曹学君
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曹学君

生物化工专业:博士生导师/硕士生导师
    生物工程专业:博士生导师/硕士生导师
    生物工程领域:工程硕士导师 

  曹学君, , 教授, 博士,中共党员,华东理工大学生物工程学院,博士生导师。1996年博士毕业, 工作在华东理工大学生物反应器工程国家重实验室(生物工程系) 从事生物分离工程研究工作,并担任相应的教学工作。五次获得国家自然科学基金项目资助:“两水相体系交联酶相转移催化合成头孢IV 29873014,1999.1-2001.12)”、“光敏可再生两水相成相材料的研制”(20474016,2005.1-2007.12)、“多孔硅胶表面分子印迹吸附剂在超临界条件下的分离行为”(20676032,2007.1-2009.12)、“促溶离子提高反胶束萃取效率的机制与应用研究”(209760522010.1-2012.12)、“再生型两水相体系成相与分配的分子调控机制及其应用研究(21376078,2014.1-2017.12)主要参与“十一五”国家重大新药创制专项-生物技术新药中试放大及分离纯化技术平台项目(2009ZX09306-0012009.1-2010.12)。牵头负责“十二五”863重大化工产品的先进生物制造重大项目-柠檬酸与葡萄糖酸的生物转化技术(2011AA02A213。在国内外主要刊物上发表包括AIChE J J. Chromatography A Bioresource Technology J. Biotechnology在内的学术论文104篇,发明专利28项。主编《现代生物分离工程》教材, 负责并主讲的《生物分离工程》国家精品资源共享课程及教育部海外留学品牌英语课程。



简历

教育经历

   1993-1996     华东理工大学化学工程系博士

   1990-1993     华东理工大学生化工程系硕士

   1979-1982      河南开封医专药学系(现为河南大学药学院)

研究与工作经历

  2000-2001     韩国仁荷大学校生物工程系博士后

  1996-至今      华东理工大学生物反应器工程国家重点实验室,生化工程系

                  研究领域: 1 重组蛋白质与天然活性成分的分离纯化

    2 再生型两水相体系萃取与酶催化反应

    3 生物分离材料的制备

   教 学:1 生物分离工程(工学硕士,工程硕士)

    2 生物分离工程(生物工程本科,双语,全英语)

   1986-1990:    河南省信阳豫南制药厂 抗生素工业生产

   1982-1986:    河南信阳卫校药学专业任教药物制剂学


发表论文

1.Chengning Xu, Wenying Dong, Junfen Wan, Xuejun Cao*Synthesis of thermo-responsive polymers recycling aqueoustwo-phase systems and phase formation mechanism with partition of -polylysineJournal of Chromatography A, 2016,1472 :44–54.

2.Yueqian Zhang,  Xuejun Cao*, Separation of cordycepin using surface molecular imprinting technology, Process Biochemistry, 2016, 51:517-527.

3.Sipeng Li, Zhaoyang Ding, Xuejun Cao*, Separation of transglutaminase by thermo-responsive affinity precipitation using L-thyroxin as ligand, SpringPlus, 2016 , 5:37-49.

4.Juan Xu, Le Wang, Xuejun Cao*Polymer Supported Graphene-CdS Composite Catalyst with Enhanced Photocatalytic Hydrogen Production from Water Splitting under Visible LightChemical Engineering Journal2016, 283 :816825.

5.Jiali Liu, Xuejun Cao* Preparation of novel alkaline pH-responsive copolymers for the formation of recyclable aqueous two-phase systems and their application in the extraction of lincomycinJournal of Separation Science2016 ,39(3): 584-594.

6.Xiaomei Huang and Xuejun Cao* Preparation of ursodeoxycholic acid from 7-ketone lithocholic acid by stereoselective electroreductionBioresources and Bioprocessing20152:27.

7.Huiyun Hou, Xuejun Cao* , pH recycling aqueous two-phase systems applied in extraction of Maitake β-Glucan and mechanism analysis using Low-Field Nuclear Magnetic ResonanceJournal of Chromatography A20151405:40–48.

8.Zhaoyang Ding, Sipeng Li, Xuejun Cao*, Microbial transglutaminase separation by pH-responsive affinity precipitation with Crocein Orange G as the ligand, Applied Biochemistry and Biotechnology ,2015, 177:253–266.

9.Zi Wang; Xuejun Cao*, Preparation of core-shell molecular imprinting polymer for lincomycin A and its application in chromatographic column, Process Biochemistry, 2015, 50(7):1136–1145

10.Juan Xu, Xuejun Cao*, Characterization and mechanism of MoS2/CdS composite photocatalyst used for hydrogen production from water splitting under visible lightChemical Engineering Journal2015 , 260642-648.

