肖啸
发布人:生工学院网站管理员  发布时间:2017-12-05   动态浏览次数:23


肖啸


生物工程专业:博士生导师/硕士生导师
     药学专业:博士生导师/硕士生导师


男,博士,教授/博导,现任美国北卡罗莱纳大学University of North Carolina at Chapel Hill杰出讲席教授,华东理工大学千人计划教授。 1982 年毕业于上海第一医学院,获药物化学学士学位;1985 年获武汉大学生物化学硕士学位;1986 年经教育部 CUSBEA(吴瑞项目)选拔赴美学习;1992 年获美国匹兹堡大学分子生物学博士学位;19931997 年受聘于 AvigenSomatix 等生物技术公司任研究员,高级研究员及科研主管;19982006 年任美国匹兹堡大学医学院助理教授,终身副教授,分子生物实验室主任;2006 至今任北卡大学药学院终身杰出讲席教授Fed Eshelman Distinguished Professor of Gene Therapy)20012006 年曾分别受聘为华中科技大学医学院,复旦大学医学院及台湾国防医学院客座教授。

研究领域基因治疗药物载体的研发及应用

研究方向①基因治疗药物载体的研发及应用,特别是重组腺相关病毒(AAV)基因载体的改进及高滴度高纯度生产工艺 ;②简易安全高效的基因载体及直接注射技术;③遗传性神经肌肉疾病,心脏病,糖尿病,血友病及宫颈癌等疾病的基因治疗研究。

学术兼职他于1999年荣获中国国家自然科学海外杰出青年基金,2013 年入选组织部千人计划。目前担任 Molecular Therapy, Human Gene Therapy, PLOS One等杂志的编委及多种生物医学杂志审稿人,历任美国国立卫生院(NIH),国防部及慈善基金会的科研基金评委,还历任美国基因及细胞治疗协会分组委员并于 2012 年当选为该协会董事会成员。

荣誉奖励:

1978-1981         Honor student for 4 consecutive years on Dean's list

                           at Shanghai Medical University

1985                    Graduated with high honors from the Wuhan University

1986               Fellowship from CUSBEA Program (China-United States Biochemistry Molecular Biology  Examination & Application), nominated by Wuhan University and selected after a nationwide contest.

1987-1992            Research and Teaching Fellowships from the University of Pittsburgh

1999                 The paper on gene therapy for limb girdle muscular dystrophy (J. Virology, 74:1436-1442) was covered by national & international news media, and posted on the NIH website as a major scientific advancement.   

2000                 Outstanding Overseas Chinese Scholar Award (Class B)

                   from Chinese Natural Science Foundation

2001                 The paper on Gene Therapy for Duchenne muscular dystrophy (PNAS,

97:13714-13719, cover story and commentary) was broadly covered by national & international news media as an important scientific advancement. The minigene is now being tested in a Phase I human gene therapy clinical trial.

2001                  PNC Foundation Innovation Award for brain cancer gene therapy

2005                The papers on systemic gene delivery in muscle (Nature Biotechnology, 23:321-8,Cover story; Circulation, 112:2650-9) were broadly covered by news media and posted on the NIH website as a major scientific advancement. Selected as one of 100 Top Science Stories of 2005 (Discover, Special Issue: Year in Science, Jan 2006)

2005                The paper on Gene Therapy for Congenital muscular dystrophy (PNAS,

2005 August 15, Epub) was broadly covered by national & international news media as an important scientific advancement. 

承担科研项目

(1)NIH/NINDSGene delivery to muscle and nerve for laminin-α2-deficient MD(MDC1A));

(2)NIH/NINDSGene delivery for fukutin-related protein deficiencies);

(3)Bamboo Therapeutics Inc.Assays for Duchenne Muscular Dystrophy gene therapy products)

(4)Eshelman Institute of InnovationTargetable and Regulatable Gene Delivery Platform Technology for Gene Therapy)

近年发表学术论文

1. Dawn E Bowles, Scott WJ McPhee, Chengwen Li, Steven J Gray, Jade J Samulski, Angelique S Camp, Juan Li, Bing Wang, Paul E Monahan, Joseph E Rabinowitz, Joshua C Grieger, Lakshmanan Govindasamy, Mavis Agbandje-McKenna, Xiao Xiao and R Jude Samulski (2012)  Phase 1 Gene Therapy for Duchenne Muscular Dystrophy using a Designer AAV Vector, Molecular Therapy, 20 2, 443–455. [Cited: 2]

