[学术报告]第343次SKLBE学术论坛
发布人:生工学院网站管理员  发布时间:2017-04-17   动态浏览次数:79

报告题目:  METABOLIC ENGINEERING OF YEAST FOR PRODUCTION OF FUELS AND CHEMICALS


开始时间:  2017-04-20 10:00:00


报告地点逸夫楼演讲厅


报 告 人瑞典查尔姆斯理工大学Jens B. Nielsen院士


主办单位生物工程学院


摘 要:     In this lecture it will be demonstrated how the Design-Build-Test cycle of Metabolic Engineering has allowed for development of yeast cell factories for production of a range of different fuels and chemicals. Some examples of different technologies will be presented together with examples of metabolic engineering designs, in particular for development of platform strains that can be used for production of a fatty acid derived products, e.g. fatty alcohols and alkanes. It will be argued that with advancement in genome-editing technologies and novel methods for rapid phenotypic screening, advancement in the field is hampered by our design abilities, i.e. to predict genotype-phenotype connections. For this genome-scale metabolic modeling is a strong technology, and in the presentation recent advancements in mathematical modeling for cell factory design will be presented. Finally, the presentation will also demonstrate how the Design-Build-Test cycle can be expanded to incorporate adaptive laboratory evolution to identify targets for engineering complex traits, such as improved tolerance to toxic metabolites like elevated temperatures or low pH.