jin-Liang Ma, Bin-Cheng Yin,* Xin Wu, and Bang-Ce Ye. Simple and Cost-Effective Glucose Detection based on Carbon Nanodots Supported on Silver Nanoparticles. Analytical Chemistry 89 (2), 1323-1328, 2017.

4.Wen Zhou, Bin-Cheng Yin,* and Bang-Ce Ye*. Highly Sensitive Surface-Enhanced Raman Scattering Detection of Hexavalent Chromium based on Hollow Sea Urchin-Like TiO2@Ag Nanoparticle Substrate. Biosensors & Bioelectronics 87, 187-194, 2017.

5.Hong-Ya Wang, Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*. Nicotinamide Adenine Dinucleotide Detection based on Silver Nanoclusters Stabilized by a Dumbbell-Shaped DNA Template. Analyst 142, 1765-1771, 2017.

6.Jin-Liang Ma, Bin-Cheng Yin,* Xin Wu, and Bang-Ce Ye*. Copper-Mediated DNA-Scaffolded Silver Nanocluster On-Off Switch for Detection of Pyrophosphate and Alkaline Phosphatase.Analytical Chemistry88 (18), 9219-9225, 2016.

7.Ru-Dong Li, Bin-Cheng Yin,* and Bang-Ce Ye*. Ultrasensitive, Colorimetric Detection of MicroRNAs based on Isothermal Exponential Amplification Reaction-Assisted Gold Nanoparticle Amplification.Biosensors & Bioelectronics 86, 1011-1016, 2016.

8.Di You, Bin-Cheng Yin,Zhi-Hai Li, Ying Zhou, Wen-Bang Yu, Peng Zuo, and Bang-Ce Ye*. Sirtuin-dependent reversible lysine acetylation of glutamine synthetases reveals an autofeedback loop in nitrogen metabolism. Proceedings of the National Academy of Sciences of the United States of America113(24), 6653-6658, 2016.

9.Qian Wang, Bin-Cheng Yin,* and Bang-Ce Ye*.A Novel Polydopamine-based Chemiluminescence Resonance Energy Transfer Method for MicroRNA Detection Coupling Duplex-Specific Nuclease-Aided Target Recycling Strategy. Biosensors & Bioelectronics 80, 366-372, 2016.

10.Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*. A Versatile Proximity-Dependent Probe based on Light-Up DNA-Scaffolded Silver Nanoclusters.Analyst141, 1301-1306, 2016.

11.Ru-Dong Li, Qian Wang, Bin-Cheng Yin,* and Bang-Ce Ye*. Enzyme-free Detection of Sequence-Specific MicroRNAs based on Nanoparticle-Assisted Signal Amplification Strategy. Biosensors & Bioelectronics 77, 995-1000, 2016.

12.Le Ying, Nuli Xie, Yanjing Yang, Xiaohai Yang, Qifeng Zhou,Bin-Cheng Yin, Jin Huang,* and Kemin Wang*. A Cell-Surface-Anchored Ratiometric I-Motif Sensor for Extracellular pH Detection. Chemical Communications52, 7818-7821, 2016.

13.Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*.DNA Template-Regulated Intergrowth of Fluorescent Silver Nanocluster Emitter Pair. RSC Advances5, 98467-98471, 2015.

14.Qian Wang, Ru-Dong Li, Bin-Cheng Yin,* and Bang-Ce Ye*. Colorimetric Detection for Specific MicroRNA Based on Duplex-Specific Nuclease-Assisted Nanoparticle Amplification. Analyst 140, 6306-6312, 2015.

15.Jin-Liang Ma, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel Linear Molecular Beacon based on DNA-Scaffolded Silver Nanocluster for DNA Detection via Exonuclease III-Assisted Cyclic Amplification.RSC Advances5, 65437-65443, 2015.