2. Bo He, Ruhang Tang, Noah Weisleder, Bin Xiao, Zhenhua Yuan, Chuanxi Cai, HuaZhu, Peihui Lin, Chunping Qiao, Jianbin Li, Christina Mayer, Juan Li, Jianjie Ma, & Xiao Xiao (2012) Enhancing muscle membrane repair by gene delivery of MG53 ameliorates

muscular dystrophy and heart failure, Molecular Therapy20(4):727-35.

3. C. Qiao, Z. Yuan, J. Li, R. Tang, J. Li, and X. Xiao (2012) Single Tyrosine Mutation in AAV8 and AAV9 Capsids Is Insufficient to Enhance Gene Delivery to Skeletal Muscle and Heart  Human Gene Therapy (Part B) 23(1): 29-37

4. Kornegay JN, Bogan JR, Bogan DJ, Childers MK, Li J, Nghiem P, Detwiler DA, Larsen CA, Grange RW, Bhavaraju-Sanka RK, Tou S, Keene BP, Howard JF Jr, Wang J, Fan Z, Schatzberg SJ, Styner MA, Flanigan KM, Xiao X, Hoffman EP (2012). Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies. Mamm Genome. 2012 Feb;23(1-2):85-108.

5. JP. Tremblay, X Xiao et al (50 international co-authors) (2013) Translating the genomics revolution: the need for an International Gene Therapy Consortium for Monogenic Diseases. Molecular Therapy,  21(2):266-8.

6. Yang, L., Xiao X (2013) Creation of a cardiotropic adeno-associated virus: the story of viral directed evolution.Virol J. 10:50. doi: 10.1186/1743-422X-10-50.

7. Lee HH, O'Malley MJ, Friel NA, Payne KA, Qiao C, Xiao X, Chu CR (2013) Persistence, Localization, and External Control of Transgene Expression After Single Injection of Adeno-Associated Virus into Injured Joints. Hum Gene Ther. 24(4):457-66

8. Xu L, Lu PJ, Wang CH, Keramaris E, Qiao C, Xiao B, Blake DJ, Xiao X, Lu QL. (2013) Adeno-associated virus 9 mediated FKRP gene therapy restores functional glycosylation of α-dystroglycan and improves muscle functions.Mol Ther. 21(10):1832-40.

9. Blaeser A, Keramaris E, Chan YM, Sparks S, Cowley D, Xiao X, Lu QL.(2013) Mouse models of fukutin-related protein mutations showarange of disease phenotypes.Hum Genet. 132(8):923-34.

10. Qiao C, Li C, Zhao C, Li J, Bian T, Grieger J, Li J, Samulski RJ, Xiao X.(2013) K137R  Mutation on Adeno-Associated Viral Capsids Had Minimal Effect on Enhancing Gene Delivery In Vivo.Hum Gene Ther Methods. 25(1):33-9.

11. HI Ma, HA Shui, CH Wang, CY Wang, DY Huang, SH Chiou, HM Chen,J Li, SY Cheng, X Xiao, YP Yang (2014) Intratumoral decorin gene delivery by AAV vector inhibits brain glioblastomas and prolongs survival of animals by inducing cell differentiation, International Journal of Molecular Sciences (IJMS) 15(3):4393-414

12. Qiao C, Wang CH, Zhao C, Lu P, Awano H, Xiao B, Li J, Yuan Z, Dai Y, Martin CB, Li J, Lu Q, Xiao X. (2014) Muscle and heart function restoration in a limb girdle muscular dystrophy 2I (LGMD2I) mouse model by systemic FKRP gene delivery.Mol Ther. [Epub ahead of print]

13. Lenhart KC, Becherer AL, Li J, Xiao X, McNally EM, Mack CP, Taylor JM (2014) GRAF1 promotes ferlin-dependent myoblast fusion.Dev Biol.  Jul 11. [Epub ahead of print]

14. Vannoy CH, Xu L, Keramaris E, Lu P, Xiao X, Lu QL. (2014) Adeno-Associated Virus-Mediated Overexpression of LARGE Rescues α-Dystroglycan Function in Dystrophic Mice with Mutations in the Fukutin-Related Protein.Hum Gene Ther Methods. 2014 Jun;25(3):187-96.

