阳大海
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阳大海


生物工程:硕士生导师

生物化学与分子生物学:硕士生导师

微生物学:硕士生导师

生物与医药工程专业:工程硕士导师

 

阳大海,博士,副教授,国家优秀青年科学基金获得者,生物反应器工程国家重点实验室PI。先后入选中国科协 “青年人才托举工程、上海市浦江人才计划晨光计划。主要研究方向为宿主先天免疫应答及其抗感染分子机制,研究成果先后发表于ImmunityNature CommunicationsCell ReportsPLoS PathogensThe Journal of Immunology等领域内高水平SCI期刊。现担任中国动物学会斑马鱼分会委员、Microbial Cell杂志学术编委。曾获中国微生物学会优秀学术交流奖、华东理工大学首届优秀研究生兼职辅导员、华东理工大学第三届校园新星等荣誉称号。

 

个人经历:

2018.09-至今:华东理工大学,副教授

2015.12- 2018.8:华东理工大学,讲师

2013.08-2015.05: 美国密歇根大学,联合培养博士

2010.09-2015.06: 华东理工大学,博士

2006.09-2010.06:湖州师范学院,学士

 

研究兴趣/领域:

(1) 宿主先天免疫应答分子机制:依托细胞生物学、分子生物学、免疫学研究平台,采用单细胞测序、反向遗传操作等手段,研究先天免疫细胞和免疫分子功能;通过建立病原-宿主感染模型,探究机体对病原体进行先天免疫防御的关键策略;

(2) 免疫防治产品开发依托模式动物斑马鱼筛选平台和水产养殖鱼类临床评价模型,开发抗感染药物和免疫增强剂产品。

 

主持或参加的科研项目或基金:

(1) 国家自然科学基金优秀青年科学基金项目32122090,水产免疫生物学,2022.01-2024.12200万元,主持;

(2) 中国科协第二批青年人才托举工程2016QNRC001,病原感染与免疫,2017.01-2019.0645万元,主持;

(3) 国家自然科学基金青年项目31602187,细菌类硫氧还蛋白调控MAPK信号通路及鱼类抗感染机制的研究,2017.01-2019.1221万元,主持;

(4) 上海市浦江人才计划2016PJD020,细菌毒力因子类硫氧还蛋白抑制斑马鱼MAPK信号通路并调控细菌感染的机制研究,2016.01-2018.1220万元,主持;

(5) 上海市科技创新行动计划面上项目20ZR1415500,鱼类焦亡信号调控中性粒细胞胞外陷阱功能研究,2020.02-2023.0620万元,主持;

(6)上海市晨光计划” (A)16CG33,斑马鱼Caspase-A炎症小体激活介导的宿主免疫保护分子机制,2017.01-2019.126万元,主持;

(7) 国家重点研发计划2018YFD0900500,水产动物疾病发生的分子机制与免疫机制,2018.06-2023.06,参加;

(8) 国家重点研发计划2018YFC0311300,高端农用海洋生物免疫制品开发,2018.01 -2021.05,参加。

 

教学工作:

本科生(大三)专业选修课《生物物理学》,32学时/年,2学分

 

代表性论文(*通讯作者):

(一)第一/通讯作者论文(按时间倒序)

(1)     Jiatiao Jiang, Wenwen Wang, Fei Sun, Yuanxing Zhang, Qin Liu, Dahai Yang*, Bacterial infection reinforces host metabolic flux from arginine to spermine for NLRP3 inflammasome evasion, Cell Reports 2021, 34(10):108832.

(2)     Weijie Chen, Jingjing Zhao, Di Mu, Zhuang Wang, Qin Liu, Yuanxing Zhang, Dahai Yang*, Pyroptosis Mediates Neutrophil Extracellular Trap Formation During Bacterial Infection in Zebrafish, The Journal of Immunology 2021, 206(8):1913-1922.

(3)     Hao Chen, Xiaoming Wu, Zhaoyan Gu, Shouwen Chen, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Zhuang Wang*, Dahai Yang*, Zebrafish gasdermin E cleavage-engaged pyroptosis by inflammatory and apoptotic caspases, Dev & Comp Immunol 2021, 124:104203.