16.Jin-Liang Ma, Bin-Cheng Yin,* Huynh-Nhu Le, and Bang-Ce Ye*. Label-Free Detection of Sequence-Specific DNA based on Fluorescent Silver Nanoclusters-Assisted Surface Plasmon Enhanced Energy Transfer. ACS Applied Materials & Interfaces7(23), 12856-12863,2015.

17.Peng-Qiang Leng, Feng-Lan Zhao, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel, Colorimetric Method for Biogenic Amine Detection based on Arylalkylamine N-Acetyltransferase. Chemical Communications51, 8712-8714, 2015.

18.Bin-Cheng Yin, Shan Wu, Jin-Liang Ma, and Bang-Ce Ye*. A Novel Molecular Beacon-based Method for Isothermal Detection of Sequence-Specific DNA via T7 RNA Polymerase-Aided Target Regeneration. Biosensors& Bioelectronics68, 365-370, 2015.

19.Cui-Yuan Yu, Bin-Cheng Yin,* Shilong Wang, Zengguang Xu, and Bang-Ce Ye*. Improved Ligation-Mediated PCR Method Coupled with T7 RNA Polymerase for Sensitive DNA Detection. Analytical Chemistry 86, 7214-7218, 2014.

20.Bin-Cheng Yin,* Jin-Liang Ma, Huynh-Nhu Le, Shilong Wang, Zengguang Xu, and Bang-Ce Ye*. A New Mode to Light Up Adjacent DNA-Scaffolded Silver Probe Pair and Its Application for Specific DNA Detection. Chemical Communications50 (100), 15991-15994, 2014.

21.Yuan-Chen He, Bin-Cheng Yin,* Lihua Jiang, and Bang-Ce Ye*. Rapid Detection of MicroRNA based on p19-Enhanced Fluorescence Polarization. Chemical Communications 50 (47), 6236-6239, 2014.

22.Xiaoyan Lin, Liang Cui, Yishun Huang, Ya Lin, Yi Xie, Zhi Zhu*, Bin-Cheng Yin, Xi Chen, and Chaoyong James Yang*. Carbon Nanoparticle-Protected Aptamers for Highly Sensitive and Selective Detection of Biomolecules based on Nuclease-Assisted Target Recycling Signal Amplification.Chemical Communications 50, 7646-7648, 2014.

23.Jin Huang, Yong He, Xiaohai Yang, Kemin Wang, Le Ying, Ke Quan, Yanjing Yang, and Bin-Cheng Yin. I-Motif-Based Nano-Flares for Sensing pH Changes in Live Cells. Chemical Communications50, 15768-15771, 2014.

24.Bin-Cheng Yin,Yu-Qiang Liu, and Bang-Ce Ye*. Sensitive Detection of MicroRNA in Complex Biological Samples via Enzymatic Signal Amplification Using DNA Polymerase Coupled with Nicking Endonuclease.Analytical Chemistry 85 (23), 11487-11493, 2013.

25.Cui-Yuan Yu, Bin-Cheng Yin,* and Bang-Ce Ye*. A Universal Real-Time PCR Assay for Rapid MicroRNA Quantification via the Enhancement of Base-Stacking Hybridization. Chemical Communications 49 (74),8247-8249, 2013.

26.Min Zhang, Yu-Qiang Liu, Cui-Yuan Yu, Bin-Cheng Yin,* and Bang-Ce Ye*. Multiplexed Detection of MicroRNAs by Tuning DNA-Scaffolded Silver Nanoclusters. Analyst138 (17), 4812- 4817, 2013.

27.Xin-Ping Wang, Bin-Cheng Yin,* and Bang-Ce Ye*. A Novel Fluorescence Probe of dsDNA-Templated Copper Nanoclusters for Quantitative Detection of MicroRNAs. RSC Advances 3, 8633-8636, 2013.