11.Daisong Hou, Xuejun Cao∗,Synthesis of two thermo-responsive copolymers forming recyclableaqueous two-phase systems and its application in cefprozil partitionJournal of Chromatography A20141349 30–36

12.Chaohui Zhu and Xuejun Cao*, Synthesis of Cefprozil Using Penicillin G Acylase in Recyclable Aqueous Two-phase Systems, Biotechnology and Bioprocess Engineering , 2014,19: 844-850.

13.Xiaolei Ma, Xuejun Cao*, Separation of ursodeoxycholic acid by silylation crystallization, Bioresources and Bioprocessing, 2014, 1:5.

14.Zhaoyang Ding, Sipeng Li, Xuejun  Cao*, Separation of lysozyme from salted duck egg white by affinity precipitation using pH-responsive polymer with an L-thyroxin ligand,Separation and Purification Technology, 2014,138 :153–160.

15.Bo Yan, Xuejun Cao*, Phase diagram of novel recycling aqueous two-phase systems composed of two pH-response polymers: Experiment and modeling, Fluid Phase Equilibria, 2014, 364: 42–47.

16.Jingjing LiuXuejun Cao*, Biodegradation of Cellulose by β-glucosidase and Cellulase Immobilized on a pH-responsive Copolymer, Biotechnology and Bioprocess Engineering,  2014, 19: 829-837

17.Daisong Hou, Yanjie Li, Xuejun Cao*. Synthesis of two thermo-sensitive copolymers forming aqueous two-phase systems. Separation and Purification Technology, 2014,122 :217–224.

18.Xiangxi Yuan, Xiaolei Ma, and Xuejun Cao*, Preparation of ursodeoxycholic acid by direct electro-reduction of 7-ketolithocholic acid, Korean J. Chem. Eng., 2014, 31(7):1276-1280.

19.Tingting Yu, Xuejun Cao*, Effect of chaotropes on lipase back extraction recovery in the process of reverse micellar extraction, Applied Biochemistry and Biotechnology, 2014, 172(6):3287-3296.

20.Zhaoyang Ding, Kai Zheng, and Xuejun Cao* , Lipase Purification by Affinity Precipitation with a Thermo-responsive Polymer Immobilized Cibacron Blue F3GA Ligand, Biotechnology and Bioprocess Engineering, 2014, 19: 892-899.

21.Shutao LiXuejun Cao*,Enzymatic synthesis of Cephalexin in recyclable aqueous two-phase systems composed by two pH responsive polymers, Biochemical Engineering Journal, 2014, 90:301–306.

22.Zhaoyang Ding, Lin Kang, Xuejun Cao* Application of docking methods for metal chelate affinity precipitation of endo-glucanase using pH-response polymer, Colloids and Surfaces B: Biointerfaces, 2014,113: 412–420.

23.Songli Li, Xuejun Cao*, Extraction of tea polysaccharides (TPS) using anionic reverse micellar system, Separation and Purification Technology , 2014, 122 306–314

24.Zhaoyang Ding and Xuejun Cao*Affinity precipitation of human serum albuminusing a thermo-response polymer with an L-thyroxin ligand, BMC Biotechnology 2013, 13:109

25.Jingjing Liu, Xuejun Cao*,Biodegradation of microcrystalline cellulose in pH–pH recyclable aqueous two-phase systems with water-soluble immobilized cellulose, Biochemical Engineering Journal, 2013, 79:136-143

26.Junfen Wan, Qingxi Li, Feng Zhou, Jingjing Liu, Xuejun Cao* ,Influence of chaotropes on recovery of trypsin and micellar sizes during reverse micelle extraction, Separation and Purification Technology, 2013, 116:307–31

27.He Tian, Hongbin Zhao, Xuejun Cao * Catalytic transfer hydrogenation of 7-ketolithocholic acid to ursodeoxycholic acid with Raney nickel,Journal of Industrial and Engineering Chemistry,2013,19: 606-613

28.Zhaoyang Ding, Xuejun Cao*, Affinity precipitation of cellulase using pH-response polymer with Cibacron Blue F3GA, Separation and Purification Technology, 2013102136–141

29.Jingjing Liu, Xuejun Cao*Biodegradation of cellulose in novel recyclable aqueous two-phase systems withwater-soluble immobilized cellulose, Process Biochemistry, 2012,47: 1998–2004

30.Bo Yan.  Xuejun Cao* Preparation of aqueous two-phase systems composed of two pH-response polymers for liquid-liquid extraction of demeclocyclineJournal of Chromatography A, 2012,1245:39- 45

31.Wenjuan Liang, Xuejun Cao*, Preparation of a pH-sensitive polyacrylate amphiphilic copolymer and its application in cellulase immobilization, Bioresource Technology ,2012, 116:140-146

32.Yun-Xian Wang, Xue-Jun Cao *, Extracting keratin from chicken feathers by using a hydrophobic ionic liquid, Process Biochemistry, 2012, 47: 896–899

33.Junfen Wan,  Jiemin He,  Xuejun Cao*, A Novel Process for Preparing Pure Chenodeoxycholic Acid from Poultry Bile, J. Ind. Eng. Chem, 2012, 18: 65-71