(4)     Zhuang Wang, Zhaoyan Gu, Qing Hou, Weijie Chen, Di Mu, Yuanxing Zhang, Qin Liu, Zhihong Liu, Dahai Yang*, Zebrafish GSDMEb Cleavage-gated Pyroptosis Drives Septic Acute Kidney Injury In Vivo, The Journal of Immunology 2020, 204(7): 1929-1942.

(5)     Wenhui Wang, Jinchao Tan, Zhuang Wang, Yuanxing Zhang, Qin Liu, Dahai Yang*, Characterization of the Inflammasome Component SmASC in Turbot (Scophthalmus maximus), Fish & Shellfish Immunology 2020, 100: 324-333.

(6)     Ying Wen, Shouwen Chen, Zhiwei Jiang, Zhuang Wang, Jinchao Tan, Tianjian Hu, Qiyao Wang, Xiangshan Zhou, Yuanxing Zhang, Qin Liu, Dahai Yang*, Dysregulated Haemolysin Promotes Bacterial Outer Membrane Vesicles-Induced Pyroptotic-like Cell Death in Zebrafish, Cellular Microbiology2019, 21(6): e13010.

(7)     Dahai Yang#, Xiaohong Liu#, Wenting Xu, Zhaoyan Gu, Cuiting Yang, Lingzhi Zhang, Jinchao Tan, Xin Zheng, Zhuang Wang, Shu Quan, Yuanxing Zhang, Qin Liu*, The Edwardsiella piscicida Thioredoxin-like Protein Inhibits ASK1-MAPKs Signaling Cascades to Promote Pathogenesis during Infection, PLoS Pathogens2019, 15(7): e1007917.

(8)     Zhuang Wang, Lingyun Lin, Weijie Chen, Xin Zheng, Yuanxing Zhang, Qin Liu, Dahai Yang*, Neutrophil Plays Critical Role during Edwardsiella piscicida Immersion Infection in Zebrafish Larvae, Fish & Shellfish Immunology 2019, 87: 565-572.

(9)     Dahai Yang, Xin Zheng, Shouwen Chen, Zhuang Wang, Wenting Xu, Jinchao Tan, Mingyu Hou, Wenhui Wang, Zhaoyan Gu, Qiyao Wang, Ruilin Zhang, Yuanxing Zhang, Qin Liu*, Sensing of Cytosolic LPS through Caspy2 Pyrin Domain Mediates Noncanonical Inflammasome Activation in Zebrafish, Nature Communications2018, 9(1): 3052.

(10) Huifang Cao, Fajun Han, Jinchao Tan, Mingyu Hou, Yuanxing Zhang, DahaiYang*, Qin Liu*, Edwardsiella piscicida Type III Secretion System Effector EseK Inhibits Mitogen-Activated Protein Kinase Phosphorylation and Promotes Bacterial Colonization in Zebrafish Larva, Infection & Immunity 2018, 86(9): e00233-18.

(11) Wenting Xu, Zhaoyan Gu, Lingzhi Zhang, Yuanxing Zhang, Qin Liu, DahaiYang*, Edwardsiella piscicida Virulence Effector Trxlp Promotes the NLRC4 Inflammasome Activation during Infection, Microbial Pathogenesis2018, 123: 496-504.

(12) Huifang Cao, Cuiting Yang, Shu Quan, Tianjian Hu, Lingzhi Zhang, Yuanxing Zhang, Dahai Yang*, Qin Liu*, Novel T3SS Effector EseK in Edwardsiella piscicida Is Chaperoned by EscH and EscS to Express Virulence, Cellular Microbiology2018, 20(1): e12790.

(13) Dahai Yang, Yuan He, Raul Muñoz-Planillo, Qin Liu, Gabriel Núñez*, Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock, Immunity2015, 43(5): 923-932.