15. Catherine Gérard1, Xiao Xiao2, Zoé Coulombe1, Marie Arsenault3, Jacques Couet3, Juan Li2, Marie-Claude.Drolet3, Pierre Chapdelaine1, Amina Chikh1 and Jacques P. Tremblay1(2014) An AAV9 coding for frataxin clearly improved symptoms and prolonged the life of mouse models of Friedreich ataxia. Mol Ther. Methods & Clinical DevelopmentPublished online 08 October 2014

16. Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A. (2015) Enhanced transgene expression from recombinant single-stranded d-sequence-substituted adeno-associated virus vectors in human cell lines in vitro and in murine hepatocytes in vivo.JournalVirol. ;89(2):952-61.

17. Chunxia Zhao, Chunping Qiao, Ruhang Tang, Jiangang Jiang, Jianbin Li, Carrie Bette Martin, Karen Bulaklak, Juan Li, Dao Wen Wang, and Xiao Xiao(2015) Overcoming insulin insufficiency by forced follistatin expression in beta-cells of DB/DB mice. MolecularTherapy, 23(5):866-74

18. He B, Cruz-Topete D, Oakley RH, Xiao X, Cidlowski JA. (2015) Human Glucocorticoid Receptor β (hGRβ) Regulates Gluconeogenesis and Inflammation in Mouse Liver.Mol Cell Biol. pii: MCB.00908-15. [Epub ahead of print]

19. Berns KI, Byrne BJ, Flotte TR, Gao G, Hauswirth WW, Herzog RW, Muzyczka N, VandenDriessche T, Xiao X, Zolotukhin S, Srivastava A. (2015) Adeno-Associated Virus Type 2 and Hepatocellular Carcinoma?Hum Gene Ther. 26(12):779-81.

20. Lenhart KC, O'Neill TJ 4th, Cheng Z, Dee R, Demonbreun AR, Li J, Xiao X, McNally EM, Mack CP, Taylor JM. (2015) GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice.Skelet Muscle. 5:27.

21. Ling C, Wang Y, Lu Y, Wang L, Jayandharan GR, Aslanidi GV, Li B, Cheng B, Ma W, Lentz T, Ling C, Xiao X, Samulski RJ, Muzyczka N, Srivastava A. (2015) The Adeno-Associated Virus Genome Packaging Puzzle.J Mol Genet Med. 9(3).

22. Tao W, Rubart M, Ryan J, Xiao X, Qiao C, Hato T, Davidson MW, Dunn KW, Day RN. (2015) A practical method for monitoring FRET-based biosensors in living animals using two-photon microscopy.Am J Physiol Cell Physiol. 309(11):C724-35.

23. Jiang J, Shen G, Li J, Qiao C, Xiao B, Yan H, Wang DW, Xiao X. (2016) Adeno-associated virus-mediated expression of myostatin propeptide improves the growth of skeletal muscle and attenuates hyperglycemia in db/db mice.Gene Ther. 2016 Dec 16.

24. Vannoy CH, Zhou H, Qiao C, Xiao X, Bang AG, Lu QL (2017) Adeno-Associated Virus-Mediated Mini-Agrin Delivery Is Unable to Rescue Disease Phenotype in a Mouse Model of Limb Girdle Muscular Dystrophy Type 2I.Am J Pathol. 2017 Feb;187(2):431-440.

25. Charles H. Vannoy, Will Xiao, Peijuan Lu, Xiao Xiao, Qi L. Lu (2017) Efficacy of Gene Therapy is Dependent on Disease Progression in Dystrophic Mice with Mutations in the FKRP Gene. Molecular Therapy - Methods & Clinical Development. Accepted for publication

26. Hui Zheng1,2#, Chunping Qiao1#,  Ruhang Tang1,  Jianbin Li1, Karen Bulaklak1, Zhenhua, Huang1, Chunxia Zhao1,  Yi Dai1 , Juan Li1 & Xiao Xiao (2017) Follistatin N-terminus differentially regulates muscle size and fat in vivo. Experimental and Molecular Medicine. Manuscript revised and resubmitted.


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