34.Bo Zhou, Junfen Wan,Jinzhi Wang, Xuejun Cao*, Effect of chaotropes in reverse micellar extraction of kallikrein, Process Biochemistry, 2012, 47:229–233

35.Zhihua Jia, Xiaoli Zhang*, Xuejun Cao*, Jiandang Liu, Baofu Qin, Production of lovastatin by a self-resistant mutant of Aspergillus terreus, Ann Microbiol ,2011, 61:615–621

36.Yingying Wang, Xuejun Cao*,  Enzymatic synthesis of fatty acid ethyl esters by utilizing camellia oil soapstocks and diethyl carbonate, Bioresource Technology,2011,102:10173–10179

37.Li Hui, Cao Xuejun*, Bioconversion of Cephalosporin-G to 7-ADCA in a pH-thermo       sensitive Recycling Aqueous Two-Phase Systems, Process Biochemistry, 201146 1753–1758

38.Baojun Yang and Xuejun CAO*, Synthesis the artemisinin-imprinting polymers on silica surface and its adsorption behavior in supercritical CO2 fluid, AIChE J, 2011, 57(12):3512-3521

39.Xiao-Yan Gong, Xue-Jun Cao*, Preparation of molecularly imprinted polymers for artemisinin based on the surfaces of silica gel , Journal of Biotechnology, 2011, 153:  8–14

40.Junfen Wan, Xuejun Cao*, Wei Wang,  Biao Ning, Xian Li,Partition of Several Model Bioproducts in recycling aqueous two-phase systems with pH/light responsive copolymers, Separation and Purification Technology , 2010,76:104–109

41.Siliang Zhang, Xuejun Cao, Ju Chu, Jiangchao Qian, and Yingping Zhuang, Bioreactors and Bioseparation, Adv Biochem Engin/Biotechnol, 2010,122: 105–150

42.Shu Miao, Jinpeng Chen, Xuejun Cao* Preparation of a novel hermo-sensitive copolymer forming recyclable aqueous two-phase systems and its application in bioconversion of Penicillin G,Separation and Purification Technology,2010,75: 156–164

43.Yanjie Li, Xuejun Cao*, Prediction of phase diagrams for new pH-thermo sensitive recycling aqueous two-phase systems, Fluid Phase Equilibria, 2010, 298:206–211

44.Jinpeng Chen, Shu Miao , Junfen Wan, Jinan Xia, Xuejun Cao*, Synthesis and Initial Application of Two Light-Sensitive Copolymers Forming Recyclable Aqueous Two-Phase Systems, Process Biochemistry, 2010, 45:1928–1936

45. Hongbin Zhao, He Tian, Yonghong Jin, Xuejun Cao*, Synthesis of 7-ketolithocholic   acid via indirect electrooxidation of chenodeoxycholic acid, J Appl. Electrochem, 2010,40:1307–1316

46. LIANG Shuang, WAN Junfen*, ZHU Jianliang, CAO Xuejun*, Effects of porogens on the morphology and enantioselectivity of core-shell molecularly imprinted polymers with ursodeoxycholic acid, Separation and Purification Technology, 2010, 72: 208–216

47.ZHOU Libo, WAN Junfen*, CAO  Xuejun*, Synthesis of thermo-sensitive copolymer with affinity butyl ligand and its application in lipase purification, Journal of Chromatography B, 2010, 878 : 1025–1030

48. Song Qingrong, Zhu Jianliang, Wan Junfen, Cao Xuejun*, Measurement and modelling of epigallocatechin gallate solubility in supercritical carbon dioxide fluid with ethanol  cosolvent, Journal of Chemical Engineering Data, 2010, 55, 3946–3951

49. Xian Li, Junfen Wan, Xuejun Cao*, Preliminary application of light-pH sensitive recycling aqueous two-phase systems to purification of lipase, Process Biochemistry, 201045598–601

50. Zhihua Jia, Xiaoli Zhang, Yaling Zhao, Xuejun Cao*, Effects of divalent metal cations on lovastatin biosynthesis from Aspergillus terreus in chemically defined medium, World J Microbiol Biotechnol 2009,25:1235–1241

51. Zhihua Jia, Xiaoli Zhang,2* and Xuejun Cao*, Effects of carbon sources on fungal morphology and lovastatin biosynthesis by submerged cultivation of Aspergillus terreus, Asia-Pac. J. Chem. Eng. 2009;,4: 672–677

52. Zhihua Jia, Xiaoli Zhang, Yaling Zhao*, Xuejun Cao*, Enhancement of Lovastatin Production by Supplementing Polyketide Antibiotics to the Submerged Culture of Aspergillus terreusAppl Biochem BiotechnolDOI 10.1007/s12010-009-8762-1