(14) Dahai Yang, Qin Liu*, Chunshan Ni, Shuai Li, Haizhen Wu, Qiyao Wang, Jinfan Xiao, Yuanxing Zhang, Gene Expression Profiling in Live Attenuated Edwardsiella tarda Vaccine Immunized and Challenged Zebrafish: Insights into the Basic Mechanisms of Protection Seen in Immunized Fish. Dev & Comp Immunol 2013, 40(2):132-141.

(15) Dahai Yang, Qin Liu*, Minjun Yang, Haizhen Wu, Qiyao Wang, Jingfan Xiao, Yuanxing Zhang*, RNA-seq Liver Transcriptome Analysis Reveals an Activated MHC-I Pathway and an Inhibited MHC-II Pathway at the Early Stage of Vaccine Immunization in Zebrafish,BMC Genomics2012, 13(1):319.

(二)合作发表论文(按时间倒序)

(1) Lingzhi Zhang, Jiatiao Jiang, Jin Zhang, Xiaohong Liu, Dahai Yang, Yuanxing Zhang, Qin Liu*. Edwardsiella piscicida Interferes with Classical Endocytic Trafficking and Replicates in a Specialized Replication-Permissive Niche in Nonphagocytic Cells, J Bacteriol 2021, 203(16): e0050520.

(2) Hao Chen, Shuangfei Ding, Jinchao Tan, Dahai Yang, Yuanxing Zhang, Qin Liu*, Characterization of the Japanese Flounder NLRP3 Inflammasome in Restricting Edwardsiella piscicida Colonization In Vivo, Fish & Shellfish Immunology2020, 103: 169-180.

(3) Shouwen Chen, Xin Ma, Di Wu, Dahai Yang, Yuanxing Zhang, Qin Liu*, Scophthalmus maximus Interleukin-1β Limits Edwardsiella piscicida Colonization In Vivo, Fish & Shellfish Immunology 2019, 95: 277-286.

(4) Tianjian Hu, Ran Chen, Lingzhi Zhang, Zhuang Wang, Dahai Yang, Yuanxing Zhang, Xiaohong Liu, Qin Liu*, Balanced Role of T3SS and T6SS in Contribution to the Full Virulence of Edwardsiella piscicida, Fish & Shellfish Immunology 2019, 93: 871-878.

(5) Jinchao Tan, Dahai Yang, Zhuang Wang, Xin Zheng, Yuanxing Zhang, Qin Liu*, EvpP Inhibits Neutrophils Recruitment via Jnk-Caspy Inflammasome Signaling In Vivo, Fish & Shellfish Immunology2019, 92: 851-860.

(6) Tianjian Hu, Lingzhi Zhang, Wei Wang, Dahai Yang, Jingfan Xiao, Yuanxing Zhang, Xiaohong Liu, Qin Liu*, Edwardsiella piscicida Enters Nonphagocytic Cells via a Macropinocytosis-Involved Hybrid Mechanism, Journal of Bacteriology2019, 201(5): e00548-18.

(7) Mingyu Hou, Wenhui Wang, Feizi Hu, Yuanxing Zhang, Dahai Yang, Qin Liu*, Phosphothreonine Lyase Promotes p65 Degradation in a Mitogen-Activated Protein Kinase/Mitogen- and Stress-Activated Protein Kinase 1-Dependent Manner, Infection and Immunity 2018, 87(1): e00508-18.

(8) Chengyuan Xu, Yunfeng Yan, Jinchao Tan, Dahai Yang, Xianjing Jia, Lu Wang, Yisheng Xu, Song Cao, Shengtong Sun*, Biodegradable Nanoparticles of Polyacrylic Acid–Stabilized Amorphous CaCO3 for Tunable pH‐Responsive Drug Delivery and Enhanced Tumor Inhibition, Advanced Functional Materials2019, 29(24): 1808146.

(9)  Lingzhi Zhang, Zhiwei Jiang, Shan Fang, Yajun Huang, Dahai Yang, Qiyao Wang, Yuanxing Zhang, Qin Liu*, Systematic Identification of Intracellular-Translocated Candidate Effectors in Edwardsiella piscicida, Frontiers in Cellular and Infection Microbiology2018, 8: 37.