28.Xin-Ping Wang, Bin-Cheng Yin,* Ping Wang, and Bang-Ce Ye*. Highly Sensitive Detection of MicroRNAs based on Isothermal Exponential Amplification-Assisted Generation of Catalytic G-Quadruplex DNAzyme. Biosensors& Bioelectronics 42,131-135, 2013.

29.Min Zhang, Huynh-Nhu Le, Xiao-Qin Jiang, Bin-Cheng Yin,and Bang-Ce Ye*.Time-Resolved Probes Based on Guanine/Thymine-Rich DNA-Sensitized Luminescence of Terbium (III). Analytical Chemistry 85 (23),11665-11674, 2013.

30.Bin-Cheng Yin, Yu-Qiang Liu, and Bang-Ce Ye*. One-step, Multiplexed Fluorescence Detection of microRNAs Based on Duplex-Specific Nuclease Signal Amplification. Journal of the American Chemical Society 134 (11),5064-5067, 2012.

31.Bin-Cheng Yin, Mingxu You, Weihong Tan, Bang-Ce Ye*. Mercury(II) Ions Detection via Pyrene-Mediated Photolysis of Disulfide Bonds. Chemistry - A European Journal 18(5),1286-1289, 2012.

32.Bin-Cheng Yin, Bang-Ce Ye*, Hui Wang, Zhi Zhu, Weihong Tan*. Colorimetric Logic Gates based on Aptamer-Crosslinked Hydrogel. Chemical Communications 48,1248-1250, 2012.

33.Bin-Cheng Yin, Yi-Meng Guan, and Bang-Ce Ye*. An Ultrasensitive Electrochemical DNA Sensor based on the ssDNA-assisted Cascade of Hybridization Reaction. Chemical Communications 48 (35), 4208-4210, 2012.

34.Yu-Qiang Liu, Min Zhang, Bin-Cheng Yin, and Bang-Ce Ye*. Attomolar Ultrasensitive MicroRNA Detection by DNA-Scaffolded Silver-Nanocluster Probe based on Isothermal Amplification. Analytical Chemistry 84(12), 5165-5169, 2012.

35.Di Wu, Bin-Cheng Yin, and Bang-Ce Ye*. A Label-Free Electrochemical DNA Sensor based on Exonuclease III-Aided Target Recycling Strategy for Sequence-Specific Detection of Femtomolar DNA. Biosensors& Bioelectronics 28,232-238, 2011.

36.Mingxu You, Yan Chen, Lu Peng, Da Han, Bin-Cheng Yin, Bang-Ce Ye, and Weihong Tan*. Engineering DNA Aptamers for Novel Analytical and Biomedical Applications. Chemical Science 2, 1003-1010, 2011.

37.Hui-Jie Tong, Na Jin, Bin-Cheng Yin, and Bang-Ce Ye*. A Novel Separation and Enrichment Method of 17β-Estradiol using Aptamer-Anchored Beads. Bioprocess and Biosystems Engineering 34,189-195, 2011.

38.Min Zhang, Bin-Cheng Yin, Weihong Tan, and Bang-Ce Ye*. A Versatile Graphene-Based Fluorescence “On/Off” Switch for Multiplex Detection of Various Targets. Biosensors& Bioelectronics 26,3260-3265, 2011.

39.Min Zhang, Bin-Cheng Yin, Xian-Fei Wang, and Bang-Ce Ye*. Interaction of Peptides with Graphene Oxide and Its Application for Real-Time Monitoring of Protease Activity. Chemical Communications 47,2399-2401, 2011.

40.Bin-Cheng Yin, Min Zhang, Weihong Tan*, and Bang-Ce Ye*. Peptide-Functionalized Spherical Polyelectrolyte Nanobrushes for Real-Time Sensing of Protease Activity. ChemBioChem 11, 494-497, 2010.

41.Bin-Cheng Yin, Peng Zuo, Hao Huo, Xinhua Zhong, and Bang-Ce Ye*. DNAzyme-Self-Assembled Gold Nanoparticles for Determination of Metal Ions using Fluorescence Anisotropy Assay. Analytical Biochemistry 401,47-52, 2010.