53.Haixia Wang, JunfenWan, Xuejun Cao*Preparation of a pH-sensitive affinity precipitation polymer and its application in purification of trypsin Separation and  Purification Technology, 2009,68:172–177

54.Xiao-Yan Gong, Xue-Jun Cao*, Measurement and correlation of solubility of  artemisinin in supercritical carbon dioxide, Fluid Phase Equilibria 2009,:284 26–30

55.NING Biao  WAN JunfenCAO  Xuejun*Preparation and recycling of aqueous                          two-phase systems with pH-sensitive amphiphilic terpolymer PADB, Biotechnology       Progress, 2009, 25(3):820-824  

56.SHAO  Zhihua,  KONG  Fanqi, CAO Xuejun*,Phase Diagram Prediction of  Recycling Aqueous Two-Phase Systems formed by a Light-sensitive Copolymer and Dextran, Korea Journal of Chemical Engineering, 2009,26(1): 147-152

57.WANG Wei, WAN Junfen, NING Biao,  XIA  Jinan,CAO Xuejun*, Preparation of a Novel Light-Sensitive Copolymer and its Application in Recycling Aqueous Two-Phase Systems , Journal of Chromatography A2008, 1205 (2008) 171–176

58.Ziyun Xu, Junfen Wan, Shuang Liang and Xuejun Cao*, Separation of Ursodeoxycholic acid from its isomeric mixture using core-shell molecular imprinting polymer, Biochemical Engineering Journal, 2008. 41:280–287

59.Wei QIN, Xue-Jun CAO*, Synthesis of a Novel pH-Sensitive Methacrylate Amphiphilic Polymer and Its Primary Application in Aqueous Two-phase Systems, Appl Biochem Biotechnol, 2008,150:171183

60.SHAO Zhihua  CAO Xuejun*,Prediction of BSA Partitioning in Recycling Aqueous Two Phase Systems composed of PNBC-Dextran with Light-sensitive Polymer, Journal of Chemical Engineering Data,2008, 53 (12), 2755-2757

61.HAO Liu-Ping, CAO Xue-Jun*  HUR Byung-Ki, Separation of Single Component of EPA and DHA from Fish Oil Using Silver Ion Modified Molecular Sieve 13X under Supercritical Condition,J. Ind. Eng. Chem ,200814639-643

62.WEN Wen, WAN Junfen, CAO Xuejun*, XIA Jinan, Preparation of a light-sensitive and reversible dissolution copolymer and its application in lysozyme purification, Biotechnology Progress, 2007 231124-1129

63.Lin-Jie Chen, Xue-Jun Cao*Avoiding Inactivation of Proteins in the process of  AOT/Isooctane Reverse Micellar ExtractionJournal of Chemical Engineering of Japan, 2007,40(6):511-515

64.Kong Fan-Qi, Cao Xue  Jun*, Xia Jinan, Synthesis and Application of a Light-sensitive Polymer Forming Aqueous Two-phase Systems, J. Ind. Eng. Chem. 2007, 133424-428.

65.Shen Li-Li, Cao Xuejun*, Synthesis of Thermo-sensitive Polyacrylamide Derivatives for Affinity Precipitation and its Application in Purification of Lysozyme, Biochen. Eng. J. 2007.33:66–71.

66.Xuejun Cao and Byung-Ki Hur, Separation of EPA and DHA from Fish Oil Using Modified Zeolite 13X and Supercitical CO2, J. Ind. Eng. Chem., 2005, 11(5):762-768

67.Cao Xuejun, Zhu Jianhang, Wei Dongzhi and Byung Ki Hur, Cephalexin biosysthesis in PEG400-ammoniumsulfate and PEG400-magnisum sulfate aqueous two-phase systems, J. Microb.& Biotech., 2004, 141):62-67.

68.Cao Xue-jun, Wu Xing-yan, Luis J.P. Fonseca, Joaquim M.S. Cabral and Joao Carlos Marcos, Production of 6-aminopenicillanic acid in aqueous two-phase systems by recombinant Escherichia coli with intracellular penicillin acylase, Biotechnology Letters2004, 26:97-101.

69.Xuejun Cao, Jianhua Zhou, Zhenhui Huang, Xingyan Wu and Byung Ki HurPreparation of high purity urokinase using single step hydrophobic interaction chromatography with p-aminobenzamidine ligand, J. Microb.& Biotech., 2002, 12(2):196-203 .

70. Xuejun Cao,  Hyun Shik Yun  and  Yoon -Mo Koo Recovery of L (+) Lactic Acid  by Anion Exchange Resin Amberlite IRA-400Biochem. Eng. J.20023592:1–8

71.Cao Xuejun,  Zhu Jianhang, Wei Dongzhi  and Byung Ki HurPartition improvement of cephalexin and 7-aminodeacetoxicephalospronic acid in aqueous two-phase systems for cephalexin synthesis,  J. Ind. & Eng., Chem., 2002, 8(3):203-211. .