(10)          Hideki Hara, Sergey S Seregin, DahaiYang, Koichi Fukase, Mathias Chamaillard, Emad S Alnemri, Naohiro Inohara, Grace Y Chen, Gabriel Núñez*, The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection. Cell2018, 175(6): 1651-1664.e14.

(11) Mingwei Wang#, Yisheng Xu#*, Yajing Liu, Kaizhi Gu, Jinchao Tan, Ping Shi, Dahai Yang, Zhiqian Guo*, Weihong Zhu, Xuhong Guo*, Martien A Cohen Stuart, Morphology Tuning of Aggregation-Induced Emission Probes by Flash Nanoprecipitation: Shape and Size Effects on in Vivo Imaging, ACS Applied Materials & Interfaces2018, 10(30): 25186-25193.

(12)      Meng Li, Yisheng Xu*, Jinli Sun, Mingwei Wang, Dahai Yang, Xuhong Guo, Haiyun Song, Song Cao*, Yunfeng Yan*, Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation,ACS Applied Materials & Interfaces 2018, 10(13):10752-10760.

(13)      Haihong He, Yang Xia, Yingxue Qi, Hong-Yin Wang, Zhuang Wang, Jianming Bao, Ziqian Zhang, Fu-Gen Wu, Haolu Wang, Daijie Chen, Dahai Yang, Xiaowen Liang, Jinquan Chen*, Shengmin Zhou*, Xin Liang*, Xuhong Qian, Youjun Yang*, A Water-Soluble, Green-Light Triggered, and Photo-Calibrated Nitric Oxide Donor for Biological Applications, Bioconjugation Chemistry2018, 29(4): 1194-1198.

(14)      Haihong He, Yuxin Liu, Zhongneng Zhou, Chunlei Guo, Hong-Yin Wang, Zhuang Wang, Xueli Wang, Ziqian Zhang, Fu-Gen Wu, Haolu Wang, Daijie Chen, Dahai Yang, Xiaowen Liang, Jinquan Chen*, Shengmin Zhou*, Xin Liang*, Xuhong Qian, Youjun Yang*. A Photo-Triggered and Photo-Calibrated Nitric Oxide Donor: Rational Design, Spectral Characterizations, and Biological Applications,Free Radical Biology and Medicine2018, 123: 1-7.

(15)      Hao Chen, Dahai Yang, Fajun Han, Jinchao Tan, Lingzhi Zhang, Jingfan Xiao, Yuanxing Zhang, Qin Liu*, The Bacterial T6SS Effector EvpP Prevents NLRP3 Inflammasome Activation by Inhibiting the Ca2+-Dependent MAPK-Jnk Pathway, Cell Host & Microbe2017, 21(1): 47-58.

(16)      Mingyu Hou, Ran Chen, Dahai Yang,Gabriel Núñez, Zhuang Wang, Qiyauo Wang, Yuanxing Zhang, Qin Liu*, Identification and Functional Characterization of EseH, a New Effector of the Type III Secretion System of Edwardsiella piscicida, Cellular Microbiology2017, 19(1): e12638.

(17)      Shan Fang, Lingzhi Zhang, Ying Lou, Dahai Yang, Qiyao Wang, Yuanxing Zhang, Qin Liu*, Intracellular Translocation and Localization of Edwardsiella tarda Type III Secretion System Effector EseG in Host Cells, Microbial Pathogenesis2016, 97:166-171.

(18)      Lingzhi Zhang, Chunshan Ni, Wenting Xu, Tongcheng Dai, Dahai Yang, Qiyao Wang, Yuanxing Zhuang, Qin Liu*, Intramacrophage Infection Reinforces the Virulence of Edwardsiella tarda, Journal of Bacteriology2016, 198(10):1534-1542.  

(19)      Yuan He, Melogy Y Zeng, DahaiYang, Benny Motro, Gabriel Núñez*, NEK7 Is an Essential Mediator of NLRP3 Activation Downstream of Potassium Efflux, Nature2016, 530(7590): 354-357.

 

联系方式:

地址:上海市徐汇区梅陇路130号,阿华生物工程研究所101室,200237

电话:021-64253065

E-maildahaiyang@ecust.edu.cn