沈亚领
发布人:生工学院网站管理员  发布时间:2016-10-19   动态浏览次数:179

 

亚领
 

    生物工程专业:博士生导师/硕士生导师
         生物化工专业:博士生导师
         生物工程领域:工程硕士导师

    

男,工学博士,生物反应器工程国家重点实验室和生物工程学院教授,长期从事生物工程科学领域的研究工作。承担和完成国家级、省部级及横向课题项目20多项;与企业合作研发获临床批件5件;在相关学科领域发表论文100多篇,其中Sci论文54篇,获授权发明专利16项;获省部级奖3次,出版译著两部,参编著作四部;指导的研究生学位论文三次获得上海市研究生优秀成果奖。

主要研究方向:
    1.生物工程/生物化工/微生物学:生物基化学品;代谢工程和合成生物学;发酵生理。

2.生物医药:蛋白质和单抗药物、小分子药物产业化研发;靶向递药系统;生物下游过程


近年主要论文:

1.Xin Lv, Lu Dai, Fangmin Bai, Zhanqing Wang, Liaoyuan Zhang* and Yaling Shen*, Metabolic engineering of Serratia marcescens MG1 for enhanced production of (3R)-acetoin,  Bioresour. Bioprocess.  2016,  3:52

2.Xianghai Cai, Siqi Chen, Hong Yang, Wei Wang, Lin Lin, Yaling Shen, Wei Wei, and Dong-zhi Wei, Biodegradation of waste greases and biochemical properties of a novel lipase from Pseudomonas synxantha PS1, Can. J. Microbiol.2016, 62: 588–599

3.Xinxin Lv, Jian Zhang, Rui Xu, Yuguo Dong, Aiyou Sun*, Yaling Shen, Dongzhi Wei. Gigantoxin-4-4D5 scFv is a novel recombinant immunotoxin with specific toxicity against HER2/neu-positive ovarian carcinoma cells. Applied Microbiology and Biotechnology,  2016, 100, 6403–6413

4.Xiaoxiong Han, Dan Chen, Jing Sun, Jinsong Zhou, Duan Li, Feirong Gong,* Yaling Shen* A novel cabazitaxel-loaded polymeric micelle system with superior in vitro stability and long blood circulation time, Journal of Biomaterials Science, Polymer Edition, 2016, 27(7), 626-642

5.Rao Ben , Fan Jiying , Sun Jian’an , Truong Ngoc Tu, Sun Jing, Zhou Jingsong, Qiuyi, Shen Yaling*, An auto-inducing expression system based on RhlI-RhlR Quorum sensing regulon for recombinant protein production in E.coli, Biotechnology and Bioprocess Engineering,2016, 21(1), 160-168

6.Jiying Fan, Zhanqing Wang, Liying Huang, Yaling Shen*, Efficient refolding of the bifunctional therapeutic fusion protein VAS-TRAIL by a triple agent solution, Protein Expression and Purification , 2016, 125 , 68-73

7.Liaoyuan Zhang, Zewang Guo, Jiebo Chen, Quanming Xu, Hui Lin, Kaihui Hu, Xiong Guan & Yaling Shen*, Mechanism of 2,3-butanediol stereoisomers formation in a newly isolated Serratia sp. T241, Sci. Rep. 6, 19257; doi: 10.1038/srep19257 (2016)

8.Jiying Fan, Liying Huang, Jing Sun, Yi Qiu, Jinsong Zhou, Yaling Shen*, Strategy for linker selection to enhance refolding and bioactivity of VAS-TRAIL fusion protein based on inclusion body conformation and activity, Journal of Biotechnology, 2015, 209 , 16–22

9.Fangmin Bai, Lu Dai, Jiying Fan, Ngoctu Truong, Ben Rao,  Liaoyuan Zhang,  Yaling Shen*, Engineered Serratia marcescens for efficient (3R)-acetoin and (2R,3R)- 2,3-butanediol production, Journal of Industrial Microbiology and Biotechnology, 2015, 42(6), 779-786

10.Quanming Xu, Linxiang Xie, Yongyu Li, Hui Lin, Shujing Sun, Xiong Guan, Kaihui Hu, Yaling Shen*, Liaoyuan Zhang*, Metabolic engineering of Escherichia coli for efficient production of (3R)-acetoin, Journal of Chemical Technology and Biotechnology, 20159093–100

11.Liaoyuan Zhang, Quanming Xu, Xiaoqian Peng, Boheng Xu, Yuehao Wu, Yulong Yang, Shujing Sun, Kaihui Hu, Yaling Shen*. Cloning, expression and characterization of glycerol dehydrogenase involved in 2,3-butanediol formation in Serratia marcescens H30. Journal of Industrial Microbiology and Biotechnology 201441(9)1319–1327

12.Liaoyuan Zhang*, Quanming Xu, Senran Zhan, Hui Lin, Shujing Sun, Li Sha,Xiong Guan, Kaihui Hu, Yaling Shen*A new NAD(H)-dependent meso-2,3-butanediol dehydrogenase from an industrially potential strain Serratia marcescens H30Applied Microbiology and Biotechnology201498 1175-1184

13.Jian-An Sun, Liao-Yuan Zhang, Ben Rao, Ya-Ling Shen* et al, Enhanced acetoin production by Serratia marcescens H32 with expression of a water-forming NADH oxidaseBioresource Technology201211994-98

14.Jianan Sun, Ben Rao, Liaoyuan Zhang, Yaling Shen* et al, Extraction of acetoin from fermentation broth using an acetone/phosphate aqueous two-phase system, Chemical Engineering Communications2012,19911, 1492-1503

15.Jianan SunLiaoyuan Zhang, Ben RaoYaling Shen* et alEnhanced acetoin production by Serratia marcescens H32 using statistical optimization and two-stage agitation speed control strategyBiotechnology and Bioprocess Engineering2012173),598-605

16.Ben RaoLiao Yuan ZhangJian’an SunYaling Shen* et alCharacterization and regulation of the 2,3-butanediol pathway in Serratia marcescensApplied Microbiology and Biotechnology2012935),2147-2159

要专著:
 1. Steven L Nail(美国)等著,童望宇,沈亚领,张勰旻等译,《蛋白质药物-开发与生产》,北京,化学工业出版社,2006
 2. 余儒均,李爽,沈亚领:氨基酸,《生物化学品》(王家勤主编),
1-45,北京,中国物质出版社,2001
 3.
 Moser. A 著,曲音波,沈亚领等译:《生物工艺技术学——动力学及反应器》(Springer Verlag New York Inc.授权湖南科学技术出版社,1994)