72.Xuejun  Cao,  Ho-Joon Lee, Hyun Shik Yun  and  Yoon -Mo Koo, Crystallization and Dissolution Behavior of L (+) Calcium and Zinc Lactate in Ethanol-Water Solvent,  Korea  J. Chem. Eng, 2002:19(2):301-304  

73.Zhu Jianhang  Wei Dongzhi and Cao Xuejun,  Effects of Hydrophobicity of Ethylene      oxide-Propylene oxide copolymers on Phase Diagrams of Aqueous Two-phase Systems and Partition Behaviors of Cephalexin and 7-aminodeacetoxicephalosporanic Acid, Chinese  J. Chem. Eng., 2002,(2):240-243.

74.Xuejun Cao, XingYan Wu, Tong Wu,  Keming Jin and Byung Ki HurConcentration of 6-Aminopenicillanic Acid from Penicillin Bioconversion Solution and Its Mother Liquor by Nanofiltration Membrane, Biotech. And Bioproc. Eng., 2001, 6:200-204 .

75.Xuejun Cao, Ho-Joon  Lee, Hyun Shik Yun and Yoon -Mo Koo the Solubility of Calcium and Zinc Lactate in Water and Water–ethanol MixtureKorea J. Chem. Eng., 2001, 18(1): 133-135.

76.Jian-Hang Zhu, Dong-Zhi Wei, Xue-Jun Cao, Ye-Qing Liu and Zhong-Yi Yuan, Partitioning behavior of cephalexin and 7-aminodeacetoxicephalosporanic acid in PEG/ammonium sulfate aqueous two-phase systems,  J. Chem. Tech. and Biotech. 2001, 76:1194-1200..

77.Dong-Zhi Wei, Jian-Hang Zhu and Xue-Jun Cao, High performance liquid Chromatographic Determination in the Enzyme Synthesis Process of Cephalexin, Internal Journal of Bio-Chromatography, 2001, 6:245-254.

78.Dong-Zhi Wei Jian-Hang Zhu, Xue-Jun CaoEnzymatic synthesis of cephalexin in aqueous two-phase systems, Biochem. Eng. J., 2002, 3599:1-5.

79.Meng Tang , Xuejun Cao, Zuozhen Liu, Xingyan Wu and Gance Dai, Synthesis of Glycidyl Methacrylate-Based Matrix and Its Application in Affinity Chromatography of Urokinase, Proc.  Biochem., 1999,34:857-862.

80.Cao, X.J, Zhu, J.W., Wang, D.W., Wu, X.Y., and Dai,G.C., Affinty chromatography  purification of urokinase  with epichlorohydrin activated agarose matrix , Chinese  J. Chem. Eng. 1997, 5(1): 69-73.

81.Xuejun Cao, Jiawen Zhu, Dawei Wang , Xingyan Wu  and Gance Dai, Purification of Urokinase by affinity Cross-flow Filtration Using a Water-Soluble Macroligand, Enzyme  Engineering  XIII,  New York  Annals of  Academic  and  Science, 1996,V799:454-459.

82.贾志华,张小里曹学* , 碳源对土曲霉中洛伐他汀生物合成的影响, 化学工程,2008, 36 (5):51-54

83.金科铭,曹学君* ,苏谨,马骊,庄英萍,储炬,张嗣良*, 在可回用两水相体系中进行青霉素酰化酶的相转移催化裂解青霉素G6APA,南方医科大学学报, 2008,28(3):360-362

84.金科铭,曹学君*,庄英萍, 储炬, 张嗣良*, 固定化青霉素酰化酶在光-pH敏感可回用两水相中裂解青霉素G6-APA , 中国生物工程杂志,2007,27(10):53-58

85.金科铭,曹学君*,庄英萍,储炬,张嗣良*Orawan  Duerasor,固定化青霉素酰化酶在光敏感可再生两水相体中催化青霉素G6-APA华东理工大学学报,2007333:318-322