42.Bin-Cheng Yin, Di Wu, and Bang-Ce Ye*. Sensitive DNA-based Electrochemical Strategy for Trace Bleomycins Detection. Analytical Chemistry 82(19),8272-8277, 2010.

43.Bin-Cheng Yin, Bang-Ce Ye*, Hui Wang, Weihong Tan*, and Cong-Cong Xie. An Allosteric Dual-DNAzyme Unimolecular Probe for Colorimetric Detection of Copper(II). Journal of the American Chemical Society 131, 14624-14625, 2009.

44.Bin-Cheng Yin, Xian-Fei Wang, and Ye Bang-Ce*. Multiplex Genotyping and Allele Frequency Estimation using Non-Gel Capillary Electrophoresis. Analytical Biochemistry 387, 221-229, 2009.

45.Peng Zuo, Bin-Cheng Yin, Bang-Ce Ye*. DNAzyme-based Microarray for Highly Sensitive Detection of Metal Ions. Biosensors& Bioelectronics 25, 935-939, 2009.

46.Sheng-Quan Jin, Bin-Cheng Yin, and Bang-Ce Ye*. A Multiplexed Bead-based Mesofluidic System for Foodborne Pathogen Bacteria Detection.Applied and Environmental Microbiology 75,6647-6654, 2009.

47.Bang-Ce Ye*, Yan Zhang, Hui Yu, Wen-Bang Yu, Bao-Hong Liu, Bin-Cheng Yin, Chun-Yun Yin, Yuan-Yuan Li, Ju Chu, Si-Liang Zhang. Time-resolved Transcriptome Analysis of Bacillus subtilis Responding to Valine, Glutamate, and Glutamine.PLoS ONE 4(9), e7073, 2009.

48.Bang-Ce Ye*, Bincheng Yin. Highly Sensitive Detection of Mercury (II) ion by Fluorescence Polarization via Gold Nanoparticle Enhancement. Angewandte Chemie International Edition 47, 8386-8389, 2008.

49.Bin-Cheng Yin, Honghua Li, and Bang-Ce Ye*. A Dual-Probe Hybridization Method for Reducing Variability in Single Nucleotide Polymorphism Analysis with Oligonucleotide Microarrays. Analytical Biochemistry 383,270-278, 2008.

50.Bin-Cheng Yin, Honghua Li, and Bang-Ce Ye*. Microarray-based Estimation of SNP Allele-frequency in Pooled DNA using the Langmuir Kinetic Model. BMC Genomics 9, 605, 2008.

51.Bin-Cheng Yin, Fei Yue, and Bang-Ce Ye*. Construction of Microarrays for Genotyping of DQA using Unmodified 45-mer Oligonucleotide. Molecular Biotechnology 36,142-150, 2007.

52.Bang-Ce Ye*, Xiaohe Chu, Fan Ye, Songyang Li, Bin-Cheng Yin, and Peng Zuo. Simultaneous Genotyping of DRB1/3/4/5 loci by Oligonucleotide Microarray. Molecular Diagnostics 5,592-599, 2005.

53.Bang-Ce Ye*, Peng Zuo, Bin-Cheng Yin, and Songyang Li. Estimation of Relative Allele Frequencies of Single-Nucleotide Polymorphisms in Different Populations by Microarray Hybridization of Pooled DNA. Analytical Biochemistry 333,72-78, 2004.

54.Bang-Ce Ye, Min Zhang, Bin-Cheng Yin. 英文专著《Nano-Bio Probe Design and Its Application for Biochemical Analysis, ISBN 978-3-642-29542-3, 施普林格出版社, 2012.

联系方式

上海市梅陇路130号华东理工大学实验18713(283信箱),邮编200237

办公电话:+86-21-64253832

电子邮箱:binchengyin@ecust.edu.cn