86.陈霖杰,曹学君* AOT/异辛烷反胶束萃取纯化胰蛋白酶及酶变性失活问题的解决,中国生物工程杂志,2007271):75-79

87.王金枝,曹学君*,反胶束萃取技术分离胰激肽原酶, 中国生物工程杂志,2007273):93-99

88.朱建航,魏东芝,曹学君,袁中一, 酶法合成头孢氨苄的反应-双水相萃取的耦合过程研究, 中国化学工程学报,2003, 541: 95-99

89.刘叶青,徐殿胜,曹学君,桑玉英,长秀萍,重组人酸性成纤维细胞生长因子的分离纯化华东理工大学学报,2001274):361-363

90.何汉平,刘叶青,曹学君,张秀萍,PEG 修饰青霉素酰化酶及其在两水相生物转化体系中的分配,华东理工大学学报,2001, 271):109-112

91.何汉平曹学, 有机相酶传感器, 化学传感器, 2000, 20(1):2-7

92.曹学君,刘叶青,膜分离技术在医药工业中的应用(综述,国外医药抗生素分册,2000215):212-214

93.曹学君,邬行彦,戴干策,利用锌离子从人尿中分离尿激酶,华东理工大学学报,1998244):427-430

94.曹学君,唐蒙,邬行彦,戴干策,联苯胺亲和层析纯化尿激酶,华东理工大学学报,1998245):515-520

95.曹学君,邬行彦,朱开昱,戴干策,头孢唑啉为配基亲和层析纯化尿激酶,生物化学与生物物理学报,1998,30(6):635-637

96.曹学君,邬行彦,反渗透回收结晶母液中6-APA ,生物工程学报, 199814(4):468-471

97.朱家文, 曹学,王大为,邬行彦,戴干策,水溶性亲和配基的制备及其应用,华东理工大学学报1999,25(6):563-566.

98.庞正宇,曹学君,邬行彦,聚苯乙烯亲和载体纯化尿激酶。华东理工大学学报 199622(4):417-421

99.周昕,曹学君,庞正宇,唐蒙,HD-2弱酸性树脂从人尿中提取尿激酶的研究。中国医药工业杂志1996,27(8):243-245.

100.曹学君,蒋勇灵,沈晴,邬行彦,青霉素酰化酶基因重组大肠杆菌在两水相体系中的催

化反应,中国抗生素杂志, 199419(2):131-133.

101.曹学君,邬行彦,青霉素酰化酶裂解反应的两水相体系中葡聚糖浓度的测定中国抗生素杂志.1994.191):61-62

102.曹学君,孟祥安,邬行彦,产青霉素酰化酶大肠杆菌ACCT11105在两水相体系中的动

力学性质研究。中国抗生素杂志,1994.19(1):3-5.

103.曹学君,何承梁,张保平,卷曲霉素除热原新工艺应用研究,中国药学杂志 1992.27  5):288-289

104.何承梁,曹学君,卷曲霉素两项主要质量指标分析。天津药学, 1989414-16

105.曹学君, 刘彦明邬行彦, 两水相中聚乙二醇浓度测定, 分析化学, 1993, 21(12):1470


著作:

1 新编生物工艺学(上下册),第22章,层析分离法(下册)P157-181,化工出版社,2003

2 曹学君主编,现代生物分离工程,华东理工大学出版社,(国家十五重点图书,“十一五”规划教材),20071月。

3 曹学君主编,生物科学与工程词典(双语教学),化学工业出版社,北京,20067

4. 生物炼制产品与技术(译著), 上海科学技术出版社,20131

专利:

1. 曹学君,何洁敏,一种鹅去氧胆酸的制备方法, 申请号:03151475.8, 申请日期:2003.9.29, 公开号:CN 1528779A ,授权 ZL 03 1 51475.8

2 曹学君,孔凡旗,一种用于两水相系统的光敏感可再生聚合物。申请号:200510024672.7,

申请日期:2005.3.28, 公开号:CN 1687162A,授权专利号:ZL 2005 1 0024672.7

3.曹学君,秦伟,一种用于两水相体系的pH 敏感型可再生两性离子聚合物及其制备方法。申请号:200510025520.9,申请日期:2005.4.28, 公开号:CN 1693325A,授权专利号:ZL 2005 1 0025520.9

4.曹学君,沈莉莉, 一种用于亲和沉淀分离系统的可再生聚合物及其制备方法。申请号:200510025518.1, 申请日期:2005.4.28, 公开号:CN 1693327A,授权专利号:ZL 2005 1 0025518.1

5.曹学君,文闻,离子交换溶解可逆光敏聚合物, 申请号:200610028929.0, 申请日期:2006.7.14,授权专利号:ZL 2006 1 002 8929.0

6.曹学君,晋永红,一种制备7-酮石胆酸的方法, 申请号:200610029416.1,申请日期:2005-04-28,公开号: CN 1912192A,授权专利号:ZL 2006 1 002 9416.1

7.曹学君,许紫芸,熊去氧胆酸分子印迹聚合物及其制备方法,申请号:2006100310291, 申请日期:2006-9-11, 公开号:CN 1935880A授权专利号:ZL 2006 1 0031029.1

8.曹学君,王伟,宁标, 可组成全回用两水相体系的聚合物,中国发明专利,申请号:200810032619.5, 申请日:2008.1.14 公开号:CN 101235120A

9. 曹学君,苗述,陈金朋,热敏成相聚合、其制备方法及相关的-pH敏感再生型两水相体系,中国发明专利, 申请号:200910044915.1,申请日:2009.01.06,公开号:CN101475666授权专利号:ZL 2009.1 0044915.1

10.曹学君,陈金朋,苗述,两种光敏感可逆溶解成相聚合物、其制备方法及形成的光敏性再生型两水相体系,中国发明专利,申请号:200910044916.6,申请日:2009.01.06,公开号:CN101497676授权专利号:ZL 2009.1 0044916.6

11.曹学君,王海霞,一种的pH敏感溶解可逆聚合物、其制备方法及用途,中国发明专利,申请号:200910044914.7,申请日:2009.01.06,公开号:CN101497675授权专利号:ZL 2009 1 0044914.7

12. 曹学君,杨宝君,硅胶颗粒表面青蒿素分子印迹聚合物及其制备和应用方法,申请号:CN201010156001.7,申请日: 2010.04.23,公开(公告)号: CN101831076A,授权证号:ZL 2010 1 0156001.7

13.曹学君,龚小雁,郁晓娟, 多孔硅胶表面青蒿素分子印迹聚合物及其制备和应和方法,申请号:CN201010155993.1,申请日: 2010.04.23, 公开(公告)号: CN101845126A授权专利号:ZL 2010 1 0155993.1

14. 曹学君, 朱建良, 多孔硅胶硅表面熊去氧胆酸分子印迹聚合物及其制备和应用,申请号:CN201010225662.0, 申请日: 2010.07.13,公开(公告)号:CN101885814A,授权证号:ZL 2010 1 0225662.0

15. 曹学君,李艳杰,陈金鹏,两种温度敏感可逆溶解成相聚合物、其制备方法及形成的再生型两水相体系,申请(专利)号: CN201010226067.9,申请日: 2010.07.1,公开(公告)号: CN101906185,授权证号:ZL 2010 1 0226067.9

16. 曹学君,梁文娟,刘晶晶,用于水溶性固定化纤维素酶的pH敏感再生型聚合物及其制备方法与应用,申日:2011.05.26,申请(专利)号:201110138591.5,公开(公告)日:2011.11.23,公(公告)号:CN102250278A,授权证号:ZL 2011 1 0138591.5

17. 曹学君,王云先,采用水不溶性离子液体提取家禽羽毛角蛋白的方法及相关的家禽羽毛角蛋白溶液,申日:2011.05.17,申号:201110127754.X,公开(公告)日:2011.11.02,公(公告)号:CN102229665A

18. 曹学君,颜波,两种pH敏感再生型聚合物、其制备方法和形成的再生型两水相体系及应用, :2011.07.12, :201110193602.X, 公开(公告): 2012.02.08, (公告):CN102344520A,授权证号:ZL 2011 1 0193602.X

19. 曹学君,袁向玺, 电还原制备熊去氧胆酸,号:201210180990.2,申日:2012.06.04,公(公告)号:CN102660755A,公开(公告)日:2012.09.12

20. 曹学君,伏星,刘晶晶,可形成偏酸性两水相体系的两种pH响应再生型聚合物及其制备方法与应用, 号:201210398570.1,申日:2012.10.18,(公告)号:CN102875721A,公开(公告)日:2013.01.16

21.曹学君;丁兆阳,L-甲状腺素为亲和配基的再生型亲和沉淀剂及制备方法和应用以及相关再生型聚合物, 日:2013.01.30,公开(公告)日:2013.05.22,公(公告)号:CN103113509A

22. 曹学君,祝超慧,唐子安,赵志炎,李玉丹,陈佳伶,在可回用两水相体系中利用固定化青霉素酰化酶催化合成头孢丙烯的方法,申号:201310341198.5,申日:2013.08.07,公(公告)号:CN103451259A,公开(公告)日:2013.12.18

23.曹学君,刘佳莉,可形成偏碱性两水相体系的两种pH响应再生型聚合物及其制备方法与应用,申请号:201310295740.8,申请日:2013-07-15,公开(公告)103333283A,公开(公告)2013.10.02

24. 曹学君,李淑桃,麦祺,崔鹏程,一种pH-pH响应再生型两水相体系的制备方法与应用,中国发明专利,申请号 201410255801.2, 申请日 2014.06.10,公布号 CN 104017226 A, 申请公布日 2014.09.03

25.曹学君,马小雷,硅烷化技术纯化熊去氧胆酸的方法,中国发明专利,申请号201410279478.2,申请日:2014620, 公开(公告)CN 104017043 A, 公开日:2014-09-03

26. 曹学君,黄晓梅,董东东,立体选择性制备熊去氧胆酸的方法,中国发明专利,申请号:2014105140268,申请日:2014.09.29,申请公布号:CN104328454A,申请公布日:2015.02.04.

27. 王磁, 曹学君,核壳型分子印迹聚合物的制备方法、其产物及产物的应用,中国发明利,申请号 201510140627.1申请日 2015.03.27申请公布号CN 104788711 A申请公布日2015.07.22

28. 曹学君 徐娟 王乐,有机微球支撑的三维石墨烯负载硫化镉复合催化剂及其制备方法,中国发明专利,申请号 201510446777.5申请日 2015.07.27申请公布号CN 105126907 A ,申请公布日2015.12.09




科研课题


1.再生型两水相体系成相与分配的分子调控机制及其应用研究(2014.1-2017.1221376078,国家自然科学基金,负责)

2.亲和沉淀技术分离谷氨酰胺转氨酶及多聚赖氨酸(2012.9-2016.12,企业合作,负责).

3.再生型两水相体系中固定化青霉素酰化酶合成头孢丙烯(2011.12-2016.11, 企业合作,负责)

4.食用菌功能成份的挖掘和利用研究,(2012.11-2015.12, 沪农科攻字(2012)第2-9号,上海市农委,主要参与者)

5.十二五”863重大化工产品的先进生物制造重大项目-柠檬酸了葡萄糖酸的生物转化技术(2011AA02A2132011.1-2012.12 牵头人)

6.促溶离子提高反胶束萃取效率的机制与应用研究(2010.1-2012.12国家自然科学基金,批准号:20976052,负责)

7.“十一五”国家重大新药创制专项-生物技术新药中试放大及分离纯化技术平台(2009ZX09306-001, 2009.1-2010.12主要参与者

8.pH-pH再生型两水相萃取多粘菌素(2010.4-2013.4,企业合作,负责 )

9.再生型两水相体系萃取螺旋霉素与红霉素(2010.1-2012.12,企业合作,负责)

10.再生型两水相体系的构建与应用,生物反应器工程国家重点实验室重点项目,2009.1-2010.12(负责)

11.多孔硅胶表面分子印迹吸附剂在超临界条件下的分离行为(2007-2009 国家自然科学基金,批准号:20676032负责

12.光敏可再生两水相成相材料的研制(2005-2007,国家自然科学基金,批准号:20474016,负责)

8.  两水相体系交联酶相转移催化合成头孢IV。(国家自然科学基金,批准号:298730141999-2001,负责)

9.  环境敏感型可再生两水相体系的研制(2002,教育部留学回国人员启动基金,负责)

10.  有机电化学合成熊去氧胆酸(2009-2019, 企业合作,负责)

11.  茶与茶籽资源综合利用(企业合作,2006-2010,负责)

12.  青霉素酰化酶裂解酶产物分离技术改进 (2003-2006, 企业合作,负责)

13.  环境友好的鹅去氧胆酸提取纯化方法(2007-2012,企业合作,负责)

14.  反胶束萃取胰激肽原酶与胰蛋白酶(2007-2012,企业合作,负责)

15.  硫酸软骨素A 组分的生产工艺 (2002, 负责)

16.  修饰分子筛在超临界条件下分离DHA与EPA。(2001,在韩国仁荷大学博士后研究课题)

17.  乳酸分离与偶合发酵 (2000,在韩国仁荷大学博士后研究课题)

18.  基因工程酸性成纤维细胞生长因子纯化,(1998,子课题负责)

19.  反渗透浓缩6-APA , (1997,企业合作,负责)

20.  尿激酶的分离与纯化 (1995-1997,企业合作,负责)

21.  亲和超滤大规模纯化技术的基础研究, (国家自然科学基金, 1993-1996,博士论文,主要参与)

22.  青霉素酰化酶基因工程菌在两水相中的催化反应,上海市自然科学基金,(1990-1993, 第二完成人).

23.  曲霉素除热原新工艺应用研究,1990年获河南信阳地区科技进步二等奖(1986-1990, 第二完成人).


国际交流

1.Enzyme Engineering Conference 13th (Oct. 17-19, 1995, San Diego, USA)

2.Young Asia Biochemical Engineering Conference(9th YABEC 2003, Nov 13-15, 2003, Cheju Island, Korea )

3.3rd International Symposium on Biotechnology,.Dec.13-19, 2005, Sindh, Pakistan

4.Visiting Lehigh University, University of Houston, April 8-17, 2007, USA.

5.The 13th Symposium of Young Asian Biochemical Engineers’ Community,(YABEC 07), Oct 22-24, 2007,Seoul, Korea.

6.The 14th Symposium of Young Asian Biochemical Engineers’ Community,(YABEC 08), Nov 29-31, 2008, Tokyo, Japan.

7.Visiting University of DUNDEE, Glasgow Caledonian University, Aug 9-14, 2010, UK.

8.The 17th Symposium of Young Asian Biochemical Engineers’ Community,(YABEC 2011), Oct. 7-9, 2011, Incheon, Korea.

9.Visiting University of Idaho, Washington State UniversityApril 18-23, 2011, USA.

10.The 15th International Biotechnology Symposium and Exhibition (IBS 2012) September 16-21, 2012 Daegu, Korea.

11.Visiting Technical University of Munich, May 19-24, 2013, Munich, Germany.

12.XIith European congress on catalysis, September 1-6, 2013, lyon, France.

13.5th World Congress on Biotechnology, June 25-27, 2014, Valencia Conference Centre, Spain.

14. 7th Asian Federation of Biotechnology (AFOB) Regional Symposium 2016, Hue city,     

Vietnam